CY1115407T1 - Θοριο-227 για χρηση στην ακτινοθεραπεια ασθενειων των μαλακων ιστων - Google Patents
Θοριο-227 για χρηση στην ακτινοθεραπεια ασθενειων των μαλακων ιστωνInfo
- Publication number
- CY1115407T1 CY1115407T1 CY20141100569T CY141100569T CY1115407T1 CY 1115407 T1 CY1115407 T1 CY 1115407T1 CY 20141100569 T CY20141100569 T CY 20141100569T CY 141100569 T CY141100569 T CY 141100569T CY 1115407 T1 CY1115407 T1 CY 1115407T1
- Authority
- CY
- Cyprus
- Prior art keywords
- soft tissue
- thorio
- subject
- amount
- tissue radiation
- Prior art date
Links
- 210000004872 soft tissue Anatomy 0.000 title abstract 2
- 230000005855 radiation Effects 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 208000016247 Soft tissue disease Diseases 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 231100001180 nonmyelotoxic Toxicity 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
- A61K51/1096—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Radiology & Medical Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Radiation-Therapy Devices (AREA)
- Medicinal Preparation (AREA)
Abstract
Η εφεύρεση παρέχει μία μέθοδο για την αγωγή ασθενειών των μαλακών ιστών σε ένα θηλαστικό υποκείμενο (κατά προτίμηση το υποκείμενο είναι ένας άνθρωπος ή ένας σκύλος), όπου η εν λόγω μέθοδος περιλαμβάνει τη χορήγηση στο εν λόγω υποκείμενο μίας θεραπευτικά δραστικής ποσότητας ενός στοχεύοντος τους μαλακούς ιστούς συμπλόκου θορίου-227 και ενός συμπλοκοποιητή, όπου η εν λόγω ποσότητα είναι τέτοια ώστε να παράγεται in vivo μία αποδεκτά μη μυελοτοξική ποσότητα ραδίου-223 μέσω πυρηνικής διασπάσεως του χορηγούμενου θορίου-227.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0308731.9A GB0308731D0 (en) | 2003-04-15 | 2003-04-15 | Method of radiotherapy |
| EP04727587.0A EP1617876B1 (en) | 2003-04-15 | 2004-04-15 | Thorium-227 for use in radiotherapy of soft tissue disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1115407T1 true CY1115407T1 (el) | 2017-01-04 |
Family
ID=35385222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20141100569T CY1115407T1 (el) | 2003-04-15 | 2014-07-28 | Θοριο-227 για χρηση στην ακτινοθεραπεια ασθενειων των μαλακων ιστων |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1617876B1 (el) |
| JP (2) | JP5006032B2 (el) |
| KR (2) | KR101274867B1 (el) |
| CN (1) | CN100586484C (el) |
| AU (1) | AU2004229218B2 (el) |
| BR (1) | BRPI0409387B8 (el) |
| CA (1) | CA2522148C (el) |
| CY (1) | CY1115407T1 (el) |
| DK (1) | DK1617876T3 (el) |
| EA (1) | EA008195B1 (el) |
| ES (1) | ES2486845T3 (el) |
| IL (1) | IL171148A (el) |
| MX (1) | MXPA05010804A (el) |
| NO (1) | NO332931B1 (el) |
| NZ (3) | NZ543044A (el) |
| PL (1) | PL1617876T3 (el) |
| PT (1) | PT1617876E (el) |
| ZA (1) | ZA200507983B (el) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ543044A (en) * | 2003-04-15 | 2010-04-30 | Algeta As | Thorium-227 for use in radiotherapy of soft tissue disease |
| GB201002508D0 (en) * | 2010-02-12 | 2010-03-31 | Algeta As | Product |
| GB201007354D0 (en) * | 2010-04-30 | 2010-06-16 | Algeta Asa | Method |
| GB201105298D0 (en) * | 2011-03-29 | 2011-05-11 | Algeta Asa | Pharmaceutical preparation |
| GB201600153D0 (en) * | 2016-01-05 | 2016-02-17 | Bayer As | Isotope preparation method |
| GB201600154D0 (en) * | 2016-01-05 | 2016-02-17 | Bayer As | Isotope preparation method |
| WO2018109667A1 (en) | 2016-12-15 | 2018-06-21 | Nestec Sa | Compositions and methods that modulate white blood cells or neutrophils in a companion animal |
| FR3088769B1 (fr) * | 2018-11-15 | 2020-12-25 | Orano Med | Procede de preparation d'au moins un generateur a haute teneur en radium-228 |
| RU2767567C1 (ru) * | 2020-10-27 | 2022-03-17 | Станислав Анатольевич Дороватовский | Комплексные соединения, содержащие в своем составе радионуклид 227Th, а также бисфосфонатный фрагмент, способы их получения, а также потенциальное применение в качестве действующего вещества в составе остеотропного радиофармацевтического лекарственного препарата |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69007430T2 (de) * | 1989-06-19 | 1994-07-07 | Akzo Nobel N.V., Arnheim/Arnhem | Radioimmuntherapie unter alphapartikelausstrahlung. |
| SG52470A1 (en) * | 1992-04-13 | 1998-09-28 | Dow Chemical Co | Process for preparing macrocyclic chelating agents and formation of chelates and conjugates thereof |
| CN1073860C (zh) * | 1998-08-20 | 2001-10-31 | 中国核动力研究设计院 | 用于骨肿瘤治疗或诊断的放射性药物药盒的制备方法 |
| MY133346A (en) * | 1999-03-01 | 2007-11-30 | Biogen Inc | Kit for radiolabeling ligands with yttrium-90 |
| NO314537B1 (no) * | 1999-12-06 | 2003-04-07 | Anticancer Therapeutic Inv Sa | Reseptorbindende konjugater |
| NO312708B1 (no) * | 2000-02-21 | 2002-06-24 | Anticancer Therapeutic Inv Sa | Radioaktive liposomer til terapi |
| HUP0203743A2 (en) * | 2000-02-25 | 2003-02-28 | R Keith Frank | Actinium-225 complexes and conjugates for radioimmunotherapy |
| NO313180B1 (no) | 2000-07-04 | 2002-08-26 | Anticancer Therapeutic Inv Sa | Bensökende alfapartikkel emitterende radiofarmasöytika |
| ITMI20022411A1 (it) * | 2002-11-14 | 2004-05-15 | Bracco Imaging Spa | Agenti per la diagnosi e la terapia di tumori che espongono sulla superficie delle cellule proteine alterate. |
| NZ543044A (en) * | 2003-04-15 | 2010-04-30 | Algeta As | Thorium-227 for use in radiotherapy of soft tissue disease |
-
2004
- 2004-04-15 NZ NZ543044A patent/NZ543044A/en not_active IP Right Cessation
- 2004-04-15 CA CA2522148A patent/CA2522148C/en not_active Expired - Lifetime
- 2004-04-15 PT PT47275870T patent/PT1617876E/pt unknown
- 2004-04-15 AU AU2004229218A patent/AU2004229218B2/en not_active Expired
- 2004-04-15 NZ NZ606996A patent/NZ606996A/en not_active IP Right Cessation
- 2004-04-15 KR KR1020117003862A patent/KR101274867B1/ko not_active Expired - Lifetime
- 2004-04-15 ES ES04727587.0T patent/ES2486845T3/es not_active Expired - Lifetime
- 2004-04-15 JP JP2006506137A patent/JP5006032B2/ja not_active Expired - Lifetime
- 2004-04-15 PL PL04727587T patent/PL1617876T3/pl unknown
- 2004-04-15 CN CN200480016329A patent/CN100586484C/zh not_active Expired - Lifetime
- 2004-04-15 ZA ZA200507983A patent/ZA200507983B/en unknown
- 2004-04-15 KR KR1020057019497A patent/KR20060015507A/ko not_active Ceased
- 2004-04-15 NZ NZ595758A patent/NZ595758A/xx not_active IP Right Cessation
- 2004-04-15 DK DK04727587.0T patent/DK1617876T3/da active
- 2004-04-15 EA EA200501456A patent/EA008195B1/ru not_active IP Right Cessation
- 2004-04-15 BR BRPI0409387A patent/BRPI0409387B8/pt not_active IP Right Cessation
- 2004-04-15 EP EP04727587.0A patent/EP1617876B1/en not_active Expired - Lifetime
- 2004-04-15 MX MXPA05010804A patent/MXPA05010804A/es active IP Right Grant
-
2005
- 2005-09-28 IL IL171148A patent/IL171148A/en active IP Right Grant
- 2005-11-15 NO NO20055390A patent/NO332931B1/no unknown
-
2011
- 2011-12-02 JP JP2011265169A patent/JP5468597B2/ja not_active Expired - Lifetime
-
2014
- 2014-07-28 CY CY20141100569T patent/CY1115407T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1115407T1 (el) | Θοριο-227 για χρηση στην ακτινοθεραπεια ασθενειων των μαλακων ιστων | |
| CY1110256T1 (el) | Διαμεμβρανικο αντιγονο λεκτινης τυπου c εκφραζομενο σε καρκινο στον προστατη ανθρωπου και χρησεις αυτου | |
| ATE305313T1 (de) | Radiotherapy | |
| ATE523224T1 (de) | Verifizierung von läsionsmerkmalen mit strahlformen | |
| CY1121113T1 (el) | Θεραπεια της νοσου ρομρε | |
| CR8380A (es) | Metodos para preparar y utilizar compuestos novedosos de celulas madre y sus conjuntos | |
| Cengel et al. | PDT: what's past is prologue | |
| BR9914969A (pt) | Métodos para formar imagem, tratar e localizar tecido doente, e, dispositivo integrado de formação de imagem e de tratamento | |
| CY1120445T1 (el) | Συνδυασμοι και τροποι χορηγησης θεραπευτικων παραγοντων και θεραπεια συνδυασμου | |
| ID22689A (id) | Metode untuk mengaktifkan sel-sel yang menunjukan-sifat antigen manusia, sel-sel teraktifkan yang menunjukan sifat antigen manusia, dan penggunaannya | |
| CY1110889T1 (el) | C-αρυλο γλυκοζιτικοι sglt2 αναστολεις και μεθοδος για την παραγωγη τους | |
| CY1113489T1 (el) | Αντισωμα το οποιο δεσμευει αλφα4βητα7 ιντεγκρινη και η χρηση αυτου εις τη θεραπευτικη αγωγη της φλεγμονωδους νοσου του εντερου | |
| CR8396A (es) | Anticuerpos que se unen al receptor del interleuquina-4 | |
| CY1107084T1 (el) | Παραγωγα πυρρολοπυριδαζινης | |
| DK1217943T3 (da) | Fremgangsmåde og apparat til bestemmelse af autofluorescens af hudvæv | |
| CY1110341T1 (el) | Παραγωγα κιναζολινης και η χρηση τους στην θεραπευτικη αγωγη θρομβοκυτταραιμιας | |
| UY29284A1 (es) | Anticuerpos ab(beta) humanizados usados en mejorar la cognicion | |
| CY1114644T1 (el) | Χρηση ραδιοεπισημασμενων παραγωγων θειοφλαβινης στην απεικονιση αμυλοειδους για την αξιολογηση αντι-αμυλοειδικων θεραπειων | |
| ATE526037T1 (de) | Verfahren zum abtöten von tumorzellen mittels targeting von auf apoptotischen tumorzellen exponierten internen antigenen | |
| CY1108629T1 (el) | Συνδυασμος ετ 743 με 5 φθοριοουρακιλο προ-φαρμακα δια την θεραπευτικη αγωγη του καρκικου | |
| BRPI0607460A2 (pt) | braquiterapia periférica de órgãos protrusos moldáveis | |
| DK1699480T3 (da) | Allogent terapeutisk tumormiddel | |
| CY1119790T1 (el) | Θεραπευτικο σχημα κλαδριβινης για την θεραπευτικη αντιμετωπιση της σκληρυνσης κατα πλακας | |
| ATE442861T1 (de) | Gegen antikörper gerichtete photodynamische therapie | |
| Morton et al. | Review of the European society for photodynamic therapy (Euro-PDT) annual congress 2022 |