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CY1115388T1 - Τροποποιητες υποδοχεων κανναβινοειδων - Google Patents

Τροποποιητες υποδοχεων κανναβινοειδων

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Publication number
CY1115388T1
CY1115388T1 CY20131100499T CY131100499T CY1115388T1 CY 1115388 T1 CY1115388 T1 CY 1115388T1 CY 20131100499 T CY20131100499 T CY 20131100499T CY 131100499 T CY131100499 T CY 131100499T CY 1115388 T1 CY1115388 T1 CY 1115388T1
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CY
Cyprus
Prior art keywords
meta
ortho
group
phenyl
alkyl
Prior art date
Application number
CY20131100499T
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English (en)
Inventor
Masahiro Okuyama
David Baker
Gareth Pryce
David Selwood
Cristina Visintin
Original Assignee
Ucl Business Plc
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Filing date
Publication date
Application filed by Ucl Business Plc filed Critical Ucl Business Plc
Publication of CY1115388T1 publication Critical patent/CY1115388T1/el

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    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
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    • C07C233/66—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
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    • C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/69—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
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    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
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    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
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    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C237/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Amplifiers (AREA)

Abstract

Η παρούσα εφεύρεση αφορά μία ένωση του τύπου Ι ή ένα φαρμακευτικά αποδεκτό άλας αυτής όπου το Ζ είναι ΟR1 ή ΝR1R2 όπου έκαστο από τα R1 και R2 είναι ανεξάρτητα Η ή μία υδροκαρβυλική ομάδα· το Χ είναι μία αλκυλενική, αλκενυλενική ή αλκυνυλενική ομάδα, έκαστη εκ των οποίων μπορεί να είναι ενδεχομένως υποκατεστημένη με έναν ή περισσότερους υποκατάστατες οι οποίοι επιλέγονται από αλκύλιο, CΟΟΗ, CΟ2-αλκύλιο, αλκενύλιο, CΝ, ΝΗ2, υδροξυ, αλογόνο, αλκοξυ, CF3 και νίτρο· το Υ είναι μία πολική δραστική ομάδα η οποία επιλέγεται από ΟΗ, ΝΟ2, CΝ, CΟR3, CΟΟR3, ΝR3R4, CΟΝR3R4, SΟ3Η, SΟ2-R3, SΟ2ΝR3R4 και CF3, όπου έκαστο από τα R3 και R4 είναι ανεξάρτητα Η ή μία υδροκαρβυλική ομάδα· το Α είναι μία αρυλική ή ετεροαρυλική ομάδα, έκαστη από τις οποίες μπορεί να είναι ενδεχομένως υποκατεστημένη· και το Β είναι (CΗ2)n, όπου το n είναι 0, 1, 2, 3, 4 ή 5 ˙ με τον όρο ότι: (i) όταν το Α είναι φαινύλιο, το n είναι 0 και το Ζ είναι ΟΗ, το Χ-Υ είναι διαφορετικό από μετα-C≡C-(CΗ2)2CO2Η, μετα-C≡C-(CΗ2)2OΗ, μετα-C≡C-(CΗ2)2CO2Me, μετα-(CΗ2)4CO2Η, ορθο-CΗ2CO2Η, ορθο-(CΗ2)2CΟ2Η και ορθο-(CΗ2)4CO2Η και (ii) όταν το Α είναι φαινύλιο, το η είναι 0 και το Ζ είναι ΟΜe, ΤΟ Χ-Υ είναι διαφορετικό από μετα-C≡C-(CΗ2)4ΟΗ. Επιπλέον μορφές της εφεύρεσης αφορούν τη χρήση τέτοιων ενώσεων στην παρασκευή ενός φαρμάκου για τη θεραπευτική αγωγή μίας μυϊκής διαταραχής, μίας γαστρεντερικής διαταραχής ή για τον έλεγχο της σπαστικότητας ή του τρόμου.
CY20131100499T 2004-02-20 2013-06-19 Τροποποιητες υποδοχεων κανναβινοειδων CY1115388T1 (el)

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GB0403864A GB0403864D0 (en) 2004-02-20 2004-02-20 Modulator
EP20090012361 EP2177503B1 (en) 2004-02-20 2005-02-21 Modulators of cannabinoid receptors

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TW201808950A (zh) 2016-05-06 2018-03-16 英塞特公司 作為免疫調節劑之雜環化合物
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