[go: up one dir, main page]

CY1111693T1 - Αντιιικοι παραγοντες - Google Patents

Αντιιικοι παραγοντες

Info

Publication number
CY1111693T1
CY1111693T1 CY20111100658T CY111100658T CY1111693T1 CY 1111693 T1 CY1111693 T1 CY 1111693T1 CY 20111100658 T CY20111100658 T CY 20111100658T CY 111100658 T CY111100658 T CY 111100658T CY 1111693 T1 CY1111693 T1 CY 1111693T1
Authority
CY
Cyprus
Prior art keywords
compounds
antique
factors
formula
mammals
Prior art date
Application number
CY20111100658T
Other languages
English (en)
Inventor
Keith Watson
Guy Krippner
Pauline Stanislawski
Darryl Mcconnell
Original Assignee
Biota Scientific Management Pty. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biota Scientific Management Pty. Ltd. filed Critical Biota Scientific Management Pty. Ltd.
Publication of CY1111693T1 publication Critical patent/CY1111693T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Η εφεύρεση αυτή σχετίζεται με χημικές ενώσεις με τύπο Ι, τα άλατά τους, και τα φαρμακευτικά αποδεκτά παράγωγα αυτών, με τις φαρμακευτικές συνθέσεις που περιλαμβάνουν αυτές τις ενώσεις και τη χρήση τους στη θεραπεία μολύνσεων από πικορναϊούς σε θηλαστικά καθώς και με νέες ενδιάμεσες οι οποίες είναι χρήσιμες στην παρασκευή των ενώσεων με τύπο Ι.
CY20111100658T 2000-12-18 2011-07-06 Αντιιικοι παραγοντες CY1111693T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPR2137A AUPR213700A0 (en) 2000-12-18 2000-12-18 Antiviral agents
EP01271365A EP1353911B1 (en) 2000-12-18 2001-12-18 Antiviral agents

Publications (1)

Publication Number Publication Date
CY1111693T1 true CY1111693T1 (el) 2015-10-07

Family

ID=3826171

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100658T CY1111693T1 (el) 2000-12-18 2011-07-06 Αντιιικοι παραγοντες

Country Status (14)

Country Link
US (7) US7166604B2 (el)
EP (2) EP2314582B1 (el)
JP (3) JP4601901B2 (el)
AT (1) ATE504579T1 (el)
AU (3) AUPR213700A0 (el)
BR (1) BRPI0116299B1 (el)
CA (1) CA2431483C (el)
CY (1) CY1111693T1 (el)
DE (1) DE60144392D1 (el)
DK (2) DK2314582T3 (el)
ES (2) ES2477571T3 (el)
MX (1) MXPA03005464A (el)
PT (1) PT1353911E (el)
WO (1) WO2002050045A1 (el)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR213700A0 (en) * 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
EP1343782B1 (en) 2000-12-21 2009-05-06 SmithKline Beecham Corporation Pyrimidineamines as angiogenesis modulators
AU2002361846A1 (en) * 2001-12-21 2003-07-15 Bayer Pharmaceuticals Corporation Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
CA2522522A1 (en) 2003-04-16 2004-10-28 F. Hoffmann-La Roche Ag Quinazoline compounds
AU2004229163A1 (en) 2003-04-16 2004-10-28 F. Hoffmann-La Roche Ag (6-(phenoxy)-pyrido`3,4-d! PYRIMIDIN-2-YL)-AMINE DERIVATIVES AS P38 KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORYY CONDITIONS SUCH AS RHEUMATOIS ARTRITIS
WO2006017505A2 (en) * 2004-08-04 2006-02-16 Schering Corporation Pharmaceutical formulations comprising pleconaril for the treatment of airway diseases
US7766210B2 (en) * 2006-01-31 2010-08-03 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting and fastening instrument with user feedback system
EP1991540A1 (en) * 2006-02-21 2008-11-19 Amgen Inc. Cinnoline derivatives as phosphodiesterase 10 inhibitors
MX2008010953A (es) * 2006-02-28 2008-09-08 Amgen Inc Derivados de cinolina y quinoxalina como inhibidores de la fosfodiesterasa 10.
PE20080359A1 (es) 2006-04-19 2008-06-06 Novartis Ag Compuestos de benzoxazol y benzotiazol 6-0-sustituidos y metodos de inhibicion de la senalizacion de csf-1r
GB0608899D0 (en) * 2006-05-05 2006-06-14 Leuven K U Res & Dev Novel viral replication inhibitors
US8314119B2 (en) 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
US20080147082A1 (en) * 2006-12-13 2008-06-19 Joel Pynson Injector apparatus for use with intraocular lenses and methods of use
EP2112880A4 (en) 2006-12-14 2011-12-21 Merck Sharp & Dohme ACYLBIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND TREATMENT METHOD
NZ590286A (en) * 2008-05-27 2011-08-26 Biota Scient Management Phosphate and sulphate salts of 6-{ 2-[1-(6-methyl-3-pyrazinyl)-4-piperidinyl]ethoxy} -3-ethoxy-1,2-benzisoxazole
US20120172329A1 (en) * 2009-09-14 2012-07-05 Thailand Excellence Center For Tissue Engineering Phytochemical compositions including xanthones for anti-inflammatory, anti-cytokine storm, and other uses
JP5894540B2 (ja) 2010-02-18 2016-03-30 ブイティーブイ・セラピューティクス・エルエルシー フェニル−ヘテロアリール誘導体とその使用の方法
SG184430A1 (en) 2010-04-15 2012-11-29 Biota Scient Management Compound for treatment of respiratory condition or disease
WO2011133920A1 (en) 2010-04-23 2011-10-27 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
EP2585067B1 (en) * 2010-06-25 2017-08-09 Biota Scientific Management Pty Ltd Compound for the treatment of enteroviruses
UA111163C2 (uk) 2010-07-22 2016-04-11 Гайлід Сайєнсіз, Інк. Способи й сполуки для лікування вірусних інфекцій paramyxoviridae
CN106074548A (zh) 2010-09-23 2016-11-09 艾伯维巴哈马有限公司 氮杂金刚烷衍生物的一水合物
CN102485717B (zh) * 2010-12-06 2015-12-02 中国人民解放军军事医学科学院毒物药物研究所 噻唑胺衍生物及其作为抗小rna病毒感染药物的用途
CN103476783A (zh) 2011-04-13 2013-12-25 吉里德科学公司 用于抗病毒治疗的1’-取代的嘧啶n-核苷类似物
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use
BR112016029942A2 (pt) * 2014-06-20 2017-08-22 Aviragen Therapeutics Inc composto, forma de base livre cristalina anidra, composição farmacêutica, método para fabricação de uma forma de base livre cristalina, método de tratamento de uma infecção viral, método de tratar, aliviar, prevenir ou reduzir os sintomas ou exacerbações de asma ou doença pulmonar obstrutiva crônica e método de tratamento de doença mão, pé e boca
TWI767201B (zh) 2014-10-29 2022-06-11 美商基利科學股份有限公司 絲狀病毒科病毒感染之治療
MA52371A (fr) 2015-09-16 2021-09-22 Gilead Sciences Inc Méthodes de traitement d'infections dues aux coronaviridae
US11168068B2 (en) 2016-07-18 2021-11-09 Janssen Pharmaceutica Nv Tau PET imaging ligands
CA3056072C (en) 2017-03-14 2022-08-23 Gilead Sciences, Inc. Methods of treating feline coronavirus infections
JP2020518578A (ja) 2017-05-01 2020-06-25 ギリアード サイエンシーズ， インコーポレイテッド （Ｓ）−２−エチルブチル２−（（（Ｓ）−（（（２Ｒ，３Ｓ，４Ｒ，５Ｒ）−５−（４−アミノピロロ［２，１−ｆ］［１，２，４］トリアジン−７−イル）−５−シアノ−３，４−ジヒドロキシテトラヒドロフラン−２−イル）メトキシ）（フェノキシ）ホスホリル）アミノ）プロパノエートの結晶形態
ES3000461T3 (en) 2017-07-11 2025-02-28 Gilead Sciences Inc Compositions comprising an rna polymerase inhibitor and cyclodextrin for treating viral infections
WO2020097398A1 (en) 2018-11-07 2020-05-14 Dana-Farber Cancer Institute, Inc. Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof
JP2023512656A (ja) 2020-01-27 2023-03-28 ギリアード サイエンシーズ， インコーポレイテッド ＳＡＲＳ ＣｏＶ－２感染を治療するための方法
TWI791193B (zh) 2020-02-18 2023-02-01 美商基利科學股份有限公司 抗病毒化合物
TWI775313B (zh) 2020-02-18 2022-08-21 美商基利科學股份有限公司 抗病毒化合物
AR121356A1 (es) 2020-02-18 2022-05-11 Gilead Sciences Inc Compuestos antivirales
TWI794742B (zh) 2020-02-18 2023-03-01 美商基利科學股份有限公司 抗病毒化合物
TWI890963B (zh) 2020-03-12 2025-07-21 美商基利科學股份有限公司 1'-氰基核苷之製備方法
AU2021251689B2 (en) 2020-04-06 2024-06-13 Gilead Sciences, Inc. Inhalation formulations of 1'-cyano substituted carbanucleoside analogs
US20230144186A1 (en) * 2020-04-21 2023-05-11 The Trustees Of The University Of Pennsylvania Quinine and its use to generate innate immune response
CA3181537A1 (en) 2020-05-06 2021-11-11 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
TW202532084A (zh) 2020-05-29 2025-08-16 美商基利科學股份有限公司 瑞德西韋之治療方法
IL299202A (en) 2020-06-24 2023-02-01 Gilead Sciences Inc 1'-cyano nucleoside analogs and uses thereof
US11773122B2 (en) 2020-08-24 2023-10-03 Gilead Sciences. Inc. Phospholipid compounds and uses thereof
PE20231983A1 (es) 2020-08-27 2023-12-12 Gilead Sciences Inc Compuestos y metodos para el tratamiento de infecciones virales
TWI811812B (zh) 2020-10-16 2023-08-11 美商基利科學股份有限公司 磷脂化合物及其用途
CN112274046B (zh) * 2020-10-29 2022-07-22 温州欧迪家居用品有限公司 一种抑菌毛巾架及其制备工艺
WO2022140527A1 (en) 2020-12-23 2022-06-30 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
CA3216679A1 (en) * 2021-05-05 2022-11-10 George R. Painter Nucleotide and nucleoside therapeutic compositions, combinations and uses related thereto
EP4346772A1 (en) 2021-05-26 2024-04-10 Gilead Sciences, Inc. Phospholipid formulations of 1'-cyano substituted carba-nucleoside analogs
EP4387977A1 (en) 2021-08-18 2024-06-26 Gilead Sciences, Inc. Phospholipid compounds and methods of making and using the same
TW202325289A (zh) 2021-11-09 2023-07-01 美商雅捷可斯治療公司 Ｊａｋ２抑制劑之形式及組合物
CA3234638A1 (en) 2021-11-09 2023-05-19 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
TWI878811B (zh) 2022-03-02 2025-04-01 美商基利科學股份有限公司 用於治療病毒感染的化合物及方法
CA3244278A1 (en) 2022-03-02 2023-09-07 Gilead Sciences Inc COMPOUNDS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
US20230382940A1 (en) 2022-03-03 2023-11-30 Gilead Sciences, Inc. Antiviral compounds and methods of making and using the same
CA3252494A1 (en) 2022-03-03 2023-09-07 Gilead Sciences Inc ANTIVIRAL COMPOUNDS AND THEIR MANUFACTURING AND USAGE PROCESSES
EP4536223A1 (en) 2022-06-06 2025-04-16 Gilead Sciences, Inc. Methods for treatment of viral infections including sars-cov-2
US20240051962A1 (en) 2022-06-29 2024-02-15 Gilead Sciences, Inc. Solid forms of a nucleoside analogue and uses thereof
EP4547665A1 (en) 2022-06-30 2025-05-07 Gilead Sciences, Inc. Solid forms of a nucleoside analogue and uses thereof
US20240309028A1 (en) 2023-02-16 2024-09-19 Gilead Sciences, Inc. Phospholipid compounds and methods of making and using the same
TWI898554B (zh) 2023-04-28 2025-09-21 美商基利科學股份有限公司 用於治療病毒感染的化合物及方法
WO2025049699A1 (en) 2023-08-31 2025-03-06 Gilead Sciences, Inc. Antiviral compounds and methods of making and using the same
US20250084088A1 (en) 2023-08-31 2025-03-13 Gilead Sciences, Inc. Antiviral compounds and methods of making and using the same
WO2025054278A1 (en) 2023-09-06 2025-03-13 Gilead Sciences, Inc. Solid forms of a nucleoside analogue and uses thereof
TW202517647A (zh) 2023-09-28 2025-05-01 美商基利科學股份有限公司 用於治療病毒感染的化合物及方法
US12357577B1 (en) 2024-02-02 2025-07-15 Gilead Sciences, Inc. Pharmaceutical formulations and uses thereof

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3997565A (en) 1975-09-19 1976-12-14 E. I. Du Pont De Nemours And Company Acylcrownether oximes and oxime ethers
US4268678A (en) 1979-09-04 1981-05-19 Sterling Drug Inc. 4-(Arylaliphatic)isoxazoles
DE3132335A1 (de) 1981-08-17 1983-03-03 Bayer Ag, 5090 Leverkusen Substituierte azolyl-phenoxy-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
US4475416A (en) * 1982-07-27 1984-10-09 Borg-Warner Corporation Continuously variable transmission down shift control
US4451476A (en) 1982-12-13 1984-05-29 Sterling Drug Inc. Isoxazoles as antiviral agents
US5002960A (en) 1983-08-29 1991-03-26 Sterling Drug, Inc. N-haloalkyl-4-(isoxazol-5-yl)alkoxy benzamides
US4843087A (en) 1983-08-29 1989-06-27 Sterling Drug Inc. Di-heterocyclic compounds and their use as antiviral agents
US4861791A (en) 1983-08-29 1989-08-29 Sterling Drug Inc. Dihydro-oxazolyl substituted-phenyl-aliphatic lower alkyl and their use as antiviral agents
ZA846525B (en) * 1983-08-29 1985-04-24 Sterling Drug Inc (substituted)phenyl-aliphatic-isoxazoles useful as antiviral agents and preparation thereof
US5001125A (en) 1984-03-26 1991-03-19 Janssen Pharmaceutica N.V. Anti-virally active pyridazinamines
JPS62252783A (ja) * 1986-02-13 1987-11-04 ワ−ナ−−ランバ−ト・コンパニ− ベンズ複素環式化合物
US4861869A (en) 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
DE3618379A1 (de) 1986-05-31 1987-12-03 Bayer Ag Verfahren zur herstellung eines azol-derivates
US5051437A (en) 1986-06-24 1991-09-24 Sterling Drug Inc. Thiazolylphenoxyalkylisoxazoles, related compounds, and their use as antiviral agents
DE3716023A1 (de) 1987-05-14 1988-12-08 Bayer Ag Azolyl-tetrahydrofuran-2-yliden-methane
NZ225045A (en) 1987-07-01 1990-06-26 Janssen Pharmaceutica Nv Antiviral pharmaceutical compositions containing cyclodextrin and an antiviral agent
US4992433A (en) 1987-11-23 1991-02-12 Janssen Pharmaceutica N.V. Novel pyridazinamine derivatives
US5106973A (en) 1987-11-23 1992-04-21 Janssen Pharmaceutica N.V. Pyridzainamine derivatives
US5231184A (en) 1987-11-23 1993-07-27 Janssen Pharmaceutica N.V. Pridazinamine derivatives
MY104343A (en) * 1987-11-23 1994-03-31 Janssen Pharmaceutica Nv Novel pyridizinamine deravatives
GB8807275D0 (en) 1988-03-26 1988-04-27 Synphar Lab Inc Chemical compounds
DE3825170A1 (de) 1988-07-23 1990-01-25 Hoechst Ag, 65929 Frankfurt Substituierte 5-(4-(4,5-dihydro-2-oxazolyl)-phenoxyalkylenoxyalkyl)-isoxazole, verfahren sowie 5-(phenoxyalkylenoxyalkyl)-isoxazole als zwischenprodukte zu ihrer herstellung und ihre verwendung zur bekaempfung von krankheiten, die durch infektion mit viren hervorgerufen wurden
WO1990001874A1 (en) 1988-08-24 1990-03-08 Teijin Limited Oxime derivatives and herbicides containing the same as an active ingredient
JPH02104584A (ja) * 1988-10-14 1990-04-17 Fujisawa Pharmaceut Co Ltd 新規キノリン誘導体およびその医薬用途
US5070090A (en) 1989-05-15 1991-12-03 Janssen Pharmaceutica N.V. Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers
NZ233526A (en) 1989-05-15 1991-09-25 Janssen Pharmaceutica Nv Pyridazine derivatives and their pharmaceutical compositions
NZ233525A (en) * 1989-05-15 1991-09-25 Janssen Pharmaceutica Nv Piperidinyl, pyrrolidinyl and piperazinyl alkylphenol ethers and pharmaceutical compositions
GB8911158D0 (en) 1989-05-16 1989-07-05 Janssen Pharmaceutica Nv Antiviral pyridazinamines
US4942241A (en) 1989-08-21 1990-07-17 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5110821A (en) 1989-08-18 1992-05-05 Sterling Drug Inc. 1,3,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5175178A (en) 1989-08-21 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US4945164A (en) 1989-08-18 1990-07-31 Sterling Drug Inc. 1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof
ZA9010357B (en) 1989-12-26 1992-08-26 Janssen Pharmaceutica Nv Antipicornaviral pyridazinamines
JO1645B1 (en) 1989-12-26 1991-11-27 شركة جانسين فارماسوتيكا ان. في Pyridazine compounds are antibacterial viruses
JPH05320117A (ja) 1990-01-25 1993-12-03 Teijin Ltd オキシム誘導体のｒ光学異性体およびそれを有効成分とする除草剤
US5100893A (en) 1990-04-18 1992-03-31 Janssen Pharmaceutica N.V. Antipicornaviral pyridazinamines
US5349068A (en) 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5242924A (en) 1992-07-02 1993-09-07 Sterling Winthrop Inc. Tetrazolyl-(phenoxy and phenoxyalkyl)-piperidinylpyridazines as antiviral agents
US5364865A (en) 1992-12-30 1994-11-15 Sterling Winthrop Inc. Phenoxy- and phenoxyalkyl-piperidines as antiviral agents
WO1995004723A1 (en) * 1993-08-04 1995-02-16 Yamanouchi Pharmaceutical Co., Ltd. Imidazolylalkylamine derivative and pharmaceutical composition thereof
US5453433A (en) 1994-05-13 1995-09-26 Sterling Winthrop Inc. Thiadiazoles and antipicornaviral compositions
US5514679A (en) 1994-05-13 1996-05-07 Sterling Winthrop Inc. Therapeutic phenoxyalklpyridazines and intermediates therefor
US5552420A (en) 1994-05-13 1996-09-03 Sterling Winthrop Inc. Therapeutic phenoxyalkylazoles and phenoxyalkylazines
WO1995031438A1 (en) 1994-05-13 1995-11-23 Sanofi Winthrop, Inc. Therapeutic phenoxyalkylheterocycles
WO1996004270A1 (en) * 1994-08-04 1996-02-15 Synaptic Pharmaceutical Corporation Novel benzimidazole derivatives
JPH0881314A (ja) 1994-09-09 1996-03-26 Kumiai Chem Ind Co Ltd 除草剤組成物
US5523312A (en) 1994-09-27 1996-06-04 Sterling Winthrop Inc. Antipicornaviral agents
DE19517448A1 (de) 1995-05-12 1996-11-14 Thomae Gmbh Dr K Neue Benzothiazole und Benzoxazole, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
US5763461A (en) 1995-05-26 1998-06-09 Sanofi Therapeutic phenoxyalkylheterocycles
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
ZA9610745B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
US5891874A (en) 1996-06-05 1999-04-06 Eli Lilly And Company Anti-viral compound
GB9619284D0 (en) * 1996-09-16 1996-10-30 Celltech Therapeutics Ltd Chemical compounds
AU6811698A (en) 1996-10-23 1998-05-15 Novartis Ag Pesticides
EP1001767A4 (en) 1997-06-04 2001-07-04 Lilly Co Eli ANTIVIRAL CONNECTIONS
HUP0100287A3 (en) * 1997-11-11 2003-04-28 Pfizer Prod Inc Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
AU3665199A (en) * 1998-04-29 1999-11-16 Vertex Pharmaceuticals Incorporated Inhibitors of impdh enzyme
TR200003414T2 (tr) * 1998-05-20 2001-03-21 Eli Lilly And Company Anti-viral terkipler
JP4548642B2 (ja) * 1998-09-29 2010-09-22 アメリカン・サイアナミド・カンパニー プロテインチロシンキナーゼインヒビターとしての置換３−シアノキノリン
EP1119548B1 (en) * 1998-10-08 2004-12-08 SmithKline Beecham plc 3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1h-pyrrole-2,5-dione as glycogen synthase kinase-3 inhibitor (gsk-3)
AUPQ105499A0 (en) * 1999-06-18 1999-07-08 Biota Scientific Management Pty Ltd Antiviral agents
AUPQ288499A0 (en) 1999-09-16 1999-10-07 Biota Scientific Management Pty Ltd Antiviral agents
DE60023025T2 (de) * 1999-11-23 2006-07-13 Smithkline Beecham Corp. 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p39-kinase-inhibitoren
AU1783201A (en) * 1999-11-23 2001-06-04 Smithkline Beecham Corporation 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors
AU3789901A (en) 1999-12-17 2001-06-25 Bristol-Myers Squibb Company Antipsychotic heterocycle compounds
CN1186326C (zh) * 2000-07-05 2005-01-26 山之内制药株式会社 丙－1,3－二酮衍生物
AUPR213700A0 (en) * 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
JP5320117B2 (ja) 2009-03-18 2013-10-23 積水化学工業株式会社 電子部品用接着剤

Also Published As

Publication number Publication date
BRPI0116299B1 (pt) 2016-08-09
US20140179709A1 (en) 2014-06-26
US7579465B2 (en) 2009-08-25
JP2004517848A (ja) 2004-06-17
DE60144392D1 (de) 2011-05-19
US9303026B2 (en) 2016-04-05
US8217171B2 (en) 2012-07-10
US20040077633A1 (en) 2004-04-22
US8624025B2 (en) 2014-01-07
AU2134402A (en) 2002-07-01
ES2363234T3 (es) 2011-07-27
MXPA03005464A (es) 2004-04-20
US20090030000A1 (en) 2009-01-29
CA2431483C (en) 2013-04-30
WO2002050045A1 (en) 2002-06-27
AUPR213700A0 (en) 2001-01-25
US7829705B2 (en) 2010-11-09
US20110212966A1 (en) 2011-09-01
ES2477571T3 (es) 2014-07-17
BR0116299A (pt) 2004-03-02
EP1353911A4 (en) 2005-01-05
DK1353911T3 (da) 2011-07-18
US20070149530A1 (en) 2007-06-28
US20070149531A1 (en) 2007-06-28
AU2002221344C1 (en) 2012-02-02
CA2431483A1 (en) 2002-06-27
EP1353911B1 (en) 2011-04-06
US7166604B2 (en) 2007-01-23
JP2010031025A (ja) 2010-02-12
ATE504579T1 (de) 2011-04-15
US7951955B2 (en) 2011-05-31
EP2314582A1 (en) 2011-04-27
JP2010189434A (ja) 2010-09-02
DK2314582T3 (da) 2014-06-10
US20130005736A1 (en) 2013-01-03
JP4601901B2 (ja) 2010-12-22
PT1353911E (pt) 2011-07-06
EP1353911A1 (en) 2003-10-22
AU2002221344B2 (en) 2006-02-09
EP2314582B1 (en) 2014-04-02

Similar Documents

Publication Publication Date Title
CY1111693T1 (el) Αντιιικοι παραγοντες
NL300877I2 (nl) obeticholzuur
MA27040A1 (fr) Nucleosides substitues en 4'
DE602004008098D1 (de) Substituierte 2h-ä1,2,4ütriazoloä4,3-aüpyrazine als gsk-3-inhibitoren
BR0113838A (pt) Derivados de n-fenil-2-pirimidina-amina
ATE453636T1 (de) Substituierte 2,3-dihydro-1h-isoindol-1-one derivate und anwendungsverfahren
EA201000643A1 (ru) Замещенное производное этилендиамина для лечения микобактериальных заболеваний и фармацевтическая композиция на его основе
PT1259489E (pt) Compostos azapoliciclicos condensados con arilo.
EA199901014A1 (ru) C-4"-замещенные макролидные производные
DE60003863D1 (de) Dioxocyclopentylhydroxamsäure
ATE372995T1 (de) Benzo(b)(1,4)dioxepinderivate
PT992509E (pt) Novos derivados macrolidos
AP1564A (en) Piperazinyl sulfonic acid derivatives, their pharmaceutical compositions and methods of use.
EA200400086A1 (ru) Новые производные оксазолидинонов в качестве антибактериальных агентов
ATE268337T1 (de) C11-carbamate von antibakteriellen makroliden
SE0102055D0 (sv) New Compounds
EA200301203A1 (ru) Новые соединения и композиции как ингибиторы катепсина
ATE308540T1 (de) Antithrombosemittel
ATE284882T1 (de) Chromenylmethylpyrimidindiamine als antibakterielle wirkstoffe
EP1482933A4 (en) SIMPLIFIED AND EFFICIENT DERIVATIVES OF IMMUNOSUPPRESSANT AGENTS
DK0952157T3 (da) 9a, 11b-dehydroderivater af 9-oxim-3-keto-6-0-methylerythromycin
DE60008430D1 (de) Verbindungen mit antithrombotischer wirkung
DK1257538T3 (da) 9-alkylamino-1-nitroacridin-derivater