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CY1111211T1 - Ιμιδαζο[1,2-b]πυριδαζινες, οι διαδικασιες παρασκευης τους και η χρηση τους ως προσδεματων υποδοχεα gaba. - Google Patents

Ιμιδαζο[1,2-b]πυριδαζινες, οι διαδικασιες παρασκευης τους και η χρηση τους ως προσδεματων υποδοχεα gaba.

Info

Publication number
CY1111211T1
CY1111211T1 CY20101100829T CY101100829T CY1111211T1 CY 1111211 T1 CY1111211 T1 CY 1111211T1 CY 20101100829 T CY20101100829 T CY 20101100829T CY 101100829 T CY101100829 T CY 101100829T CY 1111211 T1 CY1111211 T1 CY 1111211T1
Authority
CY
Cyprus
Prior art keywords
imidazo
fireworks
gaba receptor
preparation procedures
compounds
Prior art date
Application number
CY20101100829T
Other languages
English (en)
Inventor
José Luis Falcó
Albert Palomer
Antonio Guglietta
Original Assignee
Ferrer Internacional, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Internacional, S.A. filed Critical Ferrer Internacional, S.A.
Publication of CY1111211T1 publication Critical patent/CY1111211T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Η εφεύρεση παρέχει νέες ιμιδαζο[1,2-b]πυριδαζίνες του τύπου (I) και φαρμακευτικά αποδεκτά άλατα, πολύμορφα, ένυδρα άλατα, ταυτομερή, στερεά διαλύματα και στερεοϊσομερή αυτών. Οι ενώσεις του τύπου (I) είναι χρήσιμες για την αγωγή ή την πρόληψη ασθενειών που σχετίζονται με τη ρύθμιση των GABAA υποδοχέων, το άγχος, την επιληψία, τις διαταραχές του ύπνου συμπεριλαμβανομένης της αϋπνίας και για την επαγωγή καταστολής-υπνώσεως, αναισθησίας, ύπνου και μυϊκής χαλαρώσεως. Η εφεύρεση παρέχει επίσης διαδικασίες συνθέσεως για την παρασκευή των εν λόγω ενώσεων και ορισμένων ενδιαμέσων καθώς επίσης και των ιδίων των ενδιαμέσων.
CY20101100829T 2006-03-29 2010-09-13 Ιμιδαζο[1,2-b]πυριδαζινες, οι διαδικασιες παρασκευης τους και η χρηση τους ως προσδεματων υποδοχεα gaba. CY1111211T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06111899A EP1845098A1 (en) 2006-03-29 2006-03-29 Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands
EP07727460A EP2010536B1 (en) 2006-03-29 2007-03-28 Imidazo [1, 2-b]pyridazines, their processes of preparation and their use as gaba receptor ligands

Publications (1)

Publication Number Publication Date
CY1111211T1 true CY1111211T1 (el) 2015-06-11

Family

ID=36323447

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100829T CY1111211T1 (el) 2006-03-29 2010-09-13 Ιμιδαζο[1,2-b]πυριδαζινες, οι διαδικασιες παρασκευης τους και η χρηση τους ως προσδεματων υποδοχεα gaba.

Country Status (22)

Country Link
US (2) US8153789B2 (el)
EP (2) EP1845098A1 (el)
JP (1) JP5091944B2 (el)
KR (1) KR20090008275A (el)
CN (1) CN101448831B (el)
AR (1) AR060212A1 (el)
AT (1) ATE471325T1 (el)
AU (1) AU2007231362B2 (el)
BR (1) BRPI0709207A2 (el)
CA (1) CA2647116C (el)
CY (1) CY1111211T1 (el)
DE (1) DE602007007203D1 (el)
DK (1) DK2010536T3 (el)
ES (1) ES2347182T3 (el)
MX (1) MX2008012274A (el)
NO (1) NO20084375L (el)
PL (1) PL2010536T3 (el)
PT (1) PT2010536E (el)
RU (1) RU2486188C9 (el)
SI (1) SI2010536T1 (el)
TW (1) TWI403512B (el)
WO (2) WO2007110437A1 (el)

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CA2555263A1 (en) * 2004-02-12 2005-09-01 Neurogen Corporation Imidazo-pyridazines, triazolo-pyridazines and related benzodiazepine receptor ligands
US8217177B2 (en) 2006-07-14 2012-07-10 Amgen Inc. Fused heterocyclic derivatives and methods of use
PE20121506A1 (es) 2006-07-14 2012-11-26 Amgen Inc Compuestos triazolopiridinas como inhibidores de c-met
US8198448B2 (en) 2006-07-14 2012-06-12 Amgen Inc. Fused heterocyclic derivatives and methods of use
FR2918061B1 (fr) 2007-06-28 2010-10-22 Sanofi Aventis Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique.
AU2008319986A1 (en) * 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. Use of novel compound having affinity for amyloid, and process for production of the same
US7868001B2 (en) * 2007-11-02 2011-01-11 Hutchison Medipharma Enterprises Limited Cytokine inhibitors
AU2008340182A1 (en) 2007-12-21 2009-07-02 The University Of Sydney Translocator protein ligands
EP2103614A1 (en) * 2008-03-18 2009-09-23 Santhera Pharmaceuticals (Schweiz) AG Substituted imidazopyrimidine, imidazopyrazine and imidazopyridazine derivatives as melanocortin-4 receptor modulators
WO2009143156A2 (en) * 2008-05-19 2009-11-26 Sepracor Inc. IMIDAZO[1,2-a]PYRIDINE COMPOUNDS
MX2011000175A (es) * 2008-06-25 2011-06-27 Envivo Pharmaceuticals Inc Compuestos heterociclicos 1,2-di-substituidos.
US20100267730A1 (en) * 2008-10-09 2010-10-21 Giuseppe Alvaro Novel compounds
PE20120900A1 (es) 2009-05-07 2012-08-14 Envivo Pharmaceuticals Inc Compuestos heterociclicos de fenoximetilo
TWI617559B (zh) * 2010-12-22 2018-03-11 江蘇恆瑞醫藥股份有限公司 ２－芳基咪唑并［１，２－ｂ］嗒．２－苯基咪唑并［１，２－ａ］吡啶，和２－苯基咪唑并［１，２－ａ］吡衍生物
UA112028C2 (uk) * 2012-12-14 2016-07-11 Пфайзер Лімітед Похідні імідазопіридазину як модулятори гамка-рецептора
GB201321734D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents

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Also Published As

Publication number Publication date
ES2347182T3 (es) 2010-10-26
BRPI0709207A2 (pt) 2011-06-28
KR20090008275A (ko) 2009-01-21
NO20084375L (no) 2008-10-17
CN101448831B (zh) 2013-05-01
AR060212A1 (es) 2008-06-04
ATE471325T1 (de) 2010-07-15
SI2010536T1 (sl) 2010-10-29
US8153789B2 (en) 2012-04-10
WO2007110437A1 (en) 2007-10-04
PT2010536E (pt) 2010-09-03
TW200813062A (en) 2008-03-16
CA2647116A1 (en) 2007-10-04
US8993562B2 (en) 2015-03-31
DE602007007203D1 (de) 2010-07-29
EP2010536A1 (en) 2009-01-07
TWI403512B (zh) 2013-08-01
WO2007110438A1 (en) 2007-10-04
AU2007231362B2 (en) 2012-07-19
EP1845098A1 (en) 2007-10-17
MX2008012274A (es) 2008-11-12
HK1127917A1 (en) 2009-10-09
US20090176788A1 (en) 2009-07-09
JP5091944B2 (ja) 2012-12-05
RU2486188C2 (ru) 2013-06-27
JP2009531384A (ja) 2009-09-03
AU2007231362A1 (en) 2007-10-04
DK2010536T3 (da) 2010-10-04
CA2647116C (en) 2013-12-31
RU2008142841A (ru) 2010-05-10
US20120040979A1 (en) 2012-02-16
PL2010536T3 (pl) 2010-11-30
EP2010536B1 (en) 2010-06-16
CN101448831A (zh) 2009-06-03
RU2486188C9 (ru) 2013-08-10

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