[go: up one dir, main page]

CY1110867T1 - Μεθοδος για τον καθαρισμο του παραγοντα vii - Google Patents

Μεθοδος για τον καθαρισμο του παραγοντα vii

Info

Publication number
CY1110867T1
CY1110867T1 CY20101100968T CY101100968T CY1110867T1 CY 1110867 T1 CY1110867 T1 CY 1110867T1 CY 20101100968 T CY20101100968 T CY 20101100968T CY 101100968 T CY101100968 T CY 101100968T CY 1110867 T1 CY1110867 T1 CY 1110867T1
Authority
CY
Cyprus
Prior art keywords
factor vii
cleaning
rfvii
rfviia
recombinant
Prior art date
Application number
CY20101100968T
Other languages
English (en)
Inventor
Rikkle Bolding Jensen
Frank Bech Nygaard
Original Assignee
Bayer Healthcare, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare, Llc filed Critical Bayer Healthcare, Llc
Publication of CY1110867T1 publication Critical patent/CY1110867T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Processing Of Solid Wastes (AREA)

Abstract

Μία μέθοδος για τον καθαρισμό του ανασυνδυασμένου Παράγοντα VII (rFVII) ή ανασυνδυασμένου ενεργοποιημένου Παράγοντα VII (rFVIIa), που περιλαμβάνει την υποβολή του rFVII ή του rFVIIa σε υγρή χρωματογραφία σε μία στήλη υδροξυαπατίτη (ΗΑΡ).
CY20101100968T 2005-01-14 2010-10-27 Μεθοδος για τον καθαρισμο του παραγοντα vii CY1110867T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64412605P 2005-01-14 2005-01-14
EP06700982A EP1841863B1 (en) 2005-01-14 2006-01-13 Method for purification of factor vii

Publications (1)

Publication Number Publication Date
CY1110867T1 true CY1110867T1 (el) 2015-06-10

Family

ID=36010990

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100968T CY1110867T1 (el) 2005-01-14 2010-10-27 Μεθοδος για τον καθαρισμο του παραγοντα vii

Country Status (10)

Country Link
US (1) US20090047723A1 (el)
EP (1) EP1841863B1 (el)
AT (1) ATE476501T1 (el)
CY (1) CY1110867T1 (el)
DE (1) DE602006015907D1 (el)
DK (1) DK1841863T3 (el)
ES (1) ES2349112T3 (el)
PL (1) PL1841863T3 (el)
PT (1) PT1841863E (el)
WO (1) WO2006074664A1 (el)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8703706B2 (en) * 2005-04-28 2014-04-22 Novo Nordisk Healthcare Ag Closed container comprising an activated factor VII polypeptide, processes for the preparation of the same, and a kit and a method for use of the kit
FR2901796A1 (fr) * 2006-05-31 2007-12-07 Lab Francais Du Fractionnement Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait
JP5956331B2 (ja) * 2009-06-16 2016-07-27 ジェンザイム・コーポレーション 組換えａａｖベクターの改良された精製方法
CA2787009C (en) 2010-01-15 2018-04-03 Bio-Rad Laboratories, Inc. Surface neutralization of apatite
US8895707B2 (en) * 2010-08-18 2014-11-25 Bio-Rad Laboratories, Inc. Elution of proteins from hydroxyapatite resins without resin deterioration
CN103282042B (zh) 2010-09-17 2014-12-10 巴克斯特国际公司 通过具有组氨酸的水性制剂在弱酸性至中性pH稳定的免疫球蛋白
AU2011343813B2 (en) 2010-12-15 2015-05-21 Takeda Pharmaceutical Company Limited Eluate collection using conductivity gradient
US9592540B2 (en) 2011-02-02 2017-03-14 Bio-Rad Laboratories, Inc. Apatite surface neutralization with alkali solutions
CN104507952B (zh) 2012-05-30 2018-08-10 生物辐射实验室股份有限公司 基于磷灰石的色谱树脂的原位恢复
CN104507955A (zh) * 2012-05-31 2015-04-08 新加坡科技研究局 采用具有多形式官能性的颗粒对免疫球蛋白g制备物的色谱纯化
US9175279B1 (en) 2013-03-15 2015-11-03 Csl Limited Method of purifying factor VII and/or factor VIIa
US10092857B2 (en) 2014-06-23 2018-10-09 Bio-Rad Laboratories, Inc. Apatite in-situ restoration
WO2015200282A1 (en) 2014-06-23 2015-12-30 Bio-Rad Laboratories, Inc. Apatite pretreatment
SG10202112746PA (en) 2016-09-13 2021-12-30 Coagulant Therapeutics Corp Factor viia glycoforms

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4470969A (en) * 1983-12-02 1984-09-11 Miles Laboratories, Inc. Process for producing a concentrate of coagulation factors VII and VIIa
US4473553A (en) * 1983-12-02 1984-09-25 Miles Laboratories, Inc. Process for producing a lipoprotein-poor concentrate of coagulation factors VII and VIIa
US4637932A (en) * 1984-10-15 1987-01-20 Miles Laboratories, Inc. Process for producing a concentrate enriched in coagulation factors VII and VIIa
US4981952A (en) * 1988-10-04 1991-01-01 Eli Lilly And Company Method for the purification of vitamin K-dependent proteins
DK38293D0 (da) * 1993-03-31 1993-03-31 Novo Nordisk As Fremstilling af proteiner
DE4406515C1 (de) * 1994-02-28 1995-10-19 Immuno Ag Verfahren zur Isolierung und Reinigung Vitamin K-abhängiger Proteine
AT408613B (de) * 1998-06-17 2002-01-25 Immuno Ag Pharmazeutisches faktor vii-präparat
US6451987B1 (en) * 1999-03-15 2002-09-17 Novo Nordisk A/S Ion exchange chromatography of proteins and peptides
DE19937218A1 (de) * 1999-08-06 2001-02-08 Aventis Behring Gmbh Verfahren zur Reindarstellung der den Blutgerinnungsfaktor VII aktivierenden Protease, ihres Proenzyms oder eines Gemisches beider Proteine mittels Affinitätschromatographie
US7897734B2 (en) * 2003-03-26 2011-03-01 Novo Nordisk Healthcare Ag Method for the production of proteins
US20070037966A1 (en) * 2004-05-04 2007-02-15 Novo Nordisk A/S Hydrophobic interaction chromatography purification of factor VII polypeptides

Also Published As

Publication number Publication date
DK1841863T3 (da) 2010-11-29
ATE476501T1 (de) 2010-08-15
DE602006015907D1 (de) 2010-09-16
ES2349112T3 (es) 2010-12-28
EP1841863A1 (en) 2007-10-10
US20090047723A1 (en) 2009-02-19
EP1841863B1 (en) 2010-08-04
PL1841863T3 (pl) 2011-05-31
WO2006074664A1 (en) 2006-07-20
PT1841863E (pt) 2010-10-25

Similar Documents

Publication Publication Date Title
CY1110867T1 (el) Μεθοδος για τον καθαρισμο του παραγοντα vii
DE502006007617D1 (de) Flüssigkeitsabsorption durch metallorganische Gerüstmaterialien
EA200702210A1 (ru) Способ очистки белков
ITTO20050525A1 (it) Lembi perfezionati per ridurre gli effetti dannosi dei detriti.
ES1058674Y (es) Maquina licuadora perfeccionada.
BRPI0407319B1 (pt) aparelho de bandeja de contato de vapor-lÍquido.
NL1030597A1 (nl) Geurafgiftesysteem.
NL1030571A1 (nl) Geurafgiftesysteem.
ITRM20020148U1 (it) Filtro aggiuntivo per sigaretta.
ITGE20040016A1 (it) Copriruota per carrelli preferibilmente per uso domestico.
DE502005007197D1 (de) Einrichtung für das Zusammentragen bzw. Sammeln von Druckprodukten
ITTO20050784A1 (it) Ruota per veicoli e procedimento per la sua realizzazione.
WO2007047539A3 (en) Localized delivery to the lymphatic system
BR0302020B1 (pt) sistema de direÇço.
ITCE20040004A1 (it) Pneumocestello per la cattura dei calcoli del coledoco.
ES1054682Y (es) Paso salvacunetas perfeccionado.
EP1899586A4 (en) STAINLESS STEEL FOR FILTER APPLICATIONS
ITRM20020188U1 (it) Traversa assorbente per letto.
NL1025449A1 (nl) Werkwijze voor de behandeling met nelfinavir.
ES1056574Y (es) Maquina envasadora de liquidos.
ITTV20050036U1 (it) Impianto per la lavorazione dei rifiuti urbani.
ES1056210Y (es) Apoyabrazos escamoteable para butacas de vehiculos o similares.
ES1057241Y (es) Dispositivo de mesa de restaurante para avisar mediante luz al camarero.
NL1025728A1 (nl) Filter voor sigaretten, die schadelijke stoffen in de sigaret vermindert.
ITVE20050001U1 (it) Borraccia.