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CY1109743T1 - Παραγωγα των 2-βενζοϋλο-ιμιδαζοπυριδινων, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη - Google Patents

Παραγωγα των 2-βενζοϋλο-ιμιδαζοπυριδινων, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη

Info

Publication number
CY1109743T1
CY1109743T1 CY20101100057T CY101100057T CY1109743T1 CY 1109743 T1 CY1109743 T1 CY 1109743T1 CY 20101100057 T CY20101100057 T CY 20101100057T CY 101100057 T CY101100057 T CY 101100057T CY 1109743 T1 CY1109743 T1 CY 1109743T1
Authority
CY
Cyprus
Prior art keywords
preparation
therapeutic
benzoylo
imidazopyridines
production
Prior art date
Application number
CY20101100057T
Other languages
English (en)
Inventor
Youssef El-Ahmad
Jean-François Peyronel
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of CY1109743T1 publication Critical patent/CY1109743T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η εφεύρεση αφορά τα παράγωγα γενικού τύπου (I) όπου : το Χ δηλώνει μια ομάδα φαινυλίου ενδεχομένως υποκαθιστούμενη, το R1 δηλώνει ένα άτομο υδρογόνου, ένα αλογόνο, μια ομάδα (C1-C6)άλκοξυ ενδεχομένως υποκαθιστούμενη, μια ομάδα (C1-C6)αλκυλίου ενδεχομένως υποκαθιστούμενη, μια ομάδα (C3-C7)κυκλοαλκυλο (C1-C6)αλκυλίου, μια ομάδα (C3-C7)κυκλοαλκυλο (C1-C6)άλκοξυ, ανυδροξύ, ένα αμίνιο, το R2 δηλώνει μία από τις ακόλουθες ομάδες : ένα άτομο υδρογόνου, μια ομάδα (C1-C6)αλκυλίου ενδεχομένως υποκαθιστούμενη, μια ομάδα (C1-C6)άλκοξυ ενδεχομένως υποκαθιστούμενη, μια ομάδα (C3-C7)κυκλοαλκυλο (C1-C6)αλκυλίου, μια ομάδα (C3-C7)κυκλοαλκυλο (C1-C6)άλκοξυ, μια ομάδα (C2-C6)αλκενυλίου, μια ομάδα (C2-C6)αλκυνυλίου, μια ομάδα -CO-R5 μια ομάδα -CO-NR6R7 μια ομάδα -CO-O-R8 μια ομάδα -NR9-CO-R10 μια ομάδα -NR11R12 ένα άτομο αλογόνου, μια ομάδα κυανό, μια ομάδα φαινυλίου ενδεχομένως υποκαθιστούμενη, το R3 δηλώνει ένα άτομο υδρογόνου, μια ομάδα (C1-C6)αλκυλίου ή ένα άτομο αλογόνου, το R4 δηλώνει ένα άτομο υδρογόνου ή ένα άτομο αλογόνου, στην κατάσταση βάσης ή σε άλας προσθήκης σε ένα οξύ. Διαδικασία παρασκευής και εφαρμογή στη θεραπευτική.
CY20101100057T 2006-07-03 2010-01-20 Παραγωγα των 2-βενζοϋλο-ιμιδαζοπυριδινων, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη CY1109743T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0606010A FR2903105A1 (fr) 2006-07-03 2006-07-03 Derives de 2-benzoyl-imidazopyridines, leur preparation et leur application en therapeutique
EP07803831A EP2040703B1 (fr) 2006-07-03 2007-07-03 Derives de 2-benzoyl-imidazopyridines, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
CY1109743T1 true CY1109743T1 (el) 2014-09-10

Family

ID=37661856

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100057T CY1109743T1 (el) 2006-07-03 2010-01-20 Παραγωγα των 2-βενζοϋλο-ιμιδαζοπυριδινων, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη

Country Status (21)

Country Link
US (1) US7902219B2 (el)
EP (1) EP2040703B1 (el)
JP (1) JP2009541469A (el)
KR (1) KR20090024775A (el)
CN (1) CN101484163A (el)
AT (1) ATE446089T1 (el)
AU (1) AU2007271082A1 (el)
BR (1) BRPI0713260A2 (el)
CA (1) CA2656045A1 (el)
CY (1) CY1109743T1 (el)
DE (1) DE602007002915D1 (el)
DK (1) DK2040703T3 (el)
ES (1) ES2335323T3 (el)
FR (1) FR2903105A1 (el)
IL (1) IL195818A0 (el)
MX (1) MX2008016558A (el)
PL (1) PL2040703T3 (el)
PT (1) PT2040703E (el)
RU (1) RU2009103300A (el)
SI (1) SI2040703T1 (el)
WO (1) WO2008003854A2 (el)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2925905B1 (fr) * 2008-01-02 2010-11-05 Sanofi Aventis DERIVES DE 2-BENZOYL-IMIDAZO°1,2-a!PYRIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2925907B1 (fr) * 2008-01-02 2010-10-15 Sanofi Aventis DERIVES DE 2-HETEROAROYL-IMIDAZO°1,2-a!PYRIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2928924B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique
FR2928922B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique
FR2928921B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines, leur preparation et leur application en therapeutique
FR2928923B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques
FR2933609B1 (fr) 2008-07-10 2010-08-27 Fournier Lab Sa Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson.
FR2950053B1 (fr) 2009-09-11 2014-08-01 Fournier Lab Sa Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson
FR2955110A1 (fr) 2010-01-08 2011-07-15 Fournier Lab Sa Nouveaux derives de type pyrrolopyridine benzoique
CN103772381B (zh) * 2013-09-16 2015-11-25 广东华南新药创制中心 一种四稠环喹啉类化合物及其制备方法
WO2021204626A1 (en) 2020-04-06 2021-10-14 Almirall, S.A. Aryl and heteroaryl-carboxamide substituted heteroaryl compounds as tyk2 inhibitors

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FR2638161B1 (fr) * 1988-10-24 1991-01-11 Centre Nat Rech Scient Nouvelles benzoyl-2 imidazo (1,2-a) pyridines et leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
AU2001249672A1 (en) * 2000-03-31 2001-10-15 Ortho-Mcneil Pharmaceutical, Inc. Method for using 2- or 3-aryl substituted imidazo(1,2-a) pyridines as h3 antagonists
DE10117184A1 (de) 2001-04-05 2002-10-17 Gruenenthal Gmbh Substituierte Imidazol[1,2-a]-pyridin-3-yl-amid- und -aminverbindungen
JP5082033B2 (ja) * 2001-12-21 2012-11-28 エグゼリクシス パテント カンパニー エルエルシー Ｌｘｒのモジュレーター
GB0303503D0 (en) 2003-02-14 2003-03-19 Novartis Ag Organic compounds
WO2004089366A1 (en) * 2003-04-10 2004-10-21 Pfizer Japan, Inc. Bicyclic compounds as nr2b receptor antagonists
PE20050952A1 (es) 2003-09-24 2005-12-19 Novartis Ag Derivados de isoquinolina como inhibidores de b-raf
JP4842829B2 (ja) * 2003-10-31 2011-12-21 武田薬品工業株式会社 含窒素縮合複素環化合物
EP1684762A4 (en) 2003-11-13 2009-06-17 Ambit Biosciences Corp UREA DERIVATIVES AS MODULATORS OF KINASE
AU2005278959A1 (en) 2004-08-31 2006-03-09 Astrazeneca Ab Quinazolinone derivatives and their use as B-Raf inhibitors
EP1831198B1 (en) 2004-12-22 2009-04-08 AstraZeneca AB Pyridine carboxamide derivatives for use as anticancer agents
AR053992A1 (es) 2004-12-22 2007-05-30 Astrazeneca Ab Compuestos quimicos con actividad anticancerosa, un procedimiento para su preparacion, su uso en la preparacion de medicamentos y composicion farmaceutica.

Also Published As

Publication number Publication date
CN101484163A (zh) 2009-07-15
RU2009103300A (ru) 2010-08-10
DK2040703T3 (da) 2010-03-08
KR20090024775A (ko) 2009-03-09
JP2009541469A (ja) 2009-11-26
DE602007002915D1 (de) 2009-12-03
FR2903105A1 (fr) 2008-01-04
ES2335323T3 (es) 2010-03-24
EP2040703B1 (fr) 2009-10-21
WO2008003854A3 (fr) 2008-03-06
PL2040703T3 (pl) 2010-03-31
SI2040703T1 (sl) 2010-02-26
ATE446089T1 (de) 2009-11-15
BRPI0713260A2 (pt) 2012-04-03
US7902219B2 (en) 2011-03-08
IL195818A0 (en) 2009-09-01
MX2008016558A (es) 2009-05-20
AU2007271082A1 (en) 2008-01-10
PT2040703E (pt) 2010-01-19
WO2008003854A2 (fr) 2008-01-10
CA2656045A1 (fr) 2008-01-10
US20090143420A1 (en) 2009-06-04
EP2040703A2 (fr) 2009-04-01

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