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CY1105573T1 - Πυρρολο πυριμιδινες ως ανασταλτικοι παραγοντες των πρωτεασων κυστεϊνης - Google Patents

Πυρρολο πυριμιδινες ως ανασταλτικοι παραγοντες των πρωτεασων κυστεϊνης

Info

Publication number
CY1105573T1
CY1105573T1 CY20061101095T CY061101095T CY1105573T1 CY 1105573 T1 CY1105573 T1 CY 1105573T1 CY 20061101095 T CY20061101095 T CY 20061101095T CY 061101095 T CY061101095 T CY 061101095T CY 1105573 T1 CY1105573 T1 CY 1105573T1
Authority
CY
Cyprus
Prior art keywords
inhibitors
cysteine proteases
cathepsin
pyrimidines
pyrrolo
Prior art date
Application number
CY20061101095T
Other languages
English (en)
Inventor
Claudia Betschart
Kenji Hayakawa
Osamu Irie
Junichi Sakaki
Genji Iwasaki
Rene Lattmann
Martin Missbach
Naoki Teno
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1105573T1 publication Critical patent/CY1105573T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Η ανακάλυψη παρέχει ενώσεις με τύπο I ή ένα φαρμακευτικώς αποδεκτό άλας ή εστέρα τους όπου τα σύμβολα έχουν τους προαναφερθέντες ορισμούς, οι οποίες είναι αναστολείς της καθεψίνης Κ και χρησιμοποιούνται στη φαρμακευτική για την αγωγή νόσων και ιατρικών καταστάσεων όπου εμπλέκεται η καθεψίνη Κ, π.χ. διαφόρων διαταραχών συμπεριλαμβανομένης της φλεγμονής, της ρευματοειδούς αρθρίτιδας, της οστεοαρθρίτιδας, της οστεοπόρωσης και των όγκων.
CY20061101095T 2001-08-30 2006-08-03 Πυρρολο πυριμιδινες ως ανασταλτικοι παραγοντες των πρωτεασων κυστεϊνης CY1105573T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0121033.5A GB0121033D0 (en) 2001-08-30 2001-08-30 Organic compounds
PCT/EP2002/009663 WO2003020721A1 (en) 2001-08-30 2002-08-29 Pyrrolo pyrimidines as agents for the inhibition of cystein proteases

Publications (1)

Publication Number Publication Date
CY1105573T1 true CY1105573T1 (el) 2010-07-28

Family

ID=9921234

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061101095T CY1105573T1 (el) 2001-08-30 2006-08-03 Πυρρολο πυριμιδινες ως ανασταλτικοι παραγοντες των πρωτεασων κυστεϊνης

Country Status (29)

Country Link
US (2) US7452886B2 (el)
EP (1) EP1423391B8 (el)
JP (1) JP4629334B2 (el)
KR (1) KR100695845B1 (el)
CN (1) CN100372849C (el)
AR (1) AR036374A1 (el)
AT (1) ATE326469T1 (el)
AU (1) AU2002333760B2 (el)
BR (1) BR0212226A (el)
CA (1) CA2458684C (el)
CY (1) CY1105573T1 (el)
DE (1) DE60211530T2 (el)
DK (1) DK1423391T3 (el)
EC (1) ECSP044998A (el)
ES (1) ES2262888T3 (el)
GB (1) GB0121033D0 (el)
HU (1) HUP0401301A3 (el)
IL (3) IL160367A0 (el)
MX (1) MXPA04001935A (el)
MY (1) MY157368A (el)
NO (1) NO328890B1 (el)
NZ (1) NZ531343A (el)
PE (1) PE20030418A1 (el)
PL (1) PL368280A1 (el)
PT (1) PT1423391E (el)
RU (1) RU2331644C2 (el)
TW (1) TWI297690B (el)
WO (1) WO2003020721A1 (el)
ZA (1) ZA200401042B (el)

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Also Published As

Publication number Publication date
CN100372849C (zh) 2008-03-05
US7452886B2 (en) 2008-11-18
CA2458684A1 (en) 2003-03-13
US20090054467A1 (en) 2009-02-26
TWI297690B (en) 2008-06-11
NZ531343A (en) 2006-01-27
PT1423391E (pt) 2006-09-29
NO20041180L (no) 2004-03-19
CA2458684C (en) 2009-04-07
ZA200401042B (en) 2004-10-25
RU2331644C2 (ru) 2008-08-20
GB0121033D0 (en) 2001-10-24
ATE326469T1 (de) 2006-06-15
JP4629334B2 (ja) 2011-02-09
ECSP044998A (es) 2004-04-28
CN1549817A (zh) 2004-11-24
HK1072254A1 (zh) 2005-08-19
EP1423391A1 (en) 2004-06-02
BR0212226A (pt) 2004-08-17
IL160367A (en) 2009-12-24
KR100695845B1 (ko) 2007-03-20
EP1423391B1 (en) 2006-05-17
US20050054851A1 (en) 2005-03-10
EP1423391B8 (en) 2007-12-12
DE60211530D1 (de) 2006-06-22
HUP0401301A2 (hu) 2004-10-28
AU2002333760B2 (en) 2007-01-04
IL160367A0 (en) 2004-07-25
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RU2004109815A (ru) 2005-10-20
JP2005502683A (ja) 2005-01-27
MXPA04001935A (es) 2004-06-15
IL198643A (en) 2010-12-30
NO328890B1 (no) 2010-06-07
WO2003020721A1 (en) 2003-03-13
ES2262888T3 (es) 2006-12-01
KR20040029123A (ko) 2004-04-03
PL368280A1 (en) 2005-03-21
DE60211530T2 (de) 2006-12-21
MY157368A (en) 2016-06-15
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PE20030418A1 (es) 2003-06-12
AR036374A1 (es) 2004-09-01

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