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CU23701A1 - Método de tratamiento de enfermedades inflamatorias intestinales y diabetes tipo i - Google Patents

Método de tratamiento de enfermedades inflamatorias intestinales y diabetes tipo i

Info

Publication number
CU23701A1
CU23701A1 CU20080254A CU20080254A CU23701A1 CU 23701 A1 CU23701 A1 CU 23701A1 CU 20080254 A CU20080254 A CU 20080254A CU 20080254 A CU20080254 A CU 20080254A CU 23701 A1 CU23701 A1 CU 23701A1
Authority
CU
Cuba
Prior art keywords
type
treatment
peptide
diabetes
inflammatory diseases
Prior art date
Application number
CU20080254A
Other languages
English (en)
Inventor
Valdes Ivon Menendez
Cama Viviana Falcon
Betancourt Ariana Barbera
Perez Norailys Lorenzo
Horta Maria Del Carmen Dominguez
Palomares Gabriel Ramon Padron
Original Assignee
Ct Ingenieria Genetica Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Ingenieria Genetica Biotech filed Critical Ct Ingenieria Genetica Biotech
Priority to CU20080254A priority Critical patent/CU23701A1/es
Priority to PCT/CU2009/000009 priority patent/WO2010075824A1/es
Priority to MX2011007033A priority patent/MX2011007033A/es
Priority to EP09804226.0A priority patent/EP2374468B1/en
Priority to DK09804226.0T priority patent/DK2374468T3/da
Priority to RU2011131872/15A priority patent/RU2524630C2/ru
Priority to US13/142,471 priority patent/US8410057B2/en
Priority to ES09804226.0T priority patent/ES2438096T3/es
Priority to BRPI0923832-8A priority patent/BRPI0923832B1/pt
Priority to KR1020117017870A priority patent/KR101620341B1/ko
Priority to CN200980156252.0A priority patent/CN102307587B/zh
Priority to JP2011543973A priority patent/JP5646506B2/ja
Priority to AU2009335405A priority patent/AU2009335405B2/en
Priority to CA2748493A priority patent/CA2748493C/en
Priority to ZA2011/05320A priority patent/ZA201105320B/en
Publication of CU23701A1 publication Critical patent/CU23701A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se relaciona con el campo de la medicina, particularmente con el uso de péptido tipo APL, derivado de la proteína de estrés térmico de 60 kDa humana, o sus análogos para la fabricación de una composición farmacéutica para el tratamiento de la enfermedad de Crohn, la colitis ulcerosa y la diabetes mellitus tipo I. Dicho péptido se biodistribuye al tracto gastrointestinal y promueve la inducción de apoptosis de células T activadas de la lámina propia intestinal y de la sangre periférica de pacientes con la enfermedad de Crohn. Además, este péptido induce apoptosis en células mononucleares de pacientes con diabetes mellitus tipo I.
CU20080254A 2008-12-29 2008-12-29 Método de tratamiento de enfermedades inflamatorias intestinales y diabetes tipo i CU23701A1 (es)

Priority Applications (15)

Application Number Priority Date Filing Date Title
CU20080254A CU23701A1 (es) 2008-12-29 2008-12-29 Método de tratamiento de enfermedades inflamatorias intestinales y diabetes tipo i
PCT/CU2009/000009 WO2010075824A1 (es) 2008-12-29 2009-12-29 Uso de peptido tipo apl para el tratamiento de enfermedades inflamatorias intestinales y diabetes tipo i
MX2011007033A MX2011007033A (es) 2008-12-29 2009-12-29 Uso de peptido tipo apl para el tratamiento de enfermedades inflamatorias intestinales y diabetes tipo i.
EP09804226.0A EP2374468B1 (en) 2008-12-29 2009-12-29 Use of apl-type peptide for treating intestinal inflammatory diseases and type 1 diabetes
DK09804226.0T DK2374468T3 (da) 2008-12-29 2009-12-29 Anvendelse af peptid af APL-typen til behandling af inflammatoriske tarmsygdomme og type 1-diabetes
RU2011131872/15A RU2524630C2 (ru) 2008-12-29 2009-12-29 Применение apl пептида для лечения воспалительной болезни кишечника и диабета типа 1
US13/142,471 US8410057B2 (en) 2008-12-29 2009-12-29 Method of inducing T cell apoptosis by administering Altered Peptide Ligand
ES09804226.0T ES2438096T3 (es) 2008-12-29 2009-12-29 Utilización de péptidos tipo LPA para el tratamiento de enfermedades inflamatorias intestinales y diabetes tipo 1
BRPI0923832-8A BRPI0923832B1 (pt) 2008-12-29 2009-12-29 Uso de um peptídeo tipo apl para o tratamento de doenças inflamatórias intestinais e diabetes tipo 1.
KR1020117017870A KR101620341B1 (ko) 2008-12-29 2009-12-29 염증성장질환 및 1형 당뇨병치료를 위한 ａｐｌ 펩티드의 사용
CN200980156252.0A CN102307587B (zh) 2008-12-29 2009-12-29 Apl肽用于治疗炎症性肠病和1型糖尿病的用途
JP2011543973A JP5646506B2 (ja) 2008-12-29 2009-12-29 腸の炎症性疾患及び１型糖尿病を治療するためのａｐｌ型ペプチドの使用
AU2009335405A AU2009335405B2 (en) 2008-12-29 2009-12-29 Use of an APL peptide for the treatment of inflammatory bowel disease and type 1 diabetes
CA2748493A CA2748493C (en) 2008-12-29 2009-12-29 Use of apl-type peptide for treating intestinal inflammatory diseases and type 1 diabetes
ZA2011/05320A ZA201105320B (en) 2008-12-29 2011-07-19 Use of apl-type peptide for treating intestinal inflammatory diseases and type 1 diabetes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20080254A CU23701A1 (es) 2008-12-29 2008-12-29 Método de tratamiento de enfermedades inflamatorias intestinales y diabetes tipo i

Publications (1)

Publication Number Publication Date
CU23701A1 true CU23701A1 (es) 2011-09-21

Family

ID=41820665

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20080254A CU23701A1 (es) 2008-12-29 2008-12-29 Método de tratamiento de enfermedades inflamatorias intestinales y diabetes tipo i

Country Status (15)

Country Link
US (1) US8410057B2 (es)
EP (1) EP2374468B1 (es)
JP (1) JP5646506B2 (es)
KR (1) KR101620341B1 (es)
CN (1) CN102307587B (es)
AU (1) AU2009335405B2 (es)
BR (1) BRPI0923832B1 (es)
CA (1) CA2748493C (es)
CU (1) CU23701A1 (es)
DK (1) DK2374468T3 (es)
ES (1) ES2438096T3 (es)
MX (1) MX2011007033A (es)
RU (1) RU2524630C2 (es)
WO (1) WO2010075824A1 (es)
ZA (1) ZA201105320B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1258048A1 (zh) 2015-09-01 2019-11-01 First Wave Bio, Inc. 用於治疗与异常炎症反应相关的病症的方法和组合物
CU24508B1 (es) * 2017-12-29 2021-04-07 Centro De Ingenieria Genetica Y Biotecnologia Biocubafarma Composición farmacéutica que comprende péptido tipo apl
US10980756B1 (en) 2020-03-16 2021-04-20 First Wave Bio, Inc. Methods of treatment
CU20200026A7 (es) * 2020-04-13 2021-11-04 Ct Ingenieria Genetica Biotecnologia Péptido para el tratamiento del síndrome de la tormenta de citocinas
CN115671253B (zh) * 2021-07-30 2024-02-27 河北菲尼斯生物技术有限公司 Se-dr亲和肽在制备治疗风湿疾病的药物中的用途
KR20250040663A (ko) * 2022-07-22 2025-03-24 센트로 데 인제니에리아 제네티카 와이 바이오테크놀로지아 아포지질단백질 ai 또는 트랜스티레틴 내 문제와 연관된 질병을 치료하기 위한 펩타이드

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8003A (en) * 1851-03-25 Improvement in scythe-tastenings
PL184145B1 (pl) * 1994-12-21 2002-09-30 Yeda Res & Dev Analogi peptydu p277, środek diagnostyczny do diagnozowania IDDM, sposób wykrywania IDDM, środek farmaceutyczny do leczenia lub zapobiegania IDDM
US6180103B1 (en) * 1994-12-21 2001-01-30 Yeda Research And Development Co., Ltd. Peptide p277 analogs, and pharmaceutical compositions comprising them for treatment or diagnosis of diabetes
US6110746A (en) * 1995-06-30 2000-08-29 Yeda Research And Development Co. Ltd. Peptides derived from human heat shock protein 60 for treatment of diabetes, compositions, methods and kits
IL114407A0 (en) * 1995-06-30 1995-10-31 Yeda Res & Dev Novel peptides and pharmaceutical compositions comprising them
WO2001043691A2 (en) * 1999-12-15 2001-06-21 Peptor Ltd. Fragments and antagonists of heat shock protein 60
EP1687423A4 (en) * 2003-11-24 2007-04-18 Yeda Res & Dev HSP60 PEPTIDE FRAGMENT-ENCODING DNA VACCINES FOR THE TREATMENT OF AUTOIMMUNE DISEASES
CU23504A1 (es) * 2004-09-24 2010-04-13 Ct Ingenieria Genetica Biotech Péptidos y derivados tipo apl de la hsp60 y composiciones farmacéuticas

Also Published As

Publication number Publication date
US20120035106A1 (en) 2012-02-09
DK2374468T3 (da) 2013-12-09
ES2438096T3 (es) 2014-01-15
EP2374468B1 (en) 2013-09-11
EP2374468A1 (en) 2011-10-12
CN102307587B (zh) 2014-04-30
AU2009335405A1 (en) 2011-08-25
CA2748493A1 (en) 2010-07-08
BRPI0923832A2 (pt) 2015-07-21
JP5646506B2 (ja) 2014-12-24
RU2524630C2 (ru) 2014-07-27
BRPI0923832B1 (pt) 2019-09-24
US8410057B2 (en) 2013-04-02
RU2011131872A (ru) 2013-02-10
KR20110119677A (ko) 2011-11-02
CN102307587A (zh) 2012-01-04
CA2748493C (en) 2017-08-22
ZA201105320B (en) 2012-04-25
WO2010075824A1 (es) 2010-07-08
KR101620341B1 (ko) 2016-05-12
AU2009335405B2 (en) 2013-07-18
JP2012514013A (ja) 2012-06-21
MX2011007033A (es) 2011-07-20

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