CO6321168A2 - Nuevos derivados de 2-amidotiadiazol - Google Patents
Nuevos derivados de 2-amidotiadiazolInfo
- Publication number
- CO6321168A2 CO6321168A2 CO11040295A CO11040295A CO6321168A2 CO 6321168 A2 CO6321168 A2 CO 6321168A2 CO 11040295 A CO11040295 A CO 11040295A CO 11040295 A CO11040295 A CO 11040295A CO 6321168 A2 CO6321168 A2 CO 6321168A2
- Authority
- CO
- Colombia
- Prior art keywords
- groups
- group
- hydrogen atom
- alkyl
- substituents selected
- Prior art date
Links
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 abstract 3
- -1 hydroxycarbonyl groups Chemical group 0.000 abstract 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical group OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Nuevos derivados de 2-amidotiadiazol que tienen la estructura química representada por la fórmula (I) o sales o N-óxidos de los mismos farmacéuticamente aceptablesR1 representa:un grupo heteroarilo que contiene N, bicíclico, de 8 a 10 miembros, opcionalmente sustituido con uno o más sustituyentes seleccionados de átomos de halógeno, grupos hidroxicarbonilo, grupos alquilo C1-4, grupos haloalquilo C1-4, grupos alcoxi C1-4 y grupos cicloalquilo C3-4;un grupo piridilo sustituido con uno o más sustituyentes seleccionados de átomos de halógeno, grupos hidroxi, grupos hidroxicarbonilo, grupos alquilo C1-4, grupos haloalquilo C1-4, grupos alcoxi C1-4, grupos cicloalquilo C3-4 y grupos -NR'R", donde R' representa un átomo de hidrógeno o un grupo alquilo C1-4 y R" representa un átomo de hidrógeno o un grupo alquilo C1-4 opcionalmente sustituido con un grupo hidroxi;un grupo piridona sustituido con uno o más sustituyentes seleccionados de átomos de halógeno, grupos alquilo C1-4 y grupos haloalquilo C1-4; oun grupo de fórmula:donde:Ra representa un átomo de hidrógeno o un grupo alquilo C1-4,Rb representa un átomo de hidrógeno, átomo de halógeno o grupo alquilo C1-4,Rd representa un átomo de hidrógeno, un grupo alquilo C1-4 o un grupo cicloalquilo C3-4,Rc representa un grupo hidroxi; un grupo alcoxi C1-4 que está opcionalmente sustituido con uno o más sustituyentes seleccionados de grupos hidroxi, grupos alcoxi C1-3, ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08382042A EP2177521A1 (en) | 2008-10-14 | 2008-10-14 | New 2-Amidothiadiazole Derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6321168A2 true CO6321168A2 (es) | 2011-09-20 |
Family
ID=40386238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO11040295A CO6321168A2 (es) | 2008-10-14 | 2011-04-01 | Nuevos derivados de 2-amidotiadiazol |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20110200557A1 (es) |
| EP (2) | EP2177521A1 (es) |
| JP (1) | JP2012505260A (es) |
| KR (1) | KR20110067034A (es) |
| CN (1) | CN102186847A (es) |
| AR (1) | AR073821A1 (es) |
| AU (1) | AU2009304274A1 (es) |
| BR (1) | BRPI0914371A2 (es) |
| CA (1) | CA2740614A1 (es) |
| CL (1) | CL2011000795A1 (es) |
| CO (1) | CO6321168A2 (es) |
| EA (1) | EA201100612A1 (es) |
| EC (1) | ECSP11010842A (es) |
| IL (1) | IL211290A0 (es) |
| MX (1) | MX2011003692A (es) |
| PE (1) | PE20110420A1 (es) |
| TW (1) | TW201018679A (es) |
| UY (1) | UY32167A (es) |
| WO (1) | WO2010043377A1 (es) |
| ZA (1) | ZA201101236B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ606849A (en) * | 2010-08-31 | 2014-08-29 | Dow Agrosciences Llc | Substituted amino thiadiazole pesticidal compositions |
| RU2448961C1 (ru) * | 2011-02-03 | 2012-04-27 | Открытое акционерное общество "Всероссийский научный центр по безопасности биологически активных веществ" (ОАО "ВНЦ БАВ") | Фармацевтическая композиция, обладающая противовоспалительной, бронхолитической, противотуберкулезной активностями |
| ES2564972T3 (es) | 2011-03-18 | 2016-03-30 | Bayer Intellectual Property Gmbh | Derivados de N-(3-carbamoilfenil)-1H-pirazol-5-carboxamida y su uso para combatir parásitos animales |
| CN102276554B (zh) * | 2011-06-28 | 2013-10-30 | 四川大学 | 4-（（2-氨基-5-巯基-1,3,4-噻二唑）-甲基）-苯甲酰胺衍生物及其制备方法和用途 |
| FR2988000A1 (fr) * | 2012-03-16 | 2013-09-20 | Thomas Wandji | Composition pharmaceutique active dans la therapie des affections virales humaines et animales |
| JP6482466B2 (ja) * | 2012-11-03 | 2019-03-13 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | サイトメガロウイルスの阻害剤 |
| EP2914592B1 (en) | 2012-11-03 | 2017-10-11 | Boehringer Ingelheim International GmbH | Inhibitors of cytomegalovirus |
| WO2014111871A1 (en) | 2013-01-17 | 2014-07-24 | Aurigene Discovery Technologies Limited | 4,5-dihydroisoxazole derivatives as nampt inhibitors |
| MA41139A (fr) | 2014-12-11 | 2017-10-17 | Actelion Pharmaceuticals Ltd | Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1 |
| WO2016091996A1 (en) | 2014-12-11 | 2016-06-16 | Actelion Pharmaceuticals Ltd | Dosing regimen for a selective s1p1 receptor agonist |
| CN106397149B (zh) * | 2016-08-26 | 2019-05-21 | 大连奇凯医药科技有限公司 | 五氟苯甲醛的制备方法 |
| PL3619196T3 (pl) | 2017-05-04 | 2022-08-29 | Bayer Cropscience Aktiengesellschaft | Pochodne 2-{[2-(fenyloksymetylo)pirydyn-5-yl]oksy}-etanoaminy i związki pokrewne jako środki do zwalczania szkodników np. do ochrony upraw |
| RU2672887C1 (ru) * | 2018-03-13 | 2018-11-20 | Акционерное общество "Всесоюзный научный центр по безопасности биологически активных веществ (АО "ВНЦ БАВ") | N-(5-Этил-1,3,4-тиадиазол-2-ил)-2-пропилпентанамид, обладающий противоэпилептической и обезболивающей активностями |
| CN114149297A (zh) * | 2021-12-07 | 2022-03-08 | 北京中医药大学 | 一种微波辅助的选择性芳基甲醛的绿色合成方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2303792A (en) | 1992-06-23 | 1994-01-24 | Motorola, Inc. | Multi-modulation scheme compatible radio |
| CA2378713C (en) | 1995-06-21 | 2003-08-12 | Asta Medica Aktiengesellschaft | Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments |
| RU2003133750A (ru) * | 2001-04-19 | 2005-05-10 | Байер АГ (DE) | Арилсульфонамиды в качестве антивирусных агентов |
| DE10129703A1 (de) | 2001-06-22 | 2003-01-02 | Sofotec Gmbh & Co Kg | Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren |
| DE10202940A1 (de) | 2002-01-24 | 2003-07-31 | Sofotec Gmbh & Co Kg | Patrone für einen Pulverinhalator |
| ES2316758T3 (es) | 2002-05-16 | 2009-04-16 | Novartis Ag | Uso de aglutinantes del receptor edg en el cancer. |
| GB0217152D0 (en) | 2002-07-24 | 2002-09-04 | Novartis Ag | Organic compounds |
| EP1484057A1 (en) | 2003-06-06 | 2004-12-08 | Aventis Pharma Deutschland GmbH | Use of 2-amino-1-3-propanediol derivatives for the manufacture of a medicament for the treatment of various types of pain |
| EP1663188B1 (en) | 2003-09-12 | 2016-08-10 | Newron Sweden AB | Treatment of disorders of the nervous system |
| CN1859908A (zh) * | 2003-10-01 | 2006-11-08 | 默克公司 | 作为s1p受体激动剂的3,5－芳基、杂芳基或环烷基取代的－1,2,4－噁二唑类化合物 |
| GB0329498D0 (en) | 2003-12-19 | 2004-01-28 | Novartis Ag | Organic compounds |
| EP1986623A2 (en) | 2006-01-27 | 2008-11-05 | University Of Virginia Patent Foundation | Method for treatment of neuropathic pain |
| TWI389683B (zh) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
| US8318812B2 (en) | 2006-06-02 | 2012-11-27 | The Ohio State University Research Foundation | Therapeutic agents for the treatment of lymphoid malignancies |
| GB0612721D0 (en) | 2006-06-27 | 2006-08-09 | Novartis Ag | Organic compounds |
| SI2056807T1 (sl) | 2006-08-17 | 2012-12-31 | University Of Chicago | Zdravljenje vnetnih bolezni |
| CL2007002594A1 (es) * | 2006-09-08 | 2008-06-06 | Actelion Pharmaceuticals Ltd | Compuestos derivados de piridin-3-il, agentes inmunomoduladores; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de enfermedades asociadas con un sistema inmunologico activado. . |
| WO2008091967A1 (en) * | 2007-01-26 | 2008-07-31 | Smithkline Beecham Corporation | Chemical compounds |
| GB0704394D0 (en) * | 2007-03-07 | 2007-04-11 | Senexis Ltd | Compounds |
-
2008
- 2008-10-14 EP EP08382042A patent/EP2177521A1/en not_active Withdrawn
-
2009
- 2009-10-07 UY UY0001032167A patent/UY32167A/es unknown
- 2009-10-12 TW TW098134501A patent/TW201018679A/zh unknown
- 2009-10-13 KR KR1020117008028A patent/KR20110067034A/ko not_active Withdrawn
- 2009-10-13 PE PE2011000839A patent/PE20110420A1/es not_active Application Discontinuation
- 2009-10-13 CN CN2009801409906A patent/CN102186847A/zh active Pending
- 2009-10-13 CA CA2740614A patent/CA2740614A1/en not_active Abandoned
- 2009-10-13 JP JP2011531391A patent/JP2012505260A/ja active Pending
- 2009-10-13 AU AU2009304274A patent/AU2009304274A1/en not_active Abandoned
- 2009-10-13 BR BRPI0914371A patent/BRPI0914371A2/pt not_active IP Right Cessation
- 2009-10-13 US US13/123,932 patent/US20110200557A1/en not_active Abandoned
- 2009-10-13 MX MX2011003692A patent/MX2011003692A/es not_active Application Discontinuation
- 2009-10-13 EP EP09820269A patent/EP2334670A1/en not_active Withdrawn
- 2009-10-13 WO PCT/EP2009/007348 patent/WO2010043377A1/en not_active Ceased
- 2009-10-13 AR ARP090103915A patent/AR073821A1/es unknown
- 2009-10-13 EA EA201100612A patent/EA201100612A1/ru unknown
-
2011
- 2011-02-16 ZA ZA2011/01236A patent/ZA201101236B/en unknown
- 2011-02-17 IL IL211290A patent/IL211290A0/en unknown
- 2011-02-21 EC EC2011010842A patent/ECSP11010842A/es unknown
- 2011-04-01 CO CO11040295A patent/CO6321168A2/es not_active Application Discontinuation
- 2011-04-08 CL CL2011000795A patent/CL2011000795A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20110200557A1 (en) | 2011-08-18 |
| ZA201101236B (en) | 2011-09-28 |
| MX2011003692A (es) | 2011-04-27 |
| WO2010043377A1 (en) | 2010-04-22 |
| BRPI0914371A2 (pt) | 2019-09-24 |
| AU2009304274A1 (en) | 2010-04-22 |
| UY32167A (es) | 2010-01-05 |
| KR20110067034A (ko) | 2011-06-20 |
| ECSP11010842A (es) | 2011-03-31 |
| CN102186847A (zh) | 2011-09-14 |
| JP2012505260A (ja) | 2012-03-01 |
| CL2011000795A1 (es) | 2011-08-19 |
| EA201100612A1 (ru) | 2011-12-30 |
| AR073821A1 (es) | 2010-12-01 |
| PE20110420A1 (es) | 2011-07-01 |
| TW201018679A (en) | 2010-05-16 |
| CA2740614A1 (en) | 2010-04-22 |
| EP2334670A1 (en) | 2011-06-22 |
| IL211290A0 (en) | 2011-04-28 |
| EP2177521A1 (en) | 2010-04-21 |
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