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CO6251362A2 - Derivados de n-heteroaril-carboxamidas triciclicas su preparacion y su aplicacion en la terapeutica - Google Patents

Derivados de n-heteroaril-carboxamidas triciclicas su preparacion y su aplicacion en la terapeutica

Info

Publication number
CO6251362A2
CO6251362A2 CO10010102A CO10010102A CO6251362A2 CO 6251362 A2 CO6251362 A2 CO 6251362A2 CO 10010102 A CO10010102 A CO 10010102A CO 10010102 A CO10010102 A CO 10010102A CO 6251362 A2 CO6251362 A2 CO 6251362A2
Authority
CO
Colombia
Prior art keywords
atom
pyrrolo
pyridinyl
group
therapeutics
Prior art date
Application number
CO10010102A
Other languages
English (en)
Inventor
Laurent Dubois
Yannick Evanno
Andre Malanda
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of CO6251362A2 publication Critical patent/CO6251362A2/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención se refiere a os derivados de N-heteroaril-carboxamidas tricíclicas, de fórmula general (I) en la que A representa, con el enlace Z2-Z3 del biciclo al que está unido, un grupo cicloalquilo C4-C7, un heteroarilo monocíclico o un heterociclo monocíclico de 4 a 7 eslabones que comprende de uno a tres heteroátomos elegidos entre O, S o N, incluidos los átomos Z2 y Z3 Z1, Z5, Z6, Z7 y Z8 representan, independientemente uno de otro, un átomo de nitrógeno, un átomo de carbono o un grupo C-R2; Z2, Z3, Z4 y Z9 representan, independientemente uno de otro, un átomo de nitrógeno o un átomo de carbono y Z1, Z2, Z3, Z4, Z5, Z6, Z7, Z8 y Z9 forman juntos un heteroarilo bicíclico unido al átomo de nitrógeno de la amida o la tioamida de fórmula (I) por las posiciones Z5, Z6, Z7 o Z8 cuando estas posiciones corresponden a un átomo de carbono, correspondiendo uno al menos de Z4, Z5, Z6, Z7, Z8 y Z9 a un átomo de nitrógeno; W representa un átomo de oxígeno o de azufre; P representa un grupo indolilo, pirrolo[2.3-c]piridinilo, pirrolo[2.3b]piridinilo, pirrolo[3.2-b]piridinilo o pirrolo[3.2-c]piridinilo, estando este grupo sustituido. Procedimiento de preparación y aplicación en terapéutica.
CO10010102A 2007-08-02 2010-02-01 Derivados de n-heteroaril-carboxamidas triciclicas su preparacion y su aplicacion en la terapeutica CO6251362A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0705677A FR2919610B1 (fr) 2007-08-02 2007-08-02 Derives de n-heteroaryl-carboxamides tricycliques,leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
CO6251362A2 true CO6251362A2 (es) 2011-02-21

Family

ID=39185736

Family Applications (1)

Application Number Title Priority Date Filing Date
CO10010102A CO6251362A2 (es) 2007-08-02 2010-02-01 Derivados de n-heteroaril-carboxamidas triciclicas su preparacion y su aplicacion en la terapeutica

Country Status (24)

Country Link
US (2) US8153796B2 (es)
EP (1) EP2185558B1 (es)
JP (1) JP5259713B2 (es)
KR (1) KR20100041804A (es)
CN (1) CN101772499B (es)
AR (1) AR067754A1 (es)
AU (1) AU2008313601B2 (es)
BR (1) BRPI0814756A2 (es)
CA (1) CA2694994C (es)
CL (1) CL2008002289A1 (es)
CO (1) CO6251362A2 (es)
EA (1) EA017808B1 (es)
FR (1) FR2919610B1 (es)
MA (1) MA31687B1 (es)
MX (1) MX2010001238A (es)
MY (1) MY150428A (es)
NZ (1) NZ582970A (es)
PA (1) PA8790901A1 (es)
PE (1) PE20090565A1 (es)
SG (1) SG183080A1 (es)
TW (1) TWI366566B (es)
UY (1) UY31264A1 (es)
WO (1) WO2009050348A1 (es)
ZA (1) ZA201000745B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA032315B1 (ru) * 2015-03-18 2019-05-31 Бристол-Маерс Сквибб Компани Замещенные трициклические гетероциклические соединения
US20170009890A1 (en) 2015-07-09 2017-01-12 Vistadeltek, Llc Control plate in a valve
RU2721419C2 (ru) 2015-08-28 2020-05-19 СиЭйчДиАй ФАУНДЕЙШН, ИНК. Зонды визуализации белка гентингтина
WO2022111473A1 (en) * 2020-11-26 2022-06-02 Bioardis Llc Compounds as mrgprx2 antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0156327B1 (ko) * 1995-07-12 1998-11-16 김종인 벤즈 또는 피리도이미다졸 유도체
US6313242B1 (en) * 1996-05-20 2001-11-06 Fina Technology, Inc. Stereorigid bis-fluorenyl metallocenes
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
ES2337254T3 (es) * 2003-02-14 2010-04-22 Glaxo Group Limited Derivados de carboxamida.
EP1628661A2 (en) * 2003-06-05 2006-03-01 Vertex Pharmaceuticals Incorporated Modulators of vr1 receptor
GB0319151D0 (en) * 2003-08-14 2003-09-17 Glaxo Group Ltd Novel compounds
FR2888847B1 (fr) * 2005-07-22 2007-08-31 Sanofi Aventis Sa Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique
FR2888848B1 (fr) * 2005-07-22 2007-09-28 Sanofi Aventis Sa Derives de n-(arylalkyl)-1h-pyrrrolopyridine-2-carboxamides, leur preparation et leur application en therapeutique
FR2897061B1 (fr) * 2006-02-03 2010-09-03 Sanofi Aventis Derives de n-heteroaryl-carboxamides tricycliques contenant un motif benzimidazole, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
CN101772499A (zh) 2010-07-07
JP5259713B2 (ja) 2013-08-07
KR20100041804A (ko) 2010-04-22
WO2009050348A1 (fr) 2009-04-23
EP2185558B1 (fr) 2014-06-18
PA8790901A1 (es) 2009-03-31
US8420817B2 (en) 2013-04-16
MY150428A (en) 2014-01-30
CL2008002289A1 (es) 2009-10-23
CA2694994A1 (fr) 2009-04-23
NZ582970A (en) 2012-03-30
AR067754A1 (es) 2009-10-21
TWI366566B (en) 2012-06-21
MA31687B1 (fr) 2010-09-01
AU2008313601B2 (en) 2013-10-24
US20120165531A1 (en) 2012-06-28
CA2694994C (fr) 2015-05-19
PE20090565A1 (es) 2009-06-01
FR2919610B1 (fr) 2009-10-16
FR2919610A1 (fr) 2009-02-06
SG183080A1 (en) 2012-08-30
TW200922936A (en) 2009-06-01
US8153796B2 (en) 2012-04-10
EP2185558A1 (fr) 2010-05-19
CN101772499B (zh) 2013-03-20
AU2008313601A1 (en) 2009-04-23
US20100173929A1 (en) 2010-07-08
JP2010535179A (ja) 2010-11-18
MX2010001238A (es) 2010-03-04
UY31264A1 (es) 2009-03-02
EA017808B1 (ru) 2013-03-29
ZA201000745B (en) 2011-04-28
EA201070217A1 (ru) 2010-08-30
BRPI0814756A2 (pt) 2019-09-24

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