CO5690596A2 - Derivados de hexahidropirazino [1,2-a]pirimidin-4,7-diona sustituidos, en el nitrogeno, metodo para su produccion y su uso como medicamentos - Google Patents
Derivados de hexahidropirazino [1,2-a]pirimidin-4,7-diona sustituidos, en el nitrogeno, metodo para su produccion y su uso como medicamentosInfo
- Publication number
- CO5690596A2 CO5690596A2 CO05079786A CO05079786A CO5690596A2 CO 5690596 A2 CO5690596 A2 CO 5690596A2 CO 05079786 A CO05079786 A CO 05079786A CO 05079786 A CO05079786 A CO 05079786A CO 5690596 A2 CO5690596 A2 CO 5690596A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- alkenylene
- coo
- heterocycle
- alkylene
- Prior art date
Links
- 229910052757 nitrogen Inorganic materials 0.000 title abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 12
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
- 125000006590 (C2-C6) alkenylene group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1.- Un compuesto de la fórmula I en la que los significados son A anillo mono, bi o espirobiclclico de 3-12 miembros que puede comprender uno o más heteroátomos del grupo de N, O Y S y cuyo anillo de 3-12 miembros puede tener sustituyentes adicionales tales como F, CI, Br, NO2, CF3, O CF3, CN, alquilo (C1-C6), arilo, CON(R11)(R12), N(R13)(R14), OH, O-alquilo(C1-C6), S-alquilo(C1-C6), N(R15)CO-alquilo(C1-C6) o COO-alquilo(C1-C6);R11, R12, R13, R14, R15 independientemente entre sí H, alquilo (C1-C6), heterociclo;n 0,1;m 0,1,2,3,4,5,6;R1 R8, alquilen(C1-C6)-R8, alquenilen(C2-C6)-R9, (SO2)-R8, (SO2)alquilen(C1-C6)-R8, (SO2)-alquenilen(C2-C6)-R9, (C=O)-R8, (C=O)-alquilen(C1-C6)-R8, (C=O)NH-R8, (C=O)-alquenilen(C2-C6)-R9, (C=O)-NH-alquilen(C1-C6)-R8, (C=O)-NH-alquenilen(C2-C6)-R9, COO-R8, COO-alquilen(C1-C6)-R8, COO-alquenilen(C2-C6)-R9, alquinilen-R9, (alquil-C1-C4)-heterociclo, donde los grupos alquileno pueden estar sustituidos con F;R8, R9 independientemente entre sí H, F, CI, Br, I, OH, CF3, arilo, heterociclo, cicloalquilo (C3-C8), donde los anillos o sistemas de anillos pueden estar sustituidos hasta 3 veces con F, CI, Br, I, OH, CF3, NO2, CN, OCF3, O-alquilo{C1-C6), alquilo (C1-C6), NH2, CON(R11)(R12), N(R13)(R14), SO2-CH3, COOH, COO-alquilo(C1-C6), CONH2;R2 NH2, NO2, N(R13)(R14), NH-SO2CH3, NH-SO2-R12, NR11-SO2-R12, N(CO)R11, un heterociclo que contiene nitrógeno, donde el heterociclo está unido por un átomo de nitrógeno, NHCONR11, N(alquil-C1-C6)N+(alquilo-C1-C4)3;R3, R4, R5 independientemente entre si H, F, CI, Br, I, OH, CF3, NO2, CN, OCF3, O-alquilo(C1-C6), O-aIcoxi(C1-C4)-alquilo(C1-C6), S-alquilo(C1-C6), alquilo (C1-C6), alquenilo (C2-C6), cicloalquilo (C3-C8), ...
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10305885A DE10305885A1 (de) | 2003-02-13 | 2003-02-13 | Substituierte Hexahydro-pyrazino(1,2-a)pyrimidin-4,7-dionderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE10349671A DE10349671A1 (de) | 2003-10-24 | 2003-10-24 | Stickstoff substituierte Hexahydro-pyrazino(1,2-a)pyrimidin-4,7-dionderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5690596A2 true CO5690596A2 (es) | 2006-10-31 |
Family
ID=32870333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO05079786A CO5690596A2 (es) | 2003-02-13 | 2005-08-11 | Derivados de hexahidropirazino [1,2-a]pirimidin-4,7-diona sustituidos, en el nitrogeno, metodo para su produccion y su uso como medicamentos |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1597259B1 (es) |
| JP (1) | JP2006517551A (es) |
| KR (1) | KR20050100686A (es) |
| AR (1) | AR043154A1 (es) |
| AT (1) | ATE393769T1 (es) |
| AU (1) | AU2004212043A1 (es) |
| BR (1) | BRPI0407387A (es) |
| CA (1) | CA2514791A1 (es) |
| CO (1) | CO5690596A2 (es) |
| DE (1) | DE502004007000D1 (es) |
| HR (1) | HRP20050711A2 (es) |
| MA (1) | MA27734A1 (es) |
| MX (1) | MXPA05008288A (es) |
| NO (1) | NO20054208L (es) |
| PE (1) | PE20040949A1 (es) |
| PL (1) | PL377660A1 (es) |
| RS (1) | RS20050572A (es) |
| RU (1) | RU2005128499A (es) |
| TW (1) | TW200510417A (es) |
| WO (1) | WO2004072077A1 (es) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7566711B2 (en) | 2001-10-12 | 2009-07-28 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| US20040072831A1 (en) * | 2001-10-12 | 2004-04-15 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| US8080657B2 (en) | 2001-10-12 | 2011-12-20 | Choongwae Pharma Corporation | Compounds of reverse turn mimetics and the use thereof |
| US7232822B2 (en) | 2001-10-12 | 2007-06-19 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| US7671054B1 (en) | 2001-10-12 | 2010-03-02 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| US7576084B2 (en) | 2001-10-12 | 2009-08-18 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| BRPI0407507A (pt) * | 2003-02-13 | 2006-02-14 | Aventis Pharma Gmbh | derivados de hexahidro-pirazino[1,2-a]pirimidin-4,7-diona, processos para sua preparação de sua aplicação como medicamento |
| DE102004042441A1 (de) * | 2004-08-31 | 2006-04-06 | Sanofi-Aventis Deutschland Gmbh | Mit Aminosäuren substituierte Hexahydro-pyrazino(1,2-a)pyrimidin-4,7-dionderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| KR20080027908A (ko) | 2005-06-30 | 2008-03-28 | 프로시디온 리미티드 | Ｇｐｃｒ 효능제 |
| JP5102985B2 (ja) * | 2006-07-18 | 2012-12-19 | 東ソ−・エフテック株式会社 | 含フッ素２級アミン化合物の製造方法 |
| BRPI0715160A2 (pt) | 2006-08-08 | 2013-06-11 | Sanofi Aventis | imidazolidina-2,4-dionas substituÍdas por arilamimoaril-alquil-, processo para preparÁ-las, medicamentos compeendendo estes compostos, e seu uso |
| GB0700122D0 (en) | 2007-01-04 | 2007-02-14 | Prosidion Ltd | GPCR agonists |
| SI2114933T1 (sl) | 2007-01-04 | 2012-01-31 | Prosidion Ltd Windrush Court | Piperidinski gpcr-agonisti |
| AR064735A1 (es) | 2007-01-04 | 2009-04-22 | Prosidion Ltd | Agonistas de gpcr y composicion farmaceutica en base al compuesto |
| JP2010514832A (ja) | 2007-01-04 | 2010-05-06 | プロシディオン・リミテッド | ピペリジンｇｐｃｒアゴニスト |
| AR064736A1 (es) | 2007-01-04 | 2009-04-22 | Prosidion Ltd | Agonistas de gpcr |
| JP5204438B2 (ja) * | 2007-07-31 | 2013-06-05 | 東ソ−・エフテック株式会社 | 含フッ素アミン化合物の製造方法 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| GB0720389D0 (en) | 2007-10-18 | 2008-11-12 | Prosidion Ltd | G-Protein Coupled Receptor Agonists |
| GB0720390D0 (en) | 2007-10-18 | 2007-11-28 | Prosidion Ltd | G-Protein coupled receptor agonists |
| US8470841B2 (en) | 2008-07-09 | 2013-06-25 | Sanofi | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| JP5545573B2 (ja) | 2008-10-14 | 2014-07-09 | 株式会社 ＰＲＩＳＭ ＢｉｏＬａｂ | アルファへリックスミメティック及び関連の方法 |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| CN102482258B (zh) | 2009-05-07 | 2014-06-25 | 株式会社棱镜制药 | α-螺旋模拟物和与其相关的方法 |
| ES2443016T3 (es) | 2009-08-26 | 2014-02-17 | Sanofi | Nuevos hidratos cristalinos de fluoroglicósidos heteroaromáticos, productos farmacéuticos que comprenden estos compuestos, y su empleo |
| US8809325B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Benzyl-oxathiazine derivatives substituted with adamantane and noradamantane, medicaments containing said compounds and use thereof |
| WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683703B1 (de) | 2011-03-08 | 2015-05-27 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120050A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| EP2683701B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| CN109640970B (zh) | 2016-06-23 | 2023-05-23 | 马里兰大学巴尔的摩分校 | 选择性p38α特异性MAPK抑制剂 |
| MX2021006731A (es) | 2018-12-07 | 2021-09-23 | Univ Maryland | Inhibidores de proteínas quinasas activadas por mitógeno p38 en sitio no atp/catalítico. |
| JP7495526B2 (ja) | 2020-05-18 | 2024-06-04 | ジーニー ライフサイエンシズ インコーポレイテッド | Ｐ３８アルファマイトジェン活性化プロテインキナーゼ阻害剤 |
| JP2023546835A (ja) | 2020-10-29 | 2023-11-08 | ジーニー ライフサイエンシズ インコーポレイテッド | 結晶性５－（ジメチルアミノ）－ｎ－（４－（モルホリノメチル）フェニル）ナフタレン－１－スルホンアミド二塩酸塩二水和物 |
| IL306101A (en) | 2021-03-23 | 2023-11-01 | Gen1E Lifesciences Inc | Naphthyl-mutated p38 alpha mitogen-activated protein kinase inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6184223B1 (en) * | 1995-10-27 | 2001-02-06 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
| DE69837264T2 (de) * | 1997-06-25 | 2008-01-31 | Pfizer Inc. | Dipeptidverbindungen, die Wachstumshormon-Sekretagoga sind |
| US6294525B1 (en) * | 1999-09-01 | 2001-09-25 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
| BRPI0407507A (pt) * | 2003-02-13 | 2006-02-14 | Aventis Pharma Gmbh | derivados de hexahidro-pirazino[1,2-a]pirimidin-4,7-diona, processos para sua preparação de sua aplicação como medicamento |
-
2004
- 2004-01-29 HR HR20050711A patent/HRP20050711A2/xx not_active Application Discontinuation
- 2004-01-29 AU AU2004212043A patent/AU2004212043A1/en not_active Abandoned
- 2004-01-29 KR KR1020057014986A patent/KR20050100686A/ko not_active Withdrawn
- 2004-01-29 BR BR0407387-8A patent/BRPI0407387A/pt not_active IP Right Cessation
- 2004-01-29 EP EP04706145A patent/EP1597259B1/de not_active Expired - Lifetime
- 2004-01-29 AT AT04706145T patent/ATE393769T1/de not_active IP Right Cessation
- 2004-01-29 PL PL377660A patent/PL377660A1/pl unknown
- 2004-01-29 RS YUP-2005/0572A patent/RS20050572A/sr unknown
- 2004-01-29 MX MXPA05008288A patent/MXPA05008288A/es not_active Application Discontinuation
- 2004-01-29 JP JP2006501650A patent/JP2006517551A/ja active Pending
- 2004-01-29 DE DE502004007000T patent/DE502004007000D1/de not_active Expired - Lifetime
- 2004-01-29 CA CA002514791A patent/CA2514791A1/en not_active Abandoned
- 2004-01-29 RU RU2005128499/04A patent/RU2005128499A/ru not_active Application Discontinuation
- 2004-01-29 WO PCT/EP2004/000770 patent/WO2004072077A1/de not_active Ceased
- 2004-02-11 AR ARP040100426A patent/AR043154A1/es unknown
- 2004-02-11 TW TW093103120A patent/TW200510417A/zh unknown
- 2004-02-11 PE PE2004000150A patent/PE20040949A1/es not_active Application Discontinuation
-
2005
- 2005-08-11 MA MA28429A patent/MA27734A1/fr unknown
- 2005-08-11 CO CO05079786A patent/CO5690596A2/es not_active Application Discontinuation
- 2005-09-09 NO NO20054208A patent/NO20054208L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2514791A1 (en) | 2004-08-26 |
| PE20040949A1 (es) | 2005-01-12 |
| MA27734A1 (fr) | 2006-02-01 |
| HRP20050711A2 (en) | 2006-09-30 |
| AU2004212043A1 (en) | 2004-08-26 |
| WO2004072077A1 (de) | 2004-08-26 |
| PL377660A1 (pl) | 2006-02-06 |
| BRPI0407387A (pt) | 2006-02-07 |
| ATE393769T1 (de) | 2008-05-15 |
| DE502004007000D1 (de) | 2008-06-12 |
| KR20050100686A (ko) | 2005-10-19 |
| TW200510417A (en) | 2005-03-16 |
| JP2006517551A (ja) | 2006-07-27 |
| EP1597259A1 (de) | 2005-11-23 |
| RU2005128499A (ru) | 2006-01-27 |
| EP1597259B1 (de) | 2008-04-30 |
| RS20050572A (sr) | 2007-09-21 |
| AR043154A1 (es) | 2005-07-20 |
| MXPA05008288A (es) | 2006-03-21 |
| NO20054208L (no) | 2005-09-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO5690596A2 (es) | Derivados de hexahidropirazino [1,2-a]pirimidin-4,7-diona sustituidos, en el nitrogeno, metodo para su produccion y su uso como medicamentos | |
| CO5690597A2 (es) | Derivados de hexahidropirazino[1,2-a]pirimidina-4,7-diona sustituidos, metodo para producirlos y sus uso cxomo medicamentos | |
| AR046200A1 (es) | Derivados de pirazina y su uso farmaceutico. procesos de preparacion y composiciones farmaceuticas | |
| AR045134A1 (es) | Compuesto de 1h - imidazo [4,5-c] piridin-ilo, composicion farmaceutica que lo comprende, proceso para prepararla, su uso para preparar dicha composicion farmaceutica, combinacion farmaceutica, uso de la combinacion farmaceutica para la preparacion de un medicamento, procedimientos para preparar dic | |
| AR074543A1 (es) | Derivados de imidazo[1,2-a]piridin-2-il, agonistas de receptores 1-fosfato de esfingosina(1s1p1), composiciones farmaceuticas que los contienen, metodo para prepararlos y uso de los mismos en el tratamiento de enfermedades autoinmunes | |
| AR080785A1 (es) | Derivados de imidazo[1,2-a]pirimidina ,proceso para prepararlos e intermediarios de dicha sintesis, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de patologias del sistema nervioso central,tales como esquizofrenia y parkinson, entre otros. | |
| BRPI0514644A (pt) | composto fosforamidita, composto ácido ribonucléico, e método para produzir oligo-rna | |
| AR036778A1 (es) | Compuesto derivado de oxazolidinona sustituida y/o isoxazolina sustituida, profarmacos, su uso en la fabricacion de medicamentos, composicion farmaceutica y proceso para prepararlos | |
| GT200400092A (es) | Preparacion y uso de derivados de alquilarilo para el tratamiento de la obesidad | |
| AR068538A1 (es) | Compuesto heterociclico de 5 miembros con actividad supresora de la secrecion de acido | |
| AR038326A1 (es) | Antibacterianos feniloxazolidinonas sustituidos con heterociclicos biciclicos y composiciones relacionadas y metodos | |
| CY1114836T1 (el) | Παραγωγο δικυκλικου γ-αμινοξεος | |
| PE20040373A1 (es) | Composiciones herbicidas que comprenden derivados de isoxazolina | |
| TW200833329A (en) | 2-aryl-6-phenylimidazo[1,2-a]pyridine derivatives, preparation thereof and therapeutic use thereof | |
| AR050267A1 (es) | Derivados de urea ciclicos sustituidos con heterociclo, su preparacion y su uso farmaceutico como inhibidores de quinasa | |
| AR036093A1 (es) | Compuestos derivados de tiazolidinilo, pirrolidinilo, oxazolidinilo, piperidilo, morfolinilo y tiomorfolinilo, su uso, composiciones farmaceuticas que los comprenden, y compuestos intermediarios | |
| ES2688575T3 (es) | Compuestos heterocíclicos y sus usos | |
| AR049401A1 (es) | Aza-biciclononanos | |
| UY27803A1 (es) | Derivados de benzoxazina y usos de los mismos. | |
| MY128442A (en) | Diphenyl ether compounds useful in therapy | |
| MY144633A (en) | New tricyclic derivatives, method of preparing same and pharmaceutical compositions containing them | |
| CO6150157A2 (es) | Derivados de 7-alquinil-1,8- naftiridonas su preparacion y su aplicacion en terapeutica | |
| CO5690582A2 (es) | Derivados de n-tiazol-2-il-benzamida | |
| AR045156A1 (es) | Derivados de 5-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos | |
| BRPI0511610A (pt) | derivados de amino-propanol |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |