CO5690579A2 - Derivados de diarilcicloalquilo, metodo para su produccion y su uso como medicamentos - Google Patents
Derivados de diarilcicloalquilo, metodo para su produccion y su uso como medicamentosInfo
- Publication number
- CO5690579A2 CO5690579A2 CO05085505A CO05085505A CO5690579A2 CO 5690579 A2 CO5690579 A2 CO 5690579A2 CO 05085505 A CO05085505 A CO 05085505A CO 05085505 A CO05085505 A CO 05085505A CO 5690579 A2 CO5690579 A2 CO 5690579A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- ring
- case
- phenyl
- alkanediyl
- Prior art date
Links
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 9
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 3
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1.- Un compuesto de la fórmula Ien la que e anillo A es cicloalcanodiilo (C3-C8) o cicloalquenodiilo(C3-C8), donde en los anillos cicloalcanodiilo o cicloalquenodiilo uno o más átomos de carbono pueden estar reemplazados con átomos de oxígeno;e anillo B es a) fenilo; o b) un anillo heteroaromático de 5 a 12 miembros que puede contener de uno a cuatro heteroátomos seleccionados entre el grupo compuesto por N, O y S, y un anillo aromático de 8 a 14 miembros o cicloalquilo (C3-C8);R1 es a) en el caso del anillo B = a):SCF3, OCF2-CHF2, O-fenilo, O-alquil (C1-C6)-O-alquilo (C1-C3):b) en el caso del anillo B = b):H, F, CI, Br, OH, NO2, CF3, OCF3, OCF2-CF3, SCF3, OCF2-CHF2, O-fenilo, alquilo (C1-C6), O-alquilo (C1-C6), O-alquil (C1-C6)-O-alquilo (C1-C3);c) en el caso del anillo B = a) y R4 = fenilo:alquilo (C1-C6) o O-alquilo (C1-C6);R2 es H o CF3;R4 es a) en el caso del anillo B = a):fenilo;b) en el caso del anillo B = b):H, F, CI, Br, OH, NO2, CF3, OCF3, alquilo (C1-C6), O-alquilo (C1-C6);c) en el caso del anillo B = a) y R1 = a):alquilo (C1-C6);R5 es H, F, CI, Br, OH, NO2, CF3, OCF3, alquilo (C1-C6), O-alquilo (C1-C6);R3 es H o alquilo (C1-C6);X es alcanodiilo (C1-C6), donde en el grupo alcanodiilo, uno o más átomos de carbono pueden reemplazarse por átomos de oxígeno;Y es alcanodiilo (C1-C6), donde en el grupo alcanodiilo, uno o más átomos de carbono pueden reemplazarse por átomos de oxígeno;y sus sales fisiológicamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10308353A DE10308353A1 (de) | 2003-02-27 | 2003-02-27 | Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5690579A2 true CO5690579A2 (es) | 2006-10-31 |
Family
ID=32920627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO05085505A CO5690579A2 (es) | 2003-02-27 | 2005-08-26 | Derivados de diarilcicloalquilo, metodo para su produccion y su uso como medicamentos |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7160911B2 (es) |
| EP (1) | EP1599454B1 (es) |
| JP (1) | JP2006519197A (es) |
| KR (1) | KR20050106053A (es) |
| CN (1) | CN100439346C (es) |
| AR (1) | AR043430A1 (es) |
| AU (1) | AU2004216520B2 (es) |
| BR (1) | BRPI0407901A (es) |
| CA (1) | CA2516573A1 (es) |
| CO (1) | CO5690579A2 (es) |
| DE (1) | DE10308353A1 (es) |
| HR (1) | HRP20050740A2 (es) |
| IL (1) | IL170313A (es) |
| MA (1) | MA27741A1 (es) |
| MX (1) | MXPA05008993A (es) |
| NO (1) | NO20054382L (es) |
| PL (1) | PL377741A1 (es) |
| RU (1) | RU2005129999A (es) |
| TW (1) | TW200505880A (es) |
| WO (1) | WO2004075815A2 (es) |
| ZA (1) | ZA200505763B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7399777B2 (en) * | 2001-08-31 | 2008-07-15 | Sanofi-Aventis Deutschland Gmbh | Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmceuticals |
| IL160556A0 (en) * | 2001-08-31 | 2004-07-25 | Aventis Pharma Gmbh | Diaryl cycloalkyl derivatives, method for producing the same and the use thereof as ppar activators |
| US20040242566A1 (en) | 2003-03-25 | 2004-12-02 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
| JP2007511467A (ja) | 2003-05-14 | 2007-05-10 | タケダ サン ディエゴ インコーポレイテッド | ジペプチジルペプチダーゼインヒビター |
| MXPA06001601A (es) | 2003-08-13 | 2006-08-25 | Takeda Pharmaceutical | Derivados de 4-pirimidona y su uso como inhibidores de dipeptidilpeptidasa. |
| CN101014595A (zh) | 2004-08-11 | 2007-08-08 | 杏林制药株式会社 | 新型环状氨基苯甲酸衍生物 |
| DE102004040736B4 (de) * | 2004-08-23 | 2007-01-11 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Diarylcycloalkylderivaten |
| DE102004060227B3 (de) * | 2004-12-15 | 2006-07-20 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Oxazolen durch Kondensation von aromatischen Aldehyden mit α-Ketoximen zu N-Oxiden und nachfolgende Reaktion mit aktivierten Säurederivaten |
| WO2006101108A1 (ja) * | 2005-03-23 | 2006-09-28 | Kyorin Pharmaceutical Co., Ltd. | 新規環状アミノフェニルアルカン酸誘導体 |
| SI1942898T2 (sl) | 2005-09-14 | 2014-08-29 | Takeda Pharmaceutical Company Limited | Dipeptidil-peptidazni inhibitorji za zdravljenje diabetesa |
| EP1924567B1 (en) | 2005-09-16 | 2012-08-22 | Takeda Pharmaceutical Company Limited | Process for the preparation of pyrimidinedione derivatives |
| BRPI0617207A2 (pt) | 2005-09-29 | 2011-07-19 | Sanofi Aventis | derivados de fenil-1,2,4-oxadiazolona, processos para sua preparação e seu uso como produtos farmacêuticos |
| WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
| TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
| US8115011B2 (en) * | 2007-05-22 | 2012-02-14 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8153644B2 (en) * | 2007-05-22 | 2012-04-10 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8211884B2 (en) * | 2008-08-06 | 2012-07-03 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8324385B2 (en) * | 2008-10-30 | 2012-12-04 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| CN102245024A (zh) * | 2008-12-17 | 2011-11-16 | 维尔制药公司 | 二酰甘油酰基转移酶抑制剂 |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2663336B1 (fr) | 1990-06-18 | 1992-09-04 | Adir | Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| AU658955B2 (en) * | 1992-01-28 | 1995-05-04 | Sumitomo Chemical Company, Limited | An oxazoline derivative, its production and its use |
| ZA941003B (en) | 1993-02-15 | 1995-08-14 | Wellcome Found | Hypolipidaemic compounds |
| IL108634A0 (en) | 1993-02-15 | 1994-05-30 | Wellcome Found | Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them |
| JP3144624B2 (ja) | 1995-06-02 | 2001-03-12 | 杏林製薬株式会社 | Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
| IL125071A0 (en) | 1996-01-17 | 1999-01-26 | Novo Nordisk As | Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives their preparation and use |
| ES2283025T3 (es) | 1996-08-30 | 2007-10-16 | Novo Nordisk A/S | Derivados de glp-1.1. |
| TW492957B (en) | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
| JP4339402B2 (ja) | 1996-12-31 | 2009-10-07 | ドクター・レディーズ・ラボラトリーズ・リミテッド | 新規なヘテロ環化合物、これらの製造方法及びこれらを含有する薬学的組成物、並びに糖尿病及び関連疾患の治療におけるこれらの使用 |
| AUPO713297A0 (en) * | 1997-06-02 | 1997-06-26 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compound |
| DE19726167B4 (de) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
| CA2294830A1 (en) | 1997-07-16 | 1999-01-28 | John Bondo Hansen | Fused 1,2,4-thiadiazine derivatives, their preparation and use |
| CO4970713A1 (es) | 1997-09-19 | 2000-11-07 | Sanofi Synthelabo | Derivados de carboxamidotiazoles, su preparacion, composiciones farmaceuticas que los contienen |
| DE69941777D1 (de) * | 1998-03-10 | 2010-01-21 | Ono Pharmaceutical Co | Carbonsäurederivate und medikamente die diese als aktiven wirkstoff enthalten |
| DE19823831A1 (de) | 1998-05-28 | 1999-12-02 | Probiodrug Ges Fuer Arzneim | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
| MA26634A1 (fr) | 1998-06-04 | 2004-12-20 | Astra Ab | Nouveaux derives de l'acide 3-aryl propionique et analogues |
| SE9801992D0 (sv) | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl-2-hydroxypropionic acid derivative I |
| US6221897B1 (en) | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| DE19828114A1 (de) | 1998-06-24 | 2000-01-27 | Probiodrug Ges Fuer Arzneim | Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV |
| DE19828113A1 (de) | 1998-06-24 | 2000-01-05 | Probiodrug Ges Fuer Arzneim | Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV |
| EP1092711A4 (en) * | 1998-07-01 | 2002-07-31 | Takeda Chemical Industries Ltd | RETINOID ASSOCIATED RECEPTOR REGULATORS |
| DE19845405C2 (de) | 1998-10-02 | 2000-07-13 | Aventis Pharma Gmbh | Arylsubstituierte Propanolaminderivate und deren Verwendung |
| US6589969B1 (en) * | 1998-10-16 | 2003-07-08 | Ono Pharmaceutical Co., Ltd. | Carboxylic acid derivatives and drugs containing the same as the active ingredient |
| GB9900416D0 (en) | 1999-01-08 | 1999-02-24 | Alizyme Therapeutics Ltd | Inhibitors |
| DE19916108C1 (de) | 1999-04-09 | 2001-01-11 | Aventis Pharma Gmbh | Mit Zuckerresten substituierte 1,4-Benzothiazepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und deren Verwendung |
| EP1173438A1 (en) | 1999-04-16 | 2002-01-23 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
| EE200100558A (et) * | 1999-04-28 | 2002-12-16 | Aventis Pharma Deutschland Gmbh | Triarüülhappe derivaat, seda sisaldav farmatseutiline kompositsioon ja ühendi raviotstarbeline kasutamine |
| CN101070316A (zh) | 1999-04-28 | 2007-11-14 | 萨诺费－阿文蒂斯德国有限公司 | 作为ppar受体配体的二芳基酸衍生物 |
| EP1175421A1 (en) | 1999-04-30 | 2002-01-30 | Neurogen Corporation | 9H-PYRIMIDO[4,5-b]INDOLE DERIVATIVES: CRF1 SPECIFIC LIGANDS |
| GB9911863D0 (en) | 1999-05-21 | 1999-07-21 | Knoll Ag | Therapeutic agents |
| JP2003502369A (ja) | 1999-06-18 | 2003-01-21 | メルク エンド カムパニー インコーポレーテッド | アリールチアゾリジンジオン誘導体およびアリールオキサゾリジンジオン誘導体 |
| WO2001004146A2 (en) | 1999-07-09 | 2001-01-18 | Cohesion Technologies, Inc. | Ecarin polypeptides, polynucleotides encoding ecarin, and methods for use thereof |
| PT1204654E (pt) | 1999-07-29 | 2003-11-28 | Lilly Co Eli | Benzofurilpiperazinas agonistas do receptor 5-ht2c da serotonina |
| WO2001016094A1 (de) | 1999-09-01 | 2001-03-08 | Aventis Pharma Deutschland Gmbh | Sulfonylcarboxamidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE60008763T2 (de) * | 1999-09-08 | 2005-02-10 | Glaxo Group Ltd., Greenford | Oxazol ppar antagonisten |
| TW200514783A (en) | 1999-09-22 | 2005-05-01 | Bristol Myers Squibb Co | Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method |
| US6414002B1 (en) * | 1999-09-22 | 2002-07-02 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
| SE9904413D0 (sv) | 1999-12-03 | 1999-12-03 | Astra Ab | Comminuted form |
| WO2001040171A1 (en) | 1999-12-03 | 2001-06-07 | Astrazeneca Ab | Crystalline form of (s)-2 ethoxy-3-[4-(2-{4-methanesulfonyloxyphenyl} ethoxy) phenyl] propanoic acid |
| DK1283735T4 (da) | 2000-03-31 | 2013-02-04 | Royalty Pharma Collection Trust | Fremgangsmåde til forbedring signalering af øceller ved diabetes mellitus og til forebyggelse deraf |
| EA004244B1 (ru) | 2000-04-25 | 2004-02-26 | Киорин Фармасьютикал Ко., Лтд. | Новый стабильный кристалл производного тиазолидиндиона и способ его получения |
| WO2001083451A1 (en) | 2000-04-28 | 2001-11-08 | Asahi Kasei Kabushiki Kaisha | Novel bicyclic compounds |
| JP2004507456A (ja) | 2000-05-11 | 2004-03-11 | ブリストル−マイヤーズ スクイブ カンパニー | 成長ホルモン分泌促進薬として有用なテトラヒドロイソキノリン類縁体 |
| CA2410597A1 (en) | 2000-05-30 | 2001-12-06 | Merck & Co., Inc. | Melanocortin receptor agonists |
| AU2001262318B2 (en) | 2000-06-09 | 2005-09-08 | Sanofi-Aventis Deutschland Gmbh | Acylphenyl urea derivatives, methods for the production thereof and use thereof as a medicament |
| EP1182251A1 (en) * | 2000-08-11 | 2002-02-27 | Yissum Research Development Company of the Hebrew University of Jerusalem | Methods for identifying compounds that inhibit ubiquitin-mediated proteolysis of IkB |
| TWI243162B (en) | 2000-11-10 | 2005-11-11 | Taisho Pharmaceutical Co Ltd | Cyanopyrrolidine derivatives |
| ES2277890T3 (es) | 2000-12-21 | 2007-08-01 | Sanofi-Aventis Deutschland Gmbh | Nuevas difenilazetidinonas, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su uso para el tratamiento de trastornos del metabolismo de lipidos. |
| JP3491635B2 (ja) * | 2000-12-25 | 2004-01-26 | 小野薬品工業株式会社 | ジヒドロナフタレン誘導体化合物およびその化合物を有効成分とする薬剤 |
| PE20021091A1 (es) | 2001-05-25 | 2003-02-04 | Aventis Pharma Gmbh | Derivados de fenilurea sustituidos con carbonamida y procedimiento para su preparacion |
| DE10154689A1 (de) | 2001-11-09 | 2003-05-22 | Probiodrug Ag | Substituierte Aminoketonverbindungen |
| US6623261B2 (en) | 2001-07-21 | 2003-09-23 | Thomas C. Edwards | Single-degree-of-freedom controlled-clearance univane™ fluid-handling machine |
| IL160556A0 (en) * | 2001-08-31 | 2004-07-25 | Aventis Pharma Gmbh | Diaryl cycloalkyl derivatives, method for producing the same and the use thereof as ppar activators |
| DE10142734A1 (de) * | 2001-08-31 | 2003-03-27 | Aventis Pharma Gmbh | Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE10215907A1 (de) | 2002-04-11 | 2003-11-06 | Aventis Pharma Gmbh | Acyl-4-carboxyphenyl-harnstoffderivate, Verfahren zu deren Herstellung und deren Verwendung |
| DE10215908B4 (de) | 2002-04-11 | 2005-08-18 | Aventis Pharma Deutschland Gmbh | Acyl-3-carboxyphenyl-harnstoffderivate und deren Verwendung als Arzneimittel |
| DE10225635C1 (de) | 2002-06-07 | 2003-12-24 | Aventis Pharma Gmbh | N-Benzoylureido-Zimtsäurederivate, Verfahren zu deren Herstellung und deren Verwendung |
| DE10231370B4 (de) | 2002-07-11 | 2006-04-06 | Sanofi-Aventis Deutschland Gmbh | Thiophenglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
| DE10258007B4 (de) | 2002-12-12 | 2006-02-09 | Sanofi-Aventis Deutschland Gmbh | Aromatische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
| DE10258008B4 (de) | 2002-12-12 | 2006-02-02 | Sanofi-Aventis Deutschland Gmbh | Heterocyclische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
| DE10308351A1 (de) * | 2003-02-27 | 2004-11-25 | Aventis Pharma Deutschland Gmbh | 1,3-substituierte Cycloalkylderivate mit sauren, meist heterocyclischen Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE10308355A1 (de) * | 2003-02-27 | 2004-12-23 | Aventis Pharma Deutschland Gmbh | Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
| US7094795B2 (en) * | 2003-02-27 | 2006-08-22 | Sanofi-Aventis Deutschland Gmbh | Process for preparing the enantiomeric forms of cis-configured 1,3-cyclohexanediol derivatives |
| US7148246B2 (en) * | 2003-02-27 | 2006-12-12 | Sanofi-Aventis Deutschland Gmbh | Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals |
-
2003
- 2003-02-27 DE DE10308353A patent/DE10308353A1/de not_active Withdrawn
-
2004
- 2004-02-19 WO PCT/EP2004/001584 patent/WO2004075815A2/de not_active Ceased
- 2004-02-19 RU RU2005129999/04A patent/RU2005129999A/ru not_active Application Discontinuation
- 2004-02-19 CA CA002516573A patent/CA2516573A1/en not_active Abandoned
- 2004-02-19 CN CNB2004800054472A patent/CN100439346C/zh not_active Expired - Fee Related
- 2004-02-19 PL PL377741A patent/PL377741A1/pl not_active Application Discontinuation
- 2004-02-19 MX MXPA05008993A patent/MXPA05008993A/es active IP Right Grant
- 2004-02-19 BR BRPI0407901-9A patent/BRPI0407901A/pt not_active IP Right Cessation
- 2004-02-19 HR HR20050740A patent/HRP20050740A2/xx not_active Application Discontinuation
- 2004-02-19 EP EP04712502A patent/EP1599454B1/de not_active Expired - Lifetime
- 2004-02-19 AU AU2004216520A patent/AU2004216520B2/en not_active Ceased
- 2004-02-19 KR KR1020057016020A patent/KR20050106053A/ko not_active Ceased
- 2004-02-19 JP JP2006501890A patent/JP2006519197A/ja active Pending
- 2004-02-25 TW TW093104700A patent/TW200505880A/zh unknown
- 2004-02-27 AR ARP040100633A patent/AR043430A1/es not_active Application Discontinuation
- 2004-02-27 US US10/789,019 patent/US7160911B2/en not_active Expired - Lifetime
-
2005
- 2005-07-19 ZA ZA200505763A patent/ZA200505763B/en unknown
- 2005-08-16 IL IL170313A patent/IL170313A/en not_active IP Right Cessation
- 2005-08-26 CO CO05085505A patent/CO5690579A2/es not_active Application Discontinuation
- 2005-08-26 MA MA28464A patent/MA27741A1/fr unknown
- 2005-09-21 NO NO20054382A patent/NO20054382L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006519197A (ja) | 2006-08-24 |
| HRP20050740A2 (en) | 2006-08-31 |
| BRPI0407901A (pt) | 2006-02-14 |
| CA2516573A1 (en) | 2004-09-10 |
| KR20050106053A (ko) | 2005-11-08 |
| EP1599454A2 (de) | 2005-11-30 |
| IL170313A (en) | 2010-11-30 |
| US20040204462A1 (en) | 2004-10-14 |
| PL377741A1 (pl) | 2006-02-20 |
| EP1599454B1 (de) | 2012-12-26 |
| MA27741A1 (fr) | 2006-02-01 |
| US7160911B2 (en) | 2007-01-09 |
| AU2004216520B2 (en) | 2010-01-07 |
| CN100439346C (zh) | 2008-12-03 |
| CN1753880A (zh) | 2006-03-29 |
| NO20054382L (no) | 2005-09-21 |
| MXPA05008993A (es) | 2005-10-18 |
| AU2004216520A1 (en) | 2004-09-10 |
| TW200505880A (en) | 2005-02-16 |
| ZA200505763B (en) | 2006-05-31 |
| DE10308353A1 (de) | 2004-12-02 |
| RU2005129999A (ru) | 2006-03-27 |
| WO2004075815A3 (de) | 2004-12-29 |
| AR043430A1 (es) | 2005-07-27 |
| WO2004075815A2 (de) | 2004-09-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO5690579A2 (es) | Derivados de diarilcicloalquilo, metodo para su produccion y su uso como medicamentos | |
| ES2486267T3 (es) | 2-(Fenil 2-fluoro-substituido)-6-amino-5-cloro-4-pirimidinacarboxilatos y su uso como herbicidas | |
| AR068479A1 (es) | (carboxilalquilenfenil) feniloxamidas, procedimiento para su preparacion y una coomposicion farmaceutica | |
| CO5611131A2 (es) | Derivados de 5-feniltiazol y su uso como inhibidores de pi3 cinasa | |
| AR068538A1 (es) | Compuesto heterociclico de 5 miembros con actividad supresora de la secrecion de acido | |
| AR069596A1 (es) | Regulador del crecimiento de plantas | |
| CO5560562A2 (es) | Derivados de diarilcicloalquilo, procedmientos para su preparacion y su utilizacion como agentes activadores del ppar | |
| UY27699A1 (es) | Inhibidores. | |
| CO6321248A2 (es) | Derivados de triazol utiles para el tratamiento de enfermedades | |
| PE20040373A1 (es) | Composiciones herbicidas que comprenden derivados de isoxazolina | |
| UY26727A1 (es) | Derivados de tropano útiles en terapia | |
| AR054130A1 (es) | Procedimiento para la preparacion de 1-alquil-3-feniluracilos | |
| AR063988A1 (es) | Derivados heterociclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
| PA8776401A1 (es) | Nuevos compuestos hetericiclicos nitrogenados, su preparación y su utilización como medicamentos antibacterianos | |
| GT200300010A (es) | Esteres hidroxamato del acido n-(4-fenil sustituido)-antranilico | |
| PE20070097A1 (es) | Agonistas del receptor de niacina y composiciones que contienen tales compuestos | |
| AR052568A1 (es) | Derivados de pirazolo -pirimidina como antagonstas de mglur2 | |
| ECSP088194A (es) | Antagonistas de cgrp seleccionados, procedimientos para su preparación, así como su uso como medicamentos | |
| CO5631434A2 (es) | Derivados de piridina-carboxamida y su uso como plaguicidas | |
| AR049883A1 (es) | Antagonistas de cgrp seleccionados, procedimientos para su preparacion, y su empleo como medicamentos | |
| ES2606839T3 (es) | Tetraaza-ciclopenta[a]indenilo y su uso como moduladores alostéricos positivos | |
| CO5690578A2 (es) | Derivados de acido 4-(3-(2-feniloxazol-4-ilmetoxi)ciclohexiloxi)-butanoico y compuestos relacionados como moduladores de ppar para tratar la diabetes tipo 2 y la aterosclerosis | |
| AR070264A1 (es) | Derivados de oxazepinopirimidona heteroarilamida sustituidos | |
| ECSP088805A (es) | 2-(piridin-2-il)-pirimidinas como fungicidas | |
| ES2578628T3 (es) | Compuestos de L-dihidro-2-oxoquinolina como ligandos del receptor de 5-HT4 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |