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CO5640137A2 - N-pirazinil-fenilsulfonamidas y su uso en el tratamiento de enfermedades mediadas por quimosina - Google Patents

N-pirazinil-fenilsulfonamidas y su uso en el tratamiento de enfermedades mediadas por quimosina

Info

Publication number
CO5640137A2
CO5640137A2 CO04067437A CO04067437A CO5640137A2 CO 5640137 A2 CO5640137 A2 CO 5640137A2 CO 04067437 A CO04067437 A CO 04067437A CO 04067437 A CO04067437 A CO 04067437A CO 5640137 A2 CO5640137 A2 CO 5640137A2
Authority
CO
Colombia
Prior art keywords
alkyl
hydroxy
halogen
optionally substituted
cyano
Prior art date
Application number
CO04067437A
Other languages
English (en)
Inventor
Andrew Baxter
Timothy Johnson
Nicholas Kindon
Bryan Roberts
Michael Stocks
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0200119A external-priority patent/SE0200119D0/xx
Priority claimed from SE0201857A external-priority patent/SE0201857D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CO5640137A2 publication Critical patent/CO5640137A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
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    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
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  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
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Abstract

1.- Un compuesto de la fórmula (I) o una sal o solvato farmacéuticamente aceptable del mismo: en donde:R1, R2 y R3 son, independientemente, hidrógeno, halógeno, ciano, CF3, OCF3, alquilo OC1-6 O alquilo C1-6 ;R4 es halógeno, CO2R12 ,aIcoxi C1-6 en donde el grupo alquilo puede formar un anillo saturado de 3-6 miembros o puede estar sustituido con 1-3 átomos de flúor o un grupo ciano, oxialquenilo C1-6 u oxialquinilo C1-6 en donde cualquiera puede estar opcionalmente sustituido con hidroxi o NR14R15,O-alquilo C1-6 X-alquilo C1-6 en donde los grupos alquilo pueden formar un anillo saturado de 3-6 miembros,O-alquilo1-6 R11 u O-alquilo C2-6 -X-R11 en donde el grupo alquilo puede formar un anillo saturado de 3-6 miembros y está opcionalmente sustituido con 1-3 grupos escogidos entre hidroxi, halógeno, NR14R15, SR13, S(O)2R13, S(O)R13 o COR13 ,O-alquiloC1-6 R16 ;R5 y R6 son, independientemente, hidrógeno, ciano, halógeno, CO2R12, CONR14R15 ,alquilo C1-6 opcionalmente sustituido por hidroxi, NR14R15 o 1-3 flúoros,alquinilo C1-6 o XCH(R11)alquilo C1-6 o XCH(R16)alquilo C1-6 en donde el grupo alquilo puede estar opcionalmente sustituido con 1-3 grupos escogidos entre hidroxi y NR14R15NR14R15, N(R11)R11, X-(CH2)qNR14R15, (CH2)nNR14R15, alquilo NHC(O)C1-6 opcionalmente sustituido por uno o varios grupos hidroxi,alquinilo C3-6 o alquenilo C3-6 opcionalmente ramificado y opcionalmente sustituido con 1-2 grupos escogidos entre hidroxi, ciano, halógeno y =O,R11, X-R11, X-R12; X-alquilo C1-6-R16; X-R16; X-(CH2)nCO2R12; X-(CH2)nCONR14R15;X-(CH2)nR11; X-(CH2)nCN; X-(CH2)qOR12; (CH2)nOR12; (CH2)nX¯¯R11; X-(CH2)qNHC(O)NHR12; X-(CH2)qNHC(O)R12; X-(CH2)qNHS(O)2R11; X-alquenilo C3-6; X-alquinilo C3-6;n es 1, 2, 3, 4 o 5q es 2, 3, 4, 5 o 6; ...
CO04067437A 2002-01-16 2004-07-15 N-pirazinil-fenilsulfonamidas y su uso en el tratamiento de enfermedades mediadas por quimosina CO5640137A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0200119A SE0200119D0 (sv) 2002-01-16 2002-01-16 Novel compounds
SE0201857A SE0201857D0 (sv) 2002-06-17 2002-06-17 Novel compounds

Publications (1)

Publication Number Publication Date
CO5640137A2 true CO5640137A2 (es) 2006-05-31

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CO04067437A CO5640137A2 (es) 2002-01-16 2004-07-15 N-pirazinil-fenilsulfonamidas y su uso en el tratamiento de enfermedades mediadas por quimosina

Country Status (21)

Country Link
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JP4504021B2 (ja) 2010-07-14
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AR038179A1 (es) 2005-01-05
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