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CO5580816A2 - Metodos para la preparacion de o-desmetilvenlafaxina - Google Patents

Metodos para la preparacion de o-desmetilvenlafaxina

Info

Publication number
CO5580816A2
CO5580816A2 CO04050957A CO04050957A CO5580816A2 CO 5580816 A2 CO5580816 A2 CO 5580816A2 CO 04050957 A CO04050957 A CO 04050957A CO 04050957 A CO04050957 A CO 04050957A CO 5580816 A2 CO5580816 A2 CO 5580816A2
Authority
CO
Colombia
Prior art keywords
preparation
demetilvenlafaxin
methods
desmethylvenlafaxine
venlafaxine
Prior art date
Application number
CO04050957A
Other languages
English (en)
Inventor
Beat Theodor Weber
Abdul Ali Nabi Kadum
Jun Han
Yong Jai Lee
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23309595&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO5580816(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CO5580816A2 publication Critical patent/CO5580816A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

1.- Un método para la preparación de O-desmetilvenlafaxina que comprende la desmetilación de venlafaxina con un alcano de alto peso molecular, arilalquilo o anión tiolato de areno en un solvente hidroxílico o etéreo, o mezcla de estos.21.- Un método para la preparación de O-desmetilvenlafaxina que comprende los pasos de demetilación de la venlafaxina con dodecil tiolato y polietilen glicol 400 en presencia de metilato de sodio en metanol, de aproximadamente 180°C a aproximadamente 200 °C, durante aproximadamente 2 a aproximadamente 5 horas; y la neutralización del producto a pH de aproximadamente 9.5 en presencia de isopropanol.
CO04050957A 2001-12-04 2004-06-01 Metodos para la preparacion de o-desmetilvenlafaxina CO5580816A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33495301P 2001-12-04 2001-12-04

Publications (1)

Publication Number Publication Date
CO5580816A2 true CO5580816A2 (es) 2005-11-30

Family

ID=23309595

Family Applications (1)

Application Number Title Priority Date Filing Date
CO04050957A CO5580816A2 (es) 2001-12-04 2004-06-01 Metodos para la preparacion de o-desmetilvenlafaxina

Country Status (28)

Country Link
US (4) US6689912B2 (es)
EP (1) EP1451143B9 (es)
JP (1) JP4342312B2 (es)
KR (1) KR100939650B1 (es)
CN (1) CN1319934C (es)
AR (1) AR037622A1 (es)
AT (1) ATE403641T1 (es)
AU (1) AU2002357049B2 (es)
BR (1) BR0214701A (es)
CA (1) CA2466779C (es)
CO (1) CO5580816A2 (es)
DE (1) DE60228118D1 (es)
DK (1) DK1451143T3 (es)
EC (1) ECSP045135A (es)
ES (1) ES2311647T4 (es)
HU (1) HUP0402269A3 (es)
IL (3) IL162253A0 (es)
MX (1) MXPA04005309A (es)
NO (1) NO20042680L (es)
NZ (1) NZ533316A (es)
PL (1) PL369299A1 (es)
PT (1) PT1451143E (es)
RU (1) RU2317286C2 (es)
SI (1) SI1451143T1 (es)
TW (1) TWI260982B (es)
UA (1) UA80543C2 (es)
WO (1) WO2003048104A1 (es)
ZA (1) ZA200405250B (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
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US6342533B1 (en) * 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
PL350924A1 (en) * 1999-04-06 2003-02-10 Sepracor Inc Derivatives of venlafaxine and methods of preparing and using the same
JP4220243B2 (ja) * 2001-02-12 2009-02-04 ワイス Ｏ−デスメチル−ベンラファキシンの新規コハク酸塩
UA80543C2 (en) * 2001-12-04 2007-10-10 Wyeth Corp Method for the preparation of o-desmethylvenlafaxine
CA2614209A1 (en) * 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and o-desmethylvenlafaxine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
JP2009518407A (ja) * 2005-12-05 2009-05-07 ワイス 置換１−（２−アミノ−１−フェニル−エチル）−シクロヘキサノールのエナンチオマーを選択的に合成するための方法
WO2007071404A1 (en) * 2005-12-20 2007-06-28 Synthon B.V. Process for making desvenlafaxine
MX2007016179A (es) * 2006-04-17 2008-03-11 Teva Pharma Formas cristalinas de o-desmetilvenlafaxina.
WO2007120923A1 (en) 2006-04-17 2007-10-25 Teva Pharmaceutical Industries Ltd. Substantially pure o-desmethylvenlafaxine and processes for preparing it
WO2008035369A2 (en) * 2006-06-30 2008-03-27 Alembic Limited Novel form of o-desmethyl venlafaxine
CA2656167A1 (en) 2006-07-26 2008-01-31 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of o-desmethylvenlafaxine
US20090137846A1 (en) * 2006-07-26 2009-05-28 Valerie Niddam-Hildesheim Processes for the synthesis of O-Desmethylvenlafaxine
CA2656285A1 (en) * 2006-07-26 2008-01-31 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of o-desmethylvenlafaxine
EP2046725A2 (en) * 2006-07-26 2009-04-15 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of o-desmethylvenlafaxine
JP4763788B2 (ja) * 2006-07-26 2011-08-31 テバ ファーマシューティカル インダストリーズ リミティド Ｏ−デスメチルベンラファキシンの合成方法
US20090069601A1 (en) * 2006-07-26 2009-03-12 Valerie Niddam-Hildesheim Processes for the synthesis of O-desmethylvenlafaxine
US20080221356A1 (en) * 2006-07-26 2008-09-11 Valerie Niddam-Hildesheim Processes for the synthesis of O-desmethylvenlafaxine
EP2061750A2 (en) * 2006-08-04 2009-05-27 Medichem, S.A. Improved process for synthesizing desvenlafaxine free base and salts or solvates thereof
EP2114862A1 (en) * 2007-01-31 2009-11-11 Merck Generics (UK) Limited Process for the preparation of o-desmethyl venlafaxine
EP2049465A2 (en) * 2007-03-14 2009-04-22 Teva Pharmaceutical Industries Ltd. Processes for preparing solid states of o-desmethylvenlafaxine succinate
BRPI0812501A2 (pt) * 2007-07-12 2015-06-16 Reddys Lab Ltd Dr O-desmetil venlafaxina
WO2009010990A2 (en) * 2007-07-16 2009-01-22 Matrix Laboratories Limited Process for the preparation of o-desmethylvenlafaxine succinate polymorphic forms
WO2009034434A2 (en) * 2007-09-10 2009-03-19 Cadila Pharmaceuticals Limited An improved process for the preparation of o-desmethylvenlafaxine
WO2009053731A1 (en) 2007-10-26 2009-04-30 Generics [Uk] Limited Process for preparing o-desmethylvenlafaxine
KR101343027B1 (ko) * 2007-11-26 2013-12-18 테바 파마슈티컬 인더스트리즈 리미티드 Ｏ-데스메틸벤라팍신 푸마레이트의 결정형
WO2009084038A2 (en) * 2007-12-28 2009-07-09 Ind-Swift Laboratories Limited Improved process for the preparation of 0-desmethyl-venlafaxine
WO2009151494A1 (en) * 2008-03-06 2009-12-17 Teva Pharmaceutical Industries Ltd. Processes for the preparation of o-desmethylvenlafaxine, free from its dimer impurities
EP2119695A1 (en) 2008-05-16 2009-11-18 Krka Preparation of O-desmethylvenlafaxine salts
EP2119696A1 (en) 2008-05-16 2009-11-18 Krka Preparation of O-desmethylvenlafaxine salts
US20110112200A1 (en) * 2008-06-16 2011-05-12 Valerie Niddam-Hildesheim Solid states of o-desmethylvenlafaxine salts
US20100016638A1 (en) * 2008-07-21 2010-01-21 Zdenko Hamersak Method for preparation of o-desmethylvenlafaxine using polythiolates
AU2009275667A1 (en) * 2008-07-30 2010-02-04 Generics [Uk] Limited Process for the preparation of O-desmethylvenlafaxine
CZ2008756A3 (cs) 2008-11-27 2010-03-24 Zentiva, A. S. Zpusob prípravy desvenlafaxinu a jeho solí
CZ301820B6 (cs) 2009-02-06 2010-06-30 Zentiva, K.S. Nové soli desvenlafaxinu a zpusob jejich prípravy
CZ2009454A3 (cs) 2009-07-15 2010-11-10 Zentiva, K. S. Zpusob prípravy desvenlafaxinu a jeho solí
NZ597550A (en) 2009-07-16 2013-08-30 Cipla Ltd Process for the preparation of o-desmethyl venlafaxine and intermediate for use therein
US20110098506A1 (en) * 2009-10-26 2011-04-28 Intas Pharmaceuticals Limited Method of preparing o-desmethylvenlafaxine
US20110184067A1 (en) * 2010-01-25 2011-07-28 Intas Pharmaceuticals Ltd. O-desmethylvenlafaxine succinate polymorph & process for preparing thereof
US8569371B2 (en) * 2010-03-29 2013-10-29 Pliva Hrvatska D.O.O. Crystal forms of O-desmethylvenlafaxine fumarate
CZ303249B6 (cs) 2010-04-06 2012-06-20 Zentiva, K.S. Zpusob výroby 4-(2-(substituovaných)-1-(1-hydroxycyklohexyl)ethyl)fenolu O-demethylací jejich methyletheru pomocí nepáchnoucích aromatických thiolu
EP2394976A1 (en) 2010-06-11 2011-12-14 LEK Pharmaceuticals d.d. Process for demethylating aromatic methyl ethers using 3-mercaptopropionic acid
US10464873B2 (en) 2017-02-09 2019-11-05 R L Finechem Private Limited Process for preparation of 1-[2-(dimethyl amino)-1-(4-hydroxyphenyl) ethyl]-cyclohexanol and salts thereof
CN109232189B (zh) * 2018-09-25 2021-10-08 杭州盛弗泰新材料科技有限公司 一种高纯度1-羟基芘的制备方法
CN109665966A (zh) * 2018-11-01 2019-04-23 山东蒲济医药科技有限公司 一种琥珀酸去甲文拉法辛化合物的制备方法

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DE2741009A1 (de) * 1976-09-22 1978-03-23 Sandoz Ag 4-styryl-4-indolinol-derivate, ihre verwendung und herstellung
US4535186A (en) 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
CA1227304A (en) * 1984-08-01 1987-09-29 Raymond C. Francis Delignification of pulp
GB8902209D0 (en) 1989-02-01 1989-03-22 Wyeth John And Brother Limited Preparation of cyclohexanol derivatives and novel thioamide intermediates
US6342533B1 (en) * 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
US6197828B1 (en) * 1998-12-01 2001-03-06 Sepracor, Inc. Derivatives of (+)-venlafaxine and methods of preparing and using the same
PL350924A1 (en) 1999-04-06 2003-02-10 Sepracor Inc Derivatives of venlafaxine and methods of preparing and using the same
WO2000076955A1 (en) 1999-06-15 2000-12-21 American Home Products Corporation Enantiomers of o-desmethyl venlafaxine
JP2004504026A (ja) 2000-07-18 2004-02-12 バイエル　アクチェンゲゼルシャフト ヒトｄｅｓｃ１様セリンプロテアーゼの調節
JP4220243B2 (ja) * 2001-02-12 2009-02-04 ワイス Ｏ−デスメチル−ベンラファキシンの新規コハク酸塩
UA80543C2 (en) * 2001-12-04 2007-10-10 Wyeth Corp Method for the preparation of o-desmethylvenlafaxine

Also Published As

Publication number Publication date
RU2004120284A (ru) 2005-04-10
NZ533316A (en) 2005-12-23
US20030105358A1 (en) 2003-06-05
CA2466779A1 (en) 2003-06-12
UA80543C2 (en) 2007-10-10
JP2005511681A (ja) 2005-04-28
HUP0402269A2 (hu) 2005-02-28
DK1451143T3 (da) 2008-11-10
US20090018365A1 (en) 2009-01-15
PL369299A1 (en) 2005-04-18
ATE403641T1 (de) 2008-08-15
KR100939650B1 (ko) 2010-02-05
JP4342312B2 (ja) 2009-10-14
EP1451143A1 (en) 2004-09-01
ES2311647T4 (es) 2009-11-10
HK1065778A1 (en) 2005-03-04
ES2311647T3 (es) 2009-02-16
CN1319934C (zh) 2007-06-06
KR20050044671A (ko) 2005-05-12
US7435854B2 (en) 2008-10-14
MXPA04005309A (es) 2004-09-13
EP1451143B9 (en) 2009-08-12
AU2002357049B2 (en) 2009-07-16
SI1451143T1 (sl) 2008-12-31
US20040158101A1 (en) 2004-08-12
EP1451143B1 (en) 2008-08-06
US20070225525A1 (en) 2007-09-27
ZA200405250B (en) 2005-12-28
IL162253A0 (en) 2005-11-20
IL194034A (en) 2010-12-30
AR037622A1 (es) 2004-11-17
TW200301102A (en) 2003-07-01
NO20042680L (no) 2004-06-25
WO2003048104A1 (en) 2003-06-12
CN1625546A (zh) 2005-06-08
PT1451143E (pt) 2008-10-21
US6689912B2 (en) 2004-02-10
AU2002357049A1 (en) 2003-06-17
BR0214701A (pt) 2004-08-31
RU2317286C2 (ru) 2008-02-20
ECSP045135A (es) 2004-07-23
TWI260982B (en) 2006-09-01
HUP0402269A3 (en) 2010-06-28
IL162253A (en) 2009-02-11
CA2466779C (en) 2013-11-19
DE60228118D1 (de) 2008-09-18

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