ATE300283T1 - Propofol-formulierung - Google Patents
Propofol-formulierungInfo
- Publication number
- ATE300283T1 ATE300283T1 AT99970917T AT99970917T ATE300283T1 AT E300283 T1 ATE300283 T1 AT E300283T1 AT 99970917 T AT99970917 T AT 99970917T AT 99970917 T AT99970917 T AT 99970917T AT E300283 T1 ATE300283 T1 AT E300283T1
- Authority
- AT
- Austria
- Prior art keywords
- benzyl alcohol
- propofol formulation
- propofol
- directed
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Anesthesiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/178,347 US6140373A (en) | 1998-10-23 | 1998-10-23 | Propofol composition |
| US09/354,017 US6140374A (en) | 1998-10-23 | 1999-07-15 | Propofol composition |
| PCT/US1999/024347 WO2000024376A1 (en) | 1998-10-23 | 1999-10-19 | Propofol composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE300283T1 true ATE300283T1 (de) | 2005-08-15 |
Family
ID=26874222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99970917T ATE300283T1 (de) | 1998-10-23 | 1999-10-19 | Propofol-formulierung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6140374A (de) |
| EP (1) | EP1124537B1 (de) |
| JP (1) | JP2002528405A (de) |
| AT (1) | ATE300283T1 (de) |
| AU (1) | AU768302B2 (de) |
| CA (1) | CA2347925C (de) |
| DE (1) | DE69926386T2 (de) |
| ES (1) | ES2245133T3 (de) |
| WO (1) | WO2000024376A1 (de) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6979456B1 (en) | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
| ES2211151T3 (es) | 1998-08-19 | 2004-07-01 | Skyepharma Canada Inc. | Dispersiones acuosas inyectables de propofol. |
| US6100302A (en) * | 1999-04-05 | 2000-08-08 | Baxter International Inc. | Propofol formulation with enhanced microbial characteristics |
| IL152774A0 (en) * | 2000-05-25 | 2003-06-24 | Astrazeneca Ab | Pharmaceutical composition comprising a free-radical scavenging sedative agent and a metal ion chelating agent |
| GB0012597D0 (en) * | 2000-05-25 | 2000-07-12 | Astrazeneca Ab | Formulation |
| EP2036540A3 (de) | 2000-06-16 | 2009-12-16 | Jagotec AG | Verbesserte injektierbare Propofoldispersionen |
| US6399087B1 (en) * | 2000-12-20 | 2002-06-04 | Amphastar Pharmaceuticals, Inc. | Propofol formulation with enhanced microbial inhibition |
| AU2002334675A1 (en) | 2001-09-26 | 2003-04-07 | Theravance, Inc. | Substituted phenol compounds useful for anesthesia and sedation |
| CN1257152C (zh) * | 2002-01-25 | 2006-05-24 | 施万制药 | 用于麻醉和镇静的短效镇静催眠剂 |
| EP1492522A4 (de) * | 2002-04-10 | 2009-01-14 | Conforma Therapeutics Corp | Ansamycin-formulierungen und verfahren zu ihrer herstellung und verwendung |
| CA2489391A1 (en) * | 2002-06-18 | 2003-12-24 | Martek Biosciences Corporation | Stable emulsions of oils in aqueous solutions and methods for producing same |
| HRP20050182A2 (en) * | 2002-07-29 | 2006-11-30 | Transform Pharmaceuticals | Aqueous 2,6-diisopropylphenol pharmaceutical compositions |
| US7550155B2 (en) * | 2002-07-29 | 2009-06-23 | Transform Pharmaceuticals Inc. | Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses |
| US20040220283A1 (en) * | 2002-07-29 | 2004-11-04 | Transform Pharmaceuticals, Inc. | Aqueous 2,6-diisopropylphenol pharmaceutical compositions |
| WO2004039326A2 (en) * | 2002-10-29 | 2004-05-13 | Transform Pharmaceuticals, Inc. | Propofol with cysteine |
| US20060148776A1 (en) * | 2003-03-13 | 2006-07-06 | Conforma Therapeutics Corporation | Drug formulations having long and medium chain triglycerides |
| JP2006514994A (ja) * | 2003-03-13 | 2006-05-18 | コンフォーマ・セラピューティクス・コーポレイション | 長鎖および中鎖トリグリセリドを有する医薬製剤 |
| US7439268B2 (en) * | 2003-07-18 | 2008-10-21 | Idexx Laboratories | Compositions containing prodrugs of florfenicol and methods of use |
| DK1648413T3 (da) * | 2003-07-23 | 2010-01-11 | Theravance Inc | Farmaceutiske præparater af kortvirkende sedativt sövndyssende middel |
| US8546453B2 (en) | 2003-08-14 | 2013-10-01 | Rensheng Zhang | Propofol compositions and methods for reducing pain associated with propofol injection |
| US20050049210A1 (en) * | 2003-08-27 | 2005-03-03 | Idexx Laboratories, Inc. | Methods for the controlled delivery of pharmacologically active compounds |
| KR20070058608A (ko) * | 2004-09-13 | 2007-06-08 | 바라트 쎄럼스 앤드 백신스 리미티드 | 항미생물 방부 효능을 갖는 정맥 내 투여를 위한 안정한에멀젼 조성물 |
| US20060067953A1 (en) * | 2004-09-29 | 2006-03-30 | Conforma Therapeutics Corporation | Oral pharmaceutical formulations and methods for producing and using same |
| WO2007000662A2 (en) * | 2005-02-03 | 2007-01-04 | Taro Pharmaceuticals U.S.A., Inc. | Novel propofol composition comprising ascorbic acid or pharmaceutically acceptable salts thereof |
| CA2602257A1 (en) * | 2005-03-30 | 2006-10-05 | Conforma Therapeutics Corporation | Alkynyl pyrrolopyrimidines and related analogs as hsp90-inhibitors |
| CA2603462A1 (en) * | 2005-04-07 | 2006-10-09 | Conforma Therapeutics Corporation | Phospholipid-based pharmaceutical formulations and methods for producing and using same |
| WO2006128088A1 (en) * | 2005-05-27 | 2006-11-30 | Sandhya Goyal | Novel propofol composition comprising a pharmaceutically acceptable salt of formaldehyde sulfoxylate |
| JP2009503059A (ja) * | 2005-08-05 | 2009-01-29 | ブハラット セルムズ アンド ヴァクシンズ リミテッド | 防腐効果を有する静脈プロポフォールエマルジョン組成物 |
| JP2009504634A (ja) * | 2005-08-12 | 2009-02-05 | ブハラット セルムズ アンド ヴァクシンズ リミテッド | プロポフォールを含む水性麻酔剤組成物 |
| LT3311805T (lt) * | 2005-08-31 | 2020-04-27 | Abraxis Bioscience, Llc | Kompozicijos, apimančios silpnai vandenyje tirpius farmacinius agentus ir priešmikrobinius agentus |
| CN101291658B (zh) | 2005-08-31 | 2014-04-16 | 阿布拉科斯生物科学有限公司 | 用于制备稳定性增加的水难溶性药物的组合物和方法 |
| WO2007035963A2 (en) * | 2005-09-23 | 2007-03-29 | Conforma Therapeutics Corporation | Anti-tumor methods using multi drug resistance independent synthetic hsp90 inhibitors |
| CN101360492A (zh) * | 2005-12-01 | 2009-02-04 | 康福玛医药公司 | 含安莎霉素的组合物 |
| EP2810927A1 (de) | 2007-05-09 | 2014-12-10 | Sowood Healthcare LLC | Therapeutische Verbindungen |
| KR20100017435A (ko) * | 2007-05-09 | 2010-02-16 | 파마코포어, 인크. | 치료 화합물 |
| US7550625B2 (en) * | 2007-10-19 | 2009-06-23 | Idexx Laboratories | Esters of florfenicol |
| US9132090B2 (en) | 2009-01-13 | 2015-09-15 | Chetan Majmudar | Propofol based anesthetic with preservative |
| IN2012DN06581A (de) | 2010-03-17 | 2015-10-23 | Novaliq Gmbh | |
| EP2624820A4 (de) * | 2010-10-05 | 2014-03-19 | Medicines Co | Antimikrobielle konservierung von propofolemulsionen |
| EP2444063A1 (de) | 2010-10-20 | 2012-04-25 | Novaliq GmbH | Flüssige pharmazeutische Zusammensetzungen zur Abgabe von Wirkstoffen |
| EP2462921A1 (de) | 2010-11-11 | 2012-06-13 | Novaliq GmbH | Flüssige pharmazeutische Zusammensetzungen zur Behandlung einer Erkrankung der Hinterseite des Auges |
| BR112013016661B1 (pt) | 2011-01-04 | 2021-08-03 | Novaliq Gmbh | Emulsões de o/a compreendendo alcanos semifluorados |
| JP6039145B2 (ja) | 2011-05-25 | 2016-12-07 | ノバリック ゲーエムベーハー | 半フッ化アルカンを基礎にした局所薬学的組成物 |
| KR101773648B1 (ko) | 2011-05-25 | 2017-08-31 | 노바리크 게엠베하 | 조갑에 투여를 위한 제약학적 조성물 |
| PT2806886T (pt) | 2012-01-23 | 2017-03-24 | Novaliq Gmbh | Composições de proteínas estabilizadas baseadas em alcanos semifluorados |
| EP3181119B1 (de) | 2012-09-12 | 2019-07-10 | Novaliq GmbH | Zusammensetzungen semifluorierter alkane zur verwendung in der behandlung von keratoconjunctivitis sicca |
| CN113952321B (zh) | 2012-09-12 | 2023-03-28 | 诺瓦利克有限责任公司 | 包含半氟化烷烃的混合物的组合物 |
| PT3024484T (pt) | 2013-07-23 | 2018-10-24 | Novaliq Gmbh | Composições de anticorpo estabilizadas |
| CN111743882A (zh) | 2015-09-30 | 2020-10-09 | 诺瓦利克有限责任公司 | 半氟化化合物和其组合物 |
| PT3356313T (pt) | 2015-09-30 | 2020-07-13 | Novaliq Gmbh | 2-perfluoro-hexiloctano para administração oftálmica |
| CN109640900B (zh) | 2016-06-23 | 2020-07-07 | 诺瓦利克有限责任公司 | 一种试剂盒 |
| CN109890374A (zh) | 2016-09-22 | 2019-06-14 | 诺瓦利克有限责任公司 | 用于治疗睑缘炎的药物组合物 |
| US10813976B2 (en) | 2016-09-23 | 2020-10-27 | Novaliq Gmbh | Ophthalmic compositions comprising ciclosporin |
| KR102288022B1 (ko) | 2016-12-23 | 2021-08-10 | 노바리크 게엠베하 | 건성 안 질환 치료용 안구 조성물 |
| MX388460B (es) | 2017-04-21 | 2025-03-20 | Dermaliq Therapeutics Inc | Composiciones de yodo. |
| CN110650734B (zh) | 2017-05-12 | 2024-11-15 | 诺瓦利克有限责任公司 | 治疗与隐形眼镜有关病症的包含半氟化烷烃的药物组合物 |
| KR20200059272A (ko) | 2017-09-27 | 2020-05-28 | 노바리크 게엠베하 | 안구 질환의 치료에서의 사용을 위한 라타노프로스트를 포함하는 안과적 조성물 |
| WO2019068763A1 (en) | 2017-10-04 | 2019-04-11 | Novaliq Gmbh | OPHTHALMIC COMPOSITIONS COMPRISING F6H8 |
| CA3091308A1 (en) | 2018-03-02 | 2019-09-06 | Novaliq Gmbh | Pharmaceutical compositions comprising nebivolol |
| CN112153970A (zh) | 2018-04-27 | 2020-12-29 | 诺瓦利克有限责任公司 | 用于治疗青光眼的包含他氟前列素的眼用组合物 |
| SG11202102820VA (en) | 2018-10-12 | 2021-04-29 | Novaliq Gmbh | Ophthalmic composition for treatment of dry eye disease |
| CN113710228A (zh) | 2019-02-13 | 2021-11-26 | 诺瓦利克有限责任公司 | 用于治疗眼部新生血管形成的组合物和方法 |
| MX2022002667A (es) | 2019-09-06 | 2022-04-07 | Novaliq Gmbh | Composicion oftalmica para el tratamiento de uveitis. |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1472793A (en) * | 1974-03-28 | 1977-05-04 | Ici Ltd | Pharmaceutical compositions |
| US4798846A (en) * | 1974-03-28 | 1989-01-17 | Imperial Chemical Industries Plc | Pharmaceutical compositions |
| IL78929A0 (en) * | 1985-07-29 | 1986-09-30 | Abbott Lab | Microemulsion compositions for parenteral administration |
| US4866096A (en) * | 1987-03-20 | 1989-09-12 | Air Products And Chemicals, Inc. | Stable fluorochemical aqueous emulsions |
| JPH05170742A (ja) * | 1991-05-24 | 1993-07-09 | Ishihara Sangyo Kaisha Ltd | ジアミノトリフルオロメチルピリジン誘導体、それらの製造方法及びそれらを含有するホスホリパーゼ▲ａ２▼阻害剤 |
| JP3005275B2 (ja) * | 1990-10-18 | 2000-01-31 | 石原産業株式会社 | キヌクリジン誘導体及びその製造方法 |
| JP3559039B2 (ja) * | 1992-04-28 | 2004-08-25 | フレセニウス・アーゲー | 炎症性疾患の治療のための非経口的に投与される医薬を調製するためのエマルジョンの使用 |
| JP2683783B2 (ja) * | 1992-07-10 | 1997-12-03 | 雪印乳業株式会社 | シェーグレン症候群治療剤 |
| US5731356A (en) * | 1994-03-22 | 1998-03-24 | Zeneca Limited | Pharmaceutical compositions of propofol and edetate |
| GB9405593D0 (en) * | 1994-03-22 | 1994-05-11 | Zeneca Ltd | Pharmaceutical compositions |
| WO1997010814A1 (en) * | 1995-09-18 | 1997-03-27 | Vesifact Ag | Propofol nanodispersions |
| US5637625A (en) * | 1996-03-19 | 1997-06-10 | Research Triangle Pharmaceuticals Ltd. | Propofol microdroplet formulations |
-
1999
- 1999-07-15 US US09/354,017 patent/US6140374A/en not_active Expired - Lifetime
- 1999-10-19 DE DE69926386T patent/DE69926386T2/de not_active Expired - Lifetime
- 1999-10-19 WO PCT/US1999/024347 patent/WO2000024376A1/en not_active Ceased
- 1999-10-19 ES ES99970917T patent/ES2245133T3/es not_active Expired - Lifetime
- 1999-10-19 CA CA002347925A patent/CA2347925C/en not_active Expired - Fee Related
- 1999-10-19 JP JP2000577987A patent/JP2002528405A/ja active Pending
- 1999-10-19 AT AT99970917T patent/ATE300283T1/de not_active IP Right Cessation
- 1999-10-19 EP EP99970917A patent/EP1124537B1/de not_active Expired - Lifetime
- 1999-10-19 AU AU12106/00A patent/AU768302B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002528405A (ja) | 2002-09-03 |
| CA2347925A1 (en) | 2000-05-04 |
| US6140374A (en) | 2000-10-31 |
| CA2347925C (en) | 2009-03-17 |
| DE69926386T2 (de) | 2006-05-24 |
| EP1124537A1 (de) | 2001-08-22 |
| EP1124537B1 (de) | 2005-07-27 |
| AU1210600A (en) | 2000-05-15 |
| DE69926386D1 (de) | 2005-09-01 |
| ES2245133T3 (es) | 2005-12-16 |
| WO2000024376A1 (en) | 2000-05-04 |
| AU768302B2 (en) | 2003-12-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |