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CO5560574A2 - Procesos para la preparacion de compuestos de aminopirimidina, halogenopirimidina, sulfoniloxipirimidina e hidroxipirimidina; y un compuesto de hidroxipirimidina - Google Patents

Procesos para la preparacion de compuestos de aminopirimidina, halogenopirimidina, sulfoniloxipirimidina e hidroxipirimidina; y un compuesto de hidroxipirimidina

Info

Publication number
CO5560574A2
CO5560574A2 CO04001313A CO04001313A CO5560574A2 CO 5560574 A2 CO5560574 A2 CO 5560574A2 CO 04001313 A CO04001313 A CO 04001313A CO 04001313 A CO04001313 A CO 04001313A CO 5560574 A2 CO5560574 A2 CO 5560574A2
Authority
CO
Colombia
Prior art keywords
compound
formula
sulphonyloxypirimidine
hydroxypirimidine
hydroxipirimidine
Prior art date
Application number
CO04001313A
Other languages
English (en)
Inventor
Akio Matsushita
Mizuho Oda
Yasuhiro Kawachi
Jun-Ichi Chika
Original Assignee
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd
Publication of CO5560574A2 publication Critical patent/CO5560574A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1.- Un proceso para preparar un compuesto de 2-(N-metil-N-metanosulfonilamino)pirimidina que tiene la fórmula (3): en la cual R es un grupo hidrocarbilo, que comprende los pasos de:hacer reaccionar un compuesto de hidroxipirimidina que tiene la fórmula (1): en la cual R es idéntico al de más arriba, con un halogenuro sulfonilo orgánico que tiene la fórmula (2) R´SO2X (2)en la cual R´ es un grupo hidrocarbilo y X es un átomo de halógeno, o un anhídrido sulfónico orgánico que tiene la fórmula (2a): (R´SO2)2O (2a)en la cual R´ significa lo mismo que antes, yse hace reaccionar el producto de reacción resultante con N-metil-N-metanosulfonamida.9.- Un compuesto de hidroxipirimidina que tiene la fórmula (1) en la cual R es un grupo hidrocarbilo.
CO04001313A 2001-07-13 2004-01-09 Procesos para la preparacion de compuestos de aminopirimidina, halogenopirimidina, sulfoniloxipirimidina e hidroxipirimidina; y un compuesto de hidroxipirimidina CO5560574A2 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2001213417 2001-07-13
JP2001213418 2001-07-13
JP2001310900 2001-10-09
JP2001360339 2001-11-27
JP2002007015 2002-01-16
JP2002042076 2002-02-19

Publications (1)

Publication Number Publication Date
CO5560574A2 true CO5560574A2 (es) 2005-09-30

Family

ID=27554967

Family Applications (1)

Application Number Title Priority Date Filing Date
CO04001313A CO5560574A2 (es) 2001-07-13 2004-01-09 Procesos para la preparacion de compuestos de aminopirimidina, halogenopirimidina, sulfoniloxipirimidina e hidroxipirimidina; y un compuesto de hidroxipirimidina

Country Status (27)

Country Link
US (4) US7304156B2 (es)
EP (1) EP1417180B1 (es)
JP (2) JP4359141B2 (es)
KR (1) KR100888408B1 (es)
CN (2) CN100349877C (es)
AR (2) AR034772A1 (es)
AT (1) ATE349431T1 (es)
AU (1) AU2002318041B2 (es)
BR (1) BR0211072A (es)
CA (1) CA2453505C (es)
CO (1) CO5560574A2 (es)
CY (1) CY1107551T1 (es)
DE (1) DE60217126T2 (es)
DK (1) DK1417180T3 (es)
EG (1) EG24848A (es)
ES (1) ES2278032T3 (es)
HU (1) HUP0401248A3 (es)
IL (2) IL159741A0 (es)
IS (1) IS2399B (es)
MX (1) MXPA04000322A (es)
MY (1) MY133579A (es)
NO (1) NO326173B1 (es)
NZ (1) NZ531033A (es)
PL (1) PL366831A1 (es)
PT (1) PT1417180E (es)
SI (1) SI1417180T1 (es)
WO (1) WO2003006439A1 (es)

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US20040176401A1 (en) 2004-09-09
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