CO5540339A2 - PROCESS FOR THE PREPARATION OF CICLOHEXANOL DERIVATIVES - Google Patents
PROCESS FOR THE PREPARATION OF CICLOHEXANOL DERIVATIVESInfo
- Publication number
- CO5540339A2 CO5540339A2 CO03111625A CO03111625A CO5540339A2 CO 5540339 A2 CO5540339 A2 CO 5540339A2 CO 03111625 A CO03111625 A CO 03111625A CO 03111625 A CO03111625 A CO 03111625A CO 5540339 A2 CO5540339 A2 CO 5540339A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- hydrogen
- cycloalkyl
- formula
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 229920000642 polymer Polymers 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000007810 chemical reaction solvent Substances 0.000 abstract 1
- HPXRVTGHNJAIIH-PTQBSOBMSA-N cyclohexanol Chemical class O[13CH]1CCCCC1 HPXRVTGHNJAIIH-PTQBSOBMSA-N 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002524 organometallic group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
1.- Un proceso para la preparación de derivados de ciclohexanol de la fórmula I ( I )en donde R6 y R7 son sustituyentes orto o para, independientemente seleccionados del grupo compuesto por hidrógeno, hidroxilo, alquilo C1-C6, alcoxi C1-C6, aralcoxi C7-C9, alcanoiloxi C2-C7, alquilmercapto C1-C6, halo o trifluorometilo; R8 es hidrógeno o alquilo C1-C6; p es uno de los enteros 0, 1, 2, 3 o 4; y R9 es hidrógeno o alquilo C1-C6; comprendiendo la reacción de un compuesto de la fórmula II con un compuesto de la fórmula III,en presencia de un catalizador de una base no organometálica representada por la fórmula IV o V, en presencia o ausencia de un solvente de reacción.en donde A es -(CH2)n - en donde n es un entero del 2 al 4; B es -(CH2)m - donde m es un entero del 2 al 5; X es CH2, O, NH o NRAND#39, donde RAND#39 es un alquilo C1-C4 o acilo o un polímero de soporte alquilo; cada uno de R1 a R4 son independientemente hidrógeno, un alquilo, un cicloalquilo o un polímero de soporte alquilo o cicloalquilo, y todos de R1 a R4 no son hidrógeno, y R5 es un alquilo, un cicloalquilo o un polímero de soporte alquilo o cicloalquilo, y en donde R9 es un alquilo, el grupo alquilo es introducido por alquilación.1.- A process for the preparation of cyclohexanol derivatives of the formula I (I) in which R6 and R7 are ortho or para substituents, independently selected from the group consisting of hydrogen, hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, C7-C9 aralkoxy, C2-C7 alkanoyloxy, C1-C6 alkylmercapto, halo or trifluoromethyl; R8 is hydrogen or C1-C6 alkyl; p is one of the integers 0, 1, 2, 3 or 4; and R9 is hydrogen or C1-C6 alkyl; comprising the reaction of a compound of the formula II with a compound of the formula III, in the presence of a catalyst of a non-organometallic base represented by the formula IV or V, in the presence or absence of a reaction solvent. wherein A is - (CH2) n - where n is an integer from 2 to 4; B is - (CH2) m - where m is an integer from 2 to 5; X is CH2, O, NH or NRAND # 39, where RAND # 39 is a C1-C4 alkyl or acyl or an alkyl support polymer; each of R1 to R4 are independently hydrogen, an alkyl, a cycloalkyl or an alkyl or cycloalkyl support polymer, and all of R1 to R4 are not hydrogen, and R5 is an alkyl, a cycloalkyl or an alkyl or cycloalkyl support polymer , and wherein R9 is an alkyl, the alkyl group is introduced by alkylation.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020010035889A KR20030000217A (en) | 2001-06-22 | 2001-06-22 | Process for the preparation of cyclohexanol derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5540339A2 true CO5540339A2 (en) | 2005-07-29 |
Family
ID=36604137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO03111625A CO5540339A2 (en) | 2001-06-22 | 2003-12-22 | PROCESS FOR THE PREPARATION OF CICLOHEXANOL DERIVATIVES |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1397344A1 (en) |
| JP (1) | JP2004531577A (en) |
| KR (2) | KR20030000217A (en) |
| CN (1) | CN1267410C (en) |
| AR (1) | AR034609A1 (en) |
| BR (1) | BR0210542A (en) |
| CA (1) | CA2450914A1 (en) |
| CO (1) | CO5540339A2 (en) |
| EA (1) | EA007486B1 (en) |
| EC (1) | ECSP034920A (en) |
| HU (1) | HUP0400867A3 (en) |
| IL (1) | IL159448A0 (en) |
| MX (1) | MXPA03011401A (en) |
| NO (1) | NO20035586L (en) |
| NZ (1) | NZ530594A (en) |
| PL (1) | PL366613A1 (en) |
| SG (1) | SG156520A1 (en) |
| TW (1) | TWI250973B (en) |
| UA (1) | UA78511C2 (en) |
| WO (1) | WO2003000652A1 (en) |
| ZA (1) | ZA200400451B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100651353B1 (en) * | 2002-02-01 | 2006-11-28 | 에스케이 주식회사 | Process for continuously preparing venlafaxine intermediates in high yield |
| WO2005049560A2 (en) * | 2003-09-29 | 2005-06-02 | Sun Pharmaceutical Industries Limited | Process for the preparation of anti-depressant compound |
| TW200523258A (en) * | 2003-10-02 | 2005-07-16 | Wyeth Corp | Process for the preparation of 1-[cyano(phenyl)methyl]-cyclohexanol compounds |
| MX2007016049A (en) * | 2005-06-29 | 2008-03-10 | Wyeth Corp | Process for the preparation of 1-[cyano (4-hydroxyphenyl)methyl]c yclohexanol compounds. |
| MX2007016179A (en) | 2006-04-17 | 2008-03-11 | Teva Pharma | Polymorphic forms of tegaserod maleate. |
| US20090062572A1 (en) * | 2006-07-26 | 2009-03-05 | Valerie Niddam-Hildesheim | Processes for the synthesis of O-desmethylvenlafaxine |
| JP4763788B2 (en) * | 2006-07-26 | 2011-08-31 | テバ ファーマシューティカル インダストリーズ リミティド | Method for synthesizing O-desmethylvenlafaxine |
| WO2011121452A2 (en) | 2010-03-29 | 2011-10-06 | Pliva Hrvatska D.O.O. | Crystal forms of o-desmethylvenlafaxine fumarate |
| US10428291B2 (en) | 2014-03-28 | 2019-10-01 | Cummins Filtration Ip, Inc. | Ashless oil additives and their use as TBN boosters |
| JP2021510385A (en) | 2018-01-10 | 2021-04-22 | ハンツマン・インターナショナル・エルエルシー | Polyurethane-containing formulation with isoanate functional value |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4535186A (en) * | 1983-04-19 | 1985-08-13 | American Home Products Corporation | 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives |
| GB8902209D0 (en) * | 1989-02-01 | 1989-03-22 | Wyeth John And Brother Limited | Preparation of cyclohexanol derivatives and novel thioamide intermediates |
| TWI228118B (en) * | 2000-08-30 | 2005-02-21 | Ciba Sc Holding Ag | Process for the preparation of substituted phenylacetonitriles |
-
2001
- 2001-06-22 KR KR1020010035889A patent/KR20030000217A/en active Pending
-
2002
- 2002-06-21 WO PCT/US2002/019753 patent/WO2003000652A1/en not_active Ceased
- 2002-06-21 HU HU0400867A patent/HUP0400867A3/en unknown
- 2002-06-21 EP EP02744526A patent/EP1397344A1/en not_active Withdrawn
- 2002-06-21 JP JP2003507059A patent/JP2004531577A/en not_active Ceased
- 2002-06-21 UA UA2004010467A patent/UA78511C2/en unknown
- 2002-06-21 NZ NZ530594A patent/NZ530594A/en not_active IP Right Cessation
- 2002-06-21 EA EA200400069A patent/EA007486B1/en not_active IP Right Cessation
- 2002-06-21 TW TW091113830A patent/TWI250973B/en not_active IP Right Cessation
- 2002-06-21 AR ARP020102341A patent/AR034609A1/en unknown
- 2002-06-21 SG SG200508264-9A patent/SG156520A1/en unknown
- 2002-06-21 CA CA002450914A patent/CA2450914A1/en not_active Abandoned
- 2002-06-21 BR BR0210542-0A patent/BR0210542A/en not_active IP Right Cessation
- 2002-06-21 KR KR1020037016739A patent/KR100874835B1/en not_active Expired - Fee Related
- 2002-06-21 IL IL15944802A patent/IL159448A0/en unknown
- 2002-06-21 MX MXPA03011401A patent/MXPA03011401A/en not_active Application Discontinuation
- 2002-06-21 CN CNB028124669A patent/CN1267410C/en not_active Expired - Fee Related
- 2002-06-21 PL PL02366613A patent/PL366613A1/en not_active Application Discontinuation
-
2003
- 2003-12-15 NO NO20035586A patent/NO20035586L/en not_active Application Discontinuation
- 2003-12-22 EC EC2003004920A patent/ECSP034920A/en unknown
- 2003-12-22 CO CO03111625A patent/CO5540339A2/en not_active Application Discontinuation
-
2004
- 2004-01-21 ZA ZA2004/00451A patent/ZA200400451B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR0210542A (en) | 2004-06-22 |
| HUP0400867A2 (en) | 2004-08-30 |
| KR20040011548A (en) | 2004-02-05 |
| KR100874835B1 (en) | 2008-12-19 |
| HUP0400867A3 (en) | 2005-04-28 |
| TWI250973B (en) | 2006-03-11 |
| JP2004531577A (en) | 2004-10-14 |
| ECSP034920A (en) | 2004-02-26 |
| MXPA03011401A (en) | 2004-04-05 |
| ZA200400451B (en) | 2005-06-29 |
| WO2003000652A8 (en) | 2004-05-21 |
| CN1531524A (en) | 2004-09-22 |
| UA78511C2 (en) | 2007-04-10 |
| IL159448A0 (en) | 2004-06-01 |
| CA2450914A1 (en) | 2003-01-03 |
| NZ530594A (en) | 2006-06-30 |
| KR20030000217A (en) | 2003-01-06 |
| WO2003000652A1 (en) | 2003-01-03 |
| SG156520A1 (en) | 2009-11-26 |
| PL366613A1 (en) | 2005-02-07 |
| CN1267410C (en) | 2006-08-02 |
| EA007486B1 (en) | 2006-10-27 |
| EA200400069A1 (en) | 2004-06-24 |
| AR034609A1 (en) | 2004-03-03 |
| EP1397344A1 (en) | 2004-03-17 |
| NO20035586D0 (en) | 2003-12-15 |
| NO20035586L (en) | 2003-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |