CO5261555A1 - Linezolid-forma cristalina ii - Google Patents
Linezolid-forma cristalina iiInfo
- Publication number
- CO5261555A1 CO5261555A1 CO01005901A CO01005901A CO5261555A1 CO 5261555 A1 CO5261555 A1 CO 5261555A1 CO 01005901 A CO01005901 A CO 01005901A CO 01005901 A CO01005901 A CO 01005901A CO 5261555 A1 CO5261555 A1 CO 5261555A1
- Authority
- CO
- Colombia
- Prior art keywords
- linezolid
- crystal form
- oxazolidinyl
- mfi
- jpeg
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 2
- TYZROVQLWOKYKF-ZDUSSCGKSA-N linezolid Chemical compound O=C1O[C@@H](CNC(=O)C)CN1C(C=C1F)=CC=C1N1CCOCC1 TYZROVQLWOKYKF-ZDUSSCGKSA-N 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
(S)-N-[[3-[3-fluoro-4-(4-morfolinil)fenil]-2-oxo-5-oxazolidinil]metil]acetamida en cristales de "Forma II" con un espectro de difracción del polvo con rayos X de: Espaciamiento d (Á) Ángulo dos-teta (°) Intensidad relativa (%)12.44 7.10 2 9.26 9.54 9 6.37 13.88 6 6.22 14.23 24 5.48 16.18 3 5.28 16.79 100 5.01 17.69 2 4.57 19.41 4 4.50 19.69 2 4.45 19.93 6 4.11 21.61 15 3.97 22.39 23 3.89 22.84 4 3.78 23.52 7 3.68 24.16 1 3.52 25.28 13 3.34 26.66 1 3.30 27.01 3 3.21 27.77 1<EMI FILE="01005901_1" ID="1" IMF=JPEG >
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17983700P | 2000-02-02 | 2000-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5261555A1 true CO5261555A1 (es) | 2003-03-31 |
Family
ID=22658183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO01005901A CO5261555A1 (es) | 2000-02-02 | 2001-01-26 | Linezolid-forma cristalina ii |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1255754B1 (es) |
| JP (1) | JP5235256B2 (es) |
| KR (3) | KR100864745B1 (es) |
| CN (1) | CN1221547C (es) |
| AR (1) | AR027261A1 (es) |
| AT (1) | ATE297920T1 (es) |
| AU (1) | AU782138B2 (es) |
| BR (1) | BR0107667A (es) |
| CA (1) | CA2395603C (es) |
| CO (1) | CO5261555A1 (es) |
| CZ (1) | CZ302292B6 (es) |
| DE (1) | DE60111497T2 (es) |
| DK (1) | DK1255754T3 (es) |
| EA (1) | EA004434B1 (es) |
| EE (1) | EE05197B1 (es) |
| ES (1) | ES2242728T3 (es) |
| HU (1) | HUP0301076A3 (es) |
| IL (1) | IL151010A0 (es) |
| MX (1) | MXPA02007471A (es) |
| MY (1) | MY122829A (es) |
| NO (2) | NO323459B1 (es) |
| NZ (1) | NZ520541A (es) |
| PE (1) | PE20011086A1 (es) |
| PL (1) | PL356433A1 (es) |
| PT (1) | PT1255754E (es) |
| SI (1) | SI1255754T1 (es) |
| SK (1) | SK287025B6 (es) |
| TW (1) | TWI297687B (es) |
| WO (1) | WO2001057035A1 (es) |
| ZA (1) | ZA200205162B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100490643B1 (ko) * | 2002-10-29 | 2005-05-19 | 한국과학기술연구원 | 새로운 메틸리덴 피페리딘일 옥사졸리딘온 유도체 및이들의 제조방법 |
| EP1673370B1 (en) | 2003-10-16 | 2009-09-09 | Symed Labs Limited | Crystalline form of linezolid |
| DE602004009344T2 (de) | 2004-04-19 | 2008-07-10 | Symed Labs Ltd., Hyderabad | Neues verfahren zur herstellung von linezolid und verwandten verbindungen |
| EP2174935A1 (en) * | 2004-06-29 | 2010-04-14 | Teva Pharmaceutical Industries Ltd | Linezolid Compositions |
| EP1745028A2 (en) * | 2004-06-29 | 2007-01-24 | Teva Pharmaceutical Industries Ltd | Solid forms of linezolid and processes for preparation thereof |
| MX2007010141A (es) * | 2005-02-24 | 2007-09-27 | Teva Pharma | Procesos para la preparacion de intermedios de linezolid. |
| EP1893195A2 (en) * | 2005-06-22 | 2008-03-05 | Teva Pharmaceutical Industries Ltd | Polymorphic forms of tegaserod maleate |
| AU2006277017A1 (en) * | 2005-07-20 | 2007-02-15 | Teva Pharmaceutical Industries Ltd. | Stable pharmaceutical composition comprising linezolid form IV |
| WO2007102082A1 (en) * | 2006-03-09 | 2007-09-13 | Glenmark Pharmaceuticals Limited | High oxazolidinone content solid dosage forms |
| US20080139563A1 (en) * | 2006-10-23 | 2008-06-12 | Concert Pharmaceuticals Inc. | Oxazolidinone derivatives and methods of use |
| WO2011050826A1 (en) | 2009-10-28 | 2011-05-05 | Synthon B.V. | Process for making crystalline form a of linezolid |
| RU2012151303A (ru) | 2010-04-30 | 2014-06-10 | Индиана Юниверсити Рисерч Эдн Текнолоджи Корпорейшн | Способы получения линезолида |
| EP2690100A1 (en) | 2010-08-11 | 2014-01-29 | Synhton B.V. | Process for making linezolid |
| EP2603505A1 (en) | 2010-08-11 | 2013-06-19 | Synthon BV | Process for making linezolid |
| WO2012114354A1 (en) * | 2011-02-24 | 2012-08-30 | Lee Pharma Limited | Anhydrous linezolid crystalline form-ii |
| WO2012119653A1 (en) | 2011-03-09 | 2012-09-13 | Synthon Bv | Process for making crystalline form a of linezolid |
| CN102731341A (zh) * | 2011-04-13 | 2012-10-17 | 上海医药工业研究院 | 用于制备利奈唑胺的中间体及其制备方法 |
| CN105461648B (zh) * | 2011-05-03 | 2018-01-12 | 江苏豪森药业集团有限公司 | 利奈唑胺的晶型及其制备方法 |
| CN102399200B (zh) * | 2011-12-14 | 2013-12-04 | 浙江新东港药业股份有限公司 | 一种利用悬浮结晶法制备利奈唑胺晶型ⅰ的方法 |
| US20150025236A1 (en) | 2012-01-24 | 2015-01-22 | Jubilant Life Sciences Limited | Process for the preparation of stable crystalline form-i of linezolid, substantially free of residual solvent |
| WO2013120496A1 (en) | 2012-02-14 | 2013-08-22 | Pharmathen S.A. | Process for the preparation of linezolid in crystalline form and salts thereof |
| CN102643245A (zh) * | 2012-04-10 | 2012-08-22 | 杭州华东医药集团生物工程研究所有限公司 | 一种利奈唑胺晶型及其制备方法 |
| ES2603252T3 (es) | 2012-11-09 | 2017-02-24 | Synthon Bv | Proceso para preparar linezolid |
| EP3541442B1 (en) | 2016-11-16 | 2022-01-19 | Persica Pharmaceuticals Ltd. | Antibiotic formulations for lower back pain |
| EP4616848A3 (en) * | 2017-11-16 | 2025-11-12 | Persica Pharmaceuticals Ltd. | Linezolid formulations |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| US5688792A (en) * | 1994-08-16 | 1997-11-18 | Pharmacia & Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
| MY115155A (en) * | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| CN1319952C (zh) * | 1996-04-11 | 2007-06-06 | 法玛西雅厄普约翰美国公司 | 制备唑烷酮胺的方法 |
| ES2284216T3 (es) * | 1997-11-07 | 2007-11-01 | PHARMACIA & UPJOHN COMPANY LLC | Procedeimiento para producir oxazolidinonas. |
-
2001
- 2001-01-22 AR ARP010100269A patent/AR027261A1/es not_active Application Discontinuation
- 2001-01-25 PE PE2001000080A patent/PE20011086A1/es not_active Application Discontinuation
- 2001-01-26 CO CO01005901A patent/CO5261555A1/es not_active Application Discontinuation
- 2001-01-29 DK DK01904805T patent/DK1255754T3/da active
- 2001-01-29 MX MXPA02007471A patent/MXPA02007471A/es active IP Right Grant
- 2001-01-29 AT AT01904805T patent/ATE297920T1/de active
- 2001-01-29 BR BR0107667-1A patent/BR0107667A/pt not_active Application Discontinuation
- 2001-01-29 AU AU32755/01A patent/AU782138B2/en not_active Ceased
- 2001-01-29 HU HU0301076A patent/HUP0301076A3/hu unknown
- 2001-01-29 PL PL01356433A patent/PL356433A1/xx unknown
- 2001-01-29 SK SK994-2002A patent/SK287025B6/sk not_active IP Right Cessation
- 2001-01-29 MY MYPI20010371A patent/MY122829A/en unknown
- 2001-01-29 EP EP01904805A patent/EP1255754B1/en not_active Expired - Lifetime
- 2001-01-29 KR KR1020077016678A patent/KR100864745B1/ko not_active Expired - Fee Related
- 2001-01-29 WO PCT/US2001/000657 patent/WO2001057035A1/en not_active Ceased
- 2001-01-29 SI SI200130405T patent/SI1255754T1/sl unknown
- 2001-01-29 JP JP2001557867A patent/JP5235256B2/ja not_active Expired - Lifetime
- 2001-01-29 EE EEP200200420A patent/EE05197B1/xx not_active IP Right Cessation
- 2001-01-29 EA EA200200819A patent/EA004434B1/ru not_active IP Right Cessation
- 2001-01-29 IL IL15101001A patent/IL151010A0/xx active IP Right Grant
- 2001-01-29 CA CA2395603A patent/CA2395603C/en not_active Expired - Lifetime
- 2001-01-29 KR KR1020087010742A patent/KR20080044358A/ko not_active Ceased
- 2001-01-29 CZ CZ20022635A patent/CZ302292B6/cs not_active IP Right Cessation
- 2001-01-29 ES ES01904805T patent/ES2242728T3/es not_active Expired - Lifetime
- 2001-01-29 CN CNB018034489A patent/CN1221547C/zh not_active Expired - Fee Related
- 2001-01-29 PT PT01904805T patent/PT1255754E/pt unknown
- 2001-01-29 NZ NZ520541A patent/NZ520541A/en not_active IP Right Cessation
- 2001-01-29 KR KR1020027009923A patent/KR100781815B1/ko not_active Expired - Fee Related
- 2001-01-29 DE DE60111497T patent/DE60111497T2/de not_active Expired - Lifetime
- 2001-02-02 TW TW090102231A patent/TWI297687B/zh not_active IP Right Cessation
-
2002
- 2002-06-27 ZA ZA200205162A patent/ZA200205162B/en unknown
- 2002-08-01 NO NO20023654A patent/NO323459B1/no not_active IP Right Cessation
-
2006
- 2006-12-15 NO NO20065836A patent/NO20065836L/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |