CO4970700A1 - Proceso para la preparacion de pirimidinas sustituidas - Google Patents
Proceso para la preparacion de pirimidinas sustituidasInfo
- Publication number
- CO4970700A1 CO4970700A1 CO00027328A CO00027328A CO4970700A1 CO 4970700 A1 CO4970700 A1 CO 4970700A1 CO 00027328 A CO00027328 A CO 00027328A CO 00027328 A CO00027328 A CO 00027328A CO 4970700 A1 CO4970700 A1 CO 4970700A1
- Authority
- CO
- Colombia
- Prior art keywords
- formula
- preparation
- meaning provided
- group
- substituted pyrimidines
- Prior art date
Links
- 150000003230 pyrimidines Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 239000012442 inert solvent Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000001409 amidines Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- -1 vinylcarbonyl compound Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Un proceso para la preparación de pirimidinas sustituidas defórmula I,en dondeR1 y R2 representan cada uno independientemente un grupo cicloalquilo, fenilo, heteroaril, o alquilo opcionalmente sustituido,R3 y R4 representan cada uno independientemente un átomo de hidrógeno o un grupo fenilo o alquilo opcionalmente sustituido, yX representa O o S,que comprendehacer reaccionar una amidina de fórmula II,o una sal de la misma, en donde R1 tiene el significado que se proporciona para la fórmula I,con un compuesto de vinilcarbonilo 3,3-disustituido de fórmula IIIen donde R3 y R4 tienen el significado que se proporciona, y L representa un átomo de halógeno o un grupo de fórmula -X-R2 ,(a) en un solvente inerte, en presencia de una base y un compuesto de fórmula IVen donde X y R2 tienen el significado que se proporciona, en el caso que L represente un átomo de halógeno, o (b) en un solvente inerte y en presencia de una base, en el caso que L represente un grupo de fórmula -X-R2 .
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29244299A | 1999-04-15 | 1999-04-15 | |
| US33352899A | 1999-06-15 | 1999-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4970700A1 true CO4970700A1 (es) | 2000-11-07 |
Family
ID=26967332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00027328A CO4970700A1 (es) | 1999-04-15 | 2000-04-13 | Proceso para la preparacion de pirimidinas sustituidas |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1200414B1 (es) |
| JP (1) | JP2002542233A (es) |
| KR (1) | KR100781851B1 (es) |
| CN (1) | CN1161342C (es) |
| AR (1) | AR023506A1 (es) |
| AT (1) | ATE293608T1 (es) |
| AU (1) | AU780907B2 (es) |
| BR (1) | BR0012736A (es) |
| CA (1) | CA2370285A1 (es) |
| CO (1) | CO4970700A1 (es) |
| CZ (1) | CZ20013691A3 (es) |
| DE (1) | DE60019606T2 (es) |
| ES (1) | ES2240093T3 (es) |
| HU (1) | HUP0200830A3 (es) |
| IL (2) | IL145888A0 (es) |
| MX (1) | MXPA01010390A (es) |
| PL (1) | PL351088A1 (es) |
| PT (1) | PT1200414E (es) |
| SK (1) | SK285728B6 (es) |
| UA (1) | UA73735C2 (es) |
| WO (1) | WO2000063183A1 (es) |
| ZA (1) | ZA200108392B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001090080A1 (en) * | 2000-05-19 | 2001-11-29 | Basf Aktiengesellschaft | Method of combating undesired plant growth on cereals |
| EA200602045A1 (ru) * | 2004-05-19 | 2007-06-29 | Басф Акциенгезельшафт | 2-замещённые пиримидины |
| KR100746582B1 (ko) * | 2005-04-19 | 2007-08-06 | 주식회사 에이스 디지텍 | 디스플레이 장치용 광학필터, 이를 포함하는 디스플레이장치, 및 디스플레이 장치용 광학필터의 제조방법 |
| KR100711858B1 (ko) * | 2005-04-25 | 2007-04-30 | 주식회사 미래건설 | 세탁물도어를 포함하는 지능형 도어 시스템 |
| CN101171237B (zh) | 2005-05-06 | 2011-04-20 | 杜邦公司 | 用于制备任选2-取代的1，6-二氢-6-氧代-4-嘧啶羧酸的方法 |
| WO2006124657A1 (en) | 2005-05-16 | 2006-11-23 | E. I. Du Pont De Nemours And Company | Method for preparing substituted pyrimidines |
| ES2374750T3 (es) | 2005-09-01 | 2012-02-21 | F. Hoffmann-La Roche Ag | Proceso de síntesis de ariloxidiaminopirimidinas. |
| WO2007056151A2 (en) * | 2005-11-03 | 2007-05-18 | Irm Llc | Protein kinase inhbitors |
| CN106496127B (zh) * | 2016-10-21 | 2019-09-27 | 苏州大学 | 一种多取代嘧啶的制备方法 |
| CN106831603B (zh) * | 2017-01-09 | 2019-07-02 | 辽宁大学 | 一种含氟嘧啶化合物的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH660589A5 (de) * | 1983-01-28 | 1987-05-15 | Lonza Ag | Verfahren zur herstellung von 2-substituierten 5-nitroso-4,6-diamino-pyrimidinen. |
| DE3642830A1 (de) * | 1986-12-16 | 1988-07-07 | Hoechst Ag | Verfahren zur herstellung von pyrimidinen |
| DE3642832A1 (de) * | 1986-12-16 | 1988-06-30 | Hoechst Ag | Verfahren zur herstellung von aminopyrimidinen |
| DK160270C (da) * | 1988-12-16 | 1991-08-05 | Cheminova Agro As | Fremgangsmaade til fremstilling af 2,4- eller 2,4,5-substituerede 6-hydroxypyrimidiner |
| CZ290330B6 (cs) * | 1995-01-26 | 2002-07-17 | American Cyanamid Company | 2,6-Disubstituované pyridinové a 2,4-disubstituované pyrimidinové deriváty, způsob a meziprodukty pro jejich výrobu, jejich pouľití a herbicidní prostředky na jejich bázi a způsob potlačování růstu neľádoucích rostlin |
| PT802193E (pt) * | 1996-04-09 | 2002-04-29 | Lonza Ag | Processo para a fabricacao de pirimidinas substituidas |
| WO1998030549A1 (de) * | 1997-01-13 | 1998-07-16 | Lonza Ag | Verfahren zur herstellung von substituierten pyrimidinderivaten |
| CA2280515A1 (en) * | 1997-03-11 | 1998-09-17 | E.I. Du Pont De Nemours And Company | Heteroaryl azole herbicides |
| AU7831398A (en) * | 1997-06-10 | 1998-12-30 | E.I. Du Pont De Nemours And Company | Pyrimidinyl azole herbicides |
-
2000
- 2000-04-10 PL PL00351088A patent/PL351088A1/xx not_active Application Discontinuation
- 2000-04-10 MX MXPA01010390A patent/MXPA01010390A/es active IP Right Grant
- 2000-04-10 CA CA002370285A patent/CA2370285A1/en not_active Abandoned
- 2000-04-10 KR KR1020017013141A patent/KR100781851B1/ko not_active Expired - Fee Related
- 2000-04-10 WO PCT/US2000/009522 patent/WO2000063183A1/en not_active Ceased
- 2000-04-10 AU AU43371/00A patent/AU780907B2/en not_active Ceased
- 2000-04-10 JP JP2000612275A patent/JP2002542233A/ja not_active Withdrawn
- 2000-04-10 IL IL14588800A patent/IL145888A0/xx active IP Right Grant
- 2000-04-10 EP EP00923205A patent/EP1200414B1/en not_active Expired - Lifetime
- 2000-04-10 SK SK1475-2001A patent/SK285728B6/sk not_active IP Right Cessation
- 2000-04-10 ES ES00923205T patent/ES2240093T3/es not_active Expired - Lifetime
- 2000-04-10 CZ CZ20013691A patent/CZ20013691A3/cs unknown
- 2000-04-10 AT AT00923205T patent/ATE293608T1/de not_active IP Right Cessation
- 2000-04-10 HU HU0200830A patent/HUP0200830A3/hu not_active Application Discontinuation
- 2000-04-10 DE DE60019606T patent/DE60019606T2/de not_active Expired - Fee Related
- 2000-04-10 BR BR0012736-1A patent/BR0012736A/pt not_active Application Discontinuation
- 2000-04-10 PT PT00923205T patent/PT1200414E/pt unknown
- 2000-04-10 CN CNB008079315A patent/CN1161342C/zh not_active Expired - Fee Related
- 2000-04-13 CO CO00027328A patent/CO4970700A1/es unknown
- 2000-04-14 AR ARP000101750A patent/AR023506A1/es unknown
- 2000-10-04 UA UA2001117794A patent/UA73735C2/uk unknown
-
2001
- 2001-10-11 IL IL145888A patent/IL145888A/en unknown
- 2001-10-12 ZA ZA200108392A patent/ZA200108392B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1200414B1 (en) | 2005-04-20 |
| AU4337100A (en) | 2000-11-02 |
| ZA200108392B (en) | 2002-12-24 |
| MXPA01010390A (es) | 2002-03-27 |
| KR100781851B1 (ko) | 2007-12-03 |
| IL145888A (en) | 2006-08-20 |
| ES2240093T3 (es) | 2005-10-16 |
| CN1355792A (zh) | 2002-06-26 |
| KR20020000167A (ko) | 2002-01-04 |
| DE60019606T2 (de) | 2005-08-18 |
| HUP0200830A2 (hu) | 2002-07-29 |
| ATE293608T1 (de) | 2005-05-15 |
| IL145888A0 (en) | 2002-07-25 |
| AU780907B2 (en) | 2005-04-21 |
| CN1161342C (zh) | 2004-08-11 |
| CZ20013691A3 (cs) | 2002-04-17 |
| HUP0200830A3 (en) | 2003-04-28 |
| SK14752001A3 (sk) | 2002-05-09 |
| PL351088A1 (en) | 2003-03-24 |
| BR0012736A (pt) | 2005-07-05 |
| SK285728B6 (sk) | 2007-07-06 |
| AR023506A1 (es) | 2002-09-04 |
| PT1200414E (pt) | 2005-09-30 |
| CA2370285A1 (en) | 2000-10-26 |
| EP1200414A1 (en) | 2002-05-02 |
| UA73735C2 (en) | 2005-09-15 |
| DE60019606D1 (de) | 2005-05-25 |
| WO2000063183A1 (en) | 2000-10-26 |
| JP2002542233A (ja) | 2002-12-10 |
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