CO2019008941A2 - Moduladores del receptor de estrógeno - Google Patents
Moduladores del receptor de estrógenoInfo
- Publication number
- CO2019008941A2 CO2019008941A2 CONC2019/0008941A CO2019008941A CO2019008941A2 CO 2019008941 A2 CO2019008941 A2 CO 2019008941A2 CO 2019008941 A CO2019008941 A CO 2019008941A CO 2019008941 A2 CO2019008941 A2 CO 2019008941A2
- Authority
- CO
- Colombia
- Prior art keywords
- estrogen receptor
- receptor modulators
- compounds
- processes
- formula
- Prior art date
Links
- 239000002834 estrogen receptor modulator Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La memoria descriptiva se refiere a compuestos de Fórmula (I): (I) y a sales farmacéuticamente aceptables de estos, a procesos e intermedios utilizados para su preparación, a composiciones farmacéuticas que los contienen y a su uso en el tratamiento de trastornos celulares proliferativos.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762451971P | 2017-01-30 | 2017-01-30 | |
| US201762523695P | 2017-06-22 | 2017-06-22 | |
| US201762560304P | 2017-09-19 | 2017-09-19 | |
| US201762592485P | 2017-11-30 | 2017-11-30 | |
| PCT/EP2018/052040 WO2018138303A1 (en) | 2017-01-30 | 2018-01-29 | Estrogen receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2019008941A2 true CO2019008941A2 (es) | 2019-08-30 |
Family
ID=61223883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2019/0008941A CO2019008941A2 (es) | 2017-01-30 | 2019-08-16 | Moduladores del receptor de estrógeno |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US10221173B2 (es) |
| EP (2) | EP3689873B1 (es) |
| JP (1) | JP6951451B2 (es) |
| KR (1) | KR102246668B1 (es) |
| CN (1) | CN110214140B (es) |
| AU (1) | AU2018211495B2 (es) |
| CL (1) | CL2019001991A1 (es) |
| CO (1) | CO2019008941A2 (es) |
| CR (1) | CR20190379A (es) |
| CY (1) | CY1122731T1 (es) |
| DK (1) | DK3494116T3 (es) |
| DO (1) | DOP2019000183A (es) |
| EC (1) | ECSP19062381A (es) |
| ES (2) | ES2931320T3 (es) |
| HU (1) | HUE047761T2 (es) |
| IL (1) | IL268263B (es) |
| JO (1) | JOP20190183B1 (es) |
| LT (1) | LT3494116T (es) |
| MA (1) | MA52555A (es) |
| MX (1) | MX2019008438A (es) |
| MY (1) | MY196317A (es) |
| NI (1) | NI201900080A (es) |
| PE (1) | PE20191500A1 (es) |
| PH (1) | PH12019501724A1 (es) |
| PL (1) | PL3494116T3 (es) |
| PT (1) | PT3494116T (es) |
| RS (1) | RS59770B1 (es) |
| SG (1) | SG11201906767XA (es) |
| SI (1) | SI3494116T1 (es) |
| SM (1) | SMT202000010T1 (es) |
| TN (1) | TN2020000009A1 (es) |
| TW (1) | TWI794205B (es) |
| UA (1) | UA125043C2 (es) |
| WO (1) | WO2018138303A1 (es) |
| ZA (1) | ZA201904696B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6905539B2 (ja) | 2016-02-05 | 2021-07-21 | インベンティスバイオ リミテッド ライアビリティ カンパニー | 選択的エストロゲン受容体分解剤およびその使用 |
| JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| SI3555097T1 (sl) | 2016-12-16 | 2022-09-30 | Janssen Pharmaceutica Nv | Imidazo(4,5-d)pirolo(2,3-b)piridinske spojine kot zaviralci janus kinaz |
| TW202016110A (zh) | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Ｊａｋ激酶家族之小分子抑制劑 |
| US20220370625A1 (en) * | 2019-09-19 | 2022-11-24 | Totus Medicines Inc. | Therapeutic conjugates |
| MX2023010642A (es) | 2021-03-11 | 2023-11-28 | Janssen Pharmaceutica Nv | Lorpucitinib para uso en el tratamiento de trastornos mediados por jak. |
| CN115557920B (zh) * | 2022-09-22 | 2024-02-20 | 吉林奥来德光电材料股份有限公司 | 一种发光辅助材料、其制备方法及有机电致发光器件 |
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| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| MXPA03001169A (es) | 2000-08-10 | 2003-06-30 | Pharmacia Italia Spa | Biciclo-pirazoles activos como inhibidores de quinasa, proceso para su preparacion y composiciones farmaceuticas que comprenden los mismos. |
| EP1746157A4 (en) * | 2004-04-27 | 2009-02-18 | Chugai Pharmaceutical Co Ltd | PROCESS FOR PLASMA CELL PROGRAMMING |
| WO2006101434A1 (en) | 2005-03-22 | 2006-09-28 | Astrazeneca Ab | NOVEL TETRAHYDRO-1H-PYRIDO [4,3-b] INDOLE DERIVATIVES AS CB1’ RECEPTOR LIGANDS |
| FR2884252B1 (fr) | 2005-04-08 | 2007-05-18 | Aventis Pharma Sa | Nouveaux derives d'isoindoles, compositions les contenant, leur preparation et leurs utilisations pharmaceutiques notamment en tant qu'inhibiteurs d'activites de la proteine chaperone hsp90 |
| AR058223A1 (es) | 2005-11-25 | 2008-01-23 | Palau Pharma Sa | Un comuesto de derivados de pirazoloisoquinolina, un procedimiento para l a preparacion de dicho compuesto y una composicion farmaceutica que comprende dicho compuesto |
| EP2223925A1 (en) | 2006-10-09 | 2010-09-01 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| CN102480957A (zh) | 2009-05-27 | 2012-05-30 | Ptc医疗公司 | 治疗癌症及非肿瘤病症的方法 |
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| LT3004090T (lt) | 2013-05-28 | 2018-01-10 | Astrazeneca Ab | Cheminiai junginiai |
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| WO2015092634A1 (en) | 2013-12-16 | 2015-06-25 | Novartis Ag | 1,2,3,4-tetrahydroisoquinoline compounds and compositions as selective estrogen receptor antagonists and degraders |
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| RU2730508C2 (ru) | 2015-06-16 | 2020-08-24 | Цзянсу Хэнжуй Медицин Ко., Лтд. | Производное пиперидина, способ его получения и его фармацевтическое применение |
| CN106518768B (zh) | 2015-09-15 | 2021-07-02 | 江苏恒瑞医药股份有限公司 | 丙烯酸类衍生物、其制备方法及其在医药上的应用 |
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| TWI735681B (zh) | 2016-10-24 | 2021-08-11 | 瑞典商阿斯特捷利康公司 | 化合物 |
| BR102016024814A2 (pt) | 2016-10-24 | 2018-05-08 | Aché Laboratórios Farmacêuticos S.A. | composto, processo de obtenção do composto, composição farmacêutica, uso do composto e método de tratamento de desordens psiquiátricas e/ou distúrbios do sono |
| SI3555097T1 (sl) | 2016-12-16 | 2022-09-30 | Janssen Pharmaceutica Nv | Imidazo(4,5-d)pirolo(2,3-b)piridinske spojine kot zaviralci janus kinaz |
| AU2017374992A1 (en) | 2016-12-16 | 2019-06-20 | Basf Se | Pesticidal compounds |
| CN110325530B (zh) | 2016-12-16 | 2022-01-11 | 辉瑞大药厂 | Glp-1受体激动剂及其用途 |
| EA036112B1 (ru) | 2016-12-16 | 2020-09-29 | Эли Лилли Энд Компани | 7-фенилэтиламино-4h-пиримидо[4,5-d][1,3]оксазин-2-оновые соединения в качестве ингибиторов мутантных idh1 и idh2 |
| JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| TWI831738B (zh) | 2016-12-16 | 2024-02-11 | 美商瑞塔醫藥有限責任公司 | 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物 |
| MX393050B (es) | 2017-01-30 | 2025-03-24 | Chiesi Farm Spa | Derivados de amida de tirosina como inhibidores de rho-cinasa. |
-
2018
- 2018-01-29 PL PL18705097T patent/PL3494116T3/pl unknown
- 2018-01-29 ES ES19203383T patent/ES2931320T3/es active Active
- 2018-01-29 LT LTEP18705097.6T patent/LT3494116T/lt unknown
- 2018-01-29 EP EP19203383.5A patent/EP3689873B1/en active Active
- 2018-01-29 JP JP2019538615A patent/JP6951451B2/ja active Active
- 2018-01-29 SI SI201830022T patent/SI3494116T1/sl unknown
- 2018-01-29 RS RS20200018A patent/RS59770B1/sr unknown
- 2018-01-29 DK DK18705097.6T patent/DK3494116T3/da active
- 2018-01-29 MA MA052555A patent/MA52555A/fr unknown
- 2018-01-29 TN TNP/2020/000009A patent/TN2020000009A1/en unknown
- 2018-01-29 SM SM20200010T patent/SMT202000010T1/it unknown
- 2018-01-29 US US15/881,962 patent/US10221173B2/en active Active
- 2018-01-29 TW TW107103088A patent/TWI794205B/zh active
- 2018-01-29 WO PCT/EP2018/052040 patent/WO2018138303A1/en not_active Ceased
- 2018-01-29 SG SG11201906767XA patent/SG11201906767XA/en unknown
- 2018-01-29 HU HUE18705097A patent/HUE047761T2/hu unknown
- 2018-01-29 PE PE2019001434A patent/PE20191500A1/es unknown
- 2018-01-29 ES ES18705097T patent/ES2766249T3/es active Active
- 2018-01-29 MY MYPI2019004298A patent/MY196317A/en unknown
- 2018-01-29 CN CN201880008715.8A patent/CN110214140B/zh active Active
- 2018-01-29 UA UAA201909412A patent/UA125043C2/uk unknown
- 2018-01-29 JO JOP/2019/0183A patent/JOP20190183B1/ar active
- 2018-01-29 AU AU2018211495A patent/AU2018211495B2/en active Active
- 2018-01-29 MX MX2019008438A patent/MX2019008438A/es unknown
- 2018-01-29 KR KR1020197025253A patent/KR102246668B1/ko active Active
- 2018-01-29 PT PT187050976T patent/PT3494116T/pt unknown
- 2018-01-29 EP EP18705097.6A patent/EP3494116B1/en active Active
- 2018-01-29 CR CR20190379A patent/CR20190379A/es unknown
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2019
- 2019-01-31 US US16/263,683 patent/US10590132B2/en active Active
- 2019-07-15 CL CL2019001991A patent/CL2019001991A1/es unknown
- 2019-07-16 DO DO2019000183A patent/DOP2019000183A/es unknown
- 2019-07-17 ZA ZA2019/04696A patent/ZA201904696B/en unknown
- 2019-07-25 IL IL268263A patent/IL268263B/en unknown
- 2019-07-26 PH PH12019501724A patent/PH12019501724A1/en unknown
- 2019-07-26 NI NI201900080A patent/NI201900080A/es unknown
- 2019-08-16 CO CONC2019/0008941A patent/CO2019008941A2/es unknown
- 2019-08-28 EC ECSENADI201962381A patent/ECSP19062381A/es unknown
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2020
- 2020-01-08 CY CY20201100014T patent/CY1122731T1/el unknown
- 2020-01-29 US US16/775,781 patent/US11046689B2/en active Active
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