[go: up one dir, main page]

CO2018012925A2 - Composición de hidrogel médico, e hidrogel médico, método de preparación del mismo y aplicación del mismo - Google Patents

Composición de hidrogel médico, e hidrogel médico, método de preparación del mismo y aplicación del mismo

Info

Publication number
CO2018012925A2
CO2018012925A2 CONC2018/0012925A CO2018012925A CO2018012925A2 CO 2018012925 A2 CO2018012925 A2 CO 2018012925A2 CO 2018012925 A CO2018012925 A CO 2018012925A CO 2018012925 A2 CO2018012925 A2 CO 2018012925A2
Authority
CO
Colombia
Prior art keywords
medical hydrogel
component
medical
composition
hydrogel composition
Prior art date
Application number
CONC2018/0012925A
Other languages
English (en)
Inventor
Limin Lin
Yaya Yang
Cheng Ma
Kunxue Deng
Yuyu Yuan
Original Assignee
Medprin Regenerative Medical Technologies Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medprin Regenerative Medical Technologies Co Ltd filed Critical Medprin Regenerative Medical Technologies Co Ltd
Publication of CO2018012925A2 publication Critical patent/CO2018012925A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0052—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Una composición de hidrogel médico, un hidrogel médico, un método de preparación del mismo y una aplicación del mismo, y un kit de hidrogel médico; la composición de hidrogel médico comprende un primer componente y un segundo componente; el primer componente comprende polilisina y polietilen imina; el segundo componente comprende uno o más de polietilen glicol de cuatro brazos-glutarato de succinimidilo, polietilen glicol de cuatro brazos-succinato de succinimidilo, y polietilen glicol de cuatro brazos-carbonato de succinimidilo; el grado de polimerización de la polilisina es 20 o más; el hidrogel médico se forma al reaccionar el primer componente con el segundo componente de la composición de hidrogel médico; el kit de hidrogel médico comprende la composición de hidrogel médico y una solución reguladora de pH usada para disolver los componentes de la composición de hidrogel médico; el hidrogel médico tiene un grado de hinchamiento de -10 % - 50 %, y puede aplicarse en partes estrechas donde los nervios craneal, espinal, y periféricos están densamente distribuidos.
CONC2018/0012925A 2016-04-29 2018-11-28 Composición de hidrogel médico, e hidrogel médico, método de preparación del mismo y aplicación del mismo CO2018012925A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610286118.4A CN105963792B (zh) 2016-04-29 2016-04-29 医用水凝胶组合物，医用水凝胶及其制备方法与应用
PCT/CN2017/082425 WO2017186168A1 (zh) 2016-04-29 2017-04-28 医用水凝胶组合物，医用水凝胶及其制备方法与应用

Publications (1)

Publication Number Publication Date
CO2018012925A2 true CO2018012925A2 (es) 2018-12-28

Family

ID=56994270

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2018/0012925A CO2018012925A2 (es) 2016-04-29 2018-11-28 Composición de hidrogel médico, e hidrogel médico, método de preparación del mismo y aplicación del mismo

Country Status (8)

Country Link
US (1) US11065360B2 (es)
EP (1) EP3449956B1 (es)
KR (1) KR102203199B1 (es)
CN (1) CN105963792B (es)
CO (1) CO2018012925A2 (es)
MX (1) MX385437B (es)
RU (1) RU2724057C2 (es)
WO (1) WO2017186168A1 (es)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017139487A1 (en) 2016-02-09 2017-08-17 Northwind Medical, Inc. Methods, agents, and devices for local neuromodulation of autonomic nerves
CN105963792B (zh) * 2016-04-29 2019-03-22 深圳迈普再生医学科技有限公司 医用水凝胶组合物，医用水凝胶及其制备方法与应用
CN110035754A (zh) 2016-06-29 2019-07-19 图拉维治疗股份有限公司 通过自主神经系统的局部神经调节治疗败血症及相关炎性病况
CN106693039B (zh) * 2017-01-24 2019-10-01 南开大学 一种具有良好生物粘附性的医用水凝胶的制备方法
CN107537056A (zh) * 2017-09-11 2018-01-05 杭州亚慧生物科技有限公司 一种硬脑膜封合凝胶及其制备方法与应用
CN107899067B (zh) * 2017-11-21 2021-05-14 赛克赛斯生物科技股份有限公司 液体眼部敷料、其制备方法及液体眼部敷料产品
CN108078676A (zh) * 2017-12-12 2018-05-29 成都美益达医疗科技有限公司 一种治疗关节部位伤口的敷贴
CN108014365B (zh) * 2017-12-14 2020-10-09 沈伟 一种封闭剂水凝胶及其试剂盒和制备方法
CN108210170A (zh) * 2018-01-02 2018-06-29 成都美益达医疗科技有限公司 用于患者伤口使用的医用敷贴
CN110193091A (zh) * 2018-02-27 2019-09-03 华东理工大学 可注射蛋白/聚乙二醇基水凝胶材料及其制备方法和应用
AU2019299519B2 (en) * 2018-07-02 2025-03-06 Incept Llc Methods and devices for in situ formed nerve cap
US20210315587A1 (en) 2018-07-02 2021-10-14 Tulavi Therapeutics, Inc. Methods and devices for in situ formed nerve cap with rapid release
CN111330075B (zh) * 2018-12-19 2022-08-23 上海交通大学医学院附属第九人民医院 一种鱿鱼ii型明胶双网络水凝胶的制备方法及应用
CN109646709A (zh) * 2019-01-29 2019-04-19 青岛中腾生物技术有限公司 一种可降解吸收的医用止血封闭材料
CN109646723B (zh) * 2019-02-02 2020-05-22 上海瑞凝生物科技有限公司 具有辐射防护作用的医用水凝胶
CN110201234B (zh) * 2019-06-26 2021-09-03 山东百多安医疗器械股份有限公司 一种组织工程用前列腺细胞微囊及其制备方法
CN110433344A (zh) * 2019-08-05 2019-11-12 北京诺康达医药科技股份有限公司 一种防粘连凝胶前体、防粘连凝胶的制备方法和试剂盒
CN110464872B (zh) * 2019-09-26 2020-09-04 海南医学院 一种医用水凝胶及其制备方法和应用
CN110643057B (zh) * 2019-10-23 2022-05-17 赛克赛斯生物科技股份有限公司 聚乙二醇类活化酯在制备低溶胀水凝胶中的应用及包括其的低溶胀水凝胶
US12016969B2 (en) * 2020-02-04 2024-06-25 Boston Scientific Scimed, Inc. Injectable in vivo crosslinking materials for use as soft tissue fillers
CN111420126B (zh) * 2020-03-24 2021-07-27 江苏地韵医疗科技有限公司 一种医用水凝胶、其成套原料及应用
CN111939324B (zh) * 2020-08-14 2022-06-17 深圳市人民医院 一种天然多糖基可注射原位成型水凝胶及其制备方法和应用
CN111956866B (zh) * 2020-08-14 2022-09-20 南方科技大学 一种用于纤维环修复的复合水凝胶及其制备方法和应用
CN112225912B (zh) * 2020-10-19 2022-11-29 上海瑞凝生物科技有限公司 可降解医用水凝胶
CN115025274B (zh) * 2021-03-04 2023-03-17 海宁侏罗纪生物科技有限公司 一种医用组织粘合胶及其制备方法
CN113171463B (zh) * 2021-03-31 2022-09-02 北京诺康达医药科技股份有限公司 原位载药水凝胶及其制备方法与应用
CN112999419B (zh) * 2021-04-23 2022-05-27 江苏地韵医疗科技有限公司 一种凝胶及其制备方法
CN113521376B (zh) * 2021-07-22 2022-08-30 赛克赛斯生物科技股份有限公司 一种外科密封剂试剂盒及其在脑、脊柱外科手术中的应用
CN115869456B (zh) * 2021-08-09 2024-12-27 上海其胜生物制剂有限公司 一种原位凝胶化抗溶胀增强型组织粘合剂材料的制备
CN115703889A (zh) * 2021-08-16 2023-02-17 西安交通大学 一种兼具术后止血及防粘连功能的水凝胶及其制备方法
CN114010585A (zh) * 2021-11-16 2022-02-08 赵丽 一种具有杀菌消毒功效的医用凝胶
CN114316309B (zh) * 2021-12-28 2023-12-05 上海瑞凝生物科技有限公司 一种聚乙二醇-聚赖氨酸水凝胶微球及其制备方法
CN116763717A (zh) * 2022-03-08 2023-09-19 上海瑞凝生物科技有限公司 一种用于疏水性药物缓释的泊洛沙姆水凝胶
CN120815208A (zh) * 2022-04-14 2025-10-21 北京博辉瑞进生物科技有限公司 胰腺封堵用医用组织胶及其制备方法和用途
CN114891242A (zh) * 2022-05-06 2022-08-12 上海益思妙医疗器械有限公司 一种可显影水凝胶及其制备方法
CN117085167A (zh) * 2022-05-12 2023-11-21 海宁侏罗纪生物科技有限公司 一种医用胶及其制备方法
CN114767920B (zh) * 2022-05-13 2023-08-29 中国科学院长春应用化学研究所 一种聚乙二醇基粘合剂及其制备方法以及应用
CN114920962A (zh) * 2022-05-27 2022-08-19 上海益思妙医疗器械有限公司 一种止血材料的制备方法
CN115177779B (zh) * 2022-06-14 2023-12-05 深圳凡旻生物科技有限公司 一种生物胶及其制备方法与应用
CN116077744B (zh) * 2022-08-05 2024-11-12 清华大学 一种可吸收自显影水凝胶及其制备方法、应用
CN115645595B (zh) * 2022-12-28 2023-04-07 北京爱特康医疗科技有限公司 医用组织封闭剂组合物、封闭剂及其制备方法和应用
US20240293572A1 (en) * 2023-03-02 2024-09-05 Boston Scientific Scimed, Inc. Therapeutic-agent-releasing hydrogels and precursors thereof
WO2024191451A1 (en) * 2023-03-10 2024-09-19 Clearstream Technologies Limited Radiation spacer hydrogels, methods of forming, and methods of use
WO2024191452A1 (en) * 2023-03-10 2024-09-19 Clearstream Technologies Limited Radiation spacer hydrogels, methods of forming, and methods of use
WO2024191447A1 (en) * 2023-03-10 2024-09-19 Clearstream Technologies Limited Radiation spacer hydrogels, methods of forming, and methods of use
WO2024191453A1 (en) * 2023-03-10 2024-09-19 Clearstream Technologies Limited Radiation spacer hydrogels, methods of forming, and methods of use
WO2024191450A1 (en) * 2023-03-10 2024-09-19 Clearstream Technologies Limited Radiation spacer hydrogels, methods of forming, and methods of use
CN116271188A (zh) * 2023-03-28 2023-06-23 赛克赛斯生物科技股份有限公司 医用水凝胶及制备方法与其在制备血管渗漏封合剂的应用
CN116983466A (zh) * 2023-08-16 2023-11-03 南方科技大学 一种医用凝胶敷料及其制备方法和应用
CN120678982A (zh) * 2025-07-17 2025-09-23 山东隽秀生物科技股份有限公司 一种性能稳定的生物粘合剂及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8003705B2 (en) * 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
US20090227689A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
EP2247645B1 (en) * 2008-02-13 2017-12-06 Hyperbranch Medical Technology, Inc. Crosslinked polyalkyleneimine hydrogels with tunable degradation rates
KR101020050B1 (ko) * 2008-10-06 2011-03-09 포항공과대학교 산학협력단 선형 폴리에틸렌이민-가지형폴리에틸렌글리콜 화합물을 이용한 유전자 전달체 및 그 합성 방법
US20110104280A1 (en) * 2009-05-20 2011-05-05 Olexander Hnojewyj Wound treatment systems, devices, and methods using biocompatible synthetic hydrogel compositions
US20100297235A1 (en) * 2009-05-20 2010-11-25 Cpc Of America, Inc. Vascular puncture closure systems, devices, and methods using biocompatible synthetic hydrogel compositions
KR101770844B1 (ko) * 2009-07-31 2017-08-23 아센디스 파마 에이에스 폴리에틸렌 글리콜 기반의 생분해성 수불용성 하이드로겔
CN106913902A (zh) * 2009-11-09 2017-07-04 聚光灯技术合伙有限责任公司 多糖基水凝胶
US8968783B2 (en) * 2010-05-27 2015-03-03 Covidien Lp Hydrogel implants with varying degrees of crosslinking
CN102911493A (zh) * 2012-09-28 2013-02-06 山东赛克赛斯药业科技有限公司 可生物降解的医用水凝胶及其制备方法与应用
CN105169469B (zh) * 2015-08-29 2018-05-25 北京诺康达医药科技有限公司 一种组织密封剂及其制备方法和应用
CN105963792B (zh) * 2016-04-29 2019-03-22 深圳迈普再生医学科技有限公司 医用水凝胶组合物，医用水凝胶及其制备方法与应用

Also Published As

Publication number Publication date
WO2017186168A1 (zh) 2017-11-02
US11065360B2 (en) 2021-07-20
RU2724057C2 (ru) 2020-06-19
KR20190004735A (ko) 2019-01-14
RU2018141863A (ru) 2020-05-29
MX385437B (es) 2025-03-18
US20190142994A1 (en) 2019-05-16
MX2018013150A (es) 2019-04-22
EP3449956A1 (en) 2019-03-06
RU2018141863A3 (es) 2020-05-29
CN105963792B (zh) 2019-03-22
KR102203199B1 (ko) 2021-01-14
CN105963792A (zh) 2016-09-28
EP3449956B1 (en) 2022-12-14
EP3449956A4 (en) 2019-06-26

Similar Documents

Publication Publication Date Title
CO2018012925A2 (es) Composición de hidrogel médico, e hidrogel médico, método de preparación del mismo y aplicación del mismo
MX2022003477A (es) Medio de cultivo celular complementado con taurina y metodos de uso.
BR112015007837A2 (pt) adesivos e métodos relacionados
BR112019000178A2 (pt) hidrogéis de silicone compreendendo n-alquil metacrilamidas e lentes de contato produzidas a partir dos mesmos
PE20171322A1 (es) Dinucleotidos ciclicos utiles para el tratamiento del cancer entre otros
CR20180525A (es) Producción de ácido ribonucleico libre de células
BR112018004965A2 (pt) domínios de superfamìlia de imunoglobulina variante ajustàvel
EA201991073A1 (ru) Ингибиторы magl
BR112017013153A2 (pt) polímero de poliuretano
EA201991074A1 (ru) Ингибиторы magl
AR104309A1 (es) Construcciones de anticuerpos biespecíficos para cdh3 y cd3
BR112013000386A2 (pt) combinação de polímero acrílico, composição, e, métodos para mascarar uma combinação polimérica com base em acrílico, e para espessar uma composição aquosa
CY1125033T1 (el) Σκευασμα μεθοτρεξατης
MX2020002611A (es) Activador especifico de akt3 y usos del mismo.
MX2017014000A (es) Adhesivos acrilicos en emulsion.
AR100088A1 (es) Fluido de tratamiento
BR112017012888A2 (pt) composição baseada em chlorella mixotrófica e processo para sua preparação e aplicação em plantas
MY208607A (en) Cyclooctatetraene containing dyes and compositions
PE20141946A1 (es) Liquido para reparacion de cintas transportadoras
EP3755746A4 (en) MOISTURE CURING SILICONE POLYMER AND USES THEREOF
CL2020001480A1 (es) Métodos para obtener células derivadas de músculo.
MX378857B (es) Celulas huespedes modificadas y usos de las mismas.
MX2016014245A (es) Composiciones para el cuidado de telas que comprenden polimeros de poliuretano, poliurea y/o poliuretanourea.
BR112016017609A2 (pt) Composição, e, processo
EA201792456A1 (ru) Ферментёр для получения псевдопластической среды