CO2018007133A2 - Uso de la carrimicina en la infección por micobacterium tuberculosis resistente - Google Patents
Uso de la carrimicina en la infección por micobacterium tuberculosis resistenteInfo
- Publication number
- CO2018007133A2 CO2018007133A2 CONC2018/0007133A CO2018007133A CO2018007133A2 CO 2018007133 A2 CO2018007133 A2 CO 2018007133A2 CO 2018007133 A CO2018007133 A CO 2018007133A CO 2018007133 A2 CO2018007133 A2 CO 2018007133A2
- Authority
- CO
- Colombia
- Prior art keywords
- carrimicin
- mycobacterium tuberculosis
- drugs
- resistant mycobacterium
- resistant
- Prior art date
Links
- 201000008827 tuberculosis Diseases 0.000 title 1
- 229940079593 drug Drugs 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 4
- 241000187479 Mycobacterium tuberculosis Species 0.000 abstract 3
- KGTSLTYUUFWZNW-PPJQWWMSSA-N [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate pyridine-4-carbohydrazide Chemical compound NNC(=O)c1ccncc1.CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C2=O)c2c(O)c(\C=N\N4CCN(C)CC4)c(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C KGTSLTYUUFWZNW-PPJQWWMSSA-N 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 241000193830 Bacillus <bacterium> Species 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 230000002365 anti-tubercular Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
El uso de la carrimicina en la infección debida al Micobacterium tuberculosis resistente comprende las siguientes etapas: medir la actividad de la carrimicina en el Micobacterium tuberculosis resistente mediante la adopción de un método de concentración absoluta a través de la toma, como controles, de antituberculósicos de primera línea, como la isoniazida y la rifampicina. El resultado indica que la carrimicina tiene una actividad obviamente superior contra el Micobacterium tuberculosis separado clínicamente, lo que incluye bacterias resistentes a fármacos comparadas con aquellas de los fármacos control de primera línea, es decir, la isoniazida y la rifampicina, y el uso de la carrimicina en la fabricación de fármacos para tratar las enfermedades infecciosas debidas al bacilo tuberculoso.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511030787.7A CN105497053B (zh) | 2015-12-31 | 2015-12-31 | 可利霉素在抗结核分枝杆菌感染中的应用 |
| PCT/CN2016/108502 WO2017114095A1 (zh) | 2015-12-31 | 2016-12-05 | 可利霉素在抗结核分枝杆菌感染中的应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2018007133A2 true CO2018007133A2 (es) | 2018-07-19 |
Family
ID=55705614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2018/0007133A CO2018007133A2 (es) | 2015-12-31 | 2018-07-09 | Uso de la carrimicina en la infección por micobacterium tuberculosis resistente |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11000708B2 (es) |
| EP (1) | EP3384915B1 (es) |
| JP (1) | JP6770584B2 (es) |
| KR (1) | KR102808775B1 (es) |
| CN (1) | CN105497053B (es) |
| AU (1) | AU2016382584B2 (es) |
| BR (1) | BR112018013327A2 (es) |
| CA (1) | CA3010020A1 (es) |
| CL (1) | CL2018001804A1 (es) |
| CO (1) | CO2018007133A2 (es) |
| DK (1) | DK3384915T3 (es) |
| ES (1) | ES2785644T3 (es) |
| MX (1) | MX381113B (es) |
| MY (1) | MY191800A (es) |
| PE (1) | PE20190210A1 (es) |
| PH (1) | PH12018501394A1 (es) |
| PL (1) | PL3384915T3 (es) |
| RU (1) | RU2733382C2 (es) |
| UA (1) | UA121159C2 (es) |
| WO (1) | WO2017114095A1 (es) |
| ZA (1) | ZA201804398B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105497053B (zh) * | 2015-12-31 | 2018-02-13 | 沈阳福洋医药科技有限公司 | 可利霉素在抗结核分枝杆菌感染中的应用 |
| CA3058935A1 (en) * | 2017-04-06 | 2018-10-11 | Shenyang Fuyang Pharmaceutical Technology Co., Ltd. | Use of carrimycin and pharmaceutically acceptable salts thereof for preparation of medicament for treatment and/or prevention of tumor |
| CN110384710B (zh) * | 2018-04-17 | 2023-01-10 | 沈阳福洋医药科技有限公司 | 一种用于预防和/或治疗疼痛的药物、组合产品及其应用 |
| CN110384802B (zh) * | 2018-04-17 | 2021-09-17 | 沈阳福洋医药科技有限公司 | 一种用于预防和/或治疗发热的药物、组合产品及其应用 |
| CN113577086B (zh) * | 2020-04-30 | 2023-05-02 | 沈阳福洋医药科技有限公司 | 异戊酰螺旋霉素类化合物或其组合物在制备治疗免疫失调的药物中的应用 |
| WO2021219112A1 (zh) * | 2020-04-30 | 2021-11-04 | 沈阳福洋医药科技有限公司 | 异戊酰螺旋霉素类化合物或其组合物在制备治疗脓毒症疾病药物中的应用 |
| TW202237116A (zh) * | 2020-12-02 | 2022-10-01 | 日商塩野義製藥股份有限公司 | 以組合細胞色素bc1抑制劑與克拉黴素或阿奇黴素為特徵之用於治療分枝桿菌感染之藥物 |
| CN119405677B (zh) * | 2025-01-08 | 2025-05-06 | 深圳国家感染性疾病临床医学研究中心 | 一种泰乐菌素的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2126108B1 (es) * | 1971-02-25 | 1974-08-02 | Rhone Poulenc Sa | |
| US7098219B2 (en) * | 2000-08-01 | 2006-08-29 | Wockhart Limited | Inhibitors of cellular efflux pumps of microbes |
| CN1237976C (zh) * | 2003-12-23 | 2006-01-25 | 沈阳同联集团有限公司 | 必特螺旋霉素及其在抗感染性疾病中的应用 |
| EP1827449A4 (en) * | 2004-11-17 | 2008-01-23 | Smithkline Beecham Corp | USE OF NOVEL ANTIBACTERIAL COMPOUNDS |
| DE102005058345A1 (de) * | 2005-12-06 | 2007-06-14 | Kern, Andreas, Dr. med. | Verwendung eines oral einzunehmenden Antibiotikums |
| WO2008122038A1 (en) * | 2007-04-02 | 2008-10-09 | President And Fellows Of Harvard College | Regulating autophagy |
| DK3210991T3 (da) * | 2010-05-25 | 2019-11-11 | Shenyang Fuyang Pharmaceutical Tech Co Ltd | Krystallinsk form af levoisovalerylspiramycin ii og præparater, fremstillingsfremgangsmåder og anvendelser deraf |
| US9089586B2 (en) * | 2010-05-25 | 2015-07-28 | Shenyang Tonglian Group Co., Ltd. | Levocarrimycin, pharmaceutical compositions, preparation methods and uses thereof |
| JP6116206B2 (ja) | 2012-11-26 | 2017-04-19 | クリニプロ株式会社 | 吸入用パウダーの製造方法 |
| CN103142520B (zh) * | 2013-03-15 | 2015-04-01 | 沈阳同联集团有限公司 | 一种可利霉素片及其制备方法 |
| CN105497053B (zh) * | 2015-12-31 | 2018-02-13 | 沈阳福洋医药科技有限公司 | 可利霉素在抗结核分枝杆菌感染中的应用 |
-
2015
- 2015-12-31 CN CN201511030787.7A patent/CN105497053B/zh active Active
-
2016
- 2016-12-05 PE PE2018001212A patent/PE20190210A1/es unknown
- 2016-12-05 DK DK16880885.5T patent/DK3384915T3/da active
- 2016-12-05 PL PL16880885T patent/PL3384915T3/pl unknown
- 2016-12-05 RU RU2018125622A patent/RU2733382C2/ru active
- 2016-12-05 WO PCT/CN2016/108502 patent/WO2017114095A1/zh not_active Ceased
- 2016-12-05 AU AU2016382584A patent/AU2016382584B2/en active Active
- 2016-12-05 KR KR1020187021578A patent/KR102808775B1/ko active Active
- 2016-12-05 MX MX2018008079A patent/MX381113B/es unknown
- 2016-12-05 ES ES16880885T patent/ES2785644T3/es active Active
- 2016-12-05 US US16/067,327 patent/US11000708B2/en active Active
- 2016-12-05 CA CA3010020A patent/CA3010020A1/en active Pending
- 2016-12-05 BR BR112018013327-2A patent/BR112018013327A2/pt active Search and Examination
- 2016-12-05 MY MYPI2018001121A patent/MY191800A/en unknown
- 2016-12-05 UA UAA201808048A patent/UA121159C2/uk unknown
- 2016-12-05 EP EP16880885.5A patent/EP3384915B1/en active Active
- 2016-12-05 JP JP2018553283A patent/JP6770584B2/ja active Active
-
2018
- 2018-06-28 PH PH12018501394A patent/PH12018501394A1/en unknown
- 2018-06-29 ZA ZA2018/04398A patent/ZA201804398B/en unknown
- 2018-06-29 CL CL2018001804A patent/CL2018001804A1/es unknown
- 2018-07-09 CO CONC2018/0007133A patent/CO2018007133A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN105497053A (zh) | 2016-04-20 |
| RU2733382C2 (ru) | 2020-10-01 |
| JP6770584B2 (ja) | 2020-10-14 |
| CL2018001804A1 (es) | 2018-09-28 |
| MX381113B (es) | 2025-03-12 |
| KR102808775B1 (ko) | 2025-05-16 |
| BR112018013327A2 (pt) | 2018-12-04 |
| KR20180098624A (ko) | 2018-09-04 |
| JP2019501220A (ja) | 2019-01-17 |
| UA121159C2 (uk) | 2020-04-10 |
| AU2016382584A1 (en) | 2018-07-26 |
| AU2016382584B2 (en) | 2022-01-06 |
| US11000708B2 (en) | 2021-05-11 |
| RU2018125622A3 (es) | 2020-03-26 |
| WO2017114095A1 (zh) | 2017-07-06 |
| EP3384915B1 (en) | 2020-02-19 |
| RU2018125622A (ru) | 2020-01-31 |
| DK3384915T3 (en) | 2020-05-04 |
| ZA201804398B (en) | 2019-09-25 |
| CN105497053B (zh) | 2018-02-13 |
| MY191800A (en) | 2022-07-15 |
| PE20190210A1 (es) | 2019-02-07 |
| EP3384915A1 (en) | 2018-10-10 |
| CA3010020A1 (en) | 2017-07-06 |
| PL3384915T3 (pl) | 2020-09-07 |
| ES2785644T3 (es) | 2020-10-07 |
| EP3384915A4 (en) | 2018-12-19 |
| PH12018501394A1 (en) | 2019-02-27 |
| US20190001160A1 (en) | 2019-01-03 |
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