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CO2017013293A2 - Formulaciones farmacéuticas que comprenden tenofovir y emtricitabina - Google Patents

Formulaciones farmacéuticas que comprenden tenofovir y emtricitabina

Info

Publication number
CO2017013293A2
CO2017013293A2 CONC2017/0013293A CO2017013293A CO2017013293A2 CO 2017013293 A2 CO2017013293 A2 CO 2017013293A2 CO 2017013293 A CO2017013293 A CO 2017013293A CO 2017013293 A2 CO2017013293 A2 CO 2017013293A2
Authority
CO
Colombia
Prior art keywords
emtricitabine
tenofovir
pharmaceutical formulations
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
CONC2017/0013293A
Other languages
English (en)
Inventor
Joanna M Koziara
Scott Mccallister
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56418608&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO2017013293(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of CO2017013293A2 publication Critical patent/CO2017013293A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención proporciona una forma de dosificación oral sólida que comprende alafenamida de tenofovir o una sal farmacéuticamente aceptable de la misma, y emtricitabina o una sal farmacéuticamente aceptable de la misma.
CONC2017/0013293A 2015-06-30 2017-12-21 Formulaciones farmacéuticas que comprenden tenofovir y emtricitabina CO2017013293A2 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562187113P 2015-06-30 2015-06-30
US201662298373P 2016-02-22 2016-02-22
US201662301429P 2016-02-29 2016-02-29
US201662317286P 2016-04-01 2016-04-01
PCT/US2016/040158 WO2017004244A1 (en) 2015-06-30 2016-06-29 Pharmaceutical formulations comprising tenofovir and emtricitabine

Publications (1)

Publication Number Publication Date
CO2017013293A2 true CO2017013293A2 (es) 2018-05-31

Family

ID=56418608

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2017/0013293A CO2017013293A2 (es) 2015-06-30 2017-12-21 Formulaciones farmacéuticas que comprenden tenofovir y emtricitabina

Country Status (26)

Country Link
US (3) US20180177734A1 (es)
EP (6) EP4527467A3 (es)
JP (3) JP6667556B2 (es)
KR (2) KR102313668B1 (es)
CN (2) CN107847450A (es)
AU (3) AU2016287500B2 (es)
BR (1) BR112017027843A2 (es)
CA (1) CA2990210C (es)
CL (1) CL2017003320A1 (es)
CO (1) CO2017013293A2 (es)
CU (1) CU20170168A7 (es)
DO (1) DOP2017000306A (es)
EA (1) EA201792592A1 (es)
EC (1) ECSP17084331A (es)
ES (5) ES2945345T3 (es)
HK (1) HK1248547A1 (es)
IL (1) IL256364A (es)
MA (1) MA50541A (es)
MX (1) MX2017016806A (es)
PE (1) PE20180411A1 (es)
PH (1) PH12017502431A1 (es)
PL (5) PL3316868T3 (es)
PT (4) PT3316868T (es)
SI (4) SI3316868T1 (es)
SV (1) SV2017005601A (es)
WO (1) WO2017004244A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3067358T3 (da) 2012-12-21 2019-11-04 Gilead Sciences Inc Polycykliske carbamoylpyridon-forbindelser og deres farmaceutiske anvendelse
SG11201705069YA (en) 2014-12-26 2017-07-28 Univ Emory N4-hydroxycytidine and derivatives and anti-viral uses related thereto
BR102016026127A2 (pt) 2015-11-09 2017-05-16 Gilead Sciences Inc composições terapêuticas para o tratamento do vírus da imunodeficiência humana
NZ797281A (en) 2017-02-17 2025-10-31 Eidos Therapeutics Inc Processes for preparing ag-10, its intermediates, and salts thereof
WO2018153977A1 (en) * 2017-02-24 2018-08-30 Hexal Ag Stable composition of tenofovir alafenamide
CA3054822A1 (en) * 2017-03-20 2018-09-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hiv post-exposure prophylaxis
RU2662160C9 (ru) 2017-07-03 2018-10-22 Александрович Иващенко Андрей Комбинированный лекарственный препарат для терапии вирусных инфекций
PL3706762T3 (pl) 2017-12-07 2025-02-10 Emory University N4-hydroksycytydyna i pochodne oraz związane z nimi zastosowania przeciwwirusowe
KR20200135996A (ko) 2018-03-23 2020-12-04 에이도스 테라퓨틱스, 인코포레이티드 Ag10을 사용하여 ttr 아밀로이드증을 치료하는 방법
EP4647068A2 (en) 2018-08-17 2025-11-12 Eidos Therapeutics, Inc. Formulations of ag10
CN111096954B (zh) * 2018-10-29 2022-09-16 江苏豪森药业集团有限公司 一种用于抗病毒感染的药物组合物及制备方法
MA56449A (fr) * 2019-07-03 2022-05-11 Janssen Sciences Ireland Unlimited Co Procédés de traitement du vih chez des patients pédiatriques par la rilpivirine
CN110251476B (zh) * 2019-08-01 2022-08-09 海思科制药(眉山)有限公司 一种恩曲他滨替诺福韦药物组合物
CN110917197A (zh) * 2019-12-31 2020-03-27 常州恒邦药业有限公司 一种替诺福韦酯与恩曲他滨的药物组合物及其制备方法
TWI728709B (zh) * 2020-02-19 2021-05-21 台灣森本生物科技開發股份有限公司 含有得自於藤黃樹脂的丙酮萃取產物的藥學組成物以及由該組成物所製得的配方
WO2024211882A1 (en) * 2023-04-07 2024-10-10 Navinta, Llc Stable compositions of rilpivirine hcl in combination with other anti-retroviral agents
CN117338733B (zh) * 2023-10-12 2024-05-28 杭州和泽坤元药业有限公司 一种富马酸替诺福韦二吡呋酯片及其制备工艺
WO2025229473A1 (en) * 2024-05-01 2025-11-06 Lupin Limited Tenofovir alafenamide compositions
CN119174735A (zh) * 2024-09-03 2024-12-24 安徽贝克生物制药有限公司 一种含利匹韦林的复方片及制备方法
CN119139247A (zh) * 2024-09-05 2024-12-17 安徽贝克生物制药有限公司 一种恩曲他滨丙酚替诺福韦复方片及制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2682397B1 (en) 2000-07-21 2017-04-19 Gilead Sciences, Inc. Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
US20040224917A1 (en) 2003-01-14 2004-11-11 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
TWI471145B (zh) * 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
EA021313B1 (ru) 2009-02-06 2015-05-29 Джилид Сайэнс, Инк. Таблетки для комбинированной терапии
UA115311C2 (uk) 2011-08-16 2017-10-25 Гіліад Сайєнсіз, Інк. Геміфумарат тенофовіру алафенаміду
JP6059255B2 (ja) * 2012-02-03 2017-01-11 ギリアード サイエンシス インコーポレーテッド ウイルス感染の処置における使用のためのテノホビルアラフェンアミドヘミフマル酸塩とコビシスタットを含む併用療法
EP3033084A1 (en) * 2013-08-14 2016-06-22 ratiopharm GmbH Medicament comprising a pharmaceutical combination of dolutegravir, emtricitabine and tenofovir
CZ2013985A3 (cs) * 2013-12-09 2015-06-17 Zentiva, K.S. Stabilní farmaceutická kompozice obsahující tenofovir disoproxil fumarát
NO2717902T3 (es) * 2014-06-20 2018-06-23

Also Published As

Publication number Publication date
PT4070787T (pt) 2023-05-22
MX2017016806A (es) 2018-05-07
EP4527467A3 (en) 2025-05-21
EP3316868B1 (en) 2020-02-19
DOP2017000306A (es) 2018-01-15
EP4233846A2 (en) 2023-08-30
EP3607939B1 (en) 2022-06-01
PL3607939T3 (pl) 2022-11-07
BR112017027843A2 (pt) 2018-09-04
AU2021202009B2 (en) 2023-04-13
US20180177734A1 (en) 2018-06-28
CN119606990A (zh) 2025-03-14
PL4070788T3 (pl) 2023-07-10
JP2018519297A (ja) 2018-07-19
AU2016287500B2 (en) 2019-05-02
ES2925246T3 (es) 2022-10-14
JP2020079304A (ja) 2020-05-28
US20170000807A1 (en) 2017-01-05
PL3316868T3 (pl) 2020-10-19
SI3607939T1 (sl) 2022-10-28
PE20180411A1 (es) 2018-03-01
WO2017004244A1 (en) 2017-01-05
PL4070787T3 (pl) 2023-07-24
JP6667556B2 (ja) 2020-03-18
EP3316868A1 (en) 2018-05-09
PH12017502431A1 (en) 2018-07-02
KR102121329B1 (ko) 2020-06-17
KR20180021134A (ko) 2018-02-28
EA201792592A1 (ru) 2018-06-29
JP2021185188A (ja) 2021-12-09
CN107847450A (zh) 2018-03-27
KR20200067937A (ko) 2020-06-12
CA2990210C (en) 2021-01-12
EP4070788B1 (en) 2023-03-22
EP4233846A3 (en) 2023-10-04
CA2990210A1 (en) 2017-01-05
MA50541A (fr) 2021-04-07
ES2945896T3 (es) 2023-07-10
SI3316868T1 (sl) 2020-04-30
US20250281412A1 (en) 2025-09-11
PL4233846T3 (pl) 2025-03-24
SI4070788T1 (sl) 2023-06-30
EP3607939A1 (en) 2020-02-12
SI4070787T1 (sl) 2023-07-31
SV2017005601A (es) 2018-05-04
EP4233846B1 (en) 2024-12-04
EP4527467A2 (en) 2025-03-26
EP4070787B1 (en) 2023-03-01
ES2945345T3 (es) 2023-06-30
IL256364A (en) 2018-02-28
CL2017003320A1 (es) 2018-07-13
ECSP17084331A (es) 2018-01-31
PT3607939T (pt) 2022-09-12
PT3316868T (pt) 2020-04-21
JP6978534B2 (ja) 2021-12-08
KR102313668B1 (ko) 2021-10-19
CU20170168A7 (es) 2018-07-05
EP4070788A1 (en) 2022-10-12
AU2016287500A1 (en) 2018-01-18
HK1248547A1 (zh) 2018-10-19
EP4070787A1 (en) 2022-10-12
EP4233846C0 (en) 2024-12-04
ES2786549T3 (es) 2020-10-13
AU2021202009A1 (en) 2021-04-29
AU2019210558A1 (en) 2019-08-15
AU2019210558B2 (en) 2021-04-22
PT4070788T (pt) 2023-06-06
ES3007987T3 (en) 2025-03-21

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