CN207575160U - A kind of PET/MR image quality detection body mould on apery head - Google Patents

Abstract

The utility model discloses a PET/MR imaging quality detection phantom imitating a human head, comprising: the PET/MR imaging quality detection phantom imitating a human head has a phantom body in the shape of a human head, and the body There is at least one detachable replacement module inside the mold body; the detachable replacement module is selected from brain tumor simulation module, PET/MR image fusion test module, PET/MR attenuation correction test module, PET performance parameter One or more of the test module or the MRI performance parameter test module. The phantom of the utility model is a quality detection phantom with morphological characteristics, which can simulate the real human head shape, structure and lesion, and can be used for quality control of the human head PET/MR imager, and can also be used for It has a wide range of applications for finding the optimal scanning parameters of PET/MR imagers, for teaching demonstration, for tracer screening, etc.

Description

A human head-like PET/MR imaging quality inspection phantom

technical field

The utility model relates to the field of PET/MR quality assurance and quality control, in particular to a PET/MR imaging quality detection phantom imitating a human head.

Background technique

In recent years, with the rapid development of medical imaging technology, multimodal joint imaging technology has received extensive attention, such as PET/MR (Positron Emission Tomography/Magnetic Resonance Imaging, Positron Emission Tomography/Magnetic Resonance Imaging) technology, Among them, PET can obtain functional and metabolic information very well, and belongs to functional imaging. It has high sensitivity to diseased tissues, but its spatial resolution is low, and PET information cannot be accurately positioned; while MRI images have excellent soft tissue contrast and high spatial resolution. The combination of PET and MRI (PET/MR multimodal two-in-one imaging system) can make up for the shortcomings of PET imaging and MRI imaging alone, and can simultaneously obtain multiple information of body anatomy, function, and biochemistry in one examination.

At present, the phantoms used for quality control of PET/MR imagers have problems such as single types and simple structures. Performance parameters, or those of the MRI portion alone, cannot be used to quality control the imaging quality of combined PET/MR. Therefore, there is an urgent need for a matching phantom suitable for PET/MR imagers.

Utility model content

Aiming at the deficiencies of the above-mentioned prior art, the purpose of this utility model is to provide a PET/MR imaging quality detection phantom imitating a human head. The phantom of the utility model is a three-dimensional structure quality detection phantom with morphological characteristics, which can simulate the real shape, structure and lesion of the human brain, and can be used for quality control of the PET/MR imager of the human head. It can also be used to find the optimal scanning parameters of the PET/MR imager, for teaching demonstrations, for tracer screening, etc., and has a wide range of applications.

In order to achieve the above object, the utility model adopts the following technical solutions:

The first aspect of the utility model provides a PET/MR imaging quality detection phantom imitating a human head, comprising: a phantom body having the shape of a human head, and at least one detachable replace the module;

The detachable replacement module is selected from one of the brain tumor simulation module, PET/MR image fusion test module, PET/MR attenuation correction test module, PET performance parameter test module or MRI performance parameter test module or Various.

Preferably, the detachable replacement module is located inside the phantom body above the brain.

Preferably, the brain tumor simulation module is a hollow sphere structure; the hollow sphere structure is perfused with a tracer.

More preferably, the tracer is 18F-FDG (fluorodeoxyglucose, fluorodeoxyglucose) solution.

Preferably, the PET/MR image fusion test module includes: at least one of a hollow cylinder, a hollow sphere or a cube; the hollow cylinder, hollow sphere or cube can be independently tested for image fusion.

The hollow sphere or cube is filled with a tracer, such as FDG solution.

Solid radioactive sources of different sizes, such as Na sources, are accommodated in the hollow cylinder.

More preferably, a plurality of hollow spheres with different diameters form a circumference, and the centers of the hollow spheres are on the same circumferential layer; or the hollow spheres are arranged in a row according to their diameters.

During the test, the FGD solution was injected into the hollow sphere or cube for PET/MR scanning, and the accuracy of image fusion was obtained based on the obtained scanning images.

More preferably, a plurality of hollow cylinders with different diameters form a circumference, and the centers of the sections of the hollow cylinders are on the same circumferential layer; or the hollow cylinders are arranged in a row according to the diameters.

During the test, a Na source was injected into the hollow cylinder for PET/MR scanning, and the accuracy of image fusion was obtained based on the obtained scanning images.

Preferably, the PET/MR image fusion test module composed of hollow spheres or cubes can also be used to test the low contrast resolution of PET.

The low-contrast resolution test method of PET is: use multiple hollow spheres or cubes of different diameters to test the low-contrast resolution of PET. During the test, inject tracers into multiple hollow spheres or cubes and perform PET scanning. The resulting scanned images determine the low-contrast resolution.

Preferably, the attenuation correction test module of PET/MR includes: at least one hollow cylindrical insert, the hollow cylindrical insert is divided into two parts, one part is located in the phantom body, and the other part is located in the phantom body outside.

Both the part of the hollow cylindrical insert inside the phantom body and the part outside the phantom body are filled with a tracer, such as FDG solution.

The part of the hollow cylindrical insert inside the phantom body and the part outside the phantom body are connected by threads.

During the test, the tracer is injected into the part of the hollow cylindrical insert located inside the phantom body and the part outside the phantom body, and a PET/MR scan is performed. According to the scanned image of the part of the hollow cylindrical insert located inside the phantom body The accuracy of the attenuation correction is determined by counting images of the portion of the hollow cylindrical insert located within the phantom body.

Preferably, the PET performance parameter testing module is composed of several groups of cylinders with different diameters.

The cylinder is a hollow or solid structure.

When the cylinder is a hollow structure, it is used to test the system resolution under the high contrast structure, and the tracer (such as FGD solution) is filled in the cylinder during the test.

When the cylinder is a solid structure, it is used to test the system resolution under low contrast structure, and the tracer is filled in the area outside the cylinder during the test.

During the test, the PET scan is performed after the tracer is filled, and the resolution is determined according to the smallest size (diameter) that can be resolved in the scanned image.

Preferably, the MRI performance parameter testing module includes: an MRI high-contrast resolution module and an MRI low-contrast resolution module;

The MRI high-contrast resolution module consists of several groups of circular holes with different diameters, which are used to test and measure the ability of the imaging system to resolve the smallest details of an object when there is no serious noise. The test object was observed by visual inspection.

The MRI low-contrast resolution module is composed of several groups of radially distributed circular holes with different diameters; the diameters of the circular holes in each group are the same, and the depths of the circular holes in each group are different.

Preferably, the bone structure of the phantom body is three-dimensionally printed using bone tissue equivalent materials, and the skin and other internal tissues of the phantom body are three-dimensionally printed using soft tissue equivalent materials.

Alternatively, the skeletal structure of the phantom body is three-dimensionally printed using bone tissue equivalent materials, the skin of the phantom body, that is, the scalp part, is three-dimensionally printed using ordinary materials, and other tissues inside the phantom body are made of prepared soft tissue equivalent materials Perform priming.

The bone tissue equivalent material, the soft tissue equivalent material, and the common material are all existing materials, and the prepared soft tissue equivalent material is existing or prepared agarose gel:

For example, the bone tissue equivalent material is a high-density resin with a Shore hardness greater than 90 in existing 3D printing materials.

The soft tissue equivalent material is EVA resin with lower density in existing 3D printing materials.

The common material is a common plastic material in existing 3D printing materials.

The prepared soft tissue equivalent material is prepared agarose gel.

The beneficial effects of the utility model:

(1) The PET/MR imaging quality inspection phantom of the present invention has a three-dimensional structure, which can simulate the shape and structure of the human head in the external shape and internal structure. In addition, the PET/MR imaging quality detection phantom of the human head of the utility model has one or more detachable replacement modules, wherein one replacement module is a preset lesion structure, which is used to simulate the tumor in the human head ;Other replacement modules can be used to test the parameters of the PET/MR instrument, so as to evaluate the performance of the PET/MR instrument according to the measured parameters.

(2) The PET/MR imaging quality detection phantom of the human head of the present utility model can simulate the shape, structure and focus of the cranial brain of the real human head, and can be used for quality control of the PET/MR imager of the human head, It can also be used to find the optimal scanning parameters of the PET/MR imager, for teaching demonstrations, for tracer screening, etc., and has a wide range of applications.

Description of drawings

The accompanying drawings constituting a part of the present application are used to provide further understanding of the present application, and the schematic embodiments and descriptions of the present application are used to explain the present application, and do not constitute improper limitations to the present application.

Fig. 1 is the structural representation of phantom body of the present utility model;

Fig. 2 is the structural representation of the tumor simulation module in the PET/MR imaging quality detection phantom of the human head of the utility model (side view sectional view);

Fig. 3A is the top view of the hollow sphere of the image fusion test module in the PET/MR imaging quality detection phantom of the human head of the utility model;

Fig. 3B is the front view of the hollow sphere of the image fusion test module in the PET/MR imaging quality detection phantom of the human head of the utility model;

Fig. 4A is the top view of the hollow cylinder of the image fusion test module in the PET/MR imaging quality detection phantom of the human head of the utility model;

Fig. 4B is the front view of the hollow cylinder of the image fusion test module in the PET/MR imaging quality detection phantom of the human head of the utility model;

Fig. 5 is the structure diagram of the attenuation correction test module of PET/MR in the PET/MR imaging quality detection phantom of the utility model imitating human head;

6A is a cross-sectional view of a PET high-contrast resolution module;

6B is a cross-sectional view of a PET low-contrast resolution module;

Figure 7A: Schematic diagram of the structure of the MRI high-contrast resolution module;

Figure 7B: Schematic diagram of the structure of the MRI low-contrast resolution module;

Among them, 1-skin, 2-skeleton, 3-removable replacement module, 4-brain tissue, 5-hollow sphere, 6-hollow cylinder insert, 7-the part of the hollow cylinder insert inside the phantom body, 8-hollow The part of the cylindrical insert that is outside the body of the phantom.

Detailed ways

It should be pointed out that the following detailed description is exemplary and intended to provide further explanation to the present application. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

It should be noted that the terminology used here is only for describing specific implementations, and is not intended to limit the exemplary implementations according to the present application. As used herein, unless the context clearly dictates otherwise, the singular is intended to include the plural, and it should also be understood that when the terms "comprising" and/or "comprising" are used in this specification, they mean There are features, steps, operations, means, components and/or combinations thereof.

As introduced in the background art, the phantoms used for quality control of PET/MR imagers in the prior art have problems such as single types and simple structures, and cannot perform quality control on the imaging quality of PET/MR combined use. Based on this, the utility model proposes a PET/MR imaging quality detection phantom imitating a human head.

In one embodiment of the present application, a PET/MR imaging quality detection phantom imitating the human head is provided, as shown in Figure 1, the shape of the phantom body simulates the shape of the real human head and brain , At least one detachable replacement module 3 is provided at the position above the brain inside the phantom body; the detachable replacement module 3 can be a cuboid or a cylinder, and its shape is not limited here. The phantom body comprises skin 1 , bone 2 , detachable replacement module 3 and brain tissue 4 .

For example, after the overall production of the phantom body is completed, a cuboid A is picked at the brain above the phantom body, and after the cuboid A is removed, a corresponding detachable replacement module 3 can be selected and installed on the phantom according to the test requirements. superior. When there is no need to install a replacement module, the cuboid A can be put back on the phantom body. At this time, the phantom is in the form of a complete human head and brain.

The detachable replacement module 3 is selected from one of the brain tumor simulation module, PET/MR image fusion test module, PET/MR attenuation correction test module, PET performance parameter test module or MR performance parameter test module or more.

For example, the replacement module B1 is used to simulate the brain tumor simulation module;

The replacement module C1 is the image fusion test module of PET/MR, and the replacement module C2 is the attenuation correction test module of PET/MR;

The replacement module D1 is a PET performance parameter test module, and the replacement module D2 is another PET performance parameter test module, etc.;

The replacement module E1 is an MRI performance parameter testing module, and the replacement module E2 is another MRI performance parameter testing module.

As a preferred solution, a sphere structure is used to simulate the shape of the tumor in the human head, as shown in Figure 2, after the sphere structure is perfused with a tracer, such as 18F-FDG (fluorodeoxyglucose, fluorodeoxyglucose) solution, it can be carried out under PET. imaging.

As a preferred solution, the PET/MR image fusion test module includes: at least one of a hollow cylinder, a sphere 5 or a cube; the hollow cylinder, hollow sphere 5 or cube can be independently tested for image fusion.

The hollow sphere 5 or cube is filled with a tracer, such as FDG solution.

Preferably, a plurality of hollow spheres with different diameters form a circle, and the centers of the hollow spheres 5 are on the same circumferential layer, as shown in Figure 3A; or the hollow spheres 5 are arranged in a row according to their diameters, as shown in Figure 3A 3B.

The above PET/MR image fusion test module can also be used to test the low contrast resolution of PET.

The test method is: use multiple hollow spheres 5 with different diameters to test the low-contrast resolution of PET. During the test, inject FDG solution into the multiple hollow spheres 5, perform PET scanning, and determine the low-contrast resolution according to the obtained scanned images.

Preferably, a plurality of hollow cylinders with different diameters form a circumference, and the center of the section of the hollow cylinders is on the same circumferential layer, as shown in Figure 4A; or the hollow cylinders are arranged in a row according to the diameter, as shown in Figure 4B Show.

During the test, a Na source was injected into the hollow cylinder for PET/MR scanning, and the accuracy of image fusion was obtained based on the obtained scanning images.

As a preferred solution, the attenuation correction test module of PET/MR includes: at least one hollow cylindrical insert 6, the hollow cylindrical insert 6 is divided into two parts, one part is located in the phantom body, and the other part is located in the phantom body. Outside the body of the phantom, as shown in Figure 5.

Both the part 7 of the hollow cylindrical insert inside the phantom body and the part 8 of the hollow cylindrical insert outside the phantom body are filled with a tracer, such as FDG solution.

Since the FDG solution needs to be contained in the hollow cylindrical insert, its material is required not to react with the FDG solution.

Preferably, the part 7 of the hollow cylindrical insert located inside the phantom body and the part 8 of the hollow cylindrical insert located outside the phantom body are connected by threads.

During the test, FDG solution is injected into the part 7 where the hollow cylindrical insert is located inside the phantom body and the part 8 where the hollow cylindrical insert is located outside the phantom body, and a PET/MR scan is performed. According to the scan, the hollow cylindrical insert is located in the phantom body The accuracy of the attenuation correction was determined by counting the part 7 images and the part 8 images of the hollow cylindrical insert located outside the phantom body.

As a preferred solution, the PET performance parameter testing module includes: a PET high-contrast resolution module and a PET low-contrast resolution module;

Among them, the PET high-contrast resolution module is used to test the system resolution under the high-contrast structure. Specifically, there are 6 regions of circular holes in the disc-shaped plexiglass, and the diameters of the circular holes in different regions are different. A cross-sectional view of the circular hole structure is shown in Figure 6A.

When testing, fill the tracer in the round hole.

The PET low-contrast resolution module is used to test the system resolution under the low-contrast structure. Specifically, the module consists of 6 groups of solid cylinders with different diameters. The cross-sectional view is shown in Figure 6B.

During testing, the area outside the cylinder is filled with tracer.

As a preferred solution, the MRI performance parameter testing module includes: an MRI high-contrast resolution module and an MRI low-contrast resolution module.

Among them, the high-contrast resolution of MRI is to measure the ability of the imaging system to distinguish the smallest details of the object when there is no serious noise. The common method is to observe the test object by visual inspection.

In one embodiment of the present invention, hole-like structures with different diameters are used to test high-contrast resolution. Specifically, the disc-shaped plexiglass is composed of 6 groups of solid cylinders with different diameters, and the circles in different areas The diameters of the holes vary, as shown in 7A.

MRI contrast resolution refers to the ability to distinguish details from the background when there is low contrast between the details and the background. The size of the low-contrast resolution reflects the ability of the MRI equipment to distinguish objects with similar signal sizes, that is, the sensitivity of the MRI equipment. When testing low-contrast resolution, for the same substance, under certain scanning conditions, its signal intensity is related to factors such as the area and depth of the target substance. For example, for circular holes of the same diameter, the deeper the hole, the greater the signal strength.

Specifically, the module is composed of ten groups of round holes with different diameters, which are distributed radially, as shown in FIG. 7B , three round holes in each group have the same diameter, and three round holes in each group have different depths. For example, the depths of three round holes in the same group increase sequentially from inside to outside.

It should be noted that, in the structures shown in Fig. 6A, Fig. 6B, Fig. 7A and Fig. 7B, the number of round holes/cylindrical regions and the number of round holes/cylindrical regions in each region shown in the figure below are only used as To give examples and illustrations, but not to limit the utility model. The specific number can be increased or decreased according to actual needs.

I In order to enable those skilled in the art to understand the technical solution of the present application more clearly, the technical solution of the present application will be described in detail below in conjunction with specific embodiments.

The test materials used in the embodiments of the present invention are all conventional test materials in the field, and can be purchased through commercial channels.

Example 1:

1. The structure and material of the phantom body:

The overall shape of the phantom is the shape of a simulated human head. Specifically, a simulated human head model is constructed based on MR scan data of a real human head, and a simulated human head model is produced by 3D printing technology according to the constructed model.

(1) Selection of model materials:

All bone 2 structures of the human head are 3D printed using bone tissue equivalent materials; the skin 1 of the human head and other internal tissues (brain tissue 4) of the human head are all 3D printed using soft tissue equivalent materials.

Among them, the bone tissue equivalent material is a high-density resin with a Shore hardness greater than 90 in existing 3D printing materials.

The soft tissue equivalent material is EVA resin with lower density in existing 3D printing materials.

(2) The structure of the phantom:

The phantom includes: a phantom body, on which there is a detachable replacement module 3 (for example, as shown in FIG. 1 , located at the upper brain of the human head model). When the detachable replacement module 3 is installed on the phantom body, the phantom is in the shape of a complete human head. Wherein, the detachable replacement module 3 may be a cuboid or a cylinder, and its shape is not limited here.

After the detachable replacement module is removed, other replacement modules can be installed on the phantom body to test corresponding parameters through the replacement module.

Other replacement modules can be: brain tumor simulation module, PET/MR image fusion test module, PET/MR attenuation correction test module, PET performance parameter test module, MR performance parameter test module.

Example 2:

1. The structure and material of the phantom body:

The overall shape of the phantom is the shape of a human head. Specifically, a human head model is constructed according to MR scan data of a real human head, and a human head model is produced by 3D printing technology according to the constructed model.

(1) Selection of model materials:

All bones 2 structures of the human head are printed with bone equivalent materials, the skin 1 of the human head is made with ordinary materials, and other tissues (brain tissue 4) inside the human head are printed with prepared soft tissue equivalent materials. Infusion molding.

The bone equivalent material is a high-density resin with a Shore hardness greater than 90 in existing 3D printing materials.

Ordinary materials are common plastic materials in existing 3D printing materials.

The prepared soft tissue equivalent material is prepared agarose gel.

(2) The structure of the phantom:

The phantom comprises: a phantom body, two detachable replacement modules 3 are arranged in the phantom body (for example, as shown in Figure 1, be positioned at the top brain position of human head model), wherein, a replacement module is Internal tumor simulation module, preset lesion structure, used to simulate tumors in the human head; other replacement modules can be selected from PET/MR image fusion test module, PET/MR attenuation correction test module, PET performance parameter test The module or MR performance parameter test module is used to test the parameters of the PET/MR imager, so as to evaluate the performance of the PET/MR imager according to the measured parameters.

The above descriptions are only preferred embodiments of the present application, and are not intended to limit the present application. For those skilled in the art, there may be various modifications and changes in the present application. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of this application shall be included within the protection scope of this application.

Claims (8)

1. a kind of PET/MR image quality detection body mould on apery head, which is characterized in that including：With human body head shape Body mould body, the body mould body are internally provided at least one dismountable replacement module；

Dismountable replacement module is selected from brain tumor analog module, the image co-registration degree test module of PET/MR, PET/ The correction for attenuation test module of MR, PET performance parameter tests module or MRI performance parameter test moulds are in the block one or more；

Dismountable replacement module is located at the brain localization of the top inside body mould body；

The image co-registration degree test module of the PET/MR includes：At least one of hollow cylinder, hollow ball or square；

Tracer is filled in the hollow ball or square；

Various sizes of solid source is accommodated in the hollow cylinder.

2. the PET/MR image quality detection body mould on apery head according to claim 1, which is characterized in that the brain Tumour analog module is hollow ball structure；Tracer is perfused in the hollow ball structure.

3. the PET/MR image quality detection body mould on apery head according to claim 1, which is characterized in that the PET/ The correction for attenuation test module of MR, including：An at least hollow cylinder plug-in unit, the hollow cylinder plug-in unit are divided into two parts, and one Part, which is located at, to be had in human body head outline body mould body, and another part is located at outside body mould body.

4. the PET/MR image quality detection body mould on apery head according to claim 1, which is characterized in that the PET Performance parameter test module is made of the cylinder of several groups of different-diameters；

The cylinder is hollow or solid construction.

5. the PET/MR image quality detection body mould on apery head according to claim 1, which is characterized in that the MRI Performance parameter test module, including：MRI high contrasts module resolution and MRI low contrast resolution modules.

6. the PET/MR image quality detection body mould on apery head according to claim 5, which is characterized in that the MRI High contrast module resolution is made of the circular hole of several groups of different-diameters, is not being made an uproar seriously for testing measurement imaging system To the resolution capability of object minimum details during sound；

The circular hole of different-diameter that the MRI low contrast resolutions module is radially distributed by several groups forms；Each group Circular hole diameter it is identical, the depth of each group of circular hole is different.

7. the PET/MR image quality detection body mould on apery head according to claim 1, which is characterized in that the body mould The skeletal structure of ontology carries out 3 D-printing, the skin of body mould body and other interior tissues using the tissueequivalentmaterial of bone 3 D-printing is carried out using soft tissue equivalent material.

8. the PET/MR image quality detection body mould on apery head according to claim 1, which is characterized in that the body mould The skeletal structure of ontology carries out 3 D-printing using skeletal tissue's equivalent material, and skin, that is, scalp portions of body mould body are using general Logical material carries out 3 D-printing, its hetero-organization inside body mould body is irrigated using prepared soft tissue equivalent material.