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CN106901764A - A kind of PET/CT image quality detection body mould of apery head and preparation method thereof - Google Patents

A kind of PET/CT image quality detection body mould of apery head and preparation method thereof Download PDF

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CN106901764A
CN106901764A CN201710169370.1A CN201710169370A CN106901764A CN 106901764 A CN106901764 A CN 106901764A CN 201710169370 A CN201710169370 A CN 201710169370A CN 106901764 A CN106901764 A CN 106901764A
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pet
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body mould
image quality
head
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侯坤
邱建峰
董克江
路伟钊
石丽婷
孙勇
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Taishan University
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/58Testing, adjusting or calibrating thereof
    • A61B6/582Calibration
    • A61B6/583Calibration using calibration phantoms

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Abstract

A kind of PET/CT image quality the invention discloses apery head detects body mould and preparation method thereof, including:The PET/CT image quality detection mould of the apery head has the body mould body of human body head configuration, and the body mould body is internally provided with least one dismountable replacement module;Dismountable replacement module is selected from one or more in brain tumor analog module, the image co-registration degree test module of PET/CT, the correction for attenuation test module of PET/CT, PET performance parameter tests module or CT performance parameter test modules.Body mould of the invention is the quality testing body mould with morphological feature, it is capable of human body head profile, structure and the focus of simulating realistic, can be used for carrying out quality control to human body head PET/CT imagers, can be also used for find PET/CT imagers optimal sweep parameter, for demonstration lesson, for tracer screening etc. aspect, be with a wide range of applications.

Description

一种仿人头部的PET/CT成像质量检测体模及其制备方法A PET/CT imaging quality detection phantom imitating human head and its preparation method

技术领域technical field

本发明涉及PET/CT质量保证和质量控制领域,特别是涉及一种仿人头部的PET/CT成像质量检测体模及其制备方法。The invention relates to the field of PET/CT quality assurance and quality control, in particular to a human head-like PET/CT imaging quality detection phantom and a preparation method thereof.

背景技术Background technique

近年来,随着医学成像技术的快速发展,多模态联合成像技术得到了广泛的关注,如PET/CT(Positron Emission Tomography/Computed Tomography,正电子发射断层显像/X线计算机断层显像)技术,其中,PET能够很好地获取功能和代谢信息,属于功能性成像,对于病变组织具有较高的灵敏度,但其空间分辨率较低,无法对PET信息进行精确的定位;CT能够提供高分辨率的图像,但由于属于解剖学成像,不能很好的反映组织功能性改变。PET和CT联合(PET/CT多模态二合一成像系统)能够弥补单独PET成像和单独CT成像的不足,实现了功能图像和解剖图像信息的互补,从而提供更多更精确的信息。In recent years, with the rapid development of medical imaging technology, multimodal joint imaging technology has received extensive attention, such as PET/CT (Positron Emission Tomography/Computed Tomography, Positron Emission Tomography/X-ray Computed Tomography) Among them, PET can obtain functional and metabolic information very well, which belongs to functional imaging and has high sensitivity to diseased tissues, but its spatial resolution is low, and PET information cannot be accurately positioned; CT can provide high High-resolution images, but because they belong to anatomical imaging, they cannot reflect the functional changes of tissues well. The combination of PET and CT (PET/CT multimodal two-in-one imaging system) can make up for the shortcomings of PET imaging and CT imaging alone, and realize the complementarity of functional images and anatomical image information, thereby providing more and more accurate information.

目前,用于PET/CT成像仪质量控制的体模存在种类单一、结构简单等问题,例如,现有的体模仅为一些简单的几何形态,且仅能测试单独PET部分的性能参数或单独CT部分的性能参数,无法对PET/CT联合使用的成像质量进行质控。因此,亟需一种适用于PET/CT成像仪的配套体模。At present, the phantoms used for quality control of PET/CT imagers have problems such as single types and simple structures. The performance parameters of the CT part cannot perform quality control on the imaging quality of the combined use of PET/CT. Therefore, there is an urgent need for a matching phantom suitable for PET/CT imagers.

发明内容Contents of the invention

针对上述现有技术的不足,本发明的目的在于提供一种仿人头部的PET/CT成像质量检测体模。本发明的体模为具有形态学特征的三维立体结构质量检测体模,能够仿真真实的人颅脑外形、结构以及病灶,可以用于对人体头部的PET/CT成像仪进行质量控制,还可以用于寻找PET/CT成像仪的最优扫描参数、用于教学示范、用于示踪剂筛选等方面,具有广泛的应用范围。Aiming at the deficiencies of the above-mentioned prior art, the object of the present invention is to provide a PET/CT imaging quality detection phantom imitating a human head. The phantom of the present invention is a three-dimensional structural quality detection phantom with morphological characteristics, which can simulate the real shape, structure and focus of the human brain, and can be used for quality control of the PET/CT imager of the human head. It can be used to find the optimal scanning parameters of PET/CT imager, to teach and demonstrate, to screen tracers, etc., and has a wide range of applications.

为实现上述目的,本发明采用如下技术方案:To achieve the above object, the present invention adopts the following technical solutions:

本发明的第一方面,提供一种仿人头部的PET/CT成像质量检测体模,包括:具有人体头部外形的体模本体,所述体模本体内部设置有至少一个可拆卸的替换模块;The first aspect of the present invention provides a PET/CT imaging quality detection phantom imitating a human head, comprising: a phantom body having the shape of a human head, at least one detachable replacement module;

所述可拆卸的替换模块选自脑部肿瘤模拟模块、PET/CT的图像融合度测试模块、PET/CT的衰减校正测试模块、PET性能参数测试模块或CT性能参数测试模块中的一种或多种。The detachable replacement module is selected from one of the brain tumor simulation module, PET/CT image fusion test module, PET/CT attenuation correction test module, PET performance parameter test module or CT performance parameter test module or Various.

优选的,所述可拆卸的替换模块位于体模本体内部的上方的脑部位置。Preferably, the detachable replacement module is located inside the phantom body above the brain.

优选的,所述脑部肿瘤模拟模块为空心球体结构;所述空心球体结构内灌注有示踪剂。Preferably, the brain tumor simulation module is a hollow sphere structure; the hollow sphere structure is perfused with a tracer.

更为优选的,所述示踪剂为18F-FDG(fluorodeoxyglucose,氟代脱氧葡萄糖)溶液。More preferably, the tracer is 18F-FDG (fluorodeoxyglucose, fluorodeoxyglucose) solution.

优选的,所述PET/CT的图像融合度测试模块包括:线源和空心球体或正方体中的至少一种;线源、空心球体或正方体均可单独进行图像融合度测试。Preferably, the PET/CT image fusion test module includes: at least one of a line source and a hollow sphere or a cube; the line source, hollow sphere or cube can be used for the image fusion test independently.

所述线源为铝制管状结构,内部可灌注示踪剂,如FDG溶液;The line source is an aluminum tubular structure, and a tracer, such as FDG solution, can be perfused inside;

所述空心球体或正方体内填充有示踪剂,如FDG溶液。The hollow sphere or cube is filled with a tracer, such as FDG solution.

更为优选的,多个不同直径大小的空心球体组成圆周,所述空心球体的球心在同一个圆周层上;或者所述空心球体按直径大小排成一行。More preferably, a plurality of hollow spheres with different diameters form a circumference, and the centers of the hollow spheres are on the same circumferential layer; or the hollow spheres are arranged in a row according to their diameters.

若PET/CT的图像融合度测试模块中包括线源和空心球体,则对于线源和空心球体的相对位置并没有特殊的限制,例如,线源可以设置在多个空心球体所组成圆周的外侧。If the image fusion test module of PET/CT includes a line source and a hollow sphere, there is no special restriction on the relative positions of the line source and the hollow sphere, for example, the line source can be set outside the circle formed by multiple hollow spheres .

测试时,在线源和空心球体中注入FGD溶液,进行PET/CT扫描,根据得到的扫描图像获得图像融合精确度。During the test, the FGD solution was injected into the line source and the hollow sphere for PET/CT scanning, and the image fusion accuracy was obtained based on the obtained scanning images.

所述PET/CT的图像融合度测试模块还可以用于测试PET的低对比度分辨率。The PET/CT image fusion test module can also be used to test the low contrast resolution of PET.

PET的低对比度分辨率的测试方法为:使用多个不同直径的空心球体测试PET的低对比度分辨率,测试时,在多个空心球体中注入示踪剂,进行PET扫描,根据得到的扫描图像确定低对比度分辨率。The low-contrast resolution test method of PET is: use multiple hollow spheres with different diameters to test the low-contrast resolution of PET. During the test, inject tracers into multiple hollow spheres and perform PET scanning. According to the obtained scanning images Determines low contrast resolution.

优选的,所述PET/CT的衰减校正测试模块,包括:至少一根空心圆柱插件,所述空心圆柱插件分为两部分,一部分位于所述体模本体内,另一部分位于所述体模本体外。Preferably, the attenuation correction test module of PET/CT includes: at least one hollow cylindrical insert, the hollow cylindrical insert is divided into two parts, one part is located in the phantom body, and the other part is located in the phantom body outside.

所述空心圆柱插件位于所述体模本体内的部分和位于所述体模本体外的部分均填充有示踪剂,如FDG溶液。Both the part of the hollow cylindrical insert inside the phantom body and the part outside the phantom body are filled with a tracer, such as FDG solution.

所述空心圆柱插件位于体模本体内的部分和位于体模本体外的部分采用螺纹连接。The part of the hollow cylindrical insert inside the phantom body and the part outside the phantom body are connected by threads.

测试时,在空心圆柱插件位于体模本体内的部分和位于体模本体外的部分均注入示踪剂,进行PET/CT扫描,根据扫描得到的空心圆柱插件位于体模本体内的部分的图像和空心圆柱插件位于体模本体内的部分的图像的计数来确定衰减校正的精确度。During the test, the tracer is injected into the part of the hollow cylindrical insert located inside the phantom body and the part outside the phantom body, and a PET/CT scan is performed. According to the scanned image of the part of the hollow cylindrical insert located inside the phantom body The accuracy of the attenuation correction is determined by counting images of the portion of the hollow cylindrical insert located within the phantom body.

优选的,所述PET性能参数测试模块,由若干组不同直径的圆柱体组成。Preferably, the PET performance parameter testing module is composed of several groups of cylinders with different diameters.

所述圆柱体为空心或实心结构。The cylinder is a hollow or solid structure.

当圆柱体为空心结构时,用于测试高对比结构下的系统分辨率,测试时在圆柱内灌装示踪剂(如FGD溶液)。When the cylinder is a hollow structure, it is used to test the system resolution under the high contrast structure, and the tracer (such as FGD solution) is filled in the cylinder during the test.

当圆柱体为实心结构时,用于测试低对比结构下的系统分辨率,测试时在圆柱之外的区域灌装示踪剂。When the cylinder is a solid structure, it is used to test the system resolution under low contrast structure, and the tracer is filled in the area outside the cylinder during the test.

测试时,灌装示踪剂后进行PET扫描,根据扫描得到图像中所能分辨的最小尺寸(直径)确定分辨率。During the test, the PET scan is performed after the tracer is filled, and the resolution is determined according to the smallest size (diameter) that can be resolved in the scanned image.

优选的,所述CT性能参数测试模块,包括:CT空间分辨率测试模块、CT密度分辨率测试模块和辐射剂量测试模块;Preferably, the CT performance parameter testing module includes: a CT spatial resolution testing module, a CT density resolution testing module and a radiation dose testing module;

所述CT空间分辨率测试模块由若干组不同直径的圆孔组成,各排圆孔之间的距离与所在排圆孔的直径相同。The CT spatial resolution test module is composed of several groups of round holes with different diameters, and the distance between each row of round holes is the same as the diameter of the row of round holes.

排与排之间的距离可以是固定距离;也可以不做具体限制。The distance between the rows may be a fixed distance; it may not be specifically limited.

所述CT密度分辨率测试模块由若干组呈放射状分布的不同直径的圆孔组成;每一组的圆孔的直径相同,并在圆孔内填充有不同对比度的材料。The CT density resolution testing module is composed of several groups of circular holes with different diameters distributed radially; the diameters of the circular holes in each group are the same, and the circular holes are filled with materials of different contrasts.

所述辐射剂量测试模块,包括:电离室探头和放置电离室探头的腔室;所述电离室探头与外部的辐射计量仪相连,用于测量CT扫描时的辐射剂量。The radiation dose testing module includes: an ionization chamber probe and a chamber for placing the ionization chamber probe; the ionization chamber probe is connected with an external radiation meter for measuring radiation dose during CT scanning.

优选的,所述放置电离室探头的腔室的截面为圆形或矩形。Preferably, the cross section of the chamber where the ionization chamber probe is placed is circular or rectangular.

针对上述现有技术的不足,本发明的目的在于提供一种仿人头部的PET/CT成像质量检测体模的制备方法。本发明的体模为具有形态学特征的三维立体结构质量检测体模,能够仿真真实的人颅脑外形、结构以及病灶,可以用于对人体头部的PET/CT成像仪进行质量控制,还可以用于寻找PET/CT成像仪的最优扫描参数、用于教学示范、用于示踪剂筛选等方面,具有广泛的应用范围。In view of the deficiencies in the prior art above, the object of the present invention is to provide a method for preparing a human head-like PET/CT imaging quality inspection phantom. The phantom of the present invention is a three-dimensional structural quality detection phantom with morphological characteristics, which can simulate the real shape, structure and focus of the human brain, and can be used for quality control of the PET/CT imager of the human head. It can be used to find the optimal scanning parameters of PET/CT imager, to teach and demonstrate, to screen tracers, etc., and has a wide range of applications.

为实现上述目的,本发明采用如下技术方案:To achieve the above object, the present invention adopts the following technical solutions:

本发明的第二方面,提供上述仿人头部PET/CT成像质量检测体模的制备方法,步骤如下:The second aspect of the present invention provides a method for preparing the above-mentioned human-like head PET/CT imaging quality detection phantom, the steps are as follows:

(1)根据人体头部的CT扫描数据构建具有人体头部外形的体模本体;(1) Construct a phantom body with the shape of the human head according to the CT scan data of the human head;

(2)在构建的体模本体的内部设置至少一个可拆卸的替换模块。(2) At least one detachable replacement module is arranged inside the constructed phantom body.

步骤(1)中,所述体模本体的骨骼结构采用骨骼的组织等效材料进行三维打印,体模本体的皮肤及其他内部组织均采用软组织等效材料进行三维打印。In step (1), the bone structure of the phantom body is three-dimensionally printed using bone tissue equivalent materials, and the skin and other internal tissues of the phantom body are three-dimensionally printed using soft tissue equivalent materials.

或者,所述体模本体的骨骼结构采用骨骼组织等效材料进行三维打印,体模本体的皮肤即头皮部分采用普通材料进行三维打印,体模本体内部的其他组织采用配制好的软组织等效材料进行灌注。Alternatively, the skeletal structure of the phantom body is three-dimensionally printed using bone tissue equivalent materials, the skin of the phantom body, that is, the scalp part, is three-dimensionally printed using ordinary materials, and other tissues inside the phantom body are made of prepared soft tissue equivalent materials Perform priming.

所述骨骼组织等效材料、所述软组织等效材料、所述普通材料均为现有的材料,所述配制好的软组织等效材料为现有的或配制的琼脂糖凝胶:The bone tissue equivalent material, the soft tissue equivalent material, and the common material are all existing materials, and the prepared soft tissue equivalent material is existing or prepared agarose gel:

例如,所述骨骼组织等效材料为现有3D打印材料中邵氏硬度大于90的高密度树脂。For example, the bone tissue equivalent material is a high-density resin with a Shore hardness greater than 90 in existing 3D printing materials.

所述软组织等效材料为现有3D打印材料中密度较低的EVA树脂。The soft tissue equivalent material is EVA resin with lower density in existing 3D printing materials.

所述普通材为现有3D打印材料中普通的塑料材料。The common material is a common plastic material in existing 3D printing materials.

所述配制好的软组织等效材料为配制的琼脂糖凝胶。The prepared soft tissue equivalent material is prepared agarose gel.

针对上述现有技术的不足,本发明的目的在于提供上述仿人头部的PET/CT成像质量检测体模在PET/CT成像仪的质量控制、寻找PET/CT成像仪的最优扫描参数、教学示范和/或示踪剂的筛选中的用途。本发明的体模为具有形态学特征的三维立体结构质量检测体模,能够仿真真实的人颅脑外形、结构以及病灶,可以用于对人体头部的PET/CT成像仪进行质量控制,还可以用于寻找PET/CT成像仪的最优扫描参数、用于教学示范、用于示踪剂筛选等方面,具有广泛的应用范围。For above-mentioned deficiencies in the prior art, the object of the present invention is to provide the PET/CT imaging quality detection phantom of above-mentioned human head in the quality control of PET/CT imager, find the optimal scanning parameter of PET/CT imager, Use in teaching demonstrations and/or screening of tracers. The phantom of the present invention is a three-dimensional structural quality detection phantom with morphological characteristics, which can simulate the real shape, structure and focus of the human brain, and can be used for quality control of the PET/CT imager of the human head. It can be used to find the optimal scanning parameters of PET/CT imager, to teach and demonstrate, to screen tracers, etc., and has a wide range of applications.

为实现上述目的,本发明采用如下技术方案:To achieve the above object, the present invention adopts the following technical solutions:

本发明的第三方面,提供上述仿人头部的PET/CT成像质量检测体模在PET/CT成像仪的质量控制、寻找PET/CT成像仪的最优扫描参数、教学示范和/或示踪剂的筛选中的用途。The third aspect of the present invention provides the quality control of the PET/CT imaging quality detection phantom of the human head in the PET/CT imager, searching for the optimal scanning parameters of the PET/CT imager, teaching demonstration and/or demonstration. use in the screening of tracers.

本发明的有益效果:Beneficial effects of the present invention:

(1)本发明的仿人头部的PET/CT成像质量检测体模具有三维立体结构,能够在外在形态和内部结构上模拟人体头部的形态和构造。另外,本发明的仿人头部的PET/CT成像质量检测体模具有一个或多个可拆卸的替换模块,其中,一个替换模块为预设病灶结构,用以模拟人体头部内的肿瘤;其他的替换模块可以用于测试PET/CT仪的参数,从而根据测得的参数来评价PET/CT仪性能的好坏。(1) The PET/CT imaging quality detection phantom imitating the human head of the present invention has a three-dimensional structure, which can simulate the shape and structure of the human head in terms of external shape and internal structure. In addition, the PET/CT imaging quality detection phantom of the human head of the present invention has one or more detachable replacement modules, wherein one replacement module is a preset lesion structure for simulating tumors in the human head; Other replacement modules can be used to test the parameters of the PET/CT instrument, so as to evaluate the performance of the PET/CT instrument according to the measured parameters.

(2)本发明的仿人头部的PET/CT成像质量检测体模能够仿真真实人体头部颅脑外形、结构以及病灶,可以用于对人体头部PET/CT成像仪进行质量控制,还可以用于寻找PET/CT成像仪的最优扫描参数、用于教学示范、用于示踪剂筛选等方面,具有较广的应用范围。(2) The PET/CT imaging quality detection phantom of the imitation human head of the present invention can simulate real human head craniocerebral shape, structure and lesion, can be used for carrying out quality control to human head PET/CT imager, also can It can be used to find the optimal scanning parameters of the PET/CT imager, be used for teaching demonstration, and be used for tracer screening, etc., and has a wide range of applications.

附图说明Description of drawings

构成本申请的一部分的说明书附图用来提供对本申请的进一步理解,本申请的示意性实施例及其说明用于解释本申请,并不构成对本申请的不当限定。The accompanying drawings constituting a part of the present application are used to provide further understanding of the present application, and the schematic embodiments and descriptions of the present application are used to explain the present application, and do not constitute improper limitations to the present application.

图1为本发明的体模本体的结构示意图;Fig. 1 is the structural representation of phantom body of the present invention;

图2为本发明仿人头部的PET/CT成像质量检测体模中肿瘤模拟模块结构示意图(侧视剖面图);Fig. 2 is the structural representation of the tumor simulation module in the PET/CT imaging quality detection phantom of humanoid head of the present invention (side view sectional view);

图3为本发明仿人头部的PET/CT成像质量检测体模中图像融合度测试模块的线源结构示意图(正视图);Fig. 3 is the line source structure schematic diagram (front view) of the image fusion degree test module in the PET/CT imaging quality detection phantom of human head of the present invention;

图4A为本发明仿人头部的PET/CT成像质量检测体模中图像融合度测试模块的空心球体的俯视图。Fig. 4A is a top view of the hollow sphere of the image fusion test module in the PET/CT imaging quality test phantom of the human head of the present invention.

图4B为本发明仿人头部的PET/CT成像质量检测体模中图像融合度测试模块的空心球体的正视图。Fig. 4B is a front view of the hollow sphere of the image fusion test module in the PET/CT imaging quality test phantom of the human head of the present invention.

图5为本发明仿人头部的PET/CT成像质量检测体模中PET/CT的衰减校正测试模块的结构示意图;Fig. 5 is the structural representation of the attenuation correction test module of PET/CT in the PET/CT imaging quality detection phantom of human head of the present invention;

图6A为PET高对比度分辨率模块的截面图;6A is a cross-sectional view of a PET high-contrast resolution module;

图6B为PET低对比度分辨率模块的截面图;6B is a cross-sectional view of a PET low-contrast resolution module;

图7A:CT空间分辨率测试模块的结构示意图;Figure 7A: Schematic diagram of the structure of the CT spatial resolution test module;

图7B:CT密度分辨率测试模块的结构示意图;Figure 7B: Schematic diagram of the structure of the CT density resolution test module;

图8:辐射剂量测试模块的结构示意图;Figure 8: Schematic diagram of the radiation dose test module;

其中,1-皮肤,2-骨骼,3-可拆卸的替换模块,4-脑组织,5-空心球体,6-第一线源,7-第二线源,8-空心圆柱插件,9-空心圆柱插件位于体模本体内的部分,10-空心圆柱插件位于体模本体外的部分,11-电离室探头,12-辐射计量仪。Among them, 1-skin, 2-skeleton, 3-removable replacement module, 4-brain tissue, 5-hollow sphere, 6-first line source, 7-second line source, 8-hollow cylindrical plug-in, 9-hollow The part of the cylindrical insert located inside the phantom body, 10 - the part of the hollow cylindrical insert located outside the phantom body, 11 - the ionization chamber probe, and 12 - the radiation meter.

具体实施方式detailed description

应该指出,以下详细说明都是例示性的,旨在对本申请提供进一步的说明。除非另有指明,本文使用的所有技术和科学术语具有与本申请所属技术领域的普通技术人员通常理解的相同含义。It should be pointed out that the following detailed description is exemplary and intended to provide further explanation to the present application. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

需要注意的是,这里所使用的术语仅是为了描述具体实施方式,而非意图限制根据本申请的示例性实施方式。如在这里所使用的,除非上下文另外明确指出,否则单数形式也意图包括复数形式,此外,还应当理解的是,当在本说明书中使用术语“包含”和/或“包括”时,其指明存在特征、步骤、操作、器件、组件和/或它们的组合。It should be noted that the terminology used here is only for describing specific implementations, and is not intended to limit the exemplary implementations according to the present application. As used herein, unless the context clearly dictates otherwise, the singular is intended to include the plural, and it should also be understood that when the terms "comprising" and/or "comprising" are used in this specification, they mean There are features, steps, operations, means, components and/or combinations thereof.

正如背景技术所介绍的,现有技术中用于PET/CT成像仪质量控制的体模存在种类单一、结构简单等问题,无法对PET/CT联合使用的成像质量进行质控。基于此,本发明提出了一种仿人头部的PET/CT成像质量检测体模及其制备方法。As introduced in the background technology, the phantoms used for quality control of PET/CT imagers in the prior art have problems such as single types and simple structures, and cannot perform quality control on the imaging quality of PET/CT combined use. Based on this, the present invention proposes a human head-like PET/CT imaging quality detection phantom and a preparation method thereof.

在本申请的一种实施方案中,提供了一种仿人头部的PET/CT成像质量检测体模,如图1所示,所述体模本体的外形仿真真实人体头部颅脑的形态,在体模本体内部的上方脑部位置设置有至少一个可拆卸的替换模块3;所述可拆卸的替换模块3可以是长方体,也可以是圆柱体,在此不对其形状进行限制。所述体模本体包括皮肤1、骨骼2、可拆卸的替换模块3和脑组织4。In one embodiment of the present application, a PET/CT imaging quality detection phantom imitating the human head is provided, as shown in Figure 1, the shape of the phantom body simulates the shape of the real human head and brain , At least one detachable replacement module 3 is provided at the position above the brain inside the phantom body; the detachable replacement module 3 can be a cuboid or a cylinder, and its shape is not limited here. The phantom body comprises skin 1 , bone 2 , detachable replacement module 3 and brain tissue 4 .

例如,在完成体模本体整体的制作后,在体模本体上方脑部位置抠取一个长方体A,将该长方体A取下后,可根据测试需要挑选相应可拆卸的替换模块3安装在体模上。当不需要安装替换模块时,可将该长方体A装回体模本体上,此时,体模为完整人体头部颅脑的形态。For example, after the overall production of the phantom body is completed, a cuboid A is picked at the brain above the phantom body, and after the cuboid A is removed, a corresponding detachable replacement module 3 can be selected and installed on the phantom according to the test requirements. superior. When there is no need to install a replacement module, the cuboid A can be put back on the phantom body. At this time, the phantom is in the form of a complete human head and brain.

所述可拆卸的替换模块3选自脑部肿瘤模拟模块、PET/CT的图像融合度测试模块、PET/CT的衰减校正测试模块、PET性能参数测试模块或CT性能参数测试模块中的一种或多种。The detachable replacement module 3 is selected from one of the brain tumor simulation module, PET/CT image fusion test module, PET/CT attenuation correction test module, PET performance parameter test module or CT performance parameter test module or more.

例如,替换模块B1用于模拟脑部肿瘤模拟模块;For example, the replacement module B1 is used to simulate the brain tumor simulation module;

替换模块C1为PET/CT的图像融合度测试模块,替换模块C2为PET/CT的衰减校正测试模块;The replacement module C1 is the image fusion test module of PET/CT, and the replacement module C2 is the attenuation correction test module of PET/CT;

替换模块D1为一种PET性能参数测试模块,替换模块D2为另一种PET性能参数测试模块等等;The replacement module D1 is a PET performance parameter test module, and the replacement module D2 is another PET performance parameter test module, etc.;

替换模块E1为一种CT性能参数测试模块,替换模块E2为另一种CT性能参数测试模块。The replacement module E1 is a CT performance parameter testing module, and the replacement module E2 is another CT performance parameter testing module.

作为优选的方案,用球体结构模拟人体头部内的肿瘤形态,如图2所示,球体结构内灌注示踪剂,例如18F-FDG(fluorodeoxyglucose,氟代脱氧葡萄糖)溶液后可在PET下进行显像。As a preferred solution, a sphere structure is used to simulate the shape of the tumor in the human head, as shown in Figure 2, after the sphere structure is perfused with a tracer, such as 18F-FDG (fluorodeoxyglucose, fluorodeoxyglucose) solution, it can be carried out under PET. imaging.

作为优选的方案,所述PET/CT的图像融合度测试模块包括:线源和空心球体5或正方体中的至少一种;线源、空心球体5或正方体均可单独进行图像融合度测试。As a preferred solution, the PET/CT image fusion test module includes: at least one of a line source and a hollow sphere 5 or a cube; the line source, the hollow sphere 5 or a cube can be used for image fusion testing alone.

所述线源为铝制管状结构,如图3所示,包括第一线源6和第二线源7,第一线源6和第二线源7内部可灌注示踪剂,如FDG溶液。The line source is an aluminum tubular structure, as shown in FIG. 3 , including a first line source 6 and a second line source 7 , and tracers such as FDG solution can be perfused inside the first line source 6 and the second line source 7 .

所述空心球体5或正方体内填充有示踪剂,如FDG溶液。The hollow sphere 5 or cube is filled with a tracer, such as FDG solution.

优选的,多个不同直径大小的空心球体5组成圆周,所述空心球体5的球心在同一个圆周层上,如图4A所示;或者所述空心球体5按直径大小排成一行,如图4B所示。Preferably, a plurality of hollow spheres 5 with different diameters form a circle, and the centers of the hollow spheres 5 are on the same circumferential layer, as shown in Figure 4A; or the hollow spheres 5 are arranged in a row according to the diameter, as Figure 4B.

若PET/CT的图像融合度测试模块中包括线源和空心球体5,则对于线源和空心球体5的相对位置并没有特殊的限制,例如,线源可以设置在多个空心球体5所组成圆周的外侧。If the image fusion test module of PET/CT includes the line source and the hollow sphere 5, then there is no special restriction on the relative position of the line source and the hollow sphere 5, for example, the line source can be arranged on a plurality of hollow spheres 5. outside of the circle.

测试时,在线源和空心球体5中注入FGD溶液,进行PET/CT扫描,根据得到的扫描图像获得图像融合精确度。During the test, the FGD solution is injected into the line source and the hollow sphere 5 for PET/CT scanning, and the accuracy of image fusion is obtained according to the obtained scanning images.

上述PET/CT的图像融合度测试模块还可以用于测试PET的低对比度分辨率。The above PET/CT image fusion test module can also be used to test the low contrast resolution of PET.

测试方法为:使用多个不同直径的空心球体5测试PET的低对比度分辨率,测试时,在多个空心球体5中注入FDG溶液,进行PET扫描,根据得到的扫描图像确定低对比度分辨率。The test method is: use multiple hollow spheres 5 with different diameters to test the low-contrast resolution of PET. During the test, inject FDG solution into the multiple hollow spheres 5, perform PET scanning, and determine the low-contrast resolution according to the obtained scanned images.

作为优选的方案,所述PET/CT的衰减校正测试模块,包括:至少一根空心圆柱插件8,所述空心圆柱插件8分为两部分,一部分位于所述体模本体内,另一部分位于所述体模本体外,如图5所示。As a preferred solution, the attenuation correction test module of PET/CT includes: at least one hollow cylindrical insert 8, the hollow cylindrical insert 8 is divided into two parts, one part is located in the phantom body, and the other part is located in the phantom body. Outside the body of the phantom, as shown in Figure 5.

所述空心圆柱插件位于体模本体内的部分9和空心圆柱插件位于体模本体外的部分10均填充有示踪剂,如FDG溶液。Both the part 9 of the hollow cylindrical insert inside the phantom body and the part 10 of the hollow cylindrical insert outside the phantom body are filled with a tracer, such as FDG solution.

由于空心圆柱插件内需要盛放FDG溶液,故其材质要求不与FDG溶液发生反应即可。Since the FDG solution needs to be contained in the hollow cylindrical insert, its material is required not to react with the FDG solution.

优选的,所述空心圆柱插件位于体模本体内的部分9和空心圆柱插件位于体模本体外的部分10采用螺纹连接。Preferably, the part 9 of the hollow cylindrical insert located inside the phantom body and the part 10 of the hollow cylindrical insert located outside the phantom body are connected by threads.

测试时,在空心圆柱插件位于体模本体内的部分9和空心圆柱插件位于体模本体外的部分10均注入FDG溶液,进行PET/CT扫描,根据扫描得到的空心圆柱插件位于体模本体内的部分9图像和空心圆柱插件位于体模本体外的部分10图像的计数来确定衰减校正的精确度。During the test, FDG solution is injected into the part 9 where the hollow cylindrical insert is located inside the phantom body and the part 10 where the hollow cylindrical insert is located outside the phantom body, and PET/CT scanning is performed, and the hollow cylindrical insert obtained according to the scan is located in the phantom body The accuracy of the attenuation correction was determined by counting the portion 9 images and the portion 10 images of the hollow cylindrical insert located outside the phantom body.

作为优选的方案,所述PET性能参数测试模块包括:PET高对比度分辨模块和PET低对比度分辨模块;As a preferred solution, the PET performance parameter testing module includes: a PET high-contrast resolution module and a PET low-contrast resolution module;

其中,PET高对比度分辨模块用于测试高对比结构下的系统分辨率,具体地,在圆盘状的有机玻璃内有6个区域的圆孔,不同区域内的圆孔的直径不等。圆孔结构的截面图如图6A所示。Among them, the PET high-contrast resolution module is used to test the system resolution under the high-contrast structure. Specifically, there are 6 regions of circular holes in the disc-shaped plexiglass, and the diameters of the circular holes in different regions are different. A cross-sectional view of the circular hole structure is shown in Figure 6A.

测试时,在圆孔内灌装示踪剂。When testing, fill the tracer in the round hole.

PET低对比度分辨率模块用于测试低对比结构下的系统分辨率,具体地,模块由6组不同直径的实心圆柱组成,截面图如图6B所示。The PET low-contrast resolution module is used to test the system resolution under the low-contrast structure. Specifically, the module consists of 6 groups of solid cylinders with different diameters. The cross-sectional view is shown in Figure 6B.

测试时,在圆柱之外的区域灌装示踪剂。During testing, the area outside the cylinder is filled with tracer.

作为优选的方案,所述CT性能参数测试模块包括:CT空间分辨率测试模块(即高对比度分辨率)、CT密度分辨率测试模块(即低对比度分辨率)和辐射剂量测试模块。As a preferred solution, the CT performance parameter testing module includes: a CT spatial resolution testing module (ie high contrast resolution), a CT density resolution testing module (ie low contrast resolution) and a radiation dose testing module.

其中,CT的高对比度分辨率即当图像中目标与背景的对比度大于10%时,能分辨的最小目标的能力,通常以能分辨的最小周期结构目标(如孔或线对)的尺寸来表示。Among them, the high-contrast resolution of CT refers to the ability to distinguish the smallest target when the contrast between the target and the background in the image is greater than 10%, usually represented by the size of the smallest periodic structure target (such as a hole or line pair) that can be resolved .

在本发明的一个实施例中,用不同直径的孔状结构来测试高对比度分辨率,具体地,在圆盘状的有机玻璃内排列不同直径的圆孔,各排圆孔之间的距离与圆孔直径相等,图像中主观所能分辨的最小圆孔即为CT的空间分辨率,圆孔的分布如图7A所示。In one embodiment of the present invention, the high-contrast resolution is tested with hole-like structures of different diameters, specifically, circular holes of different diameters are arranged in a disc-shaped plexiglass, and the distance between each row of circular holes is the same as The circular holes have the same diameter, and the smallest circular hole that can be distinguished subjectively in the image is the spatial resolution of CT. The distribution of the circular holes is shown in Figure 7A.

CT的低对比度分辨率即当图像中目标与背景的对比度小于1%时,能分辨最小目标的能力。通常以能区分的最小目标的尺寸以及相应的对比度来表示。The low-contrast resolution of CT is the ability to distinguish the smallest target when the contrast between the target and the background in the image is less than 1%. It is usually expressed by the size of the smallest object that can be distinguished and the corresponding contrast.

具体地,该模块由十组不同直径的圆孔组成,且呈放射状分布,如图7B所示,每组中的三个圆孔直径相同,三个圆孔内分别为不同对比度的材料,例如,对比度分别为0.3%、0.5%、1.0%。Specifically, the module consists of ten groups of circular holes with different diameters, which are distributed radially, as shown in Figure 7B. The three circular holes in each group have the same diameter, and the three circular holes contain materials with different contrasts, for example , and the contrast ratios are 0.3%, 0.5%, and 1.0%, respectively.

需要说明的是,在图6A、图6B、图7A和图7B所示结构中,圆孔/圆柱区域的个数以及下图所画出的每个区域中圆孔/圆柱的数量只是用作举例、示意,而不是对本发明的限制。具体的数目可根据实际需要进行增减。It should be noted that, in the structures shown in Fig. 6A, Fig. 6B, Fig. 7A and Fig. 7B, the number of round holes/cylindrical regions and the number of round holes/cylindrical regions in each region shown in the figure below are only used as To exemplify and illustrate, rather than limit the present invention. The specific number can be increased or decreased according to actual needs.

所述辐射剂量测试模块,如图8所示,包括:电离室探头11和放置电离室探头11的腔室;所述电离室探头11与外部的辐射计量仪12相连,用于测量CT扫描时的辐射剂量。The radiation dose test module, as shown in Figure 8, includes: an ionization chamber probe 11 and a chamber where the ionization chamber probe 11 is placed; the ionization chamber probe 11 is connected with an external radiation meter 12 for measuring CT scanning radiation dose.

优选的,所述放置电离室探头11的腔室的截面为圆形或矩形。Preferably, the cross section of the chamber where the ionization chamber probe 11 is placed is circular or rectangular.

为了使得本领域技术人员能够更加清楚地了解本申请的技术方案,以下将结合具体的实施例详细说明本申请的技术方案。In order to enable those skilled in the art to understand the technical solution of the present application more clearly, the technical solution of the present application will be described in detail below in conjunction with specific embodiments.

本发明实施例中所用的试验材料均为本领域常规的试验材料,均可通过商业渠道购买得到。The test materials used in the examples of the present invention are all conventional test materials in the field, and can be purchased through commercial channels.

实施例1:Example 1:

1.体模本体的结构与材料:1. The structure and material of the phantom body:

体模整体外形为仿真人体头部的形态。具体地,根据真实人体头部的CT扫描数据构建仿真人体头部模型,并根据所构建模型通过3D打印技术制作仿真人体头部模型。The overall shape of the phantom is the shape of a simulated human head. Specifically, a simulated human head model is constructed based on CT scan data of a real human head, and a simulated human head model is produced by 3D printing technology based on the constructed model.

(1)模型材料的选择:(1) Selection of model materials:

人体头部的所有骨骼2结构采用骨骼组织等效材料进行三维打印;人体头部的皮肤1以及人体头部的其它内部组织(脑组织4)均采用软组织等效材料进行三维打印。All bone 2 structures of the human head are 3D printed using bone tissue equivalent materials; the skin 1 of the human head and other internal tissues (brain tissue 4) of the human head are all 3D printed using soft tissue equivalent materials.

其中,骨骼组织等效材料为现有3D打印材料中邵氏硬度大于90的高密度树脂。Among them, the bone tissue equivalent material is a high-density resin with a Shore hardness greater than 90 in existing 3D printing materials.

软组织等效材料为现有3D打印材料中密度较低的EVA树脂。The soft tissue equivalent material is EVA resin with lower density in existing 3D printing materials.

(2)体模的结构:(2) The structure of the phantom:

体模包括:一个体模本体,体模本体上有一个可拆卸的替换模块3(例如,如图1所示,位于人体头部模型的上方脑部位置)。当可拆卸的替换模块3安装于体模本体上的时候,模型为一个完整人体头部的形态。其中,可拆卸的替换模块3可以是长方体,也可以是圆柱体,在此不对其形状进行限制。The phantom includes: a phantom body, on which there is a detachable replacement module 3 (for example, as shown in FIG. 1 , located at the upper brain of the human head model). When the detachable replacement module 3 is installed on the phantom body, the phantom is in the shape of a complete human head. Wherein, the detachable replacement module 3 may be a cuboid or a cylinder, and its shape is not limited here.

当把可拆卸式替换模块拆下后,可以将其它的替换模块安装在体模本体上,以通过替换的模块测试相应的参数。After the detachable replacement module is removed, other replacement modules can be installed on the phantom body to test corresponding parameters through the replacement module.

其它的替换模块可以是:脑部肿瘤模拟模块、PET/CT的图像融合度测试模块、PET/CT的衰减校正测试模块、PET性能参数测试模块、CT性能参数测试模块。Other replacement modules can be: brain tumor simulation module, PET/CT image fusion test module, PET/CT attenuation correction test module, PET performance parameter test module, CT performance parameter test module.

实施例2:Example 2:

1.体模本体的结构与材料:1. The structure and material of the phantom body:

体模整体外形为人体头部的形态。具体地,根据真实人体头部的CT扫描数据构建人体头部模型,并根据所构建模型通过3D打印技术制作人体头部模型。The overall shape of the phantom is the shape of a human head. Specifically, a human head model is constructed according to CT scan data of a real human head, and a human head model is produced by 3D printing technology according to the constructed model.

(1)模型材料的选择:(1) Selection of model materials:

人体头部的所有骨骼2结构采用骨骼等效材料进行打印,人体头部的皮肤1采用普通材料进行制作,人体头部内部的其它组织(脑组织4)均采用配制好的软组织等效材料进行灌注成型。All bones 2 structures of the human head are printed with bone equivalent materials, the skin 1 of the human head is made with ordinary materials, and other tissues (brain tissue 4) inside the human head are printed with prepared soft tissue equivalent materials. Infusion molding.

骨骼等效材料为现有3D打印材料中邵氏硬度大于90的高密度树脂。The bone equivalent material is a high-density resin with a Shore hardness greater than 90 in existing 3D printing materials.

普通材料为现有3D打印材料中普通的塑料材料。Ordinary materials are common plastic materials in existing 3D printing materials.

配制好的软组织等效材料为配制的琼脂糖凝胶。The prepared soft tissue equivalent material is prepared agarose gel.

(2)体模的结构:(2) The structure of the phantom:

体模包括:一个体模本体,体模本体内有两个可拆卸的替换模块3(例如,如图1所示,位于人体头部模型的上方脑部位置),其中,一个替换模块为脑部肿瘤模拟模块,预设病灶结构,用以模拟人体头部内的肿瘤;其他的替换模块可以选自PET/CT的图像融合度测试模块、PET/CT的衰减校正测试模块、PET性能参数测试模块或CT性能参数测试模块,用于测试PET/CT仪的参数,从而根据测得的参数来评价PET/CT仪性能的好坏。The phantom comprises: a phantom body, two detachable replacement modules 3 are arranged in the phantom body (for example, as shown in Figure 1, be positioned at the top brain position of human head model), wherein, a replacement module is Internal tumor simulation module, preset lesion structure, used to simulate tumors in the human head; other replacement modules can be selected from PET/CT image fusion test module, PET/CT attenuation correction test module, PET performance parameter test The module or CT performance parameter test module is used to test the parameters of the PET/CT instrument, so as to evaluate the performance of the PET/CT instrument according to the measured parameters.

以上所述仅为本申请的优选实施例而已,并不用于限制本申请,对于本领域的技术人员来说,本申请可以有各种更改和变化。凡在本申请的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本申请的保护范围之内。The above descriptions are only preferred embodiments of the present application, and are not intended to limit the present application. For those skilled in the art, there may be various modifications and changes in the present application. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of this application shall be included within the protection scope of this application.

Claims (10)

1. a kind of PET/CT image quality of apery head detects body mould, it is characterised in that including:With human body head profile Body mould body, the body mould body is internally provided with least one dismountable replacement module;
Dismountable replacement module is selected from brain tumor analog module, the image co-registration degree test module of PET/CT, PET/ One or more in the correction for attenuation test module of CT, PET performance parameter tests module or CT performance parameter test modules.
2. the PET/CT image quality of apery head according to claim 1 detects body mould, it is characterised in that described removable The replacement module for unloading is located at the brain localization of the top inside body mould body.
3. the PET/CT image quality of apery head according to claim 1 and 2 detects body mould, it is characterised in that described Brain tumor analog module is hollow ball structure;Tracer is perfused with the hollow ball structure.
4. the PET/CT image quality of apery head according to claim 1 and 2 detects body mould, it is characterised in that described The image co-registration degree test module of PET/CT includes:At least one in line source and hollow ball or square;
The line source is aluminum tubular structure, and inside can irrigate tracer;
Tracer is filled with the hollow ball or square.
5. the PET/CT image quality of apery head according to claim 1 and 2 detects body mould, it is characterised in that described The correction for attenuation test module of PET/CT, including:At least one hollow cylinder plug-in unit, the hollow cylinder plug-in unit is divided into two Point, a part is located to be had in human body head outline body mould body, and it is external that another part is located at body calligraphy or painting model.
6. the PET/CT image quality of apery head according to claim 1 and 2 detects body mould, it is characterised in that described PET performance parameter test modules, are made up of the cylinder of some groups of different-diameters;
The cylinder is hollow or solid construction.
7. the PET/CT image quality of apery head according to claim 1 and 2 detects body mould, it is characterised in that described CT performance parameter test modules, including:CT spatial resolutions test module, CT density resolutions test module and radiation agent are measured Die trial block;
The CT spatial resolutions test module is made up of the circular hole of some groups of different-diameters, each to arrange the distance between circular hole and institute It is identical in the diameter of row's circular hole;
The CT density resolutions test module is made up of the circular hole of some groups of different-diameters for radially distributing;Each group The diameter of circular hole is identical, and the material filled with different contrast in circular hole.
8. the PET/CT image quality of apery head according to claim 7 detects body mould, it is characterised in that the radiation Dosage test module, including:The chamber that ionisation chamber is popped one's head in and placement ionisation chamber is popped one's head in;The ionisation chamber probe and outside radiation Gauge is connected, for measuring dose of radiation during CT scan.
9. the PET/CT image quality of the apery head described in any one of claim 1-8 detects the preparation method of body mould, and it is special Levy and be, step is as follows:
(1) CT scan data according to human body head builds the body mould body with human body head profile;
(2) at least one dismountable replacement module is set in the inside of the body mould body for building.
10. the PET/CT image quality of the apery head described in any one of claim 1-8 detects body mould in PET/CT imagers Quality control, the purposes found in the optimal sweep parameter of PET/CT imagers, demonstration lesson and/or the screening of tracer.
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CN107348968A (en) * 2017-08-07 2017-11-17 泰山医学院 A kind of general high-precision body mould of conical beam CT
CN108378863A (en) * 2018-03-12 2018-08-10 北京朗视仪器有限公司 A kind of CBCT imaging performances test body mould
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CN111053567A (en) * 2020-01-06 2020-04-24 中国计量科学研究院 PET/CT performance detection die body and image evaluation method
CN111053567B (en) * 2020-01-06 2024-05-07 中国计量科学研究院 A PET/CT performance detection phantom and image evaluation method
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