CN1321695C - 用于治疗变应性嗜酸细胞性疾病的展示il-5、il-3或嗜酸细胞活化趋化因子的抗原阵列 - Google Patents
用于治疗变应性嗜酸细胞性疾病的展示il-5、il-3或嗜酸细胞活化趋化因子的抗原阵列 Download PDFInfo
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- CN1321695C CN1321695C CNB028218396A CN02821839A CN1321695C CN 1321695 C CN1321695 C CN 1321695C CN B028218396 A CNB028218396 A CN B028218396A CN 02821839 A CN02821839 A CN 02821839A CN 1321695 C CN1321695 C CN 1321695C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0007—Nervous system antigens; Prions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P37/08—Antiallergic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5409—IL-5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5437—IL-13
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
- C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
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- A—HUMAN NECESSITIES
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- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33104501P | 2001-11-07 | 2001-11-07 | |
| US60/331,045 | 2001-11-07 | ||
| US10/050,902 | 2002-01-18 | ||
| US10/050,902 US7264810B2 (en) | 2001-01-19 | 2002-01-18 | Molecular antigen array |
| WOPCT/IB02/00166 | 2002-01-21 | ||
| PCT/IB2002/000166 WO2002056905A2 (fr) | 2001-01-19 | 2002-01-21 | Jeu ordonne d'echantillons d'antigenes moleculaires |
| US39663602P | 2002-07-19 | 2002-07-19 | |
| US60/396,636 | 2002-07-19 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007101055181A Division CN101049502B (zh) | 2001-11-07 | 2002-11-07 | 用于治疗变应性嗜酸细胞性疾病的展示il-5、il-13或嗜酸细胞活化趋化因子的抗原阵列 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1558775A CN1558775A (zh) | 2004-12-29 |
| CN1321695C true CN1321695C (zh) | 2007-06-20 |
Family
ID=27452010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028218396A Expired - Fee Related CN1321695C (zh) | 2001-11-07 | 2002-11-07 | 用于治疗变应性嗜酸细胞性疾病的展示il-5、il-3或嗜酸细胞活化趋化因子的抗原阵列 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1443960B1 (fr) |
| CN (1) | CN1321695C (fr) |
| AT (1) | ATE419007T1 (fr) |
| AU (1) | AU2002363382B2 (fr) |
| BR (1) | BR0213950A (fr) |
| CA (1) | CA2466492A1 (fr) |
| DE (1) | DE60230656D1 (fr) |
| DK (1) | DK1443960T3 (fr) |
| ES (1) | ES2320638T3 (fr) |
| IL (1) | IL161147A0 (fr) |
| NZ (1) | NZ532516A (fr) |
| PL (1) | PL369863A1 (fr) |
| WO (1) | WO2003040164A2 (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7320793B2 (en) * | 2001-01-19 | 2008-01-22 | Cytos Biotechnology Ag | Molecular antigen array |
| EP2196217A1 (fr) | 2001-09-14 | 2010-06-16 | Cytos Biotechnology AG | Emballage de substances immunostimulantes dans des particules similaires aux virus: procédés de production et utilisations |
| WO2003082349A1 (fr) * | 2002-03-25 | 2003-10-09 | Mercia Pharma, Llc | Methodes therapeutiques a l'encontre d'etats inflammatoires lies a l'eotaxine |
| KR20050027168A (ko) * | 2002-07-19 | 2005-03-17 | 사이토스 바이오테크놀로지 아게 | 그렐린-캐리어 컨쥬게이트 |
| US7537767B2 (en) | 2003-03-26 | 2009-05-26 | Cytis Biotechnology Ag | Melan-A- carrier conjugates |
| CN100560719C (zh) | 2003-03-26 | 2009-11-18 | 赛托斯生物技术公司 | Melan-a肽类似物-病毒样颗粒偶联物 |
| DK3718564T3 (da) | 2003-12-23 | 2023-11-06 | Genentech Inc | Nye anti-IL-13-antistoffer og anvendelser |
| MX2007003171A (es) * | 2004-09-21 | 2007-05-23 | Cytos Biotechnology Ag | Particulas tipo virus que comprenden una proteina de fusion de la proteina de cubierta de ap205 y un polipeptido antigenico. |
| BRPI0519026A2 (pt) * | 2004-12-13 | 2008-12-23 | Cytos Biotechnology Ag | arranjos de antÍgeno de il-15 e usos dos mesmos |
| NZ561040A (en) * | 2005-03-18 | 2009-04-30 | Cytos Biotechnology Ag | Cat allergen fusion proteins and use thereof |
| EP1896068A1 (fr) * | 2005-06-14 | 2008-03-12 | Cytos Biotechnology AG | Conjugués d'antigènes et leurs utilisations |
| JP5312028B2 (ja) * | 2005-09-28 | 2013-10-09 | サイトス バイオテクノロジー アーゲー | インターロイキン−1コンジュゲート及びその使用 |
| JP5484732B2 (ja) | 2005-12-14 | 2014-05-07 | サイトス バイオテクノロジー アーゲー | 過敏症の治療のための免疫賦活性核酸パッケージ粒子 |
| KR101552227B1 (ko) | 2006-06-12 | 2015-09-10 | 사이토스 바이오테크놀로지 아게 | 올리고뉴클레오티드를 rna 박테리오파지의 바이러스-유사 입자로 패키징하는 방법 |
| CA2843274A1 (fr) | 2011-07-29 | 2013-02-07 | Selecta Biosciences, Inc. | Nanosupports synthetiques qui generent des reponses immunitaires humorales et de lymphocytes t cytotoxiques (ltc) |
| BR112014013035A2 (pt) | 2011-12-22 | 2018-10-09 | Hoffmann La Roche | métodos de seleção de células, conjuntos de expressão bicistrônica, células eucarióticas, vetores lentivirais, uso de vetor lentiviral, bibliotecas de ventores lentivirais e de células eucarióticas, métodos de seleção de células, fluxos de trabalho e uso de célula |
| ES2915378T3 (es) | 2013-09-13 | 2022-06-22 | Hoffmann La Roche | Procedimientos para detectar y cuantificar una proteína de célula huésped en líneas celulares |
| KR102571391B1 (ko) | 2013-09-13 | 2023-08-29 | 제넨테크, 인크. | 정제된 재조합 폴리펩티드를 포함하는 방법 및 조성물 |
| RU2552929C1 (ru) | 2013-11-14 | 2015-06-10 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Фармацевтическая композиция, содержащая производные глутаримидов, и их применение для лечения эозинофильных заболеваний |
| MA40824A (fr) | 2014-10-22 | 2017-08-29 | Saiba Gmbh | Particules de cmv de type virus modifié |
| AU2016207099C1 (en) | 2015-01-15 | 2021-02-04 | University Of Copenhagen | Virus-like particle with efficient epitope display |
| JP6987744B2 (ja) * | 2015-09-08 | 2022-01-05 | ウニヴェルズィテート チューリッヒ | 虫刺され過敏症の治療 |
| DK3368068T3 (da) | 2015-10-30 | 2021-02-22 | Univ Copenhagen | Viruslignende partikler med effektiv epitopdisplay |
| US11207390B2 (en) | 2017-03-07 | 2021-12-28 | Universität Zürich | Treatment of pruritus in horses |
| US20210205425A1 (en) * | 2018-05-28 | 2021-07-08 | Evax Ag | Treatment of urticaria |
| EP3574915A1 (fr) | 2018-05-29 | 2019-12-04 | Neovacs | Produit immunogène comprenant de l'il-4 et/ou de l'il-13 pour traiter des troubles associés à une expression ou une activité aberrantes de l'il-4 et/ou de l'il-13 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000023955A1 (fr) * | 1998-10-21 | 2000-04-27 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Particules assimilees a des virus pour l'induction d'anticorps |
| WO2000032227A2 (fr) * | 1998-11-30 | 2000-06-08 | Cytos Biotechnology Ag | Presentation moleculaire ordonnee d'antigenes, procede de preparation et utilisation |
| WO2000065058A1 (fr) * | 1999-04-23 | 2000-11-02 | Pharmexa A/S | Procede de regulation negative de l'interleukine 5 (il-5) |
-
2002
- 2002-11-07 PL PL02369863A patent/PL369863A1/xx not_active Application Discontinuation
- 2002-11-07 BR BR0213950-2A patent/BR0213950A/pt not_active IP Right Cessation
- 2002-11-07 AT AT02802656T patent/ATE419007T1/de not_active IP Right Cessation
- 2002-11-07 NZ NZ532516A patent/NZ532516A/en not_active IP Right Cessation
- 2002-11-07 IL IL16114702A patent/IL161147A0/xx unknown
- 2002-11-07 CA CA002466492A patent/CA2466492A1/fr not_active Abandoned
- 2002-11-07 EP EP02802656A patent/EP1443960B1/fr not_active Expired - Lifetime
- 2002-11-07 ES ES02802656T patent/ES2320638T3/es not_active Expired - Lifetime
- 2002-11-07 AU AU2002363382A patent/AU2002363382B2/en not_active Ceased
- 2002-11-07 CN CNB028218396A patent/CN1321695C/zh not_active Expired - Fee Related
- 2002-11-07 WO PCT/EP2002/012455 patent/WO2003040164A2/fr not_active Ceased
- 2002-11-07 DE DE60230656T patent/DE60230656D1/de not_active Expired - Lifetime
- 2002-11-07 DK DK02802656T patent/DK1443960T3/da active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000023955A1 (fr) * | 1998-10-21 | 2000-04-27 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Particules assimilees a des virus pour l'induction d'anticorps |
| WO2000032227A2 (fr) * | 1998-11-30 | 2000-06-08 | Cytos Biotechnology Ag | Presentation moleculaire ordonnee d'antigenes, procede de preparation et utilisation |
| WO2000065058A1 (fr) * | 1999-04-23 | 2000-11-02 | Pharmexa A/S | Procede de regulation negative de l'interleukine 5 (il-5) |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ532516A (en) | 2008-05-30 |
| CN1558775A (zh) | 2004-12-29 |
| ES2320638T3 (es) | 2009-05-27 |
| EP1443960B1 (fr) | 2008-12-31 |
| DK1443960T3 (da) | 2009-03-23 |
| IL161147A0 (en) | 2004-08-31 |
| WO2003040164A2 (fr) | 2003-05-15 |
| DE60230656D1 (de) | 2009-02-12 |
| ATE419007T1 (de) | 2009-01-15 |
| CA2466492A1 (fr) | 2003-05-15 |
| AU2002363382B2 (en) | 2007-07-19 |
| EP1443960A2 (fr) | 2004-08-11 |
| PL369863A1 (en) | 2005-05-02 |
| BR0213950A (pt) | 2004-08-24 |
| HK1068355A1 (en) | 2005-04-29 |
| WO2003040164A3 (fr) | 2003-10-23 |
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