CN1259033C - Compound toothpaste for eliminating dental plaque and its preparation method - Google Patents
Compound toothpaste for eliminating dental plaque and its preparation method Download PDFInfo
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- CN1259033C CN1259033C CN 200410013379 CN200410013379A CN1259033C CN 1259033 C CN1259033 C CN 1259033C CN 200410013379 CN200410013379 CN 200410013379 CN 200410013379 A CN200410013379 A CN 200410013379A CN 1259033 C CN1259033 C CN 1259033C
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- 239000000606 toothpaste Substances 0.000 title claims abstract description 89
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 89
- 150000001875 compounds Chemical class 0.000 title claims abstract description 40
- 208000002064 Dental Plaque Diseases 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000000463 material Substances 0.000 claims abstract description 29
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims abstract description 27
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 235000002949 phytic acid Nutrition 0.000 claims abstract description 27
- 239000011701 zinc Substances 0.000 claims abstract description 27
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 27
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims abstract description 7
- 239000011746 zinc citrate Substances 0.000 claims abstract description 7
- 235000006076 zinc citrate Nutrition 0.000 claims abstract description 7
- 229940068475 zinc citrate Drugs 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 35
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 33
- 239000003795 chemical substances by application Substances 0.000 claims description 26
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 claims description 24
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 24
- 229940068041 phytic acid Drugs 0.000 claims description 24
- 239000000467 phytic acid Substances 0.000 claims description 24
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 18
- 239000004088 foaming agent Substances 0.000 claims description 16
- 238000005406 washing Methods 0.000 claims description 16
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical class [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 13
- 239000000853 adhesive Substances 0.000 claims description 13
- 230000001070 adhesive effect Effects 0.000 claims description 13
- 239000000796 flavoring agent Substances 0.000 claims description 13
- 235000013355 food flavoring agent Nutrition 0.000 claims description 13
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 13
- 239000000080 wetting agent Substances 0.000 claims description 13
- 239000000377 silicon dioxide Substances 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 11
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N titanium dioxide Inorganic materials O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 10
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 10
- 235000010234 sodium benzoate Nutrition 0.000 claims description 10
- 239000004299 sodium benzoate Substances 0.000 claims description 10
- 235000010215 titanium dioxide Nutrition 0.000 claims description 10
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 9
- 235000019499 Citrus oil Nutrition 0.000 claims description 9
- 239000001506 calcium phosphate Substances 0.000 claims description 9
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 9
- 235000011010 calcium phosphates Nutrition 0.000 claims description 9
- 239000010500 citrus oil Substances 0.000 claims description 9
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 9
- 239000003921 oil Substances 0.000 claims description 9
- 235000019198 oils Nutrition 0.000 claims description 9
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical class [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 claims description 9
- 239000003755 preservative agent Substances 0.000 claims description 9
- 230000002335 preservative effect Effects 0.000 claims description 9
- 229940085605 saccharin sodium Drugs 0.000 claims description 9
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 9
- 235000010199 sorbic acid Nutrition 0.000 claims description 9
- 239000004334 sorbic acid Substances 0.000 claims description 9
- 229940075582 sorbic acid Drugs 0.000 claims description 9
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 9
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 9
- 239000000230 xanthan gum Substances 0.000 claims description 9
- 235000010493 xanthan gum Nutrition 0.000 claims description 9
- 229920001285 xanthan gum Polymers 0.000 claims description 9
- 229940082509 xanthan gum Drugs 0.000 claims description 9
- -1 filtration Substances 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 238000004064 recycling Methods 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- 238000001694 spray drying Methods 0.000 claims description 5
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 4
- 230000002421 anti-septic effect Effects 0.000 claims description 3
- JHJUUEHSAZXEEO-UHFFFAOYSA-M sodium;4-dodecylbenzenesulfonate Chemical compound [Na+].CCCCCCCCCCCCC1=CC=C(S([O-])(=O)=O)C=C1 JHJUUEHSAZXEEO-UHFFFAOYSA-M 0.000 claims description 3
- 239000011775 sodium fluoride Substances 0.000 claims description 2
- 235000013024 sodium fluoride Nutrition 0.000 claims description 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 abstract description 20
- 230000000694 effects Effects 0.000 abstract description 12
- 208000006558 Dental Calculus Diseases 0.000 abstract description 11
- 239000004148 curcumin Substances 0.000 abstract description 10
- 229940109262 curcumin Drugs 0.000 abstract description 10
- 235000012754 curcumin Nutrition 0.000 abstract description 10
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 abstract description 10
- 206010044029 Tooth deposit Diseases 0.000 abstract description 5
- 230000000675 anti-caries Effects 0.000 abstract description 2
- VIFUTGPSFHEVLJ-UHFFFAOYSA-N 9-n,10-n-diphenylanthracene-9,10-diamine Chemical compound C=12C=CC=CC2=C(NC=2C=CC=CC=2)C2=CC=CC=C2C=1NC1=CC=CC=C1 VIFUTGPSFHEVLJ-UHFFFAOYSA-N 0.000 abstract 4
- 229940052016 turmeric extract Drugs 0.000 abstract 2
- 235000020240 turmeric extract Nutrition 0.000 abstract 2
- 239000008513 turmeric extract Substances 0.000 abstract 2
- 208000032400 Retinal pigmentation Diseases 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 210000002189 macula lutea Anatomy 0.000 description 17
- 241001122767 Theaceae Species 0.000 description 14
- 235000019504 cigarettes Nutrition 0.000 description 14
- 229940091249 fluoride supplement Drugs 0.000 description 14
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000003082 abrasive agent Substances 0.000 description 3
- 235000012239 silicon dioxide Nutrition 0.000 description 3
- 239000000779 smoke Substances 0.000 description 3
- VDBJCDWTNCKRTF-UHFFFAOYSA-N 6'-hydroxyspiro[2-benzofuran-3,9'-9ah-xanthene]-1,3'-dione Chemical compound O1C(=O)C2=CC=CC=C2C21C1C=CC(=O)C=C1OC1=CC(O)=CC=C21 VDBJCDWTNCKRTF-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- 241000628997 Flos Species 0.000 description 2
- 206010044032 Tooth discolouration Diseases 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 229960002163 hydrogen peroxide Drugs 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical class [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- OIQPTROHQCGFEF-UHFFFAOYSA-L chembl1371409 Chemical compound [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 OIQPTROHQCGFEF-UHFFFAOYSA-L 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical class O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 1
- NJDNXYGOVLYJHP-UHFFFAOYSA-L disodium;2-(3-oxido-6-oxoxanthen-9-yl)benzoate Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=CC(=O)C=C2OC2=CC([O-])=CC=C21 NJDNXYGOVLYJHP-UHFFFAOYSA-L 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 229910001631 strontium chloride Inorganic materials 0.000 description 1
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 description 1
- 159000000008 strontium salts Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
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- Cosmetics (AREA)
Abstract
The present invention relates to compound toothpaste for eliminating smoke yellow dental plaque and a preparation method thereof. The compound toothpaste for eliminating smoke yellow dental plaque of the present invention comprises 0.5 to 1.2 portions of zinc phytate, 0.2 to 0.6 portion of a turmeric extract, 0.1 to 0.3 portion of fluoride, 70 to 95 portions of conventional toothpaste base material, and 80 to 100 portions of water by weight proportions. The compound toothpaste for eliminating smoke yellow dental plaque can also add 0.3 to 0.5 portion of zinc citrate. The present invention has the advantages of simultaneously retaining the anticaries function of the fluoride, the functions of smoke yellow spots elimination and antiphlogosis of the turmeric extract and the function of the zinc phytate of eliminating dental calculus, and skillfully borrowing the function of suppressing pigment precipitation of the zinc phytate for reducing the coloration effect of curcumin to teeth or toothbrushes.
Description
Technical field
The present invention relates to a kind of compound toothpaste for eliminating dental plaque and preparation method thereof.
Background technology
Existing toothpaste as dentifrice can divide three major types, anticarious tooth paste, antiinflammatory toothpaste, desensitizing toothpaste, the main fluoride of first kind toothpaste, second class are Chinese style Chinese herbal toothpaste and cation surfactant, as Radix Zanthoxyli, hibitane etc., the 3rd class: traditional Western-style toothpaste contains amine salt more, also has to contain strontium salt.Typical international monopoly has: U.S. Pat P4826675 in 1989, Japan Patent JP61200905, U.S. Pat A4259316, Chinese patent application 91107332,90105692 etc.
Often smoking, having tea easily to cause piling up at dental surface forms black, xanchromatic schmutzband, and common toothpaste is brushed teeth and is difficult to brush away, and has influenced the attractive in appearance and healthy of tooth.The existing method for whitening that cleans the teeth, what effect was best is the chemical bleaching method, utilizes the chemical bleaching agent, with tartar hydrochloric acid, dissolvings such as hydrogenperoxide steam generator, but when removing tartar, corrode tooth unavoidably.
Whitening toothpaste commonly used with abrasives such as calcium carbonate, silicon dioxide, mainly relies on the mechanical friction of physics, and it is better to remove food detritus effect, but it is undesirable to remove cigarette macula lutea, tea speckle, tartar effect.Cigarette macula lutea, tea speckle, tartar and tooth is solidified togather and prolong in time, more and more firm, very difficult the removal.The anticaries action of fluoride toothpaste is generally acknowledged; But the toothpaste of not only removing cigarette macula lutea tartar but also preventing decayed tooth is arranged seldom.
Domestic there are some researches show that the extract of Rhizoma Curcumae Longae extract, Radix Curcumae class has effect preferably to the smoke abatement macula lutea, but the curcumin in the Rhizoma Curcumae Longae extract allows the user produce resentment easily with the yellow of dying of tooth and toothbrush in commercial aesthetic easily.Rhizoma Curcumae Longae extract also has good antiinflammation simultaneously, has literature research to show that Rhizoma Curcumae Longae extract can be applicable in the toothpaste abroad.But how to keep the effect of Rhizoma Curcumae Longae extract smoke abatement macula lutea, antiinflammatory, can effectively the coloration of curcumin to tooth and toothbrush be reduced again, become Rhizoma Curcumae Longae key in application in toothpaste.The inventor just takes the lead in having used phytic acid zinc in the patent application of CN93112612 multipurpose tooth paste, be used to eliminate dental calculus, phytic acid zinc is white powder, certain mechanical strength is arranged, after phytic acid zinc becomes flexible the dental calculus dissolving earlier, be convenient to toothbrush with dental calculus brush down, but that cigarette macula lutea, tea speckle, tartar and tooth are solidificated in is very firm, the removal effect of phytic acid zinc is ideal not enough.
Summary of the invention
The purpose of this invention is to provide a kind of compound recipe toothpaste and preparation method thereof.The phytic acid zinc of this compound recipe toothpaste and Rhizoma Curcumae Longae extract be composite obviously to reduce in the Rhizoma Curcumae Longae extract curcumin to the coloration of tooth and toothbrush.
Technical scheme of the present invention is:
A kind of compound toothpaste for eliminating dental plaque comprises phytic acid zinc 0.5-1.2 part by weight ratio, Rhizoma Curcumae Longae extract 0.2-0.6 part, fluoride 0.1-0.3 part, conventional toothpaste base material 70-95 part, water 80-100 part.
Compound toothpaste for eliminating dental plaque also is added with zinc citrate 0.3-0.5 part.
Compound toothpaste for eliminating dental plaque, conventional toothpaste base material contains wetting agent 15-25 part, adhesive 1-1.5 part, abrasive 45-55 part, washing foaming agent 1.5-3 part, flavouring agent 0.8-1.4 part, sweeting agent 0.2-0.3 part, buffer agent 0.3-0.6 part, antiseptic 0.05-0.3 part.
Compound toothpaste for eliminating dental plaque comprises 0.6 part on phytic acid zinc by weight ratio, 0.5 part of Rhizoma Curcumae Longae extract, and 0.24 part of sodium fluoride, 100 parts in water, conventional toothpaste base material is: 10 parts of wetting agent glycerol, 5 parts of sorbic acid, 5 parts of malonic acid; 1 part of adhesive xanthan gum; 20 parts in abrasive calcium phosphate, 0 part of silica 1,20 parts of titanium dioxides; 3 parts of washing foaming agent sodium lauryl sulfates; The flavouring agent Oleum Menthae Rotundifoliae, respectively 0.2 part of Oleum menthae, Fructus Citri Limoniae oil, citrus oils; 0.3 part of sweeting agent saccharin sodium, 0.3 part of buffer agent tetrasodium pyrophosphate; 0.05 part of preservative sodium benzoate.
Compound toothpaste for eliminating dental plaque, the washing foaming agent sodium lauryl sulfate replaces with dodecylbenzene sodium sulfonate.
The preparation method of compound toothpaste for eliminating dental plaque, the preparation method that Rhizoma Curcumae Longae extract adopts is: the Rhizoma Curcumae Longae raw medicinal material is ground into coarse powder, add 70-85% alcohol reflux secondary, 2 hours for the first time, 10 times of amount ethanol, 2 hours for the second time, 8 times of amount ethanol, filtration, filtrate recycling ethanol and to be concentrated into relative density be 1.06-1.10, spray drying gets the Chinese medicine extract of dry powder; The conventional base material mix homogeneously of Chinese medicine extract and toothpaste is made toothpaste.
Compound recipe toothpaste advantage of the present invention is: kept the smoke abatement macula lutea of function, Rhizoma Curcumae Longae extract of fluoride preventing decayed tooth and the function that antiinflammation, phytic acid zinc are eliminated dental calculus simultaneously, that uses cleverly again that phytic acid zinc suppresses pigementation is used for reducing the coloration of curcumin to tooth or toothbrush.Phytic acid zinc suppresses visible the 34th page of upper right hurdle of " development of phytic acid zinc and the application in daily-use chemical industry thereof " (Beijing daily use chemicals .1991 (2) .-33-35) of report of the effect of pigementation.
The specific embodiment
Embodiment 1
Compound toothpaste for eliminating dental plaque, 0.5 part of Rhizoma Curcumae Longae extract, 0.24 part in fluoride; 100 parts in water, conventional toothpaste base material is: 10 parts of wetting agent glycerol, 5 parts of sorbic acid, 5 parts of malonic acid; 1 part of adhesive xanthan gum; 20 parts in abrasive calcium phosphate, 0 part of silica 1,20 parts of titanium dioxides; 3 parts of washing foaming agent sodium lauryl sulfates; The flavouring agent Oleum Menthae Rotundifoliae, respectively 0.2 part of Oleum menthae, Fructus Citri Limoniae oil, citrus oils; 0.3 part of sweeting agent saccharin sodium, 0.3 part of buffer agent tetrasodium pyrophosphate; 0.05 part of preservative sodium benzoate.
Embodiment 2
Compound toothpaste for eliminating dental plaque adds 0.6 part on phytic acid zinc, 0.5 part of Rhizoma Curcumae Longae extract, 0.24 part in fluoride; 100 parts in water, conventional toothpaste base material is: 10 parts of wetting agent glycerol, 5 parts of sorbic acid, 5 parts of malonic acid; 1 part of adhesive xanthan gum; 20 parts in abrasive calcium phosphate, 0 part of silica 1,20 parts of titanium dioxides; 3 parts of washing foaming agent sodium lauryl sulfates; The flavouring agent Oleum Menthae Rotundifoliae, respectively 0.2 part of Oleum menthae, Fructus Citri Limoniae oil, citrus oils; 0.3 part of sweeting agent saccharin sodium, 0.3 part of buffer agent tetrasodium pyrophosphate; 0.05 part of preservative sodium benzoate.
Embodiment 3
Compound toothpaste for eliminating dental plaque adds 0.6 part on phytic acid zinc, 0.4 part of zinc citrate, 0.24 part in fluoride; 100 parts in water, conventional toothpaste base material is: 10 parts of wetting agent glycerol, 5 parts of sorbic acid, 5 parts of malonic acid; 1 part of adhesive xanthan gum; 20 parts in abrasive calcium phosphate, 0 part of silica 1,20 parts of titanium dioxides; 3 parts of washing foaming agent sodium lauryl sulfates; The flavouring agent Oleum Menthae Rotundifoliae, respectively 0.2 part of Oleum menthae, Fructus Citri Limoniae oil, citrus oils; 0.3 part of sweeting agent saccharin sodium, 0.3 part of buffer agent tetrasodium pyrophosphate; 0.05 part of preservative sodium benzoate.
Embodiment 4
Ordinary toothpaste.0.6 part of Flos Lonicerae, Flos Chrysanthemi Indici extract, 0.24 part in fluoride; 100 parts in water, conventional toothpaste base material is: 10 parts of wetting agent glycerol, 5 parts of sorbic acid, 5 parts of malonic acid; 1 part of adhesive xanthan gum; 20 parts in abrasive calcium phosphate, 0 part of silica 1,20 parts of titanium dioxides; 3 parts of washing foaming agent sodium lauryl sulfates; The flavouring agent Oleum Menthae Rotundifoliae, respectively 0.2 part of Oleum menthae, Fructus Citri Limoniae oil, citrus oils; 0.3 part of sweeting agent saccharin sodium, 0.3 part of buffer agent tetrasodium pyrophosphate; 0.05 part of preservative sodium benzoate.
Embodiment 5
Getting cigarette macula lutea, tea speckle that hospital pulls up adheres to serious yellowish-brown and exsomatizes that 30 pieces of teeth are parallel at random to be divided into three groups:
Cigarette macula lutea, tea speckle adhere to and are meant seriously that the tooth surface cigarette macula lutea that exsomatizes, tea speckle adhere to and reach more than 50%.
Dip in toothbrush all surfaces that embodiment 1 or 2 or 4 toothpaste that provide are scrubbed the stripped tooth of moistening is provided, each one minute, each firmly uniformity was consistent.Brushed the back and more than 30 times, guaranteed to rinse well, be placed in the sealing bag, sooner or later respectively come again continuous 30 days with flushing with clean water.
The table 1 cigarette macula lutea tea speckle of the tooth variation of disappearing of observe exsomatizing.
| Sample | 3 days | 5 days | 30 days |
| Embodiment 1 | 5 teeth have obviously and disappear | 10 teeth have obviously and disappear | 10 teeth have obviously and disappear, and 7 teeth wherein expose the white flank of tooth |
| Embodiment 2 | 4 teeth have obviously and disappear | 10 teeth have obviously and disappear | 10 teeth have obviously and disappear, and 7 teeth wherein expose the white flank of tooth |
| Embodiment 4 | 0 tooth has obviously and disappears | 0 tooth has obviously and disappears | 0 tooth has obviously and disappears, and 0 tooth wherein exposes the white flank of tooth |
Get cigarette macula lutea, tea speckle that hospital pulls up and adhere to exsomatize 30 pieces of teeth of not serious yellowish-brown, add hydrochloric acid and scrub, and add hydrogen peroxide and scrub until tooth surface whitely entirely, parallelly at random be divided into three groups:
Cigarette macula lutea, tea speckle adhere to and not seriously are meant that the tooth surface cigarette macula lutea that exsomatizes, tea speckle adhere to and reach below 50%.
Dip in toothbrush all surfaces that embodiment 1 or 2 or 3 toothpaste that provide are scrubbed the stripped tooth of moistening is provided, each one minute, each firmly uniformity was consistent.After having brushed, toothpaste is immersed in stripped tooth surface 24 hours respectively, 72 hours, 144 hours, the reuse toothbrush brushed away toothpaste, and flushing with clean water is removed residue, so that investigate the adhesion condition of curcumin on tooth.
Table 2 observe to exsomatize tooth surface color change.Be used for investigating the adhesion condition of curcumin on tooth.
| Sample | 24 hours | 72 hours | 144 hours |
| Embodiment 1 | 3 teeth are still whiter by pale yellow 7 teeth of leucismus | 10 teeth Huang that all shoals | 10 teeth all deepen Huang |
| Embodiment 2 | 0 tooth is still whiter by pale yellow 10 teeth of leucismus | 3 teeth yellow 7 teeth that shoal are still whiter | 4 teeth yellow 6 teeth that shoal are still whiter |
| Embodiment 3 | 0 tooth is still whiter by pale yellow 10 teeth of leucismus | 0 tooth is still whiter by pale yellow 10 teeth of leucismus | 2 teeth are still whiter by pale yellow 8 teeth of leucismus |
The present invention produces effect to removing cigarette macula lutea tea speckle by the top Rhizoma Curcumae Longae extract that experimental results show that.
Ordinary toothpaste does not have effect to removing cigarette macula lutea tea speckle.
Phytic acid zinc and Rhizoma Curcumae Longae extract do not had negative effect to removing cigarette macula lutea tea speckle.
Curcumin easily on tooth adventitious deposit painted.
It is painted that phytic acid zinc can suppress the adventitious deposit of curcumin on tooth.
It is painted that phytic acid zinc and zinc citrate can suppress the adventitious deposit of curcumin on tooth, better effects if.
Embodiment 6
The preparation method of compound toothpaste for eliminating dental plaque, the Rhizoma Curcumae Longae raw medicinal material is ground into coarse powder, add 80% alcohol reflux secondary, 2 hours for the first time, 10 times of amount ethanol, 2 hours for the second time, 8 times of amount ethanol, filtration, filtrate recycling ethanol and to be concentrated into relative density be 1.08, spray drying gets the Chinese medicine extract of dry powder; The conventional base material mix homogeneously of Chinese medicine extract and toothpaste is made toothpaste.All the other are with embodiment 2.
Embodiment 7
The preparation method of compound toothpaste for eliminating dental plaque, the Rhizoma Curcumae Longae raw medicinal material is ground into coarse powder, add 70% alcohol reflux secondary, 2 hours for the first time, 10 times of amount ethanol, 2 hours for the second time, 8 times of amount ethanol, filtration, filtrate recycling ethanol and to be concentrated into relative density be 1.06, spray drying gets the Chinese medicine extract of dry powder; The conventional base material mix homogeneously of Chinese medicine extract and toothpaste is made toothpaste.All the other are with embodiment 2.
Embodiment 8
The preparation method of compound toothpaste for eliminating dental plaque, the Rhizoma Curcumae Longae raw medicinal material is ground into coarse powder, add 85% alcohol reflux secondary, 2 hours for the first time, 10 times of amount ethanol, 2 hours for the second time, 8 times of amount ethanol, filtration, filtrate recycling ethanol and to be concentrated into relative density be 1.10, spray drying gets the Chinese medicine extract of dry powder; The conventional base material mix homogeneously of Chinese medicine extract and toothpaste is made toothpaste.All the other are with embodiment 2.
Embodiment 9
Compound toothpaste for eliminating dental plaque, 0.5 part on phytic acid zinc, 0.2 part of Rhizoma Curcumae Longae extract, 0.1 part in fluoride; 80 parts in water, conventional toothpaste base material is: 10 parts of wetting agent glycerol, 5 parts of sorbic acid, 5 parts of malonic acid; 1 part of adhesive xanthan gum; 20 parts in abrasive calcium phosphate, 0 part of silica 1,20 parts of titanium dioxides; 3 parts of washing foaming agent sodium lauryl sulfates; The flavouring agent Oleum Menthae Rotundifoliae, respectively 0.2 part of Oleum menthae, Fructus Citri Limoniae oil, citrus oils; 0.3 part of sweeting agent saccharin sodium, 0.3 part of buffer agent tetrasodium pyrophosphate; 0.05 part of preservative sodium benzoate.
Embodiment 10
Compound toothpaste for eliminating dental plaque, 1.2 parts on phytic acid zinc, 0.3 part of zinc citrate, 0.6 part of Rhizoma Curcumae Longae extract, 0.3 part in fluoride; 100 parts in water, conventional toothpaste base material is: 10 parts of wetting agent glycerol, 5 parts of sorbic acid, 5 parts of malonic acid; 1 part of adhesive xanthan gum; 20 parts in abrasive calcium phosphate, 0 part of silica 1,20 parts of titanium dioxides; 3 parts of washing foaming agent sodium lauryl sulfates; The flavouring agent Oleum Menthae Rotundifoliae, respectively 0.2 part of Oleum menthae, Fructus Citri Limoniae oil, citrus oils; 0.3 part of sweeting agent saccharin sodium, 0.3 part of buffer agent tetrasodium pyrophosphate; 0.05 part of preservative sodium benzoate.
Embodiment 11
Compound toothpaste for eliminating dental plaque, 0.9 part on phytic acid zinc, 0.5 part of zinc citrate, 0.3 part of Rhizoma Curcumae Longae extract, 0.2 part in fluoride; 90 parts in water, conventional toothpaste base material is: 10 parts of wetting agent glycerol, 5 parts of sorbic acid, 5 parts of malonic acid; 1 part of adhesive xanthan gum; 20 parts in abrasive calcium phosphate, 0 part of silica 1,20 parts of titanium dioxides; 3 parts of washing foaming agent sodium lauryl sulfates; The flavouring agent Oleum Menthae Rotundifoliae, respectively 0.2 part of Oleum menthae, Fructus Citri Limoniae oil, citrus oils; 0.3 part of sweeting agent saccharin sodium, 0.3 part of buffer agent tetrasodium pyrophosphate; 0.05 part of preservative sodium benzoate.
Embodiment 12
Compound toothpaste for eliminating dental plaque, conventional toothpaste base material contains 25 parts of wetting agent, 1.5 parts of adhesive, 55 parts of abrasives, 3 parts of washing foaming agent, 1.4 parts of flavouring agents, 0.3 part of sweeting agent, 0.6 part of buffer agent, antiseptic-0.3 part.All the other are with embodiment 2.
Embodiment 13
Compound toothpaste for eliminating dental plaque, conventional toothpaste base material contains 20 parts of wetting agent, 1.4 parts of adhesive, 50 parts of abrasives, 2 parts of washing foaming agent, 0.9 part of flavouring agent, 0.25 part of sweeting agent, 0.34 part of buffer agent, 0.1 part of antiseptic.All the other are with embodiment 2.
Embodiment 14
Compound toothpaste for eliminating dental plaque, washing foaming agent are 3 parts of dodecylbenzene sodium sulfonate.All the other are with embodiment 1.
Embodiment 15
Compound toothpaste for eliminating dental plaque also is added with strontium chloride: 0.3～0.5 part.All the other are with embodiment 3.
Embodiment 16
Compound toothpaste for eliminating dental plaque, 45 parts of phosphoric acid hydrogen dihydrates; 2 parts of silicon dioxide; 10 parts of glycerol; 10 parts of sorbitol; 1 part of carboxymethyl cellulose; 3 parts of sodium laurylsulfates; All the other together
Embodiment 3.
Embodiment 17
Compound toothpaste for eliminating dental plaque, 0.2 part of stannous fluoride; 39 parts of calcium pyrophosphates; Glycerol 10,20 parts of sorbitol; All the other are with embodiment 2.
Embodiment 18
Compound toothpaste for eliminating dental plaque, 0.76 part of sodium monofluorophosphate; 42 parts of insoluble Polymeric sodium metaphosphate ies, 5 parts of dicalcium phosphate dihydrates; 1 part of aluminium hydroxide; Ai Er half tongue extractum 1; 0.4 part of titanium dioxide; 0.5 part of sodium benzoate; 3 parts of N-sodium lauroyl sarcosines; All the other are with embodiment 2.
Embodiment 19
Compound toothpaste for eliminating dental plaque, 5 parts of N-sodium lauroyl sarcosines; 0.5 part of sodium laurylsulfate; 0.9 part of alginate jelly; 2 parts of polyoxyethylene 20 sorbitan monolaurates; 24 parts of silicon dioxide; All the other are with embodiment 2.
Embodiment 20
Compound toothpaste for eliminating dental plaque, 0.5 part on the phytic acid zinc of weight proportion, 0.2 part of Rhizoma Curcumae Longae extract, 0.3 part in fluoride, 95 parts of conventional toothpaste base materials, 100 parts in water.
Embodiment 21
Compound toothpaste for eliminating dental plaque, 1.2 parts on the phytic acid zinc of weight proportion, 0.6 part of Rhizoma Curcumae Longae extract, 0.1 part in fluoride, 70 parts of conventional toothpaste base materials, 80 parts in water.
Embodiment 22
Compound toothpaste for eliminating dental plaque, 1.1 parts on the phytic acid zinc of weight proportion, 0.3 part of Rhizoma Curcumae Longae extract, 0.2 part in fluoride, 85 parts of conventional toothpaste base materials, 90 parts in water.
Claims (5)
1, a kind of compound toothpaste for eliminating dental plaque comprises phytic acid zinc 0.5-1.2 part by weight ratio, Rhizoma Curcumae Longae extract 0.2-0.6 part, fluoride 0.1-0.3 part, conventional toothpaste base material 70-95 part, water 80-100 part is characterized in that: also be added with zinc citrate 0.3-0.5 part.
2, compound toothpaste for eliminating dental plaque according to claim 1, it is characterized in that: conventional toothpaste base material contains wetting agent 15-25 part, adhesive 1-1.5 part, abrasive 45-55 part, washing foaming agent 1.5-3 part, flavouring agent 0.8-1.4 part, sweeting agent 0.2-0.3 part, buffer agent 0.3-0.6 part, antiseptic 0.05-0.3 part.
3, compound toothpaste for eliminating dental plaque according to claim 2, it is characterized in that: comprise 0.6 part on phytic acid zinc by weight ratio, 0.5 part of Rhizoma Curcumae Longae extract, 0.24 part of sodium fluoride, 100 parts in water, conventional toothpaste base material is: 10 parts of wetting agent glycerol, 5 parts of sorbic acid, 5 parts of malonic acid; 1 part of adhesive xanthan gum; 20 parts in abrasive calcium phosphate, 0 part of silica 1,20 parts of titanium dioxides; 3 parts of washing foaming agent sodium lauryl sulfates; The flavouring agent Oleum Menthae Rotundifoliae, respectively 0.2 part of Oleum menthae, Fructus Citri Limoniae oil, citrus oils; 0.3 part of sweeting agent saccharin sodium, 0.3 part of buffer agent tetrasodium pyrophosphate; 0.05 part of preservative sodium benzoate.
4, compound toothpaste for eliminating dental plaque according to claim 3 is characterized in that: the washing foaming agent sodium lauryl sulfate replaces with dodecylbenzene sodium sulfonate.
5, the preparation method of the described compound toothpaste for eliminating dental plaque of claim 1, it is characterized in that: the preparation method that Rhizoma Curcumae Longae extract adopts is: the Rhizoma Curcumae Longae raw medicinal material is ground into coarse powder, add 70-85% alcohol reflux secondary, 2 hours for the first time, 10 times of amount ethanol, 2 hours for the second time, 8 times of amount ethanol, filtration, filtrate recycling ethanol and to be concentrated into relative density be 1.06-1.10, spray drying gets the Chinese medicine extract of dry powder; The conventional base material mix homogeneously of Chinese medicine extract and toothpaste is made toothpaste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410013379 CN1259033C (en) | 2004-06-24 | 2004-06-24 | Compound toothpaste for eliminating dental plaque and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410013379 CN1259033C (en) | 2004-06-24 | 2004-06-24 | Compound toothpaste for eliminating dental plaque and its preparation method |
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| CN1593376A CN1593376A (en) | 2005-03-16 |
| CN1259033C true CN1259033C (en) | 2006-06-14 |
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Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2634758A1 (en) * | 2005-12-20 | 2007-07-05 | The Procter & Gamble Company | Oral care compositions comprising zinc and phytate |
| ES2280136B1 (en) * | 2006-02-17 | 2008-08-16 | Universitat De Les Illes Balears | FIXED AND ZINC FIXED DOSE ASSOCIATION. |
| FR2905596A1 (en) * | 2006-09-11 | 2008-03-14 | Innoderm Sarl | Cosmetic/pharmaceutical composition for topical use, comprises a combination of citric acid and phytic acid and/or their derivatives useful as a non-irritating preservative in the treatment of oily skin and acne |
| CN101040828B (en) * | 2007-04-28 | 2010-05-19 | 长春迈灵生物工程有限公司 | Tooth whitening agent and the method for preparing the same |
| US8580234B2 (en) | 2008-11-19 | 2013-11-12 | Kao Corporation | Method for removing solid product formed on surfaces of teeth |
| CN102218021B (en) * | 2010-04-15 | 2013-01-23 | 刘钦 | Toothpaste for removing halitosis and preventing canker sore |
| JP5097841B2 (en) | 2011-04-08 | 2012-12-12 | 花王株式会社 | Oral composition |
| CN102335108A (en) * | 2011-10-25 | 2012-02-01 | 华南理工大学 | Extract additive for Chinese herbal medicine toothpaste |
| CN112999109A (en) * | 2021-03-16 | 2021-06-22 | 江苏雪豹日化有限公司 | Modified biological lysozyme composition |
| CN113384487A (en) * | 2021-06-30 | 2021-09-14 | 广州名大实业有限公司 | Formula of toothpaste capable of efficiently removing smoke spots |
| CN115590802A (en) * | 2022-09-13 | 2023-01-13 | 广东南方洁灵科技实业有限公司（Cn） | A kind of toothpaste with anti-allergic and fresh breath effect and preparation process thereof |
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