RU2286763C2 - Dental paste - Google Patents

Abstract

FIELD: medicine, stomatology.

SUBSTANCE: invention relates to agents used in hygiene and prophylactic of the mouth cavity diseases. Dental paste contains silicon dioxide, sodium carboxymethylcellulose, sea salt from Verkhnekamsky layer, glycerol or sorbitol, sodium lauryl sulfate, preserving agent, perfume and water and these component are taken in the definite ratio. Dental paste shows curative-prophylactic effect on parodontium tissues, decreases teeth injury by caries and stimulates trophic and regenerative processes.

EFFECT: valuable medicinal properties of dental paste.

2 ex

Description

The invention relates to the field of medicine, namely dentistry, and can be used in the manufacture of therapeutic and prophylactic toothpastes.

Toothpaste is a complex system, in the formation of which abrasive, moisturizing, binders, foaming, surface-active components, preservatives, flavoring agents, water and treatment and prophylactic elements are involved, the ratio of these components determines the properties, purpose, mechanism of action and effectiveness of pastes ( one).

Pastes are produced in a wide range: toothpaste abrasive, gel, hygienic, for sensitive enamel, prophylactic, low-forming, whitening, anti-inflammatory, anti-caries, etc. The list of the main types of toothpastes indicates their diversity and the possibility of a wide choice for the consumer among hygienic and therapeutic agents.

Known toothpaste containing dicalcium phosphate, glycerin, sodium carboxymethyl cellulose, perfume (US patent 3751561, MKI A 61 K 7/16, 1993). A disadvantage of the known paste is low anticariogenic activity.

Also known is a toothpaste containing chalk, sodium carboxymethyl cellulose, glycerin or sorbitol, sodium lauryl sulfate, sodium lactate or calcium lactate (2). Known toothpaste does not have versatility, since it mainly solves the problem of increasing the cleaning and whitening ability.

Closest to the claimed paste, the prototype is a toothpaste containing silicon dioxide, glycerin or sorbitol, sodium carboxymethyl cellulose, sodium lauryl sulfate, sodium fluoride, calcium carbonate, Siberian larch resin extract, preservative, xylitol, perfume, dye and water (4).

Known paste has a good carioprophylactic effect, stimulates the processes of microcirculation and remineralization of tooth enamel, provides treatment and prevention of periodontal disease. But all these properties are ensured by the introduction of several components of sodium monofluorophosphate, calcium carbonate, and Siberian larch resin extract into the toothpaste.

In the inventive paste, these properties are provided by sea salt of the Verkhnekamsk deposit, which also has an analgesic effect.

The objective of the invention is the creation of a toothpaste with universal preventive and therapeutic properties, the ability to reduce not only the intensity of caries, but also positively affect periodontal tissues, relieving inflammation and stimulating trophic and regenerative processes in them.

The essence of the invention lies in the fact that the toothpaste contains silicon dioxide, sodium carboxymethyl cellulose, glycerin or sorbitol, sodium lauryl sulfate, sea salt of the Verkhnekamsk deposit, preservative, perfume and water in the following ratio, wt.%: Silicon dioxide - 10-30; sodium carboxymethyl cellulose - 1.0-1.7; sea salt of the Verkhnekamsk field - 1-30; glycerin or sorbitol - 10-32; sodium lauryl sulfate - 1-2; preservative - 0.1-0.5; perfume - 0.6-1.5; water is the rest.

A possible embodiment of the toothpaste, in which alcohol or sodium benzoate is used as a preservative.

A possible embodiment of a toothpaste in which mint or menthol is used as a perfume, and saccharin or xylitol is used as a flavoring additive.

Silicon dioxide is an abrasive polishing material designed to remove plaque and food debris formed by bacteria colonies from the surface of the teeth and polish them afterwards. In addition, it plays the role of a builder creating a homogeneous paste mass. When the concentration of silicon dioxide is less than 10%, the abrasive characteristics of the paste deteriorate. Exceeding the upper limit (i.e., more than 30%) leads to an excessive increase in the abrasive effect of the paste on the gums and enamel.

Glycerin (or sorbitol) inhibits the evaporation of water and helps to maintain the uniformity and plasticity of the paste. Sodium carboxymethyl cellulose (sodium - CMC) is a gelling element. The hydrocolloids that make up its composition provide the paste with viscosity, ductility, and thixotropy.

Sodium lauryl sulfate is a surfactant. It promotes the formation of foam and reduces the surface tension of the solution, which greatly facilitates the process of brushing your teeth.

The preservative prevents the development of microflora in the paste during storage and use. Usually use alcohol or sodium benzoate.

To improve the organoleptic properties of the paste, mint or menthol is used as a perfume, and saccharin or xylitol is used as a flavoring additive.

The limits of the ratios of the listed traditional basic components are taken in accordance with those commonly used in the production of toothpastes.

New in the claimed paste is the use in its composition of salt of the sea Verkhnekamsk field.

Salt is produced by Silvinit OJSC (Solikamsk, Perm Region) under the trade name Achilles (certificate for trademark No. 287540). It is a mixture of pure natural halite and carnallite minerals, sorted from different horizons of the Ancient Perm Sea, which existed more than 280 million years ago and formed a truly unique Verkhnekamsk deposit of potassium-magnesium and sodium salts without any additives and reagents. When dissolved in water, this salt gives pure transparent water, similar in composition to the water of the World Ocean and human blood plasma. This determines the exceptional effectiveness of its impact on the human body. "Achilles" contains trace elements of the entire registry of the periodic table, including sodium, magnesium, potassium, iodides, bromides, sulfate ions. The solution from it has an anti-inflammatory, healing, analgesic effect, helps to improve the nutrition of the skin and mucous membranes, increases the activity of the protective functions of the body, has a sedative effect. Sea salt of the Verkhnekamsk deposit is protected by RF patent No. 2028274 “Mineral mixture for the production of sea water”.

The Department of Dentistry of the Perm Medical Academy conducted a study of the effect of topical application of a 1.5% solution of Achilles salt on microcrystallization of oral fluid in children of different health groups. The use of this solution allowed to significantly improve (p≤0.01) the salivary mineralizing potential and, therefore, reduce the risk of tooth decay.

Toothpaste is prepared according to the known technology for the preparation of toothpastes. An aqueous solution of sodium carboxymethyl cellulose is introduced into the kneading tank, then glycerol or sorbitol, silicon dioxide, sea salt of the Verkhnekamsk deposit, as well as additives used in the paste composition are added successively with stirring. These components are mixed until a homogeneous pasty consistency, vacuum and packaged in tubes.

Specific examples of the compositions of the claimed toothpaste.

Example 1

Prepared toothpaste of the following composition, wt.%:

Silica - 20

Sodium carboxymethyl cellulose - 1.5

Sea salt of the Verkhnekamsk field - 5.5

Glycerin - 15

Sodium lauryl sulfate - 1.5

Sodium benzoate - 0.3

Mint fragrance - 0.6

Water is the rest.

Example 2

Prepared toothpaste of the following composition, wt.%:

Silicon Dioxide - 17

Sodium carboxymethyl cellulose - 1.7

Sea salt of the Verkhnekamsk field - 8.5

Sorbitol - 16

Sodium lauryl sulfate - 1.2

Sodium benzoate - 0.4

Menthol - 0.2

Water is the rest.

Clinical trials of toothpaste were carried out on a group of probans aged 12-50 years (46 people) in a private dental clinic in Perm - “Doctor Sun” (license No. 59-01-000302 dated September 8, 2005). Toothpaste was applied 1-2 times a day for 30 days. A special therapeutic effect was observed in patients with increased bleeding gums (periodontal disease) and various types of stomatitis and gingivitis, including viral etiology. In this case, a decongestant and anti-inflammatory effect occurred very quickly. Patients noted improvement within 1-2 days. Gum bleeding stopped by day 14-22.

Thus, the high clinical effectiveness of toothpaste in oral hygiene has been confirmed. Compared with the prototype, the proposed toothpaste provides a faster effect on periodontal tissues, helps to reduce tooth damage by caries by enhancing the processes of remineralization of tooth tissue, and quick healing of gingivitis. The systematic use of toothpaste provides a good anti-inflammatory, healing, antiseptic and cleansing effect, significantly improves the condition of periodontal tissues.

Information sources:

1. Ulitovsky S. B. Basic concepts of toothpaste composition. // New in dentistry. - 2000. - No. 6. - Special. release. - p. 77-84.

2. RF patent No. 2204380, publ. 05/20/2003.

3. RF patent No. 2028274, publ. 02/09/1995.

4. RF patent No. 2228167, publ. 05/10/2004.

Claims (1)

Toothpaste, including silicon dioxide, sodium carboxymethyl cellulose, glycerin or sorbitol, sodium lauryl sulfate, preservative, perfume and water, characterized in that it additionally contains sea salt of the Verkhnekamsk deposit in the following ratio, wt.%: Silica 10.0-30.0 Sodium carboxymethyl cellulose 1.0-1.7 Sea salt of Verkhnekamsk Place of Birth 1.0-30.0 Glycerol or sorbitol 10.0-32.0 Sodium lauryl sulfate 1.0-2.0 Preservative 0.1-0.5 Perfume 0.6-1.5 Water Rest