CN111729065A

CN111729065A - Production process of three-medicine medicated leaven

Info

Publication number: CN111729065A
Application number: CN202010778711.7A
Authority: CN
Inventors: 谷献旦; 金和勇; 苏玲萍; 徐建芬; 陈金钗
Original assignee: Haihe Pharma Co ltd Wenzhou
Current assignee: Haihe Pharma Co ltd Wenzhou
Priority date: 2020-08-05
Filing date: 2020-08-05
Publication date: 2020-10-02

Abstract

The application discloses a production process of three-element medicated leaven, which comprises the following steps: weighing rhizoma Cyperi, bupleuri radix, Scutellariae radix, rhizoma Pinelliae, Arecae semen, fructus Anisi Stellati, radix Gentianae Marcrophyllae, Glycyrrhrizae radix, rhizoma Kaempferiae, radix Linderae, radix et rhizoma Nardostachyos, fructus evodiae, ramulus Cinnamomi, radix Platycodi, radix Inulae and herba asari, decocting with water for 2 times, adding water 7-9 times for the first time, decocting for 1.5-2.5 hr, adding water 5-7 times for the second time, decocting for 0.5-1.5 hr, mixing decoctions, concentrating into fluid extract, drying and pulverizing into dry extract powder; weighing herba Polygoni Hydropiperis, rhizoma Zingiberis recens, pericarpium Arecae and herba Artemisiae Annuae, decocting in water, mixing filtrates, and concentrating to appropriate amount; weighing the rest 32 medicinal materials, pulverizing into coarse powder, sieving, and mixing; mixing the dry extract powder and crude drug powder, adding flour and red koji powder, adding the concentrated solution, pressing into blocks in impression mold sprinkled with white koji powder, fermenting, drying, and brushing. The application improves the fermentation effect, can make the fermentation more sufficient and complete, and ensures the drug effect of the three medicated leavens.

Description

Production process of three-medicine medicated leaven

Technical Field

The application relates to the technical field of Chinese patent medicine preparation, in particular to a production process of sanyun medicated leaven.

Background

Three medicated leavens are Chinese patent medicines with long history, old dosage forms, authentic medicinal materials and smart curative effect. The medicinal liquor is prepared by fermenting fifty-two medicinal materials under certain temperature and humidity conditions, and is in the form of offwhite rectangular blocks or brown particles; fragrant, pungent and bitter in flavor, has effects of dispelling pathogenic wind, relieving exterior syndrome, regulating stomach and regulating qi-flowing, and can be used for treating wind cold, vomiting and diarrhea due to improper diet, chest and abdomen fullness, motion sickness and vomiting.

At present, under the existing production process conditions of the three medicated leavens, the conditions of unobvious fermentation effect, insufficient and incomplete fermentation can be generated, so that the three medicated leaven blocks obtained by production turn yellow or even black, have no special fragrance after leaven fermentation, reduce the drug effect and fail to reach the national drug standard of the State food and drug administration. Therefore, it is necessary to improve the existing production process of the three medicated leavens.

Disclosure of Invention

Aiming at the defects in the prior art, the application aims to provide the production process of the three-element medicated leaven so as to achieve the effect of full fermentation, further improve the drug effect of the three-element medicated leaven and ensure the quality of products.

The technical purpose of the application is realized by the following technical scheme:

a production process of three-element medicated leaven comprises the following steps:

a. weighing 18 parts of rhizoma cyperi (prepared), 9 parts of radix bupleuri, 19 parts of radix scutellariae, 14 parts of pinellia ternate (prepared), 31 parts of semen arecae, 11 parts of star anise, 13 parts of radix gentianae macrophyllae, 20 parts of liquorice, 13 parts of rhizoma kaempferiae, 13 parts of radix linderae, 13 parts of rhizoma nardostachyos, 6 parts of fructus evodiae (prepared), 6 parts of cassia twig, 13 parts of platycodon grandiflorum, 13 parts of elecampane and 9 parts of asarum, adding water for decocting for 2 times, adding 7-9 times of water for decocting for 1.5-2.5 hours for the first time, adding 5-7 times of water for decocting for 0.5-1.5 hours for the second time, combining decoctions, filtering by 100 meshes, concentrating the filtrate into clear paste, drying under vacuum to obtain dry paste, and crushing the;

b. weighing 15 parts of polygonum hydropiper, 25 parts of ginger, 13 parts of areca peel and 15 parts of sweet wormwood, adding 11-13 times of water respectively, decocting for 1 time, decocting for 3.5-4.5 hours, filtering with 100 meshes, combining filtrates, and concentrating to a proper amount;

c. weighing 50 parts of poria cocos, 13 parts of radix peucedani, 16 parts of radix sileris, 19 parts of negundo chastetree fruit, 13 parts of ligusticum wallichii, 16 parts of fennel, 6 parts of cassia seed, 25 parts of hawthorn (fried), 31 parts of dried orange peel, 75 parts of medicated leaven (fried), 6 parts of galangal, 13 parts of schizonepeta, 13 parts of rhizoma dioscoreae hypoglaucae, 13 parts of elsholtzia, 16 parts of notopterygium root, 25 parts of elecampane, 25 parts of malt (fried), 19 parts of fructus aurantii (fried), 3 parts of nutmeg (roasted), 13 parts of perilla leaf, 6 parts of radix paeoniae alba, 25 parts of mangnolia officinalis (prepared), 6 parts of clove, 13 parts of bitter almond, 8 parts of galangal, 18 parts of rhizoma atractylodis macrocephalae (fried), 13 parts of radix angelicae, 6 parts of rhizoma alismatis, 13 parts of yam, 6 parts of ephedra, 21 parts of pogoste;

d. and c, mixing the dry paste powder obtained in the step a and the crude drug powder obtained in the step c, adding 25 parts of flour and 6.2 parts of red yeast powder into each 100 parts of dry paste powder and crude drug powder, uniformly mixing, adding the concentrated solution obtained in the step b, stirring to prepare a soft material, pressing the soft material into blocks in a die plate sprayed with white yeast powder, fermenting, drying and brushing to obtain the traditional Chinese medicine.

By adopting the technical scheme, the fermentation of the three medicated leavens is a beneficial fermentation bacterium generation effect, and incomplete fermentation indicates that the fermentation bacterium does not fully utilize a substrate in a system to play a role, so that the drug effect is reduced after fermentation. Therefore, 16 medicinal materials which can possibly inhibit the fermentation effect are extracted and dried to form dry paste, the dry paste is crushed to form dry paste powder, the obtained fermentation effect is better than that of the existing fermentation, the fermentation is more sufficient and complete, the hair length grown from the fermented koji blocks is longer, the color is whiter, and after the drying, the white hair is brushed out, the fragrance is stronger, and the drug effect of three medicated leavens is ensured.

Preferably, the production process of the three-element medicated leaven comprises the following steps:

a. weighing 18 parts of rhizoma cyperi (prepared), 9 parts of radix bupleuri, 19 parts of radix scutellariae, 14 parts of pinellia ternate (prepared), 31 parts of semen arecae, 11 parts of star anise, 13 parts of radix gentianae macrophyllae, 20 parts of liquorice, 13 parts of rhizoma kaempferiae, 13 parts of radix linderae, 13 parts of rhizoma nardostachyos, 6 parts of fructus evodiae (prepared), 6 parts of cassia twig, 13 parts of platycodon grandiflorum, 13 parts of elecampane and 9 parts of asarum, decocting the 16 medicinal materials with water for 2 times, adding 8 times of water for the first time, decocting for 2 hours, adding 6 times of water for the second time, decocting for 1 hour, combining the decoctions, filtering by 100 meshes, concentrating the filtrate into clear paste, drying under vacuum reduced pressure to obtain;

b. weighing 15 parts of polygonum hydropiper, 25 parts of ginger, 13 parts of areca peel and 15 parts of sweet wormwood, adding 12 times of water respectively, decocting for 1 time, decocting for 4 hours, filtering by 100 meshes, combining filtrates, and concentrating to a proper amount;

Further, in step b, the filtrate is concentrated to 800 portions of 750-.

By adopting the technical scheme, the concentrated solution is concentrated to 750-800 parts, so that the concentrated solution is convenient to mix with dry paste powder and crude drug powder, the soft material after mixing is moderate in hardness, the soft material is convenient to be pressed into blocks in the impression, the smooth implementation of later-stage fermentation is ensured, and the fermentation is more sufficient and complete.

Furthermore, in the step d, the total using amount of the white yeast powder is 35 parts.

Further, in the step d, the flour is a mixture of flour and corn flour, and the mixing ratio of the flour to the corn flour is 3.5-4.5: 1.

Further, the mixing ratio of the flour to the corn flour is 4: 1.

By adopting the technical scheme, the flour is replaced by the mixed flour of the flour and the corn flour, and the fermentation time is shortened from the original 24 hours to 18 hours under the same fermentation condition by changing the fermentation substrate, so that the fermentation efficiency is improved, and the production cost is reduced. The fermentation effect of the two materials is not different, and the characters of the fermented koji blocks, including the length, the color and the fragrance of the wool, are the same as the characters of the koji blocks obtained after the flour is used as the substrate for fermentation.

Further, in the step d, the fermentation temperature is controlled at 28 +/-2 ℃ and the relative humidity is controlled at 80-90%.

By adopting the technical scheme, the temperature of the fermentation room is controlled to be 28 +/-2 ℃, the relative humidity is controlled to be 80-90%, good fermentation conditions can be provided for fermenting beneficial bacteria, the fermentation is more sufficient and complete, and the characters and the drug effects of the yeast blocks obtained by fermentation are ensured.

Further, in step d, the oxygen concentration of the fermentation is controlled to be 20-22%.

Through adopting above-mentioned technical scheme, the oxygen concentration in the fermentation room has further been injectd in this application, through increase oxygen volume in fermentation process, under the same humiture condition, the fermentation effect is better than the fermentation effect of oxygen concentration in not controlling the fermentation room, has further improved fermented sufficiency and completeness, and the hair length that the yeast after the fermentation piece is grown is very long, and the colour is very white, and after the drying, the brush is clean white hair, and fragrance is very strong.

In summary, the present application has the following beneficial effects:

1. this application is through extracting the stoving and increase the oxygen volume among the fermentation process to the medicinal material that partially restraines the fermentation, makes the fermentation more abundant, more complete, and the hair length that the piece of koji after the fermentation is grown is longer, and the colour is whiter, and after the drying, the white hair of brushing clean, the fragrance is more strong, has guaranteed the drug effect of the three medicated leavens that produce and obtain.

2. According to the application, the flour is changed into the mixed flour of the flour and the corn flour, so that the fermentation time is shortened and the fermentation efficiency is improved on the premise of obtaining the same fermentation effect.

Drawings

FIG. 1 is a graph of a koji block obtained after fermentation by the methods of examples 1 and 2 of the present application;

FIG. 2 is a graph of a koji block obtained after fermentation by the method of example 3 of the present application;

FIG. 3 is a graph of koji obtained after fermentation by the method of examples 4-7 of the present application;

FIG. 4 is a graph of a koji block obtained after fermentation by the method of example 8 of the present application;

FIG. 5 is a plot of the koji obtained after fermentation by the method of comparative example 1 of the present application (first batch);

FIG. 6 is a plot of the koji obtained after fermentation according to comparative example 1 of the present application (second batch).

Detailed Description

The present application will be described in further detail with reference to the following drawings and examples.

Example 1

a. weighing 18g of rhizoma cyperi (prepared), 9g of radix bupleuri, 19g of radix scutellariae, 14g of pinellia ternate (prepared), 31g of semen arecae, 11g of fructus anisi stellati, 13g of radix gentianae macrophyllae, 20g of liquorice, 13g of rhizoma kaempferiae, 13g of radix linderae, 13g of rhizoma nardostachyos, 6g of fructus evodiae (prepared), 6g of cassia twig, 13g of radix platycodi, 13g of elecampane and 9g of asarum, decocting the 16 medicinal materials with water for 2 times, adding 7 times of water for the first time, decocting for 1.5 hours, adding 7 times of water for the second time, decocting for 1.5 hours, combining the decoctions, filtering by a sieve of 100 meshes, concentrating the filtrate into clear paste, drying the clear paste;

b. weighing 15g of polygonum hydropiper, 25g of ginger, 13g of areca peel and 15g of sweet wormwood, adding 11 times of water respectively, decocting for 1 time, decocting for 3.5 hours, filtering by a 100-mesh sieve, combining filtrates, and concentrating to 750 g;

c. weighing 50g of poria cocos, 13g of radix peucedani, 16g of radix sileris, 19g of negundo chastetree fruit, 13g of ligusticum wallichii, 16g of fennel, 6g of cassia seed, 25g of hawthorn (fried), 31g of dried orange peel, 75g of medicated leaven (fried), 6g of galangal, 13g of schizonepeta, 13g of rhizoma dioscoreae hypoglaucae, 13g of elsholtzia, 16g of notopterygium root, 25g of costus root, 25g of malt (fried), 19g of fructus aurantii (fried), 3g of nutmeg (roasted), 13g of perilla leaf, 6g of radix paeoniae alba, 25g of mangnolia officinalis (prepared), 6g of clove, 13g of bitter almond, 8g of galangal, 18g of rhizoma atractylodis macrocephalae (fried), 13g of radix angelicae, 6g of rhizoma alismatis, 13g of yam, 6g of ephedra, 21g of pogoste;

d. mixing the dry extract powder obtained in the step a and the crude drug powder obtained in the step c, adding 25g of flour and 6.2g of red yeast powder into each 100g of dry extract powder and crude drug powder, uniformly mixing, adding the concentrated solution obtained in the step b, stirring to prepare a soft material, pressing into blocks in a die sprayed with white yeast powder, controlling the total using amount of the white yeast powder in the die to be 35g, controlling the temperature in a fermentation room to be 30 ℃ and the relative humidity to be 80%, fermenting for 24h, drying and brushing to obtain the traditional Chinese medicine.

Example 2

a. weighing 18g of rhizoma cyperi (prepared), 9g of radix bupleuri, 19g of radix scutellariae, 14g of pinellia ternate (prepared), 31g of semen arecae, 11g of fructus anisi stellati, 13g of radix gentianae macrophyllae, 20g of liquorice, 13g of rhizoma kaempferiae, 13g of radix linderae, 13g of rhizoma nardostachyos, 6g of fructus evodiae (prepared), 6g of cassia twig, 13g of radix platycodi, 13g of elecampane and 9g of asarum, decocting the 16 medicinal materials with water for 2 times, adding 9 times of water for the first time, decocting for 2.5 hours, adding 5 times of water for the second time, decocting for 0.5 hour, combining the decoctions, filtering by a sieve of 100 meshes, concentrating the filtrate into clear paste, drying the clear paste;

b. weighing 15g of polygonum hydropiper, 25g of ginger, 13g of areca peel and 15g of sweet wormwood, adding 13 times of water respectively, decocting for 1 time, decocting for 4.5 hours, filtering by a 100-mesh sieve, combining filtrates, and concentrating to 800 g;

d. mixing the dry extract powder obtained in the step a and the crude drug powder obtained in the step c, adding 25g of flour and 6.2g of red yeast powder into each 100g of dry extract powder and crude drug powder, uniformly mixing, adding the concentrated solution obtained in the step b, stirring to prepare a soft material, pressing into blocks in a die sprayed with white yeast powder, controlling the total using amount of the white yeast powder in the die to be 35g, controlling the temperature of a fermentation room to be 26 ℃ and the relative humidity to be 90%, fermenting for 24h, drying and brushing to obtain the traditional Chinese medicine composition.

FIG. 1 is a graph of koji blocks obtained after fermentation in examples 1 and 2, wherein the left side is the koji block obtained by fermentation in example 1 and the right side is the koji block obtained by fermentation in example 2. As can be seen from FIG. 1, the koji obtained after fermentation in examples 1 and 2 showed longer hair length and whiter color, and white hair interconnection was formed between the two koji compared with comparative example 1. After the yeast blocks are dried, white hair is brushed off, and the fragrance is stronger. Experimental results show that after medicinal materials which can inhibit the fermentation effect are extracted and dried, the fermentation effect is improved, and the fermentation is more sufficient and complete.

Example 3

a. weighing 18g of rhizoma cyperi (prepared), 9g of radix bupleuri, 19g of radix scutellariae, 14g of pinellia ternate (prepared), 31g of semen arecae, 11g of star anise, 13g of radix gentianae macrophyllae, 20g of liquorice, 13g of rhizoma kaempferiae, 13g of radix linderae, 13g of rhizoma nardostachyos, 6g of fructus evodiae (prepared), 6g of cassia twig, 13g of radix platycodi, 13g of elecampane and 9g of asarum, decocting the 16 medicinal materials with water for 2 times, adding 8 times of water for the first time, decocting for 2 hours, adding 6 times of water for the second time, decocting for 1 hour, combining the decoctions, filtering by a sieve of 100 meshes, concentrating the filtrate into clear paste, drying under vacuum reduced pressure to;

b. weighing 15g of polygonum hydropiper, 25g of ginger, 13g of areca peel and 15g of sweet wormwood, adding 12 times of water respectively, decocting for 1 time, decocting for 4 hours, filtering by a 100-mesh sieve, combining filtrates, and concentrating to 780 g;

d. mixing the dry extract powder obtained in the step a and the crude drug powder obtained in the step c, adding 25g of flour and 6.2g of red yeast powder into each 100g of dry extract powder and crude drug powder, uniformly mixing, adding the concentrated solution obtained in the step b, stirring to prepare a soft material, pressing into blocks in a die sprayed with white yeast powder, controlling the total using amount of the white yeast powder in the die to be 35g, controlling the temperature of a fermentation room to be 28 ℃ and the relative humidity to be 85%, fermenting for 24 hours, drying and brushing to obtain the traditional Chinese medicine.

FIG. 2 is a graph of a koji block obtained after fermentation by the method of example 3. As can be seen from FIG. 2, the koji obtained after fermentation in example 3 showed longer hair length and whiter color, and white hair was formed between the two koji compared with comparative example 1. After the yeast blocks are dried, white hair is brushed off, and the fragrance is stronger. Experimental results show that after medicinal materials which can inhibit the fermentation effect are extracted and dried, the fermentation effect is better, and the fermentation is more sufficient and complete.

Example 4

The production process of the three-element medicated leaven is different from the production process of the embodiment 1 in that: in the step d, the flour is a mixture of flour and corn flour, wherein the flour is 19.44g, and the corn flour is 5.56 g; the fermentation time is controlled at 18 h.

Example 5

The production process of the three-element medicated leaven is different from the production process of the embodiment 2 in that: in the step d, the flour is a mixture of flour and corn flour, wherein the flour is 20.45g, the corn flour is 4.55g, and the fermentation time is controlled to be 18 h.

Example 6

The difference between the production process of the three-medicine medicated leaven and the embodiment 3 is that: in the step d, the flour is a mixture of flour and corn flour, wherein 20g of flour and 5g of corn flour are used, and the fermentation time is controlled to be 18 h.

Example 7

The difference between the production process of the three-medicine medicated leaven and the embodiment 3 is that: in the step d, the oxygen concentration in the fermentation process is controlled at 20%, and the fermentation time is controlled at 24 h.

FIG. 3 is a graph of koji blocks obtained after fermentation by the processes of examples 4-7, wherein the left side of the first row is koji blocks obtained by fermentation of example 4; the right side of the first row is the koji obtained by fermentation in example 5; the second row is the koji obtained by fermentation in example 6; the third row is the koji obtained by fermentation of example 7.

As can be seen from FIG. 3, although examples 4-6 shorten the fermentation time, a koji having a whiter color with no surface blackening or black spots can be obtained after the fermentation. The experimental results show that compared with the examples 1-3, the fermentation effect can be ensured, the fermentation time can be shortened, and the fermentation efficiency can be improved by changing the components and the proportion of the substrate.

As can also be seen from FIG. 3, the surface color of the koji obtained after fermentation in example 7 was very white with no blackening or black spots. The experimental results show that the fermentation effect is further improved by increasing the amount of oxygen during the fermentation process under the same temperature and humidity conditions as in example 3.

Example 8

The production process of the three-element medicated leaven is different from the production process of the embodiment 6 in that: in the step d, the oxygen concentration in the fermentation process is controlled at 22%, and the fermentation time is controlled at 18 h.

FIG. 4 is a graph of a koji block obtained after fermentation by the method of example 8. As can be seen from FIG. 4, not only the fermentation time was shortened, but also the surface color of the koji obtained after fermentation was very white, without blackening or black spots, and the hair grown on the surface of the koji was very long, and very significant white hair was formed between the two koji as compared with comparative example 1; after the yeast blocks are dried, white hair is brushed off, and the fragrance is very strong. The experimental result shows that the problem of unobvious fermentation effect is solved by changing the fermentation conditions, including extracting and drying the medicinal materials which partially inhibit the fermentation and increasing the oxygen amount during the fermentation; the substrate is completely flour, and is changed into flour and corn flour which are mixed, so that the good effects of shortening the fermentation time and improving the fermentation efficiency are achieved.

Comparative example 1

a. weighing 15g of polygonum hydropiper, 25g of ginger, 13g of areca peel and 15g of sweet wormwood, adding 12 times of water respectively, decocting for 1 time, decocting for 4 hours, filtering by a 100-mesh sieve, combining filtrates, and concentrating to 780 g;

b. weighing 50g of poria cocos, 13g of radix peucedani, 18g of rhizoma cyperi (prepared), 16g of radix saposhnikoviae, 9g of radix bupleuri, 19g of negundo chastetree fruit, 19g of radix scutellariae, 13g of ligusticum wallichii, 16g of fennel, 14g of pinellia ternate (prepared), 6g of cassia seed, 31g of areca nut, 25g of hawthorn fruit (fried), 11g of star anise, 31g of dried orange peel, 13g of large-leaf gentian root, 75g of medicated leaven (fried), 20g of liquorice, 6g of galangal, 13g of schizonepeta, 13g of rhizoma dioscoreae hypoglaucae, 13g of rhizoma kaempferiae, 13g of elsholtzia, 16g of notopterygium root, 13g of combined spicebush root, 13g of nard, 25g of costus root, 25g of malt (fried), 6g of fructus evodiae (prepared), 19g of fructus aurantii (fried), 3g of nutmeg (prepared), 13g of perilla leaf, 6g of white peony root, 6g of cassia twig, 25g of mangnolia officinalis (prepared), 6g of clove, 13g of elecampane inula root, 6g of ephedra, 9g of asarum, 21g of patchouli and 13g of mint, crushing into coarse powder, sieving with a 60-mesh sieve, and uniformly mixing;

c. adding 25g of flour and 6.2g of red yeast rice powder into 100g of crude drug powder obtained in the step b, uniformly mixing, adding the concentrated solution obtained in the step a, stirring to prepare a soft material, pressing into blocks in a die plate sprayed with white yeast rice powder, controlling the total amount of the white yeast rice powder in the die plate to be 35g, controlling the temperature in a fermentation room to be 28 ℃ and the relative humidity to be 85%, fermenting, drying and brushing to obtain the finished product.

FIGS. 5 and 6 are graphs of koji obtained after fermentation in the method of comparative example 1. As can be seen from FIGS. 5 and 6, the fermented koji had black surface and black spots, and no fuzz was formed on the surface of the koji and between the koji and the koji.

The embodiments of the present invention are preferred embodiments of the present application, and the scope of protection of the present application is not limited by the embodiments, so: all equivalent changes made according to the structure, shape and principle of the present application shall be covered by the protection scope of the present application.

Claims

1. A production process of three-element medicated leaven is characterized by comprising the following steps:

a. weighing 18 parts of rhizoma cyperi (prepared), 9 parts of radix bupleuri, 19 parts of radix scutellariae, 14 parts of pinellia ternate (prepared), 31 parts of semen arecae, 11 parts of star anise, 13 parts of radix gentianae macrophyllae, 20 parts of liquorice, 13 parts of rhizoma kaempferiae, 13 parts of radix linderae, 13 parts of rhizoma nardostachyos, 6 parts of fructus evodiae (prepared), 6 parts of cassia twig, 13 parts of platycodon grandiflorum, 13 parts of elecampane and 9 parts of asarum, decocting the 16 medicinal materials with water for 2 times, adding 7-9 times of water for the first time, decocting for 1.5-2.5 hours, adding 5-7 times of water for the second time, decocting for 0.5-1.5 hours, combining the decoctions for two times, filtering by a sieve of 100 meshes, concentrating the filtrate into clear paste, drying;

2. The process for producing a three-element medicated leaven according to claim 1, which comprises the following steps:

3. The process according to claim 1 or 2, wherein in step b, the filtrate is concentrated to 750-800 parts.

4. The process for producing a three-element medicated leaven according to claim 1 or 2, wherein the total amount of the white leaven powder used in step d is 35 parts.

5. The process for producing a three-element medicated leaven according to claim 1 or 2, wherein in the step d, the flour is a mixture of flour and corn flour, and the mixing ratio of the flour to the corn flour is 3.5-4.5: 1.

6. The process for producing a three-element medicated leaven as claimed in claim 5, wherein the mixing ratio of the flour to the corn flour is 4: 1.

7. The process for producing a trigeminal medicated leaven according to claim 1 or 2, wherein the fermentation temperature is controlled at 28 ± 2 ℃ and the relative humidity is controlled at 80-90% in step d.

8. The process for producing a medicated leaven according to any one of claims 1, 2 and 6, wherein the concentration of oxygen in the fermentation in step d is controlled to be 20 to 22%.