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CN111683703A - 适用于不同尺寸的药筒的注射器 - Google Patents

适用于不同尺寸的药筒的注射器 Download PDF

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CN111683703A
CN111683703A CN201880087763.0A CN201880087763A CN111683703A CN 111683703 A CN111683703 A CN 111683703A CN 201880087763 A CN201880087763 A CN 201880087763A CN 111683703 A CN111683703 A CN 111683703A
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CN111683703B (zh
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约西·巴尔艾尔
伊格尔·伊萨科夫
里奥·巴尔琴
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Sishi Pharmaceutical Packaging Israel Co ltd
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
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    • A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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    • A61M5/345—Adaptors positioned between needle hub and syringe nozzle
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    • A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
    • A—HUMAN NECESSITIES
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    • A61M2005/2433—Ampoule fixed to ampoule holder
    • A61M2005/2437—Ampoule fixed to ampoule holder by clamping means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2433—Ampoule fixed to ampoule holder
    • A61M2005/2437—Ampoule fixed to ampoule holder by clamping means
    • A61M2005/244—Ampoule fixed to ampoule holder by clamping means by flexible clip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
    • A61M2005/247—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase with fixed or steady piercing means, e.g. piercing under movement of ampoule

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Abstract

一种注射器，包括主体、可移动地安装到主体的注射针和主体内的通道，通道的尺寸被设计成在通道内容纳第一药筒或不同尺寸的第二药筒。通道包括安装在远端的耦合器，耦合器可与第一药筒或第二药筒接合以与注射针流体连通。至少两个适配器卡圈安装在通道中。第一适配器卡圈被配置成在插入到通道中时容纳穿过该第一适配器卡圈的两个药筒中的任一个，并且被配置成接合第一药筒的一部分以将第一药筒稳定在通道中。第二适配器卡圈也被配置成在插入到通道中时容纳穿过该第二适配器卡圈的两个药筒中的任一个，但被配置成接合第二药筒的一部分以将第二药筒稳定在所述通道中。

Description

适用于不同尺寸的药筒的注射器
相关申请的交叉引用
本申请要求2017年12月22日提交的标题为“具有用于保护隔膜穿刺针免受指状件刺伤的集成护罩的引导药筒的适配器”的美国临时专利申请62/609,740的优先权，其全部内容通过引用并入本文。
技术领域
本公开总体上涉及一种装载有药筒的注射器，并且更具体地，涉及一种与不同尺寸的药筒兼容使用的注射器。
背景技术
注射器(例如药物注射器等)通常装载有含有待分配的物质的药筒。药筒可以在交付给用户之前被预先装载，或者替代地，药筒可以在使用之前由用户装载。药筒以不同的尺码和尺寸来制造和销售。此外，即使通过相同的工艺制造的药筒也会经受尺寸的变化，即制造公差。用于形成药筒的一种或更多种制造工艺和材料造成了制造公差。例如，玻璃药筒通常形成具有较低的精度，并且因此，与模制聚合物形成的药筒相比，在药筒之间具有更大的变化，模制聚合物形成的药筒通常形成在药筒之间具有较大精度和较小变化。然而，在制药工业中，例如玻璃药筒仍然更普遍。
传统注射器的一个缺点是它们通常被制造成与特定的相应药筒一起操作。此外，如果形成的药筒表现出与预期尺寸的变化太大，则打算与特定注射器一起工作的较低精度药筒可能无法与注射器一起使用。
因此，制造一种配置成可适用于多个不同尺寸的药筒和经受较大制造公差的药筒的注射器将是有利的。
发明内容
简言之，本公开的一个方面涉及一种注射器，所述注射器包括主体和注射针，所述注射针可移动地安装到所述主体。所述注射针能够在缩回位置和注射位置之间移位。所述主体内的通道的尺寸被设计成用于在其内独立地容纳第一药筒或径向不同尺寸的第二药筒中的任一个。所述通道包括近端开口和耦合器，所述近端开口用于容纳穿过所述近端开口的第一药筒或第二药筒，所述耦合器安装在所述通道的远端并且能够与所述第一药筒或所述第二药筒接合以用于将所述第一药筒或所述第二药筒与所述注射针流体连通。至少两个适配器卡圈安装在所述通道中。所述至少两个适配器卡圈中的第一适配器卡圈被配置成在将所述第一药筒或所述第二药筒插入所述通道中时容纳穿过所述第一适配器卡圈的第一药筒或第二药筒中的一个，并且所述至少两个适配器卡圈中的第一适配器卡圈被配置成接合所述第一药筒的一部分以将所述第一药筒稳定在所述通道中。所述至少两个适配器卡圈中的第二适配器卡圈被配置成在将所述第一药筒或所述第二药筒插入所述通道中时容纳穿过所述第二适配器卡圈的第一药筒或第二药筒中的任一个，并且所述至少两个适配器卡圈中的第二适配器卡圈被配置成接合所述第二药筒的一部分以将所述第二药筒稳定在所述通道中。
本发明的另一方面涉及一种注射器，所述注射器包括主体和注射针，所述注射针可移动地安装到所述主体。所述注射针能够在缩回位置和注射位置之间移位。在所述主体内用于容纳药筒的通道包括近端开口和耦合器，所述近端开口用于容纳穿过所述通道的药筒，所述耦合器安装在所述通道的远端并且能够与所述药筒接合以用于将所述药筒与所述注射针流体连通。适配器卡圈安装在所述通道中并被配置成在所述药筒插入所述适配器卡圈中时容纳穿过所述适配器卡圈的药筒，并且所述适配器卡圈被配置成接合药筒的一部分以将所述药筒稳定在所述通道中。所述适配器卡圈包括圆盘和从所述圆盘伸入的成角度地间隔开的多个悬臂式指状件。在所述药筒推进穿过圆盘时，所述指状件定向在覆盖所述耦合器的、无偏置的且径向向内伸入的闭合位置，并且所述指状件能够通过所述药筒相对于彼此向远端和径向向外偏转到露出所述耦合器的打开位置。
本发明的另一方面涉及一种注射器装置套件，所述注射器装置套件包括注射器和多个适配器卡圈。所述注射器包括主体和注射针，所述注射针可移动地安装到所述主体。所述注射针能够在缩回位置和注射位置之间移位。所述主体内的通道的尺寸被设计成独立地容纳多个径向不同尺寸的药筒中的任一个。所述通道包括近端开口和药筒穿刺针，所述近端开口用于容纳穿过所述近端开口的药筒，所述药筒穿刺针安装在所述通道的远端并伸入到所述通道中，所述药筒穿刺针与所述注射针流体连通，并能够与所述药筒接合以将所述药筒与所述注射针流体连通。每个多个适配器卡圈可拆卸地安装在所述通道中，每个所述适配器卡圈被配置成容纳穿过所述适配器卡圈的多个径向不同尺寸的药筒中的对应一个药筒，并且每个适配器卡圈接合所述药筒的一部分以将所述药筒稳定在所述通道中，并使所述药筒与所述药筒穿刺针基本上同轴地对准。在所述通道内安装相应的适配器卡圈使得所述注射器能够与各自对应的药筒一起使用。
附图说明
当结合附图阅读时，将更好地理解本公开的各方面的以下详细描述。然而，应当理解，本发明不限于所示的精确布置和手段。在附图中：
图1为根据本公开的实施例的可穿戴式注射器的俯视透视图和主视透视图；
图2为沿图1的剖面线2-2截取的图1的注射器的剖视图，其中激活按钮组件处于其未致动位置，并且注射针处于其回缩位置；
图3为沿图1的剖面线2-2截取的图1的注射器的剖视图，其中激活按钮组件处于其致动位置，注射针处于其注射位置；
图4A为沿图1的剖面线4-4截取的图1的注射器的局部剖视图，该注射器具有安装在其中的适配器卡圈，该适配器卡圈的悬臂式指状件处于闭合位置；
图4B为图4A的局部放大图；
图5为图4A的局部放大图，其中适配器卡圈的悬臂式指状件处于打开位置，并且药筒被注射器的药筒穿刺针刺穿；
图6A为本发明的适配器卡圈的第一配置的透视图，其中其悬臂式指状件处于闭合位置；
图6B为图6A的适配器卡圈的透视图，其中其悬臂式指状件处于打开位置；
图7A为本发明的适配器卡圈的第二配置的透视图，其中其悬臂式指状件处于闭合位置，并且完整的易碎环连接悬臂式指状件；
图7B为图7A的适配器卡圈的透视图，其中其悬臂式指状件处于打开位置，从而使易碎环断裂；
图8A为图1的注射器的药筒门的示意图，具有插入其中的药筒，药筒通过安装在药筒门的内部通道中的两个适配器卡圈中的近端适配器卡圈稳定；
图8B为图1的注射器的药筒门的示意图，具有插入其中的径向不同尺寸的药筒，药筒通过安装在内部通道中的两个适配器卡圈中的远端适配器卡圈稳定；
图9A为图1的注射器的药筒门的示意图，具有插入其中的药筒，药筒通过内部通道稳定；以及
图9B为图1的注射器的药筒门的示意图，具有插入其中的径向不同尺寸的药筒，药筒通过安装在内部通道中的适配器卡圈稳定。
具体实施方式
在以下描述中使用的某些术语只是为了方便而非限制。例如，词语“下”、“底”、“上”和“顶”表示所参考的附图中的方向。根据本发明，词语“向内”、“向外”、“向上”和“向下”分别指朝向和远离注射器的几何中心及其指定部件的方向。除非本文特别提出，术语“一”、“一个”和“该”不限于一个元件，而是应当被理解为表示“至少一个”。术语包括上述词语、其派生词和类似含义的词语。
还应当理解，当涉及本发明的部件的尺寸或特性时，本文所用的术语“大约”、“大致”、“一般地”、“基本上”和类似术语指示所描述的尺寸/特性不是严格的边界或参数，并且不排除功能上类似的从中产生的微小变化。至少，包括数字参数的这种参考包括使用本领域所接受的数学和工业原理(例如，舍入、测量或其它系统误差、制造公差等)不会改变最低有效数字的变化。
详细参考附图，其中相同的附图标记始终表示相同的元件，在图1-图9B中示出了根据本公开的实施例的注射器，总体上标记为10。在所示的实施例中，注射器10采取可穿戴式注射器(贴片注射器)的形式，例如但不限于可穿戴式药物注射器，但本公开不限于此。如本领域普通技术人员应当理解的，注射器10主要包括主体11。主体11包括具有第一表面14的主壳体12，第一表面14被配置成接触用户(未示出)(例如患者)的皮肤表面，第一表面14中具有开口14a。在所示的实施例中，第一表面14限定注射器主壳体12的基部表面，但是本公开不限于此。主壳体12还包括与第一表面14相对的第二表面16。在所示实施例中，第二表面16限定注射器主壳体12的顶部外表面，但是本公开不限于此。
如图2-图3所示，例如由聚合物或金属材料、其组合等构成的针座18可移动地安装在注射器主体11的主壳体12内，并且注射针20以本领域普通技术人员公知的方式通过可移动针座18支撑。在所示的实施例中，针座18和注射针20可在缩回位置(图2)和注射位置(图3)之间沿基本上垂直于第一表面14延伸的轴线A(图2)的方向轴向平移(或以其它方式移位)，在缩回位置，其中注射针20的至少一个尖端20a容纳在注射器主壳体12内，在注射位置，其中注射针20的至少一个尖端20a通过开口14a从注射器主壳体12伸入。然而，本领域普通技术人员应当理解，轴线A可以相对于第一表面14以90°以外的角度定位。还应当理解，注射针20可以通过除了针座18之外的机构可移动地安装在注射器主壳体12内。
在一些实施例中，例如由聚合物或金属材料、其组合等构成的可压下的激活按钮组件22可移动地安装到注射器主壳体12上并且可操作地连接到注射针20上。激活按钮组件22可以以本领域普通技术人员公知的方式沿着按钮轴线B(图2)从未致动位置(图1、图2)平移(即可压下)到致动位置(图3)，以启动注射器10。在一个实施例中，按钮轴线B可以平行于轴线A，但是本公开不限于此。注射器10的激活包括例如将注射针20从其缩回位置驱动到其注射位置以执行注射。
偏置构件24可以与激活按钮组件22和注射针20(图2、图3)可操作地连接，但是本公开不限于此。作为一个替代实施例，偏置构件24可与第二表面16和注射针20连接。偏置构件24在激活按钮组件22的未致动位置(图2)稳定在储能状态，并且当激活按钮组件22平移到其致动位置(图3)时，释放到能量释放状态，以沿着轴线A的方向将注射针20从其缩回位置驱动到其注射位置。如本领域普通技术人员应当理解的，偏置构件24的存储能量状态是偏置构件24存储至少一些势能的状态。偏置构件24的能量释放状态是偏置构件24从存储能量状态释放至少一些先前存储的势能的偏置构件24的状态。
在一个实施例中，偏置构件24可以采取安装在针座18和激活按钮组件22之间的螺旋弹簧的形式，即，弹簧24在一端邻接激活按钮组件22，并且在相对端邻接针座18。在能量存储状态下，螺旋弹簧24至少部分地被压缩。在能量释放状态中，螺旋弹簧24伸展(相对于至少部分压缩的能量存储状态)以将针座18和注射针20驱动到其注射位置。然而，如本领域普通技术人员应当理解的那样，偏置构件24可以替代地采取能够存储和释放能量的其它构件的形式。非限制性示例包括其它弹簧(例如，扭转弹簧或片簧)、弹性带等。替代地，偏置构件24可以采取机电或气动致动器的形式被配置成当激活按钮组件22被压入到其致动位置时将平移力施加到注射针20上。
注射器主体11还包括药筒门26，该药筒门26在打开位置(未示出)和闭合位置(图1)之间可移动地(例如可枢转地)安装到注射器主壳体12。如图4A所示，药筒门26包括近端开口端26a和内部通道26b，近端开口端26a和内部通道26b用于在其中容纳(在门的打开位置)多个不同尺寸的药筒28中的一个，例如至少第一药筒28’或不同尺寸的第二药筒28”，例如径向不同(如下文将更详细描述的，参见例如图8A-图9B)。应当理解，适用于注射器10的药筒28包括储存器28a，储存器28a包含有待通过注射针20从注射器10分配的物质(未示出)，例如药物，并且具有第一远端开口，第一远端开口以本领域普通技术人员公知的方式通过可刺穿隔膜29密封。
药筒门26还包括安装在内部通道26b内的耦合器26c。在所示的实施例中，耦合器26c采取药筒穿刺针26c的形式，但是本公开不限于此。如图8A-图9B示意性所示，药筒穿刺针26c以本领域普通技术人员公知的方式流体连接到注射针20，例如，经由从穿刺针26c延伸到注射针20的柔性管(在图4B、图5中部分示出)。在所示实施例中，药筒穿刺针26c定位成靠近内部通道26b的封闭远端，与近端开口端26a相对(图4A、图8A-图9B)。药筒穿刺针26c向内延伸到内部通道26b中，并终止于针26c的尖端，尖端定位成当药筒28插入到药筒门26中时，面向药筒28的可刺穿隔膜29并与之对准。药筒穿刺针26c被配置成完全穿透药筒28的可刺穿隔膜29，以在药筒28充分插入到内部通道26b中时和/或在注射器10被激活时使药筒28内的物质与注射针20流体连接。
如图4-图5所示，至少一个适配器卡圈30、30’可安装在内部通道26b内(大致横向于药筒插入通道的方向上)。适配器卡圈30、30’被配置为(即尺寸和大小被设计为)在将药筒28插入内部通道26b时，容纳从该适配器卡圈穿过的适用于注射器10的任何药筒28，并且被配置为接合特定尺寸的相应药筒28的一部分以将药筒28稳定在内部通道26b中。
在一种配置中，如图6A-图6B所示，适配器卡圈30包括圆盘32和多个成角度间隔开的肋34，肋34从圆盘32径向向内伸入到内部通道26B中。在所示实施例中，适配器卡圈30包括三个肋34，三个肋34围绕圆盘32的内部大体上等角度地间隔开，但本公开不限于此。肋34的尺寸、大小和配置基本上相同，以使相应的药筒28接合并稳定在与药筒穿刺针26c对准(例如基本上同轴)的位置。
在一种配置中，如图6A-图6B所示，一个或更多个肋34中的每一个包括从圆盘32基本径向向内伸入的第一段34a、从第一段34a基本向远端(即，朝向药筒穿刺针26c)伸入的第二段34b和从第二段34b基本径向向内伸入的第三段34c。第一段34a和第三段34c也可以在肋34与药筒28接合时稍微向远端倾斜和/或向远端弯曲，以更好地将药筒28与药筒穿刺针26c对准。然而，本领域普通技术人员应当理解，肋34可以采用能够执行本文所述肋34的功能的替代配置。
在一些实施例中，适配器卡圈30也可以包括多个从圆盘32伸入的成角度地间隔开的悬臂式指状件36。在所示实施例中，适配器卡圈30包括围绕圆盘32的内部大体上等角度间隔开的三个指状件36，但是本公开不限于此。如图4A、图4B和图6A所示，当药筒28未偏置时，即当药筒28还没有推进通过指状件36时，指状件36被定向在径向向内伸入的闭合位置。指状件36的尺寸被设定成使得当处于闭合位置时指状件36覆盖药筒穿刺针26c。例如，指状件36可径向向内延伸接近圆盘32的中心轴线。因此，在其闭合位置，指状件36有助于防止药筒穿刺针26c与用户的手/手指(或用户身体的其它部位)之间的接触，并因此有助于防止针刺伤害。
如图5和图6B所示，在药筒28推进超过圆盘32时，悬臂式指状件36可彼此相对地向远端和径向向外(通常在指状件36和圆盘32之间的界面处)偏转到露出药筒穿刺针26c的打开位置。也就是说，在药筒28推进超过处于闭合位置处的指状件36的位置时，药筒28使指状件36偏转到其打开位置，从而露出药筒穿刺针26c，以穿透药筒28的隔膜29。
在一种配置中，如图6A-图6B所示，一个或更多个指状件36中的每一个包括第一段36a，其主要从圆盘32径向向内伸入。第一段36a和圆盘32之间的界面可以限定例如活动铰链，该活动铰链具有自然偏置，以在没有来自药筒28的外力时定位在闭合位置。第二段36b主要从第一段36a向远端伸入，第三段36c主要从第二段36b径向向内伸出。第四段36d可进一步径向向内伸入，并且也从第三段36c向近端伸入，以在药筒穿刺针26c上方提供额外的垂直间隙。段36a-36d中的一个或更多个也可以在它们之间的相应界面处限定活动铰链，以向指状件36提供额外的柔性。应当理解，段36a-36d的长度相当于用于使指状件36偏转的力矩臂。因此，段36a-36d的长度通常被配置成设定药筒28将指状件36从其闭合位置偏转到其打开位置所需的推进力。本领域普通技术人员还应当理解，指状件36可以采用能够执行本文所述的指状件36的功能的替代配置。
图7A-图7B示出了适配器卡圈30’的替代配置。该配置与图6A-图6B的配置相似，并且因此，为了简洁和方便，在此省略了对图7A-图7B和图6A-图6B的配置之间的某些相似性的描述，因此，该描述不是限制性的。
适配器卡圈30’与适配器卡圈30(如图所示)的一个区别在于，增加了易碎(即有意破坏的)构件38，易碎构件38在闭合位置将悬臂式指状件36’彼此连接。在示出的实施例中，易碎构件38采取易碎环的形式，但是本公开不限于此。如图7A最佳所示，易碎环38包括至少一个刻痕段38a(例如每个悬臂式指状件36’之间的刻痕段38a)限定环38的有意破坏段(图7B)。如本领域普通技术人员应当理解的那样，易碎环38的刻痕段38a限定易碎环38的预置破断力，为了使指状件36’彼此分离和断开以及使指状件36’从其闭合位置偏转到打开位置，必须超过该预置破断力以使环38分离和断开。如应理解的，适配器卡圈30的指状件36也可通过易碎构件连接，与连接适配器卡圈30’的指状件36’的易碎构件38类似。
在适配器卡圈30’的一种配置中，一个或更多个肋34’采取大致弧形构件的形式，该弧形构件从圆盘32径向向内且向远端延伸，其具有面向圆盘32的中心轴线的凸面，但本公开不限于此。另外，或可选地，一个或更多个悬臂式指状件36’限定大致S-形曲线轮廓，从圆盘32径向向内和向远端延伸(有助于药筒28导入)，但本公开不限于此。
如图4A-图5最佳所示，至少一个适配器卡圈30、30’安装在内部通道26b内。在一种配置中，适配器卡圈30、30’可以可拆卸地安装在内部通道26b中(在不损坏卡圈30、30’和/或内部通道26b的情况下有意地拆卸)。例如，内部通道26b可包括从内部通道26b的侧壁伸入的径向向内延伸的环形唇缘40，或者从内部通道26b的侧壁伸入的径向向内延伸的唇缘段40，其围绕侧壁成角度地间隔开(在基本相同的平面内)，适配器卡圈30、30’可支撑在唇缘段40上。替代地或附加地，适配器卡圈30、30’可通过与内部通道26b的侧壁摩擦配合而安装在内部通道26b内。在一个实施例中，适配器卡圈30、30’可包括在其圆盘32中的安装槽32a，安装槽32a用于接收环形唇缘段40。然而，如本领域普通技术人员应当理解的，适配器卡圈30、30’可通过目前已知或以后变为已知的多种安装方式中的任一种可拆卸地安装在内部通道26b内。替代地，适配器卡圈30、30’可以永久地(即，在不损坏卡圈30、30’和/或内部通道26b的情况下有意地拆卸)安装在内部通道26b中或与内部通道26b一体形成。对于具有更多于一个适配器卡圈30、30’安装在其内部通道26b中的注射器10(如将在下面进一步详细讨论的)，适配器卡圈30、30’可以整体地、永久地或可拆卸地或其任何组合安装在其中。
在使用中，注射器10包括至少一个安装在内部通道26b中的适配器卡圈30、30’，适配器卡圈30、30’对应于打算与注射器10一起使用的药筒28(图4A、图4B)。药筒28经由其近端开口端26a插入内部通道26b，并推进穿过适配器卡圈30、30’，并与药筒穿刺针26c接合(图5)，即刺穿隔膜29。适配器卡圈30、30’被配置成(通过肋34、34’的尺寸和大小)与相应药筒28的一部分接合，以将药筒28稳定在内部通道26b中，并使药筒28与药筒穿刺针26c对准，例如基本同轴。在适配器卡圈30、30’包括悬臂式指状件36、36’的配置中，指状件36、36’保护用户不受处于闭合位置的药筒穿刺针26c的意外针刺伤害。在将药筒28插入内部通道26b的过程中，药筒28在推进超过指状件36、36’并与药筒穿刺针26c(图5)接合时，药筒28接合指状件36、36’并使指状件36、36’偏转到其打开位置。
在一些实施例中，注射器10可配置成适用于不同尺寸的药筒28。例如，如图8A-图9B示意性所示，注射器10可配置成与至少两个不同尺寸的药筒一起使用：第一药筒28’和第二药筒28”。因此，内部通道26b的尺寸例如在直径上被设计成容纳第一药筒28’或第二药筒28”中的任一个。
在一个示例性非限制性实施例中，内部通道26c可包括安装在其中的至少两个适配器卡圈30、30’(图8A、图8B中示出的两个适配器卡圈30、30’)。如图8A和图8B的非限制性实施例所示，第一药筒28’可限定相对于第二药筒28”的远端部分径向更大的远端部分，第二药筒28”可限定相对于第一药筒28’的近端部分径向更大的近端部分。因此，相对于第二适配器卡圈30、30’，第一适配器卡圈30、30’安装在内部通道26c的远端。
第一远端适配器卡圈30、30’的尺寸和位置被设置在内部通道26b中，以允许在将药筒插入内部通道26b时第一药筒28’或第二药筒28”中的任一个通过其推进。然而，如图8B所示，第一远端适配器卡圈30、30’的尺寸和位置被设置成仅接合第一药筒28’的远端部分，以将第一药筒28’稳定在内部通道26b内，并将第一药筒28’与药筒穿刺针26c对准。即，如果第二药筒28”与注射器10一起使用，第一远端适配器卡圈30、30’的肋34、34’的大小和尺寸被设计成接合第一药筒28’的远端部分，而不干扰第二药筒28”的较小的远端部分。
类似地，第二近端适配器卡圈30、30’的尺寸和位置也设置在内部通道26b内，以允许在将药筒插入内部通道26b时第一药筒28’或第二药筒28”中的任一个通过其推进。然而，相反地，如图8A所示，第二近端适配器卡圈30、30’的尺寸和位置设置成仅接合第二药筒28”的近端部分，以将第二药筒28”稳定在内部通道26b内，并将第二药筒28”与药筒穿刺针26c对准。即，如果第一药筒28、28’与注射器10一起使用，第二近端适配器卡圈30、30’的肋34、34’的大小和尺寸被设计成接合第二药筒28”的近端部分，而不干涉第一药筒28’。因此，在图8A、图8B的实施例中，第二药筒28”不受安装在内部通道26b内的适配器卡圈30、30’中的任一个的阻碍，并且第一药筒28’也不受安装在内部通道26B内的适配器卡圈30、30’中的任一个的阻碍。然而，由于药筒28’、28”中的任一个可稳定在内部通道26b内并与药筒穿刺针26c对准，两个药筒28’、28”中的任一个可与注射器10一起使用。
在一些实施例中，安装在内部通道26b内的一些适配器卡圈30、30’，(例如最远端的适配器卡圈等)可包括从圆盘32伸入的多个成角度地间隔开的悬臂式指状件36、36’，以帮助防止用户的手/手指(或用户身体部分的其它部分)与药筒穿刺针26c之间的接触，并因此有助于防止针刺伤害。可选地，安装在内部通道26b中的所有或没有适配器卡圈30、30’可包括悬臂式指状件36、36’。
在替代的示例性非限制性实施例中，如图9A和图9B所示，内部通道可仅包括如图8A和图8B所示的远端适配器卡圈30、30’，其以与关于图8A和图8B所述的远端适配器卡圈30、30’类似的方式配置，以将第一药筒28’稳定在内部通道26b中，并将第一药筒28’与药筒穿刺针26c(图9B)对准。相反，内部通道26b本身(即其内部特征)可被配置成将第二药筒28”稳定在内部通道26b中，并将第二药筒28”与药筒穿刺针26c对准(图9A)。例如，但不限于，内部通道26b的尺寸可被设计成或包括药筒托架、药筒轨道、其组合等(未示出)，以在内部通道26b中容纳和稳定药筒28。
在一种配置中，注射器10可以设置为具有多个可拆卸地安装在内部通道26b中的适配器卡圈30、30’的套件。内部通道26b可被配置成容纳多个不同尺寸的药筒28中的任一个，即，尺码和尺寸被设计成容纳那些药筒28中的最大的药筒。所提供的每个适配器卡圈30、30’可被配置为(即，大小和尺寸被设计为)用于与多个不同尺寸的药筒28中的相应一个一起使用，以接合相应药筒28的一部分(与其肋34、34’一起)，从而将药筒28稳定在内部通道26b内，并将药筒28与药筒穿刺针26c对准。替代地或附加地，所提供的适配器卡圈30、30’可以被配置为考虑由于制造公差引起的药筒28之间的变化。因此，用户可将特定的适配器卡圈30、30’安装在内部通道26b中，以使得在将相应的药筒28插入内部通道26b之前，注射器10能够与各自相应的药筒28一起使用。
本领域技术人员将理解，在不偏离本发明的广泛发明构思的情况下，可以对上述实施例进行改变。因此，应当理解，本发明不限于所公开的特定实施例，而是旨在覆盖在如所附权利要求中阐述的本发明的精神和范围内的修改。

Claims (20)

1.一种注射器，包括：
主体；
注射针，所述注射针可移动地安装到所述主体，所述注射针能够在缩回位置和注射位置之间移位；
所述主体内的通道，所述通道的尺寸被设定成用于在其内独立地容纳第一药筒或径向不同尺寸的第二药筒中的任一个，所述通道包括近端开口和耦合器，所述近端开口用于容纳穿过所述近端开口的第一药筒或第二药筒，所述耦合器安装在所述通道的远端并且能够与所述第一药筒或所述第二药筒接合以用于将所述第一药筒或所述第二药筒与所述注射针流体连通；
至少两个适配器卡圈，所述至少两个适配器卡圈安装在所述通道中，
所述至少两个适配器卡圈中的第一适配器卡圈被配置成在将所述第一药筒或所述第二药筒插入所述通道中时容纳穿过所述第一适配器卡圈的第一药筒或第二药筒中的一个，并且所述至少两个适配器卡圈中的第一适配器卡圈被配置成接合所述第一药筒的一部分以将第一药筒稳定在所述通道中，以及
所述至少两个适配器卡圈中的第二适配器卡圈被配置成在将所述第一药筒或所述第二药筒插入所述通道中时容纳穿过所述第二适配器卡圈的第一药筒或第二药筒中的任一个，并且所述至少两个适配器卡圈中的第二适配器卡圈被配置成接合所述第二药筒的一部分以将所述第二药筒稳定在所述通道中。
2.根据权利要求1所述的注射器，其中所述第一适配器卡圈被配置成使所述第一药筒与所述耦合器基本上同轴地对准，并且其中所述第二适配器卡圈被配置成使所述第二药筒与所述耦合器基本上同轴地对准。
3.根据权利要求1或2所述的注射器，其中所述至少两个适配器卡圈中的至少一个可拆卸地安装在所述通道中。
4.根据上述任一权利要求所述的注射器，其中所述第一药筒限定相对于所述第二药筒径向较大的远端部分，并且其中所述第二药筒限定相对于所述第一药筒径向较大的近端部分，并且其中所述第一适配器卡圈相对于所述第二适配器卡圈在所述通道中向远端定位。
5.根据上述任一权利要求所述的注射器，其中所述第一适配器卡圈和所述第二适配器卡圈中的每一个包括圆盘和从各自的圆盘径向向内伸入到所述通道中的、成角度地间隔开的多个肋，所述第一适配器卡圈的肋被配置成接合所述第一药筒的所述一部分，并且所述第二适配器卡圈的肋被配置成接合所述第二药筒的所述一部分。
6.根据上述任一权利要求所述的注射器，其中所述耦合器包括伸入所述通道中的药筒穿刺针，所述药筒穿刺针与所述注射针流体连通。
7.根据权利要求6所述的注射器，其中所述至少两个适配器卡圈中的至少一个包括圆盘和从所述圆盘伸入的成角度间隔开的多个悬臂式指状件，所述指状件被定向在覆盖所述药筒穿刺针的、无偏置的且径向向内伸入的闭合位置，并且在所述第一药筒或所述第二药筒推进穿过所述圆盘时，所述指状件能够通过所述第一药筒或所述第二药筒相对于彼此而向远端和径向向外偏转到露出所述药筒穿刺针的打开位置。
8.根据权利要求7所述的注射器，其中所述悬臂式指状件在所述闭合位置通过易碎构件彼此连接，所述易碎构件限定预设的破断力，所述预设的破断力必须被超过以使所述指状件彼此分离和断开连接，并且使所述指状件从所述闭合位置偏转到所述打开位置。
9.根据权利要求8所述的注射器，其中所述易碎构件包括易碎环。
10.一种注射器，包括：
主体；
注射针，所述注射针可移动地安装到所述主体，所述注射针能够在缩回位置和注射位置之间移位；
在所述主体内的通道，所述通道用于容纳药筒，所述通道包括近端开口和耦合器，所述近端开口用于容纳穿过所述通道的药筒，所述耦合器安装在所述通道的远端并且能够与所述药筒接合以用于将所述药筒与所述注射针流体连通；
适配器卡圈，所述适配器卡圈安装在所述通道中并被配置成在所述药筒插入所述通道中时容纳穿过所述适配器卡圈的药筒，并且所述适配器卡圈被配置成接合所述药筒的一部分以将所述药筒稳定在所述通道中，所述适配器卡圈包括圆盘和从所述圆盘伸入的成角度地间隔开的多个悬臂式指状件，在所述药筒推进穿过所述圆盘时，所述指状件定向在覆盖所述耦合器的、无偏置的且径向向内伸入的闭合位置，并且所述指状件能够通过所述药筒相对于彼此向远端和径向向外偏转到露出所述耦合器的打开位置。
11.根据权利要求10所述的注射器，其中所述适配器卡圈被配置成使所述药筒与所述耦合器基本上同轴地对准。
12.根据权利要求10或11所述的注射器，其中所述耦合器包括伸入所述通道中的药筒穿刺针，所述药筒穿刺针与所述注射针流体连通。
13.根据权利要求10-12中任一项所述的注射器，其中所述悬臂式指状件在所述闭合位置通过易碎构件彼此连接，所述易碎构件限定预设的破断力，所述预设的破断力必须被超过以使所述指状件彼此分离和断开连接并且使所述指状件从所述闭合位置偏转到所述打开位置。
14.根据权利要求13所述的注射器，其中，所述易碎构件包括易碎环。
15.根据权利要求10-14中任一项所述的注射器，其中适配器卡圈可拆卸地安装在所述通道中。
16.根据权利要求10-15中任一项所述的注射器，其中所述适配器卡圈还包括成角度地间隔开的多个肋，所述肋从所述圆盘径向向内伸入到所述通道中，所述肋被配置成接合药筒的所述一部分。
17.一种注射器装置套件，包括：
注射器，具有，
主体；
注射针，所述注射针可移动地安装到所述主体，所述注射针能够在缩回位置和注射位置之间移位；
所述主体内的通道，所述通道的尺寸被设定成用于独立地容纳多个径向不同尺寸的药筒中的任一个，所述通道包括近端开口和药筒穿刺针，所述近端开口用于容纳穿过所述近端开口的药筒，所述药筒穿刺针安装在所述通道的远端并且伸入所述通道中，所述药筒穿刺针与所述注射针流体连通并且能够与所述药筒接合以用于将所述药筒与所述注射针流体连通；以及
多个适配器卡圈，每个所述适配器卡圈可拆卸地安装在所述通道中，每个所述适配器卡圈被配置成容纳穿过所述适配器卡圈的多个径向不同尺寸的药筒中的对应一个药筒，并且每个适配器卡圈接合所述药筒的一部分以将所述药筒稳定在所述通道中，并使所述药筒与所述药筒穿刺针基本上同轴地对准，由此在所述通道中安装各自的适配器卡圈使得所述注射器能够与各自对应的药筒一起使用。
18.根据权利要求17所述的注射器装置套件，其中每个适配器卡圈包括圆盘和从所述圆盘径向向内伸入的成角度地间隔开的多个肋，所述肋被配置成接合对应的药筒的所述一部分。
19.根据权利要求18所述的注射器装置套件，其中每个适配器卡圈还包括从所述圆盘伸入的成角度地间隔开的多个悬臂式指状件，所述指状件定向在覆盖所述药筒穿刺针的、无偏置的且径向向内伸入的闭合位置，并且在所述药筒推进穿过所述圆盘时，所述指状件能够通过对应的药筒而相对于彼此向远端和径向向外偏转到露出所述药筒穿刺针的打开位置。
20.根据权利要求19所述的注射器装置套件，其中每个适配器卡圈的悬臂式指状件在所述闭合位置通过易碎环彼此连接，所述易碎环限定预设的破断力，所述预设的破断力必须被超过以使所述指状件彼此分离和断开连接，并且使所述指状件从所述闭合位置偏转到所述打开位置。
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