[go: up one dir, main page]

MX2016005315A - Sistema de administracion de farmacos con control sensible a la temperatura. - Google Patents

Sistema de administracion de farmacos con control sensible a la temperatura.

Info

Publication number
MX2016005315A
MX2016005315A MX2016005315A MX2016005315A MX2016005315A MX 2016005315 A MX2016005315 A MX 2016005315A MX 2016005315 A MX2016005315 A MX 2016005315A MX 2016005315 A MX2016005315 A MX 2016005315A MX 2016005315 A MX2016005315 A MX 2016005315A
Authority
MX
Mexico
Prior art keywords
temperature
drug delivery
controller
delivery system
coupled
Prior art date
Application number
MX2016005315A
Other languages
English (en)
Inventor
Toy Stephanie
Ka Lai Lee Mark
Tamtoro Ferry
r gibson Scott
Busby Donald
Krishna Suhas
Tan-Malecki Francisca
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2016005315A publication Critical patent/MX2016005315A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/44Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for cooling or heating the devices or media
    • A61M5/445Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for cooling or heating the devices or media the media being heated in the reservoir, e.g. warming bloodbags
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14212Pumping with an aspiration and an expulsion action
    • A61M5/14216Reciprocating piston type
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/162Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033Spring-loaded one-shot injectors with or without automatic needle insertion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/3129Syringe barrels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566Means improving security or handling thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A61M2005/14252Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/02General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0227Materials having sensing or indicating function, e.g. indicating a pressure increase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/18General characteristics of the apparatus with alarm
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/27General characteristics of the apparatus preventing use
    • A61M2205/276General characteristics of the apparatus preventing use preventing unwanted use
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3306Optical measuring means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3306Optical measuring means
    • A61M2205/3313Optical measuring means used specific wavelengths
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3368Temperature
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/36General characteristics of the apparatus related to heating or cooling
    • A61M2205/364General characteristics of the apparatus related to heating or cooling by chemical reaction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/36General characteristics of the apparatus related to heating or cooling
    • A61M2205/3653General characteristics of the apparatus related to heating or cooling by Joule effect, i.e. electric resistance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/36General characteristics of the apparatus related to heating or cooling
    • A61M2205/3673General characteristics of the apparatus related to heating or cooling thermo-electric, e.g. Peltier effect, thermocouples, semi-conductors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/50General characteristics of the apparatus with microprocessors or computers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/50General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502User interfaces, e.g. screens or keyboards
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/58Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/58Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/587Lighting arrangements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/82Internal energy supply devices
    • A61M2205/8206Internal energy supply devices battery-operated

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Un sistema de administración de fármacos incluye un depósito y un dispositivo de administración de fármacos acoplado al depósito. El dispositivo de administración de fármacos también puede incluir al menos un componente sensible a la temperatura y un seguro que tiene estados bloqueados y desbloqueados. El sistema incluye además un dispositivo de salida, y un controlador acoplado al seguro y el dispositivo de salida. El controlador también puede incluir un sensor de temperatura, o puede ser acoplado al sensor de temperatura. El controlador está programado o configurado para determinar si la temperatura de un fármaco en el depósito o del componente sensible a la temperatura excede un límite superior o está por debajo de un límite inferior, y activar el seguro en cualquiera de los casos. El controlador también está programado o configurado para determinar, directa o indirectamente, si la temperatura luego está entre los límites superior e inferior, y desbloquear el seguro como consecuencia.
MX2016005315A 2013-10-24 2014-10-22 Sistema de administracion de farmacos con control sensible a la temperatura. MX2016005315A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361895285P 2013-10-24 2013-10-24
PCT/US2014/061680 WO2015061389A1 (en) 2013-10-24 2014-10-22 Drug delivery system with temperature-sensitive control

Publications (1)

Publication Number Publication Date
MX2016005315A true MX2016005315A (es) 2016-08-11

Family

ID=51845549

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016005315A MX2016005315A (es) 2013-10-24 2014-10-22 Sistema de administracion de farmacos con control sensible a la temperatura.
MX2019011734A MX2019011734A (es) 2013-10-24 2016-04-22 Sistema de administracion de farmacos con control sensible a la temperatura.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019011734A MX2019011734A (es) 2013-10-24 2016-04-22 Sistema de administracion de farmacos con control sensible a la temperatura.

Country Status (7)

Country Link
US (2) US10758683B2 (es)
EP (3) EP3957345B1 (es)
JP (4) JP7051293B2 (es)
AU (2) AU2014340174B2 (es)
CA (2) CA3168888A1 (es)
MX (2) MX2016005315A (es)
WO (1) WO2015061389A1 (es)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9788771B2 (en) 2006-10-23 2017-10-17 Abbott Diabetes Care Inc. Variable speed sensor insertion devices and methods of use
US9743862B2 (en) * 2011-03-31 2017-08-29 Abbott Diabetes Care Inc. Systems and methods for transcutaneously implanting medical devices
ATE480278T1 (de) 2005-09-12 2010-09-15 Unomedical As Einfürungssystem für ein infusionsset mit einem ersten und zweiten federeinheit
BR112012024635A2 (pt) 2010-03-30 2017-08-08 Unomedical As dispositivo médico
US10194938B2 (en) 2011-03-14 2019-02-05 UnoMedical, AS Inserter system with transport protection
US11197689B2 (en) 2011-10-05 2021-12-14 Unomedical A/S Inserter for simultaneous insertion of multiple transcutaneous parts
EP2583715A1 (en) 2011-10-19 2013-04-24 Unomedical A/S Infusion tube system and method for manufacture
CN106999650B (zh) * 2014-09-15 2020-07-24 赛诺菲 具有药剂预加热的皮肤贴片型大体积推注药物注射器
US10765361B2 (en) * 2015-03-02 2020-09-08 Verily Life Sciences Llc Automated sequential injection and blood draw
US10182969B2 (en) 2015-03-10 2019-01-22 Regeneron Pharmaceuticals, Inc. Aseptic piercing system and method
CN107683158B (zh) 2015-06-04 2021-05-14 麦迪麦珀医疗工程有限公司 用于药物释放装置的筒插入
US11207460B2 (en) 2015-12-14 2021-12-28 Amgen Inc. Drug delivery storage device and system
EP3405230A1 (en) 2016-01-19 2018-11-28 Unomedical A/S Cannula and infusion devices
JOP20170042B1 (ar) * 2016-02-12 2022-09-15 Amgen Inc وسيلة توصيل عقار، طريقة تصنيعه وطريقة استخدامه
AU2017248238B2 (en) * 2016-04-08 2022-06-02 Amgen Inc. Drug delivery device
US11238150B2 (en) 2016-05-16 2022-02-01 Amgen Inc. Data encryption in medical devices with limited computational capability
CN110461217B (zh) 2017-01-23 2022-09-16 雅培糖尿病护理公司 用于分析物传感器插入的系统、装置和方法
EP3606579B1 (en) * 2017-04-06 2023-09-06 West Pharmaceutical Services, Inc. Injector with ready to use indicator
BR112019021419A2 (pt) * 2017-04-19 2020-05-05 Medimmune Llc autoinjetores e-conectados
KR102715225B1 (ko) 2017-05-05 2024-10-14 리제너론 파아마슈티컬스, 인크. 자동 주사기
US12194284B2 (en) 2017-05-25 2025-01-14 West Pharmaceutical Services, Inc. Smart syringe using NFC communication and capacitance detection
US20190054247A1 (en) * 2017-08-17 2019-02-21 Qualcomm Incorporated Medicine delivery device
US10869961B2 (en) 2017-11-06 2020-12-22 Sorrel Medical Ltd. Local disinfection for drug delivery system
WO2019126421A1 (en) 2017-12-22 2019-06-27 West Pharma. Services Il., Ltd. Injector usable with different dimension cartridges
DK3860687T3 (da) 2018-10-03 2022-09-12 Lilly Co Eli Statusregistreringssystemer inde i en injektionsanordningsenhed
US11357909B2 (en) 2018-10-05 2022-06-14 Eitan Medical Ltd. Triggering sequence
DE102018126140B4 (de) * 2018-10-22 2023-12-07 Voco Gmbh Vorrichtung mit einem thermochromen Temperaturindikator zur Aufnahme, Erwärmung und Applikation von Dentalmaterialien
JP7390388B2 (ja) 2019-02-26 2023-12-01 ベクトン ディキンソン フランス 可聴表示器付き自動注射器
CA3141608A1 (en) 2019-05-20 2020-11-26 Unomedical A/S Rotatable infusion device and methods thereof
MX2022001112A (es) * 2019-08-01 2022-02-16 Amgen Inc Dispositivo de suministro de farmacos con medicion de la temperatura y metodo relacionado.
US12431230B2 (en) 2019-09-25 2025-09-30 Janssen Pharmaceuticals, Inc. Interconnection of drug administration systems
US20220395640A1 (en) * 2019-11-12 2022-12-15 Quio Technologies Llc Medicament delivery device and medicament delivery device add-on
CN115942909A (zh) 2020-08-31 2023-04-07 雅培糖尿病护理公司 用于分析物传感器插入的系统、装置和方法
US11311666B1 (en) 2021-02-18 2022-04-26 Fresenius Kabi Deutschland Gmbh Modular wearable medicament delivery device and method of use thereof
US11872369B1 (en) 2021-02-18 2024-01-16 Fresenius Kabi Deutschland Gmbh Wearable medicament delivery device with leakage and skin contact sensing and method of use thereof
US11464902B1 (en) 2021-02-18 2022-10-11 Fresenius Kabi Deutschland Gmbh Wearable medicament delivery device with compressible reservoir and method of use thereof
US11344682B1 (en) 2021-02-19 2022-05-31 Fresenius Kabi Deutschland Gmbh Drug supply cartridge with visual use indicator and delivery devices that use the same
US11607505B1 (en) 2021-02-19 2023-03-21 Fresenius Kabi Deutschland Gmbh Wearable injector with sterility sensors
US11426523B1 (en) 2021-02-19 2022-08-30 Fresenius Kabi Deutschland Gmbh Drug delivery assembly including a removable cartridge
US11497847B1 (en) 2021-02-19 2022-11-15 Fresenius Kabi Deutschland Gmbh Wearable injector with adhesive substrate
US11413394B1 (en) 2021-02-19 2022-08-16 Fresenius Kabi Deutschland Gmbh Display for wearable drug delivery device
US11406755B1 (en) 2021-02-19 2022-08-09 Fresenius Kabi Deutschland Gmbh Sensing fluid flow irregularities in an on-body injector
US11633537B1 (en) 2021-02-19 2023-04-25 Fresenius Kabi Deutschland Gmbh Drug delivery assembly including a pre-filled cartridge
IL305213A (en) 2021-03-08 2023-10-01 Amgen Inc Manufacturing process for a hollow piston rod
US11419976B1 (en) 2021-04-30 2022-08-23 Fresenius Kabi Deutschland Gmbh Wearable drug delivery device with pressurized fluid dispensing
US11529459B1 (en) 2021-04-30 2022-12-20 Fresenius Kabi Deutschland Gmbh Wearable injector with adhesive module
US11504470B1 (en) 2021-04-30 2022-11-22 Fresenius Kabi Deutschland Gmbh Deformable drug reservoir for wearable drug delivery device
US11351300B1 (en) 2021-04-30 2022-06-07 Fresenius Kabl Deutschland GmbH Drug dispensing system with replaceable drug supply cartridges
US11717608B1 (en) 2021-05-03 2023-08-08 Fresenius Kabi Deutschland Gmbh Drug delivery assembly including an adhesive pad
US11484646B1 (en) 2021-05-04 2022-11-01 Fresenius Kabi Deutschland Gmbh Sealing systems for a reservoir of an on-body injector
USD1007676S1 (en) 2021-11-16 2023-12-12 Regeneron Pharmaceuticals, Inc. Wearable autoinjector
US12498274B2 (en) 2022-07-26 2025-12-16 StarKrug LLC Multifunctional thermal exposure indicator
US20240416037A1 (en) * 2023-06-16 2024-12-19 Regeneron Pharmaceuticals, Inc. Auto-injector and related methods of use
US12343505B1 (en) 2024-04-19 2025-07-01 Genzyme Corporation Medicament delivery device
US12343511B1 (en) * 2024-04-19 2025-07-01 Genzyme Corporation Medicament delivery device
US12357758B1 (en) 2024-04-19 2025-07-15 Genzyme Corporation Medicament delivery device
US12377226B1 (en) 2024-04-19 2025-08-05 Genzyme Corporation Medicament delivery device
US12337160B1 (en) 2024-04-19 2025-06-24 Genzyme Corporation Medicament delivery device
US12465697B1 (en) 2025-02-26 2025-11-11 Genzyme Corporation Medicament delivery device
US12434008B1 (en) 2025-02-26 2025-10-07 Genzyme Corporation Lock ring for a medicament delivery device
US12420017B1 (en) 2025-02-26 2025-09-23 Genzyme Corporation Damping device for a medicament delivery device

Family Cites Families (226)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3771899A (en) 1971-12-13 1973-11-13 R Brumfield Pulsator pump and heat exchanger for blood
ATE28798T1 (de) * 1982-11-30 1987-08-15 Beta Phase Inc Zur flussregelung ein formgedaechtnisbauteil verwendendes intravenoeses geraet mit steuerung der stroemungsgeschwindigkeit.
NZ210501A (en) 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
KR850004274A (ko) 1983-12-13 1985-07-11 원본미기재 에리트로포이에틴의 제조방법
US4703008A (en) 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
JPH02211170A (ja) * 1989-02-10 1990-08-22 Olympus Optical Co Ltd 体内埋込型注液ポンプ
US5037396A (en) 1989-03-02 1991-08-06 Becton, Dickinson And Company Thermoelectric chiller and automatic syringe
KR100221066B1 (ko) 1989-10-13 1999-10-01 스튜어트 엘.왓트 에리트로포이에틴 유사체와 그를 포함하는 제약학적 조성물
US7217689B1 (en) 1989-10-13 2007-05-15 Amgen Inc. Glycosylation analogs of erythropoietin
US5856298A (en) 1989-10-13 1999-01-05 Amgen Inc. Erythropoietin isoforms
US5498261A (en) * 1991-12-20 1996-03-12 Advanced Cardiovascular Systems, Inc. Thermal angioplasty system
US5368562A (en) * 1993-07-30 1994-11-29 Pharmacia Deltec, Inc. Systems and methods for operating ambulatory medical devices such as drug delivery devices
ZA946122B (en) 1993-08-17 1995-03-20 Amgen Inc Erythropoietin analogs
US6562596B1 (en) 1993-10-06 2003-05-13 Amgen Inc. Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods
US5773569A (en) 1993-11-19 1998-06-30 Affymax Technologies N.V. Compounds and peptides that bind to the erythropoietin receptor
US5830851A (en) 1993-11-19 1998-11-03 Affymax Technologies N.V. Methods of administering peptides that bind to the erythropoietin receptor
US5885574A (en) 1994-07-26 1999-03-23 Amgen Inc. Antibodies which activate an erythropoietin receptor
WO1996004925A1 (en) 1994-08-12 1996-02-22 Immunomedics, Inc. Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells
US5686292A (en) 1995-06-02 1997-11-11 Genentech, Inc. Hepatocyte growth factor receptor antagonist antibodies and uses thereof
US5767078A (en) 1995-06-07 1998-06-16 Johnson; Dana L. Agonist peptide dimers
IE77523B1 (en) 1995-09-11 1997-12-17 Elan Med Tech Medicament delivery device
US5858001A (en) 1995-12-11 1999-01-12 Elan Medical Technologies Limited Cartridge-based drug delivery device
US6131570A (en) * 1998-06-30 2000-10-17 Aradigm Corporation Temperature controlling device for aerosol drug delivery
US6753165B1 (en) 1999-01-14 2004-06-22 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
IL133974A0 (en) 1997-07-14 2001-04-30 Bolder Biotechnology Inc Derivatives of growth hormone and related proteins
PT986644E (pt) 1997-07-23 2007-01-31 Roche Diagnostics Gmbh Preparação de eritropoietina por activação genética endógena com promotores virais
US5957895A (en) 1998-02-20 1999-09-28 Becton Dickinson And Company Low-profile automatic injection device with self-emptying reservoir
US6030086A (en) 1998-03-02 2000-02-29 Becton, Dickinson And Company Flash tube reflector with arc guide
US6310078B1 (en) 1998-04-20 2001-10-30 Ortho-Mcneil Pharmaceutical, Inc. Substituted amino acids as erythropoietin mimetics
US20050181482A1 (en) 2004-02-12 2005-08-18 Meade Harry M. Method for the production of an erythropoietin analog-human IgG fusion proteins in transgenic mammal milk
WO1999066054A2 (en) 1998-06-15 1999-12-23 Genzyme Transgenics Corp. Erythropoietin analog-human serum albumin fusion protein
US6175688B1 (en) 1998-07-10 2001-01-16 Belmont Instrument Corporation Wearable intravenous fluid heater
ES2283139T5 (es) 1998-10-23 2018-03-05 Amgen Inc. Métodos y composiciones para la prevención y tratamiento de la anemia
WO2000024770A2 (en) 1998-10-23 2000-05-04 Amgen Inc. Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity
US6395511B1 (en) 1998-11-27 2002-05-28 Darwin Discovery, Ltd. Nucleic acids encoding a novel family of TGF-β binding proteins from humans
EP1006184A1 (en) 1998-12-03 2000-06-07 F. Hoffmann-La Roche Ag IGF-1 receptor interacting proteins (IIPs) genes coding therefor and uses thereof
WO2000061637A1 (en) 1999-04-14 2000-10-19 Smithkline Beecham Corporation Erythropoietin receptor antibodies
US7297680B2 (en) 1999-04-15 2007-11-20 Crucell Holland B.V. Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content
FR2792841A1 (fr) 1999-04-30 2000-11-03 Medtronic Inc Procede et dispositif pour detecter une temperature dans une pompe implantable
CZ299516B6 (cs) 1999-07-02 2008-08-20 F. Hoffmann-La Roche Ag Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
WO2001031007A2 (en) 1999-10-22 2001-05-03 Millennium Pharmaceuticals, Inc. Nucleic acid molecules derived from rat brain and programmed cell death models
JP2003514552A (ja) 1999-11-12 2003-04-22 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング 改善された性質を有するエリトロポエチンの形態
US20050202538A1 (en) 1999-11-12 2005-09-15 Merck Patent Gmbh Fc-erythropoietin fusion protein with improved pharmacokinetics
AU2695101A (en) 2000-01-21 2001-07-31 Biovex Ltd Virus strains
AUPQ599700A0 (en) 2000-03-03 2000-03-23 Super Internet Site System Pty Ltd On-line geographical directory
US6586398B1 (en) 2000-04-07 2003-07-01 Amgen, Inc. Chemically modified novel erythropoietin stimulating protein compositions and methods
ES2306711T3 (es) 2000-04-21 2008-11-16 Amgen Inc. Metodo y composicion destinada a la prevencion y al tratamiento de la anemia.
US6756480B2 (en) 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US7078376B1 (en) 2000-08-11 2006-07-18 Baxter Healthcare S.A. Therapeutic methods for treating subjects with a recombinant erythropoietin having high activity and reduced side effects
SK2772003A3 (en) 2000-09-08 2003-10-07 Gryphon Therapeutics Inc Synthetic erythropoiesis stimulating proteins
US7271689B1 (en) 2000-11-22 2007-09-18 Fonar Corporation Magnet structure
WO2002049673A2 (en) 2000-12-20 2002-06-27 F. Hoffmann-La Roche Ag Conjugates of erythropoietin (pep) with polyethylene glycol (peg)
UY27087A1 (es) 2001-01-05 2002-06-20 Pfizer Anticuerpos contra el receptor del factor de crecimiento similar a insulina
DE60122465T2 (de) 2001-03-15 2007-01-04 Teijin Twaron Gmbh Penetrationsresistentes Material mit einem Gewebe mit hohem linearem Dichteverhältnis zwischen zwei Gruppen von Garnen
US8172458B2 (en) * 2001-03-23 2012-05-08 Petrakis Dennis N Temperature responsive systems
CA2443373A1 (en) 2001-04-04 2002-10-31 Genodyssee New polynucleotides and polypeptides of the erythropoietin gene
EP2845864A3 (en) 2001-05-11 2015-06-10 Amgen, Inc Peptides and related molecules that bind to TALL - 1
DK2270052T3 (en) 2001-06-26 2018-07-02 Amgen Inc Antibodies to OPGL
US6900292B2 (en) 2001-08-17 2005-05-31 Lee-Hwei K. Sun Fc fusion proteins of human erythropoietin with increased biological activities
WO2003017935A2 (en) 2001-08-23 2003-03-06 Genmab A/S Human antibodies specific for interleukin 15 (il-15)
US7247304B2 (en) 2001-08-23 2007-07-24 Genmab A/S Methods of treating using anti-IL-15 antibodies
US6930086B2 (en) 2001-09-25 2005-08-16 Hoffmann-La Roche Inc. Diglycosylated erythropoietin
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7138370B2 (en) 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
US7521053B2 (en) 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
AU2002351746A1 (en) 2001-12-21 2003-07-15 Maxygen Aps Erythropoietin conjugates
US7241444B2 (en) 2002-01-18 2007-07-10 Pierre Fabre Medicament Anti-IGF-IR antibodies and uses thereof
MXPA04006980A (es) 2002-01-18 2004-11-10 Pf Medicament Anticuerpos novedosos anti-receptor del factor de crecimiento i tipo insulina, y usos de los mismos.
WO2003064664A1 (en) 2002-01-31 2003-08-07 Oxford Biomedica (Uk) Limited Physiologically regulated erythropoietin- exprressing vector for the treatment of anaemia
GB0202252D0 (en) 2002-01-31 2002-03-20 Oxford Biomedica Ltd Anemia
DE60220451T2 (de) 2002-03-26 2008-01-24 Lek Pharmaceutical And Chemical Co. D.D. Verfahren für die herstellung eines gewünschten profils von erythropoietin glyko-isoformen
CN102212536B (zh) 2002-03-29 2013-05-08 组合化学工业株式会社 编码乙酰乳酸合酶的基因
WO2003084477A2 (en) 2002-03-29 2003-10-16 Centocor, Inc. Mammalian cdr mimetibodies, compositions, methods and uses
US6656158B2 (en) 2002-04-23 2003-12-02 Insulet Corporation Dispenser for patient infusion device
US6960192B1 (en) 2002-04-23 2005-11-01 Insulet Corporation Transcutaneous fluid delivery system
US6656159B2 (en) 2002-04-23 2003-12-02 Insulet Corporation Dispenser for patient infusion device
AU2003232122A1 (en) 2002-05-13 2003-11-11 Technion Entrepreneurial Incubator Company Ltd. Ctp-extended erythropoietin
NZ571508A (en) 2002-05-24 2010-05-28 Schering Corp Neutralizing human anti-IGFR antibody
US8034904B2 (en) 2002-06-14 2011-10-11 Immunogen Inc. Anti-IGF-I receptor antibody
US7538195B2 (en) 2002-06-14 2009-05-26 Immunogen Inc. Anti-IGF-I receptor antibody
MY139059A (en) 2002-06-24 2009-08-28 Alza Corp Reusable, spring driven autoinjector
JP2006504406A (ja) 2002-06-28 2006-02-09 セントカー・インコーポレーテツド 哺乳動物のch1欠失ミメティボディ、組成物、方法および使用
KR20050033563A (ko) 2002-06-28 2005-04-12 센토코 인코포레이티드 포유동물 epo 모방 ch1 결실된 모방체, 조성물, 방법및 용도
AU2003246486A1 (en) 2002-07-19 2004-02-09 Cangene Corporation Pegylated erythropoietic compounds
US6929619B2 (en) 2002-08-02 2005-08-16 Liebel-Flarshiem Company Injector
TWI235073B (en) * 2002-08-20 2005-07-01 Toray Industries Catheter for treating cardiac arrhythmias
WO2004018667A1 (ja) 2002-08-26 2004-03-04 Kirin Beer Kabushiki Kaisha ペプチド及びこれを含む医薬
CA2496528A1 (en) 2002-08-31 2004-03-25 Disetronic Licensing Ag Administering device comprising a temperature sensor
NZ566539A (en) 2002-09-06 2010-01-29 Medarex Inc Therapeutic human anti-IL-1R1 monoclonal antibody
AU2003255406B2 (en) 2002-09-11 2009-09-10 Fresenius Kabi Deutschland Gmbh Hydroxyalkyl starch derivatives
US7637891B2 (en) 2002-09-12 2009-12-29 Children's Hospital Medical Center Method and device for painless injection of medication
US6919426B2 (en) 2002-09-19 2005-07-19 Amgen Inc. Peptides and related molecules that modulate nerve growth factor activity
US7128727B2 (en) 2002-09-30 2006-10-31 Flaherty J Christopher Components and methods for patient infusion device
US7144384B2 (en) 2002-09-30 2006-12-05 Insulet Corporation Dispenser components and methods for patient infusion device
TWI320716B (en) 2002-10-14 2010-02-21 Abbott Lab Erythropoietin receptor binding antibodies
US20040071694A1 (en) 2002-10-14 2004-04-15 Devries Peter J. Erythropoietin receptor binding antibodies
US7396913B2 (en) 2002-10-14 2008-07-08 Abbott Laboratories Erythropoietin receptor binding antibodies
US7335743B2 (en) 2002-10-16 2008-02-26 Amgen Inc. Human anti-IFN-γ neutralizing antibodies as selective IFN-γ pathway inhibitors
US20040091961A1 (en) 2002-11-08 2004-05-13 Evans Glen A. Enhanced variants of erythropoietin and methods of use
EA009056B1 (ru) 2002-12-20 2007-10-26 Амген, Инк. Связывающие агенты, ингибирующие миостатин
JP2007528201A (ja) 2003-03-14 2007-10-11 ファルマシア・コーポレーション 癌治療のためのigf−i受容体に対する抗体
JP4473257B2 (ja) 2003-04-02 2010-06-02 エフ.ホフマン−ラ ロシュ アーゲー インスリン様成長因子i受容体に対する抗体及びその使用
US7220410B2 (en) 2003-04-18 2007-05-22 Galaxy Biotech, Llc Monoclonal antibodies to hepatocyte growth factor
EP2365001A3 (en) 2003-05-01 2012-03-28 Imclone LLC Fully human antibodies directed against the human insulin-like growth factor-1 receptor
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
BRPI0411172A (pt) 2003-05-12 2006-07-18 Affymax Inc peptìdeo, dìmero de peptìdeo, seu uso e composição farmacêutica
EA010016B1 (ru) 2003-05-12 2008-06-30 Афимакс, Инк. Новые модифицированные полиэтиленгликолем соединения и их применение
AP2042A (en) 2003-05-12 2009-09-07 Affymax Inc Novel peptides that bind to the erythropoietin receptor
US7074755B2 (en) 2003-05-17 2006-07-11 Centocor, Inc. Erythropoietin conjugate compounds with extended half-lives
KR20060032140A (ko) 2003-05-30 2006-04-14 센토코 인코포레이티드 트랜스글루타미나아제를 이용한 신규 에리트로포이에틴접합체의 형성
WO2005001136A1 (en) 2003-06-04 2005-01-06 Irm Llc Methods and compositions for modulating erythropoietin expression
US7579157B2 (en) 2003-07-10 2009-08-25 Hoffmann-La Roche Inc. Antibody selection method against IGF-IR
UA115960C2 (uk) 2003-07-15 2018-01-25 Емджен, Інк., Людські анти-ngf нейтралізуючі антитіла як селективні інгібітори метаболічних шляхів фактора росту нервової тканини (ngf)
TW201319088A (zh) 2003-07-18 2013-05-16 Amgen Inc 對肝細胞生長因子具專一性之結合劑
US20050019914A1 (en) 2003-07-24 2005-01-27 Aventis Pharma Deutschland Gmbh Perfusion process for producing erythropoietin
GB0317511D0 (en) 2003-07-25 2003-08-27 Biovex Ltd Viral vectors
US20070275871A1 (en) 2003-08-28 2007-11-29 Biorexis Technology, Inc. Epo Mimetic Peptides and Fusion Proteins
BRPI0409650A (pt) 2003-09-09 2006-04-25 Warren Pharmaceuticals Inc métodos para regular o nìvel hematócrito e humanos, produtos de eritropoietina artificial, métodos para preparar um produto de eritropoietina e pra tratar anemia em pacientes em risco de dano no tecido, e, composição farmacêutica
WO2005081687A2 (en) 2003-09-30 2005-09-09 Centocor, Inc. Human hinge core mimetibodies, compositions, methods and uses
UA89481C2 (uk) 2003-09-30 2010-02-10 Центокор, Инк. Еритропоетинові міметичні шарнірно-серцевинні міметитіла людини, композиції, способи та застосування
CA2543982C (en) 2003-11-07 2013-01-08 Immunex Corporation Antibodies that bind interleukin-4 receptor
AR046639A1 (es) 2003-11-21 2005-12-14 Schering Corp Combinaciones terapeuticas de anticuerpo anti- igfr1
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
JP4719686B2 (ja) 2003-11-24 2011-07-06 バイオジェネリックス アーゲー GlycoPEG化エリスロポエチン
WO2005058967A2 (en) 2003-12-16 2005-06-30 Pierre Fabre Medicament Novel anti-insulin/igf-i hybrid receptor or anti-insulin/igf-i hybrid receptor and igf-ir antibodies and uses thereof
EP1548031A1 (en) 2003-12-22 2005-06-29 Dubai Genetics FZ-LLC Nature-identical erythropoietin
JP2008504008A (ja) 2003-12-31 2008-02-14 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング 改良された薬物動態を有するFc−エリスロポエチン融合タンパク質
AU2004311796A1 (en) 2003-12-31 2005-07-21 Centocor, Inc. Novel recombinant proteins with N-terminal free thiol
US7423139B2 (en) 2004-01-20 2008-09-09 Insight Biopharmaceuticals Ltd. High level expression of recombinant human erythropoietin having a modified 5′-UTR
WO2005070451A1 (en) 2004-01-22 2005-08-04 Zafena Aktiebolag Pharmaceutical composition comprising non-glycosylated erythropoietin
WO2005084711A1 (en) 2004-03-02 2005-09-15 Chengdu Institute Of Biological Products A pegylated recombinant erythropoietin that has in vivo activity
WO2005092369A2 (en) 2004-03-11 2005-10-06 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyethyl starch and erythropoietin
US20050227289A1 (en) 2004-04-09 2005-10-13 Reilly Edward B Antibodies to erythropoietin receptor and uses thereof
CA2563874A1 (en) 2004-04-23 2005-11-03 Cambridge Antibody Technology Limited Erythropoietin protein variants
EA011586B1 (ru) 2004-07-07 2009-04-28 Х. Лундбекк А/С Новый карбамилированный еро и способ его получения
FR2873699B1 (fr) 2004-07-29 2009-08-21 Pierre Fabre Medicament Sa Nouveaux anticorps anti igf ir rt leurs utilisations
WO2006029094A2 (en) 2004-09-02 2006-03-16 Xencor, Inc. Erythropoietin derivatives with altered immunogenicity
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
EP1805563B1 (en) 2004-10-28 2015-12-09 Hewlett-Packard Development Company, L.P. Adhesive primer coating for printing
AU2005303887A1 (en) 2004-11-10 2006-05-18 Aplagen Gmbh Molecules which promote hematopoiesis
MY146381A (en) 2004-12-22 2012-08-15 Amgen Inc Compositions and methods relating relating to anti-igf-1 receptor antibodies
AU2006208226A1 (en) 2005-01-24 2006-08-03 Amgen Inc. Humanized anti-amyloid antibody
US8361026B2 (en) 2005-02-01 2013-01-29 Intelliject, Inc. Apparatus and methods for self-administration of vaccines and other medicaments
JP5207542B2 (ja) 2005-04-06 2013-06-12 マリンクロッド エルエルシー 医療流体及びその容器に関する情報を管理するシステム及び方法
US7592429B2 (en) 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
JP4001606B2 (ja) 2005-05-31 2007-10-31 パウダーテック株式会社 樹脂充填型キャリア及び該キャリアを用いた電子写真現像剤
CA2680945C (en) 2005-06-17 2014-03-18 Imclone Systems Incorporated Anti-pdgfralpha antibodies
WO2007000328A1 (en) 2005-06-27 2007-01-04 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Antibodies that bind to an epitope on insulin-like growth factor 1 receptor and uses thereof
US7360421B2 (en) 2005-07-01 2008-04-22 Adi Weber Detachable angular speed sensing system
RS54984B1 (sr) 2005-07-18 2016-11-30 Amgen Inc Humana anti-b7rp1 neutrališuća antitela
FR2888850B1 (fr) 2005-07-22 2013-01-11 Pf Medicament Nouveaux anticorps anti-igf-ir et leurs applications
PE20071101A1 (es) 2005-08-31 2007-12-21 Amgen Inc Polipeptidos y anticuerpos
US20080140057A1 (en) 2006-03-09 2008-06-12 Searete Llc, A Limited Liability Corporation Of State Of The Delaware Injectable controlled release fluid delivery system
US7725272B2 (en) * 2006-03-30 2010-05-25 Codman Neuro Sciences, Sarl Methods and devices for monitoring fluid of an implantable infusion pump
TWI395754B (zh) 2006-04-24 2013-05-11 Amgen Inc 人類化之c-kit抗體
US7811252B2 (en) 2006-05-17 2010-10-12 Alcon Research, Ltd. Dosage control device
US20070268340A1 (en) 2006-05-17 2007-11-22 Bruno Dacquay Ophthalmic Injection System and Method Using Piezoelectric Array
AU2007254141B2 (en) 2006-05-19 2012-10-11 Glycofi, Inc. Erythropoietin compositions
CL2007002567A1 (es) 2006-09-08 2008-02-01 Amgen Inc Proteinas aisladas de enlace a activina a humana.
US20080097379A1 (en) 2006-09-26 2008-04-24 Alcon Manufacturing, Ltd. Ophthalmic injection method
US20080097390A1 (en) 2006-09-27 2008-04-24 Alcon Manufacturing, Ltd. Spring actuated delivery system
US20080234625A1 (en) 2006-10-16 2008-09-25 Bruno Dacquay Fuse Assembly For Single Use Medical Device
CA2664160A1 (en) 2006-10-16 2008-09-12 Alcon Research, Ltd. Method of operating ophthalmic hand piece with disposable end
US20080281292A1 (en) 2006-10-16 2008-11-13 Hickingbotham Dyson W Retractable Injection Port
US20100040611A1 (en) 2006-11-07 2010-02-18 Sparrow Carl P Antagonists of pcsk9
US20100041102A1 (en) 2006-11-07 2010-02-18 Ayesha Sitlani Antagonists of pcsk9
US20100150937A1 (en) 2006-11-07 2010-06-17 Sparrow Carl P Antagonists of pcsk9
WO2008133647A2 (en) 2006-11-07 2008-11-06 Merck & Co., Inc. Antagonists of pcsk9
US20080125700A1 (en) 2006-11-29 2008-05-29 Moberg Sheldon B Methods and apparatuses for detecting medical device acceleration, temperature, and humidity conditions
WO2008067314A2 (en) 2006-11-29 2008-06-05 Medtronic Minimed, Inc. Apparatus for detecting medical device acceleration condition
CA2681397C (en) * 2007-03-19 2015-08-11 Insuline Medical Ltd. Method and device for drug delivery
JP5731120B2 (ja) 2007-03-19 2015-06-10 インスライン メディカル エルティーディー. 薬剤送達器具
US9220837B2 (en) * 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
WO2008125623A2 (en) 2007-04-13 2008-10-23 Novartis Ag Molecules and methods for modulating proprotein convertase subtilisin/kexin type 9 (pcsk9)
US7957927B2 (en) * 2007-07-05 2011-06-07 Baxter International Inc. Temperature compensation for pneumatic pumping system
US7740619B2 (en) * 2007-08-01 2010-06-22 Alcon Research, Ltd. Spring driven ophthalmic injection device with safety actuator lockout feature
SG2013014352A (en) 2007-10-26 2014-09-26 Merck Sharp & Dohme Anti-pcsk9 and methods for treating lipid and cholesterol disorders
US20090177142A1 (en) 2008-01-09 2009-07-09 Smiths Medical Md, Inc Insulin pump with add-on modules
US20090177182A1 (en) 2008-01-09 2009-07-09 Hickingbotham Dyson W Glass Drug Chamber For Automated Ophthalmic Injection Device
AR070315A1 (es) 2008-02-07 2010-03-31 Merck & Co Inc Anticuerpos 1b20 antagonistas de pcsk9
AR070316A1 (es) 2008-02-07 2010-03-31 Merck & Co Inc Antagonistas de pcsk9 (proproteina subtilisina-kexina tipo 9)
US20090227979A1 (en) 2008-03-07 2009-09-10 Sanchez Jr Robert J Drug Level Sensor for Injection Device
US9849238B2 (en) 2008-05-08 2017-12-26 Minipumps, Llc Drug-delivery pump with intelligent control
TWI445716B (zh) 2008-09-12 2014-07-21 Rinat Neuroscience Corp Pcsk9拮抗劑類
JP6288903B2 (ja) 2008-09-15 2018-03-07 デカ・プロダクツ・リミテッド・パートナーシップ 流体送達のためのシステムおよび方法
MX2011004817A (es) 2008-11-07 2011-07-28 Insuline Medical Ltd Dispositivo y metodo para suministrar farmacos.
US8337453B2 (en) 2008-12-03 2012-12-25 Alcon Research, Ltd. Drug pellet molding onto plunger assembly
JO3672B1 (ar) 2008-12-15 2020-08-27 Regeneron Pharma أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
US20100152676A1 (en) 2008-12-16 2010-06-17 Alcon Research, Ltd. Drug Loading Through Plunger
JO3382B1 (ar) 2008-12-23 2019-03-13 Amgen Inc أجسام مضادة ترتبط مع مستقبل cgrp بشري
EP4324499A3 (en) 2009-03-25 2024-04-24 DEKA Products Limited Partnership Infusion pump methods and systems
US8465459B2 (en) 2009-08-27 2013-06-18 Sanofi-Aventis Deutschland Gmbh Medicament container
US10092691B2 (en) 2009-09-02 2018-10-09 Becton, Dickinson And Company Flexible and conformal patch pump
EP2480576A4 (en) 2009-09-25 2013-04-10 Merck Sharp & Dohme PCSK9 ANTAGONISTS
WO2011053759A1 (en) 2009-10-30 2011-05-05 Merck Sharp & Dohme Corp. Ax1 and ax189 pcsk9 antagonists and variants
CA2777542A1 (en) 2009-10-30 2011-05-05 Merck Sharp & Dohme Corp. Ax213 and ax132 pcsk9 antagonists and variants
JP5755238B2 (ja) 2009-12-02 2015-07-29 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬物送達デバイス及び関連包装
AR079336A1 (es) 2009-12-11 2012-01-18 Irm Llc Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9)
US9677555B2 (en) * 2011-12-21 2017-06-13 Deka Products Limited Partnership System, method, and apparatus for infusing fluid
EP2525844B1 (en) 2010-01-22 2017-12-20 DEKA Products Limited Partnership Infusion pump system comprising temperature compensation for adjusting infusion rate
GB201002962D0 (en) 2010-02-22 2010-04-07 Univ Nottingham Microfluidic delivery systems
BR112012022917A2 (pt) 2010-03-11 2017-01-10 Pfizer anticorpos com ligação a antígeno dependente de ph
CA2800919C (en) * 2010-06-07 2019-01-15 Amgen Inc. Drug delivery device
WO2012054438A1 (en) 2010-10-22 2012-04-26 Schering Corporation Anti-pcsk9
SG191219A1 (en) 2010-12-22 2013-07-31 Genentech Inc Anti-pcsk9 antibodies and methods of use
MX347602B (es) 2011-01-28 2017-05-03 Sanofi Biotechnology Composiciones farmaceuticas que comprenden anticuerpos humanos frente a pcsk9.
KR20140006022A (ko) 2011-02-11 2014-01-15 아이알엠 엘엘씨 Pcsk9 길항제
WO2012126975A1 (en) 2011-03-22 2012-09-27 Sanofi-Aventis Deutschland Gmbh Service and maintenance station for handheld drug delivery device
GB2490721B (en) 2011-05-12 2017-03-01 Owen Mumford Ltd Injection devices
WO2012161685A1 (en) * 2011-05-23 2012-11-29 Boehringer Ingelheim International Gmbh Nebulizer
JP6210558B2 (ja) 2011-07-25 2017-10-11 プレシフレックス エスアー 流体投与装置
AU2012323142B2 (en) * 2011-10-13 2016-10-27 Mequ Aps An infusion fluid warmer
EA030868B1 (ru) 2011-10-14 2018-10-31 Эмджен Инк. Инжектор и способ его сборки
DE102011119000A1 (de) 2011-11-21 2013-05-23 Liebherr-Verzahntechnik Gmbh Verzahnmaschine und Verfahren zur Herstellung oder Bearbeitung von Verzahnungen
EP2782622B1 (en) 2011-11-22 2021-07-21 Sanofi-Aventis Deutschland GmbH Pen-type drug injection device with controller and time lock-out mechanism for its drive
WO2013115843A1 (en) 2012-01-31 2013-08-08 Medimop Medical Projects Ltd. Time dependent drug delivery apparatus
JP6254956B2 (ja) 2012-03-07 2017-12-27 デカ・プロダクツ・リミテッド・パートナーシップ 注入ポンプアセンブリ
EP2641629A1 (en) 2012-03-22 2013-09-25 Sanofi-Aventis Deutschland GmbH Medical injection device with injection site pain reduction device
CA2869181A1 (en) 2012-04-03 2013-10-10 Medimmune, Llc Devices having thermochromic response indicators
GB201210082D0 (en) 2012-06-07 2012-07-25 Consort Medical Plc Improved syringe
US20130338576A1 (en) 2012-06-15 2013-12-19 Wayne C. Jaeschke, Jr. Portable infusion pump with pressure and temperature compensation
US20130338635A1 (en) 2012-06-15 2013-12-19 Animas Corporation Pressure independent delivery method for portable infusion pump
EP2682141A1 (en) 2012-07-06 2014-01-08 Sanofi-Aventis Deutschland GmbH Injection system
US20140155827A1 (en) 2012-12-03 2014-06-05 Mylan, Inc. Medicament information system and method
US20150246179A1 (en) 2014-03-02 2015-09-03 Nissim Zur Device and method for drug dosing with administration monitoring, in particular for insulin pen integrated with smart phone apps.

Also Published As

Publication number Publication date
WO2015061389A1 (en) 2015-04-30
EP3060281A1 (en) 2016-08-31
EP3957345B1 (en) 2025-12-10
JP7051293B2 (ja) 2022-04-11
JP2016538096A (ja) 2016-12-08
JP2023039966A (ja) 2023-03-22
MX2019011734A (es) 2019-11-21
EP3957345A1 (en) 2022-02-23
CA2926110C (en) 2023-05-23
US20200215273A1 (en) 2020-07-09
AU2019279961A1 (en) 2020-01-16
US20160354555A1 (en) 2016-12-08
EP3060281B1 (en) 2019-01-30
AU2019279961B2 (en) 2021-11-25
US10758683B2 (en) 2020-09-01
CA2926110A1 (en) 2015-04-30
JP2024175092A (ja) 2024-12-17
JP7309462B2 (ja) 2023-07-18
CA3168888A1 (en) 2015-04-30
JP2019193803A (ja) 2019-11-07
EP3501575B1 (en) 2021-12-01
US11383047B2 (en) 2022-07-12
EP3501575A1 (en) 2019-06-26
AU2014340174B2 (en) 2019-09-12
AU2014340174A1 (en) 2016-03-03

Similar Documents

Publication Publication Date Title
MX2016005315A (es) Sistema de administracion de farmacos con control sensible a la temperatura.
Drakulich Perceptions of the local danger posed by crime: Race, disorder, informal control, and the police
CL2018003737A1 (es) Sistema de equipo de protección personal que tiene un sistema de analisis con monitoreo, alerta y prevención de eventos de seguridad integrados
AR100578A1 (es) Sustrato formador de aerosol y sistema suministrador de aerosol
MX2020003545A (es) Sistemas y metodos para seguimiento de emisiones de gases de efecto invernadero asociadas con una entidad.
BR112016023720A2 (pt) nebulizador
FR3026212B1 (fr) Dispositif de controle de verrouillage/deverrouillage et/ou de demarrage d'un vehicule
EP3611790A4 (en) BATTERY MODULE, BATTERY DEVICE AND BATTERY SYSTEM WITH THERMAL MANAGEMENT DESIGN
AR086842A1 (es) Uso de marcadores raman para autentificacion de documentos de seguridad
EP2943429A4 (en) LOAD HOOK, LOAD HOOK SAFETY LOCK AND LOCK LOCK LOCK AND RELEASE DEVICE
MX2017003906A (es) Sistema de cilindro integrado para asegurar puntos de acceso.
EP3071256A4 (en) MEDICAL DEVICE WITH SAFETY DEVICES
Clark et al. Mining incomplete data with singleton, subset and concept probabilistic approximations
MX2017001501A (es) Sistema de seguridad de vagones con iluminacion.
CO2017002535A2 (es) Detonador electrónico que restringe la corriente de fuga
EA201592311A1 (ru) Инъекционное устройство
EP3681570C0 (en) SAFETY ASSEMBLY AND MEDICAL DEVICE COMPRISING A SAFETY ASSEMBLY
TR201902551T4 (tr) Zarardan koruma amacı ile bir aşırı yükleme olayında etki yapan yüklerden oluşan enerjinin absorpsiyonu için yöntem ve modül.
BR112015031757A2 (pt) evento de clarão integrado ao sistema de alerta de ameaças e detecção de laser transmitido
CL2019000890A1 (es) Espejo para reflector solar, procedimiento de ensamblaje y sistema de gestion de espejos en un campo solar
BR112017004416A2 (pt) representação de contexto de sistema operacional em um módulo de plataforma confiável
CL2020000481A1 (es) Protector de puerta de barra oscilante.
EP3697480C0 (en) PASSIVE FAILURE SAFETY DEVICE AND INJECTION DEVICE COMPRISING THIS PASSIVE FAILURE SAFETY DEVICE
HRP20181051T1 (hr) Sigurnosni ventilni sklop za ekstrakcijske bušotine, bušotina opremljena navedenim ventilom i postupak upravljanja ekstrakcijskom bušotinom s navedenim ventilom u hitnim slučajevima
Pivato Social welfare with incomplete ordinal interpersonal comparisons

Legal Events

Date Code Title Description
FG Grant or registration