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CN111616358A - Composition for improving immunity and application thereof - Google Patents

Composition for improving immunity and application thereof Download PDF

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Publication number
CN111616358A
CN111616358A CN202010569170.7A CN202010569170A CN111616358A CN 111616358 A CN111616358 A CN 111616358A CN 202010569170 A CN202010569170 A CN 202010569170A CN 111616358 A CN111616358 A CN 111616358A
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Prior art keywords
protein
fulvic acid
composition
salt
immunity
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CN202010569170.7A
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Chinese (zh)
Inventor
田劭军
成卓越
田保君
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Individual
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Priority to CN202010569170.7A priority Critical patent/CN111616358A/en
Publication of CN111616358A publication Critical patent/CN111616358A/en
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/185—Vegetable proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Botany (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention belongs to the technical field of food-borne compositions, and particularly relates to a composition for improving immunity and application thereof, which are used for improving the immunity of an organism to treat or inhibit tumors of animals or human beings; the technical scheme adopted by the invention is as follows: a composition for improving immunity comprises fulvic acid or its salt, protein powder and wood vinegar powder at a weight ratio of 1-2:2-1:1-2.5, wherein the fulvic acid is derived from carbohydrate, and the pH of water soluble fulvic acid or its salt is 1-7; fulvic acid, salt, ester or derivative thereof may have any pH from acidic to basic, typically from acidic to neutral; fulvic acid may be present in the form of a solution buffered to a suitable pH; the invention has obvious effect of improving the immunity of organisms and is widely applied to the technical field of food-borne combination.

Description

Composition for improving immunity and application thereof
Technical Field
The invention belongs to the technical field of food-borne compositions, and particularly relates to a composition for improving immunity and application thereof, which are used for improving the immunity of an organism to treat or inhibit tumors of animals or human beings.
Background
Malignant tumor is one of the common diseases seriously harming human life health at present, the incidence rate of the tumor has a trend of increasing continuously in recent years, and chemotherapy is an important treatment means next to surgical treatment. Chemotherapy drugs that are commonly used clinically are poorly or only poorly selective for tumor and normal cells, and thus their toxic response can affect the quality of life of the patient for a long period or for a short time.
The modern society has unprecedented pressure on human beings due to the rapid and tense pace of life. Under the working pressure of stress, excessive mental and physical labor, the spirit of people is highly stressed for a long time, and the body of people is often in a stress state for a long time, so that the immunity of the human body is reduced, and the human body is further developed into a sub-health state. The immune function failure such as low immune function, immune dysfunction and the like is a precursor of serious diseases such as cardiovascular and cerebrovascular diseases, diabetes, hypertension, hyperlipidemia, fatty liver, cancer and the like of human beings, is also a root cause of diseases which are difficult to cure, and cannot be ignored. Immunity is a human body's own epidemic prevention mechanism, and is the ability of the body to recognize and destroy foreign invaders (viruses, bacteria, etc.) and to treat senescent, dead, injured, denatured, self-cells, and to recognize and treat mutant and virally infected cells in the body. Therefore, improving the human immunity is the basis for preventing and treating sub-health.
At present, a plurality of products for improving immunity are available in the market, but most of the existing products for improving immunity are medicines, have certain side effects, are easy to cause discomfort of users, and are not suitable for long-term taking and body conditioning. The search for more ideal daily health care products suitable for improving immunity and improving health state is still an important task in the field of immunity improvement and health care development.
Disclosure of Invention
The invention overcomes the defects in the prior art, and provides a composition for improving immunity and application thereof, which are used for improving the immunity of an organism to treat or inhibit tumors of animals or human beings.
In order to solve the technical problems, the invention adopts the technical scheme that: a composition for improving immunity comprises fulvic acid or its salt, protein powder and wood vinegar powder at a weight ratio of 1-2:2-1: 1-2.5.
The protein powder comprises vegetable protein, animal protein and insect protein, and the weight ratio of the protein powder to the insect protein is 3-1:2-1: 3-1.
The fulvic acid is derived from carbohydrate, and the pH value of the fulvic acid or the fulvic acid salt in water solution is 1-7. The fulvic acid, salt, ester or derivative thereof may have any pH from acidic to basic, typically from acidic to neutral. The fulvic acid may be present in the form of a solution buffered to a suitable pH.
The fulvic acid contains no more than 20ppm of aluminum, mercury, cadmium, lead and chromium. Fulvic acid is derived from carbohydrates such as sugars. Preferred sugars are sucrose, glucose or fructose.
The fulvic acid salt is sodium salt, potassium salt or zinc salt of fulvic acid. Preferably, the fulvic acid is present in the form of the acid or in the form of a salt such as the potassium salt.
The vegetable protein is one or more of papaya protein, soybean protein, spirulina protein or peanut protein; the animal protein is one or more of whey protein, fish protein, casein, bovine bone protein or sheep bone protein; the insect protein is one or more of ant protein, locust protein, mulberry insect protein or wasp protein. The components in the plant protein, the animal protein and the insect protein can be mixed at will in the preparation of the finished medicament, as long as the total ratio of the plant protein, the animal protein and the insect protein is ensured to be 3-1:2-1: 3-1. The vegetable protein can also be Chinese herbal medicine protein and fruit protein; the insect protein is: centipede protein and earthworm protein. The protein is not limited to the above-mentioned proteins, and any commercially available protein may be used as long as it is suitable for addition to food. The protein can be produced by using a commercially available finished protein or by itself.
The composition is formulated into a pharmaceutical dosage form, which is a liquid, tablet, capsule or gel.
Use of a composition for enhancing immunity, the medicament being for treating or inhibiting a tumor, the method comprising administering the medicament to a subject, the subject comprising an animal or human.
The invention also comprises a mixture of glucose and active polysaccharide, the weight percentage of the mixture is 1-3%, and the mixture is mainly used for helping the organism digest protein and helping peptide and amino acid which are degraded by fulvic acid and wood vinegar components.
The components adopted by the invention are all natural components, the processing technology of the invention takes the preservation of the bioactivity of the composition as a key control point, and the composition is processed by the existing low-temperature mixing and low-temperature drying method.
Fulvic acid is an organic natural electrolyte that helps to balance and promote the biological carrier in contact with it, enhancing biological properties. Fulvic acid has a unique side-effect, absorbs and adds vitamins, herbs, minerals, tinctures, and foods combined with it, which then produce other compounds. Fulvic acid enters into the body to assist and catalyze the reaction of human enzymes, so that the absorption and utilization rate of vitamins are improved, free radicals can be eliminated after the absorption of the body, the cell regeneration capacity is enhanced, the metabolism of the body is promoted, and the fulvic acid reacts with polypeptides, short peptides, amino acids and the like of digested protein to generate available compounds.
The animal protein and the insect protein are mixed to be used as the protein source, because the animal protein and the insect protein are rich in nutrition, but the animal protein contains a large amount of fat, animal experiments show that animals eating the animal protein develop and grow fast, but have short service life. The animals eating the plant protein have slow development, long service life and good endurance. Therefore, proper plant protein is added into animal protein to fully play the complementary role of protein, so that human body can obtain balanced and proper amount of amino acid.
The insect protein is a high-quality protein and contains rich natural high-quality protein, 18 amino acids, vitamins, mineral substances and trace elements; also contains antibacterial peptide, defensin, and exogenous agglutinin. Has the following effects: 1) balancing cell nutrition. Insect protein provides and converts various glycolytic lipoprotein proteases for cell metabolism according to needs, and ensures the normal conversion of absorbed energy of various nutrients. 2) Repairing cell damage. The micromolecule high-activity protein of insect protein can repair cells eroded and damaged by bacteria and viruses and restore the normal metabolic function of the cells. 3) Eliminating cytotoxin. The micromolecule high-purity chitosan after the insect proteolysis has the effect and the price which are dozens of times of those of common chitosan, can quickly and thoroughly eliminate trace harmful substances and drug toxicity residues of cells, and can eliminate aged and dead cells. 4) Activating cellular immunity. The unique antibacterial peptide of the insect protein can directly activate and supplement the cellular immunity of the human body, sterilize and expel toxin to ensure the healthy metabolism of cells. 5) High protein, low fat, low cholesterol: for example, the dry body protein content of bees is as high as 81%, and the dry body of termites is 80% protein and fat. (in animal protein, protein content of pork is 13.2%, chicken is 23.3%); 6) the nutrient medium contains 8 kinds of essential amino acids, has high content, reasonable nutrient structure and easy absorption; 7) the unsaturated fatty acid is high and the fat content is low. 70% of them are precious unsaturated fatty acids.
The main components of the wood vinegar are acetic acid, phenols, water and various trace elements, wherein the organic matter component acetic acid accounts for more than 10%. The wood vinegar contains a plurality of phenolic substances, has strong functions of bacteriostasis, sterilization and antibiosis, also has the effects of disinfection, insect prevention and insect expelling, and simultaneously has the effects of improving the photosynthetic efficiency of plants, improving the quality of crops and improving soil.
The advantage of wood vinegar is that it has remarkable effects of sterilization, detoxification, cell regeneration and immunity enhancement, and is effective for all diseases. The wood vinegar has obvious effect in the experiment of anticancer efficacy, and can successfully inhibit 98.5% of gastric cancer and 94.4% of colorectal cancer.
The invention adopts animal protein, plant protein and insect protein as supplement sources of body protein, so that when fulvic acid is accompanied by nutrient components, high-quality protein, amino acid and functional components are cooperated in vivo, and wood vinegar with anticancer effect is cooperated, thus obviously improving the immunity of the body and inhibiting tumor cells.
Compared with the prior art, the invention has the beneficial effects that: the combination of the fulvic acid, the protein powder and the wood vinegar powder adopted by the invention can certainly improve the immune function of an organism, the fulvic acid, the protein powder and the wood vinegar powder are coordinated and supplemented with each other, the protein with high quality is provided for the organism, the fulvic acid is used for adhering nutrition, the absorption and utilization of the organism are accelerated, and the immunity of the organism is further improved by the cooperation of the wood vinegar powder, so that the aims of treating and inhibiting tumors are fulfilled.
Detailed Description
The present invention will be further described with reference to the following examples.
Example 1
A composition for improving immunity is prepared from fulvic acid, protein powder and wood vinegar powder in a weight ratio of 1:1: 1.
Wherein the protein powder is prepared from vegetable protein, animal protein and insect protein according to the weight ratio of 1:1: 1.
The pH value of the fulvic acid water-soluble substance is 3-5.
The vegetable protein is papaya protein, soybean protein, spirulina protein and peanut protein, and the weight parts are as follows: 1:1:1, mixing; the animal protein is whey protein, fish protein, casein, bovine bone protein and sheep bone protein in a weight ratio of 1:1: 1:1:1, mixing; the insect protein is ant protein, locust protein, mulberry insect protein and wasp protein in a weight ratio of 1:1: 1:1 and mixing.
The composition is prepared into liquid dosage forms.
Example 2
A composition for improving immunity is prepared from fulvic acid salt, protein powder and wood vinegar powder in a weight ratio of 2:2: 2.5.
Wherein the protein powder is prepared from vegetable protein, animal protein and insect protein according to the weight ratio of 3:2: 3.
The pH value of the water soluble fulvic acid salt is 5-7.
The fulvic acid salt is potassium salt and zinc salt of fulvic acid, and the weight ratio of the fulvic acid salt to the zinc salt is 1: 2.
the vegetable protein is papaya protein, soybean protein, spirulina protein and peanut protein, and the weight parts are as follows: 3: 5: 0.5 mixing; the animal protein is whey protein, fish protein, casein, bovine bone protein and sheep bone protein in a weight ratio of 2: 1: 3:2: 1, mixing; the insect protein is ant protein, locust protein, mulberry insect protein and wasp protein in a weight ratio of 3: 1: 2.5: 1.2 mixing.
The composition is made into tablet.
Example 3
A composition for improving immunity is prepared from fulvic acid salt, protein powder and wood vinegar powder in a weight ratio of 1.5:1.5: 2.
Wherein the protein powder is prepared from vegetable protein, animal protein and insect protein according to the weight ratio of 2:1.6: 2.1.
The pH of the water soluble fulvic acid salt is 4-7.
The fulvic acid salt is sodium salt and zinc salt of fulvic acid, and the weight ratio of the fulvic acid salt to the zinc salt is 1: 0.3.
the vegetable protein is papaya protein, soybean protein, spirulina protein and peanut protein, and the weight parts are as follows: 4: 5:1.5, mixing; the animal protein is whey protein, fish protein, casein, bovine bone protein and sheep bone protein in parts by weight of 4: 1: 3: 2.5: 2, mixing; the insect protein is ant protein, locust protein, mulberry insect protein and wasp protein in a weight ratio of 2: 1.5: 3: 1 and mixing.
The composition is made into gel.
The biological efficacy of the above components is verified by the following tests.
Firstly, the influence of the composition on the immunity of experimental animals
100 clean-grade KM mice, half male and female, weighing (20 + -2) g, were randomly divided into 5 groups of 20 mice each. Taking body weight as standard, and performing intragastric administration on 3 experimental groups and 2 control groups according to the administration standard of 0.04 g/kg; meanwhile, normal saline with the same weight is used as a blank control group, and the stomach is continuously irrigated for 12 days. The effect of the different compositions on the immunity of the mice was evaluated by the following criteria.
(1) Immune organ index: the mice were sacrificed by removing the neck, and the thymus and spleen were taken and weighed, and the thymus index and spleen index were calculated. Thymus index is thymus weight/body weight; spleen index ═ spleen weight/body weight
(2) Immune function detection
Mouse carbon clearance experiment:injecting India ink diluted 4 times into mouse tail vein plexus at a weight of 100mL/kg, collecting 20 μ L of blood from canthus vein at 2min and 10min, and adding 0.1% Na2CO3In 2mL of the solution, the Optical Density (OD) was measured at a wavelength of 600nm and Na was added in an amount of 0.1%2CO3The solution was used as a blank control and the clearance index K was calculated.
K＝(lgOD1-lgOD2)/(t1-t2)
Delayed allergy assay: the abdomen of the mouse was dehaired with sodium sulfide and sensitized by smearing 40. mu.L of a 10mg/mL solution of 2, 4-dinitrofluorobenzene. After 5 days, the right ear was challenged with 10. mu.L of DNFB solution at the same concentration applied to both sides. After 24h, the mice were sacrificed by removing their necks, and the 10 mm-diameter ear pieces were taken from the left and right ear shells by a puncher, weighed, and the delayed-type allergic response value was evaluated by the difference between the two ear pieces.
(3) Serum IL-2 assay
1.5mL of blood is taken from the orbit, the orbit is kept stand for 30min, centrifugation is carried out for 15min at 2500r/min, supernatant fluid is taken, and the content of IL-2 in serum is measured.
Figure 594326DEST_PATH_IMAGE002
The above table shows that the thymus and spleen indexes of the example group and the control group are both obviously increased, which shows that the composition of the invention can obviously improve the thymus and spleen organ indexes of mice, thereby reflecting that the immune function of the mice is obviously improved.
Figure 245887DEST_PATH_IMAGE004
The above table shows that the carbon clearance indexes of the mice of the example group and the control group are obviously improved, and the difference is obvious, which indicates that the composition of the invention can obviously improve the nonspecific immunity function of the mice.
Figure DEST_PATH_IMAGE006
The above table shows that the weight difference between the right and left auricles of the mice in the example group and the control group is obviously reduced, which indicates that the composition of the invention can obviously promote the effect of delaying the allergic reaction.
Figure DEST_PATH_IMAGE008
The above table shows that the serum IL-2 of the mice of the example group and the control group is obviously increased and has obvious difference, which indicates that the composition of the invention can obviously improve the serum IL-2 content of the mouse body and enhance the body immunity.
In conclusion, the composition for improving the immunity can increase the weight of thymus and spleen of immune organs of an experimental mouse, improve the non-specific immune function of an organism and improve the content of IL-2 in serum, and the composition for improving the immunity has mutual influence and synergistic addition effect, and has the effect of improving the immunity of the mouse which is obviously higher than that of a control group.
Next, the immunity-improving effect of the composition for improving the immunity is investigated
57 patients with hypoimmunity, which are 15-72 years old, are divided into 3 groups of 19 people each, half of both men and women. After the composition for enhancing immunity prepared in 3 experimental groups of the present invention was administered for 1 month, the effect was evaluated according to the following criteria, and the results are shown in the table.
Effect evaluation criteria:
the effect is shown: the constitution is obviously enhanced, the limbs are powerful, the energy is full, the complexion is obviously improved, the symptoms such as color spots, dark skin and the like disappear or are obviously improved, and the sub-health state in the aspects of sleeping, digestion and the like is obviously improved;
the improvement is as follows: the constitution is enhanced, the four limbs are powerful, the energy and the complexion are improved to a certain extent, the symptoms such as color spots, dark skin and the like are improved, and the sub-health state in the aspects of sleeping, digestion and the like is also improved;
and (4) invalidation: the symptoms and various examinations did not improve.
Figure DEST_PATH_IMAGE010
The above table shows that the composition for improving immunity prepared by the invention can obviously improve the immunity of organisms, the total effective rate is above 89.47%, the experiment time is short, in order to prove the effectiveness of the invention, the existing experiment model is adopted, the number of samples is small, and the inventor thinks that if the period is 6 months, the effective performance is above 95%.
The above embodiments are merely illustrative of the principles of the present invention and its effects, and do not limit the present invention. It will be apparent to those skilled in the art that modifications and improvements can be made to the above-described embodiments without departing from the spirit and scope of the invention. Accordingly, it is intended that all equivalent modifications or changes be made by those skilled in the art without departing from the spirit and technical spirit of the present invention, and be covered by the claims of the present invention.

Claims (7)

1. A composition for enhancing immunity, comprising: comprises fulvic acid or fulvic acid salt, protein powder and wood vinegar powder, and the weight ratio of the fulvic acid or fulvic acid salt to the wood vinegar powder is 1-2:2-1: 1-2.5.
2. The composition for improving immunity according to claim 1, wherein: the protein powder comprises vegetable protein, animal protein and insect protein, and the weight ratio of the protein powder to the insect protein is 3-1:2-1: 3-1.
3. The composition for improving immunity according to claim 1, wherein: the fulvic acid is derived from carbohydrate, and the pH value of the fulvic acid or the fulvic acid salt in water solution is 1-7.
4. The composition for improving immunity according to claim 1, wherein: the fulvic acid salt is sodium salt, potassium salt or zinc salt of fulvic acid.
5. The composition for improving immunity according to claim 1 or 2, wherein the vegetable protein is one or more of papaya protein, soy protein, spirulina protein or peanut protein; the animal protein is one or more of whey protein, fish protein, casein, bovine bone protein or sheep bone protein; the insect protein is one or more of ant protein, locust protein, mulberry insect protein or wasp protein.
6. The composition for improving immunity according to any one of claims 1 to 4, wherein: the composition is formulated into a pharmaceutical dosage form, which is a liquid, tablet, capsule or gel.
7. Use of a composition according to claim 6 for enhancing immunity, wherein the medicament is for treating or inhibiting a tumor, the method comprising administering the medicament to a subject, the subject comprising an animal or human.
CN202010569170.7A 2020-06-20 2020-06-20 Composition for improving immunity and application thereof Pending CN111616358A (en)

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CN104083471A (en) * 2013-04-01 2014-10-08 李永君 Oral liquid for treating hypertension
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CN106929383A (en) * 2015-12-31 2017-07-07 营口富里泥炭科技有限公司 A kind of preparation method of fulvic acid apple health-care vinegar beverage
CN105707886A (en) * 2016-02-29 2016-06-29 海南大学 Composition capable of resisting to oxidation and improving immunity and preparation method and application thereof
CN106174598A (en) * 2016-07-07 2016-12-07 海南正康药业有限公司 A kind of egg albumen powder of enhancing immunity
CN108740660A (en) * 2018-06-19 2018-11-06 唐振华 A kind of health drink and preparation method thereof improving immunity

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Application publication date: 20200904