CN116035800B - A subcutaneous implantable transsemicircular canal inner ear repeated drug delivery device - Google Patents

Abstract

The present invention relates to a subcutaneously implanted transsemicircular canal inner ear repeated drug delivery device, which includes: a drug delivery device for accurately pushing a micro-dosing device for precise drug delivery, which includes a drug delivery device shell and a transmission structure. The transmission device The structure is arranged inside the shell of the drug delivery device; a micro-dosing device is used to absorb therapeutic drugs and eject the drugs, and drive the drugs under the skin of the patient; a drug delivery device; which includes a drug delivery base and a drug delivery catheter. The drug base is buried behind the patient's ear, the drug administration catheter is placed inside the patient's mastoid, the end of the drug administration catheter is inserted into the semicircular canal, the drug administration catheter is fixedly connected to the drug administration base, and the drug administration catheter is connected to the inside of the drug administration base; The micro-dosing device is detachably connected to the drug delivery device. The micro-dosing device can be connected to a catheter and inserted into the inside of the drug delivery base to inject medicine thereto, thereby treating inner ear diseases.

Description

A subcutaneous implantable transsemicircular canal inner ear repeated drug delivery device

Technical field

The invention belongs to the technical field of medical devices, and specifically relates to a subcutaneous implantable trans-semicircular canal inner ear repeated drug delivery device.

Background technique

The inner ear, also known as the labyrinth, includes the semicircular canals (external semicircular canal, anterior semicircular canal, and posterior semicircular canal), vestibule, and cochlea. The labyrinth is divided into two parts by a membranous structure, and the outer side is the gap between the bone and membranous structures.

It is called the bony labyrinth, which is filled with perilymph. The inside of the membranous structure is the membranous labyrinth, which is filled with endolymph. The volume of endolymph is about 34 microliters. The receptors of the inner ear are located in the membranous labyrinth, and the microenvironment surrounding them is endolymph. The inner ear receptors include the ampulla located in the semicircular canals, the utricle and saccule located in the vestibule, and the hair cells located in the cochlea. The inner ear receptors mainly sense linear and angular acceleration, gravity, and sound. Inner ear lesions and injuries can lead to vertigo, tinnitus and deafness. Since there is no effective inner ear drug delivery route and drug delivery device, oral, intravenous and middle ear drug delivery methods are often used in clinical treatment. Due to the side effects of drugs, oral and The dosage of intravenous administration is often difficult to achieve effective inner ear drug concentration. For patients with underlying diseases (hypertension, diabetes, kidney disease, etc.), oral and intravenous administration are even more restricted. Although middle ear drug administration can achieve the purpose of local drug administration, since the middle ear cavity and nasopharynx communicate through the Eustachian tube, the medicinal liquid often flows out of the middle ear cavity quickly through the Eustachian tube, and middle ear drug administration needs to pass through the round window membrane. Penetration, and the infiltrated medicinal solution can only reach the perilymph of the inner ear, but the inner ear receptors are located in the endolymph, so the medicinal solution still needs to cross the barrier of the membranous structure between the perilymph and endolymph, making it difficult to reach the inner ear. Effective drug concentration in lymph fluid. Although cochlear implant electrodes can currently be implanted through the round window and drug delivery to the inner ear is achieved through the side hole of the electrode, this drug delivery also releases the drug solution into the perilymph. The purpose of drug delivery is mainly to reduce the pain in the inner ear caused by electrode implantation. Inflammatory response, etc. With the development of biomedical technology, gene therapy, stem cell therapy and biological targeted therapy will be more applied to inner ear diseases, and there is an urgent need to develop a safe, effective and reproducible inner ear drug delivery device.

In order to solve the above problems, the present invention provides a subcutaneous implantable trans-semicircular canal inner ear repeated drug administration device.

Contents of the invention

In order to overcome the problems raised in the background technology, the present invention adopts the following technical solutions:

A subcutaneously implantable trans-semicircular canal inner ear repeated drug delivery device, which includes:

A drug delivery device is used to accurately push the micro-dosing device for precise drug administration; it includes a drug delivery device shell and a transmission structure, and the transmission structure is arranged inside the drug delivery device shell;

Micro-administrator is a drug delivery device used to absorb therapeutic drugs, dispense the drugs, and drive the drugs into the patient's skin; the drugs are drugs used for gene therapy, stem cell therapy, or biologically targeted therapy;

A drug administration device; it includes a drug administration base and a drug administration catheter. The drug administration base is embedded behind the patient's ear. The drug administration catheter is arranged inside the patient's ear. The end of the drug administration catheter is inserted into the semicircular canal. The drug administration catheter is connected to the drug administration catheter. The base is fixedly connected, and the administration conduit is internally connected with the administration base;

The micro-dosing device is detachably connected to the drug-delivery device, and the micro-dosing device can be connected to a catheter and inserted into the inside of the drug-delivery base to inject medicine thereon, thereby treating inner ear diseases.

Further, the transmission structure includes a driving motor, a screw, a fixed plate and a moving block; the fixed block includes a first fixed block and a second fixed block; the driving motor is fixedly connected to the screw, and the fixed plate is arranged on On both sides of the screw, the screw is rotatably connected to the fixed plate, the moving block is disposed between the first fixed plate and the second fixed plate, and the moving block is movably connected to the screw.

Further, a mounting plate is provided at the bottom of the driving motor, and at least two fixing holes are provided on the mounting plate. The driving motor is fixed on the inside of the bottom of the housing of the drug delivery device, and a hole that matches the fixing hole is provided on the inside of the bottom of the housing of the drug delivery device. .

Further, the length of the screw is greater than the distance between the first fixed block and the second fixed block.

Further, a through hole is provided in the center of the first fixed block and the second fixed block. The diameter of the through hole is larger than the diameter of the screw. Bearings are arranged inside the through holes. The screw is installed on the bearing. The second end of the screw is The through hole extending out of the second fixed block is fixedly connected to the drive motor.

Further, at least one polished rod is provided between the first fixed block and the second fixed block; optionally, two polished rods are provided between the first fixed block and the second fixed block.

Further, a threaded hole is provided in the center of the moving block, the threaded hole is adapted to the thread on the screw, and a through hole adapted to the polished rod is provided on the moving block; the moving block is arranged between the first fixed block and the second fixed block. Between the screws, the screw passes through the threaded hole, and the polished rod passes through the through hole; the above arrangement ensures that the moving block can move between the first fixed block and the second fixed block when the screw rotates.

Further, a connecting rod is provided on one side of the moving block close to the front side of the drug delivery device casing, a spraying block is provided on the rear end of the connecting rod, a T-shaped groove is provided on the side of the spraying block, and the T-shaped groove runs through the spraying block. piece.

Furthermore, a groove-shaped through hole is provided on the front side of the housing of the drug delivery device, and the length of the groove-shaped through hole is set to be the same as the length of the movement range of the moving block.

Further, an arc-shaped groove is provided on the side of the groove-shaped through hole on the front side of the shell of the drug delivery device, the arc of the arc-shaped groove is 120-180 degrees, and a circle is provided at the connection between the arc-shaped groove and the groove-shaped through hole. The circular groove is perpendicular to the front side of the drug delivery device housing; optionally, the arc of the arcuate groove is set to 180 degrees.

Further, a blocking structure is provided on the lower side of the arc-shaped groove of the shell of the drug delivery device. The blocking structure includes a cylindrical rod and a blocking block; the blocking block is in the shape of a long strip, and any part of the blocking block is A round hole is provided on one side, and the blocking block is arranged on the cylindrical rod, and the blocking block can rotate along the cylindrical rod; there is friction between the blocking block and the cylindrical rod, which will not occur without human operation. relative rotation.

Furthermore, a display screen is provided on the upper front side of the housing of the drug delivery device. A switch and at least two adjustment buttons are provided on either side of the display screen. The adjustment buttons can adjust the dosage and speed of the microdosing device. .

Furthermore, a control system is provided inside the casing of the drug delivery device, which can control the rotation speed and rotation time of the drive motor. The control system can adopt existing technology.

Furthermore, a power cord is provided at the rear end of the housing of the drug delivery device to provide power to each component.

Further, the microadministrator includes a syringe, an injection part and a syringe; the inside of the syringe is hollow, the injection part is configured inside the syringe, the injection part is movably connected to the syringe, and the syringe It is arranged at the front end of the syringe barrel, and the syringe tube and the syringe barrel are detachably linked. The inner volume of the syringe is 30-50 microliters, and the inner ear receptors are immersed in the endolymph, and the total volume of the endolymph is approximately 34 microliters.

Furthermore, the front end of the syringe barrel is provided with an injection port, and the rear end of the syringe barrel is provided with a hand-held part. The hand-held part can be placed in a circular groove, and the middle part of the syringe barrel can be placed in an arc-shaped groove to prevent it from being stuck. The structure can fix the syringe barrel and prevent the syringe barrel from falling out of the arc-shaped groove when injecting medicine.

Further, the injection part includes a piston, a connecting rod and a pressing part, the first end of the connecting rod is fixedly connected to the piston, the second end of the connecting rod is fixedly connected to the pressing part, the inner diameter of the piston and the injection barrel is the same, The above arrangement ensures that the medicine in the syringe barrel can be pressed out by pushing the pressing part.

Further, the first end of the injection tube is adapted to the injection port, and the second end of the injection tube is provided with a puncture needle.

Furthermore, the inside of the drug administration base is hollow, and a soft material is provided on the upper part of the drug administration base. The soft material can be silica gel. The puncture needle can be inserted into the patient's skin through the soft material, and the medicine can be injected into the drug administration base through The drug delivery catheter flows through the semicircular canals to achieve the therapeutic effect.

Furthermore, the length of the drug administration catheter inserted into the semicircular canal is 8-16 mm; this ensures that when the drug administration catheter is inserted into the semicircular canal, the drug administration catheter is inserted deeply and is not easy to protrude; optionally, the length of the drug administration catheter inserted into the semicircular canal is: 10mm.

Furthermore, the diameter of the drug delivery catheter is between 0.1-0.3 mm, which ensures that the diameter of the drug delivery catheter is smaller than the diameter of the semicircular canal, and the drug delivery catheter can be inserted into the semicircular canal normally.

Furthermore, the drug administration catheter is made of soft material, and the front end of the drug administration catheter is set in a smooth shape to prevent the front end of the drug administration catheter from inserting into the semicircular canal from puncturing the semicircular canal again, causing the drug to be injected into the perilymph, which will not achieve the desired effect. The role of therapy.

Further, before inserting the drug administration catheter, a window is first opened in any one of the three semicircular canals, and the window is set close to the ampulla of the semicircular canal. When the drug administration catheter is inserted into the semicircular canal, the direction of insertion of the catheter is away from the semicircular canals. of ampulla.

Furthermore, an enlarged portion is provided 10 mm from the front end of the drug delivery catheter, and the diameter of the enlarged portion is larger than the diameter of the window of the semicircular canal; the above arrangement ensures that the expanded portion can be stuck at the window of the semicircular canal after the drug delivery catheter is inserted, preventing The leakage of endolymph fluid can also prevent the drug delivery catheter from slipping in the semicircular canal, thus minimizing the disturbance to the internal receptors in the ampulla.

Furthermore, during implantation, a power drill needs to be used to remove part of the mastoid bone to expose any one of the three semicircular canals: the lateral semicircular canal, the anterior semicircular canal, and the posterior semicircular canal. Part of the bone in the semicircular canal must be removed to open a window to expose the membranous semicircular canal. At the window of each semicircular canal, a microscopic needle is used to open the membranous semicircular canal and place the drug catheter. In order to avoid irritation to the inner ear receptors, the drug catheter should be inserted away from the ampulla; the total length of the drug administration catheter is set to 150mm, and the infusion tube can be placed in the mastoid The cavity is coiled.

Beneficial effects of the present invention: By setting up a drug delivery device, the present invention can perform repeatable and precise micro-administration to the patient's inner ear, and provides a reliable drug administration route for drug treatment of inner ear diseases.

Description of the drawings

Figure 1 is a schematic diagram of the overall structure of the present invention;

Figure 2 is a schematic structural diagram of the cooperation between the drug delivery device and the micro-dosing device of the present invention;

Figure 3 is a schematic structural diagram of the drug delivery device of the present invention;

Figure 4 is a schematic cross-sectional structural view of the micro-dosing device of the present invention when it is installed on a drug delivery device;

Figure 5 is a schematic cross-sectional structural view of the drug delivery device of the present invention;

Figure 6 is a schematic structural diagram of the moving block of the present invention;

Figure 7 is a schematic structural diagram of the micro-dosing device of the present invention;

Figure 8 is a schematic structural diagram of the drug delivery device of the present invention;

Figure 9 is a schematic cross-sectional structural view of the drug delivery device of the present invention;

Figure 10 is a schematic structural diagram of the drug delivery device of the present invention after it is placed under the skin;

In the figure, 1. Administration device shell; 2. Micro-administration device; 3. Administration base; 4. Administration catheter; 5. Drive motor; 6. Lead screw; 7. Fixed plate; 8. Moving block; 9 , Polished rod; 10. Threaded hole; 11. Connecting rod; 12. Spraying block; 13. Grooved through hole; 14. Arc groove; 15. Circular groove; 16. Cylindrical rod; 17. Stuck block; 18. Display screen; 19. Switch; 20. Adjustment button; 21. Power cord; 22. Syringe barrel; 23. Injection part; 24. T-shaped slot; 25. Injection tube; 26. Hand-held part; 27. Piston; 28 , connecting rod; 29, pressing part; 30, puncture needle; 31, ampulla; 32, semicircular canal.

Detailed ways

The following is a clear and complete description of the technical solutions in the embodiments of the present invention through specific specific embodiments. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of the embodiments. Those skilled in the art can refer to this Other advantages and effects of the present invention can be easily understood from the content disclosed in the specification. The present invention can also be implemented or applied through other different specific implementations. In the case of no conflict, the following embodiments and the features in the embodiments can be combined with each other. Based on the embodiments of the present invention, those of ordinary skill in the art can All other embodiments obtained without creative efforts belong to the scope of protection of the present invention.

Example 1

Please refer to Figures 1-10. In this embodiment, a subcutaneously implantable inner ear repeated drug administration device through the semicircular canal 32 includes:

The drug delivery device is used to accurately push the micro-dosing device 2 for accurate drug administration; it includes a drug delivery device housing 1 and a transmission structure, and the transmission structure is arranged inside the drug delivery device housing 1 .

The micro-administrator 2 is a drug delivery device used to absorb therapeutic drugs, eject the drugs, and drive the drugs into the patient's skin.

Drug administration device; it includes a drug administration base 3 and a drug administration catheter 4. The drug administration base 3 is implanted behind the patient's ear. The drug administration catheter 4 is installed inside the patient's ear. The end of the drug administration catheter 4 is inserted into the semicircular canal 32. The drug administration catheter 4 It is fixedly connected to the drug administration base 3, and the drug administration conduit 4 communicates with the inside of the drug administration base 3.

The micro-dosing device 2 is detachably connected to the drug-delivery device. The micro-dosing device 2 can be connected to a catheter and inserted into the inside of the drug-delivery base 3 to inject medicine thereto, thereby treating inner ear diseases.

Example 2

Please refer to Figures 1-6. Based on Embodiment 1, this embodiment adds the following technical features: (The structure of the drug delivery device is set as follows): The transmission structure includes a drive motor 5, a screw 6, and a fixed plate 7 and the moving block 8; the fixed block includes a first fixed block and a second fixed block; the driving motor 5 is fixedly connected to the screw 6, the fixed plates 7 are arranged on both sides of the screw 6, the screw 6 is rotationally connected to the fixed plate 7, and the moving The block 8 is arranged between the first fixed plate 7 and the second fixed plate 7 , and the moving block 8 is movably connected with the screw 6 .

A mounting plate is provided at the bottom of the driving motor 5, and at least two fixing holes are provided on the mounting plate. The driving motor 5 is fixed on the inside of the bottom of the drug delivery device casing 1, and holes that match the fixing holes are provided on the inside of the bottom of the drug delivery device casing 1.

The length of the screw 6 is greater than the distance between the first fixed block and the second fixed block.

A through hole is provided in the center of the first fixed block and the second fixed block. The diameter of the through hole is larger than the diameter of the screw 6. Bearings are arranged inside the through holes. The screw 6 is installed on the bearing. The second end of the screw 6 extends out of the second fixed block. The through hole of the block is fixedly connected with the drive motor 5.

At least one polished rod 9 is provided between the first fixed block and the second fixed block; optionally, two polished rods 9 are provided between the first fixed block and the second fixed block.

A threaded hole 10 is provided in the center of the moving block 8, and the threaded hole 10 is adapted to the thread on the screw 6. A through hole is provided on the moving block 8 to adapt to the polished rod 9; the moving block 8 is provided on the first fixed block and the second fixed block. Between them, the screw 6 passes through the threaded hole 10, and the polished rod 9 passes through the through hole; the above arrangement ensures that the screw 6 rotates, and the moving block 8 can move between the first fixed block and the second fixed block.

A connecting rod 11 is provided on the side of the moving block 8 close to the front side of the drug delivery device shell 1. A spraying block 12 is provided at the rear end of the connecting rod 11. A T-shaped groove 24 is provided on the side of the spraying block 12. The T-shaped groove 24 passes through the spraying block 12. .

A groove-shaped through hole 13 is provided on the front side of the housing 1 of the drug delivery device, and the length of the groove-shaped through hole 13 is set to the movement range of the moving block 8 .

An arc-shaped groove 14 is provided on the side of the groove-shaped through hole 13 on the front side of the drug delivery device housing 1. The arc groove 14 has a curvature of 120-180 degrees. A circle is provided at the connection between the arc-shaped groove 14 and the groove-shaped through hole 13. The circular groove 15 is perpendicular to the front side of the drug delivery device housing 1; optionally, the arc of the arcuate groove 14 is set to 180 degrees.

A blocking structure is provided on the lower side of the arc-shaped groove 14 of the housing 1 of the drug delivery device. The blocking structure includes a cylindrical rod 16 and a blocking block 17; the blocking block 17 is in the shape of a long strip, and a blocking structure is provided on either side of the blocking block 17. round hole, the blocking block 17 is set on the cylindrical rod 16, the blocking block 17 can rotate along the cylindrical rod 16; there is friction between the blocking block 17 and the cylindrical rod 16, and relative rotation will not occur without human operation. .

A display screen 18 is provided on the upper front side of the drug delivery device housing 1. A switch 19 and at least two adjustment buttons 20 are provided on either side of the display screen 18. The adjustment buttons 20 can adjust the dosage and speed of the microdosing device 2.

A control system is provided inside the housing 1 of the drug delivery device, which can control the rotation speed and rotation time of the drive motor 5. The control system can adopt existing technology.

A power cord 21 is provided at the rear end of the housing 1 of the drug delivery device, which can provide power to each component.

Example 3

Please refer to Figures 1-2, 4, and 7. On the basis of Embodiment 1-2, this embodiment adds the following technical features (the following specific settings are made to the structure of the microdosing device 2): The microdosing device 2 includes an injection Barrel 22, injection part 23 and injection tube 25; the inside of the injection tube 22 is hollow, the injection part 23 is arranged inside the injection tube 22, the injection part 23 is movably connected to the injection tube 22, the injection tube 25 is arranged at the front end of the injection tube 22, the injection tube 25 is detachably linked to the syringe barrel 22. The inner volume of the syringe 22 is 30-50 microliters. The inner ear receptors are immersed in the endolymph, and the total amount of endolymph is about 34 microliters.

The front end of the syringe barrel 22 is provided with an injection port, and the rear end of the syringe barrel 22 is provided with a hand-held portion 26. The hand-held portion 26 can be placed in the circular groove 15, and the middle part of the syringe barrel 22 can be placed in the arc-shaped groove 14. The blocking structure The syringe barrel 22 can be fixed to prevent the syringe barrel 22 from falling out of the arcuate groove 14 when injecting medicine.

The injection part 23 includes a piston 27, a connecting rod 28 and a pressing part 29. The first end of the connecting rod 28 is fixedly connected to the piston 27, and the second end of the connecting rod 28 is fixedly connected to the pressing part 29. The inner diameter of the piston 27 and the injection barrel 22 are the same. The above arrangement ensures that the medicine in the syringe barrel 22 can be pressed out by pushing the pressing part 29 .

The first end of the injection tube 25 is adapted to the injection port, and the second end of the injection tube 25 is provided with a puncture needle 30 .

Example 4

Please refer to Figures 1, 8-10. On the basis of Embodiments 1-3, this embodiment adds the following technical features (the structure of the drug delivery device is specifically set as follows): the interior of the drug delivery base 3 is hollow, and the drug delivery base 3 is hollow inside. 3. The upper part is provided with a soft material, and silicone can be used as the soft material. The puncture needle 30 can be inserted into the patient's skin and penetrated through the soft material, and the medicine can be injected into the drug delivery base 3 and flows through the semicircular canal 32 through the drug delivery catheter 4 to achieve the therapeutic effect. .

The length of the administration catheter 4 inserted into the semicircular canal 32 is 8-16 mm; this ensures that when the administration catheter 4 is inserted into the semicircular canal 32, the administration catheter 4 is inserted deeply and is not easy to protrude; optionally, the length of the administration catheter 4 inserted into the semicircular canal 32 is 10mm.

The diameter of the drug delivery catheter 4 is between 0.1-0.3 mm, which ensures that the diameter of the drug delivery catheter 4 is smaller than the diameter of the semicircular canal 32 and the drug delivery catheter 4 can be inserted into the semicircular canal 32 normally.

The drug administration catheter 4 is made of soft material, and the front end of the drug administration catheter 4 is set in a smooth shape to prevent the front end of the drug administration catheter 4 from being inserted into the semicircular canal 32 and puncturing the semicircular canal 32 again, causing the drug to be injected into the perilymph, and thus no treatment can be achieved. role.

Before inserting the drug administration catheter 4, first open a window in any one of the three semicircular canals 32, and the window is set close to the ampulla 31 of the semicircular canal 32. When the drug administration catheter 4 is inserted into the semicircular canal 32, the direction of the catheter insertion is away from the semicircular canals. 32 of the ampulla 31; preferably, the outer semicircular canal 32 is best selected, as the other two semicircular canals 32 are relatively difficult to expose during surgery.

An enlarged portion is provided 10 mm away from the front end of the administration catheter 4. The diameter of the enlarged portion is larger than the diameter of the window of the semicircular canal 32; the above arrangement ensures that the enlarged portion can be stuck at the window of the semicircular canal 32 after the administration catheter 4 is inserted, preventing the administration catheter from being stuck in the window of the semicircular canal 32. 4 slips in the semicircular canal 32, so that the disturbance to the internal receptors of the ampulla 31 is minimal.

Before implanting the drug delivery catheter 4, use a power drill to remove part of the mastoid bone to expose any one of the three semicircular canals 32: the lateral semicircular canal 32, the anterior semicircular canal 32, and the posterior semicircular canal 32, and remove part of the bone of the semicircular canal 32 to open a window. Expose the membranous semicircular canal 32. At the window of the semicircular canal 32, use a microscopic needle to open the membranous semicircular canal 32 and place the drug delivery catheter. In order to avoid irritation to the inner ear receptors, the drug delivery catheter 4 should be inserted away from the ampulla 31 of the semicircular canal 32; the drug delivery catheter 4. The total length is set to 150mm, and the infusion tube can be coiled in the mastoid cavity.

After the drug delivery device is first installed and fixed under the skin, the drug delivery catheter 4 is implanted inside the semicircular canal 32. After the micro-dosing device 2 draws in the drug, the micro-dosing device 2 is connected to the subcutaneous drug delivery device. The drug delivery device is adjustable. After adjusting the amount of medication, insert the puncture needle 30 at the rear end of the microneedle applicator into the patient's skin behind the ear and into the drug delivery device.

The above embodiments are described only for the purpose of understanding the present invention. It should be noted that for those of ordinary skill in the art, several improvements can be made to the present invention without departing from the principle of the present invention, and these improvements will also fall within the protection scope of the claims of the present invention.

Claims (7)

1. A subcutaneously implantable trans-semicircular canal inner ear repeated drug delivery device, characterized by comprising: A drug delivery device is used to accurately push the micro-dosing device for precise drug administration; it includes a drug delivery device shell and a transmission structure, and the transmission structure is arranged inside the drug delivery device shell; Microapplicator is used to absorb and dispense therapeutic drugs, and inject the drugs under the patient's skin; the drugs are drugs used for gene therapy, stem cell therapy or biologically targeted therapy; A drug delivery device; it includes a drug delivery base and a drug delivery catheter. The drug delivery base is embedded behind the patient's ear. The drug delivery catheter is installed inside the bone next to the patient's ear. The end of the drug delivery catheter is inserted into the semicircular canal. The drug delivery catheter It is fixedly connected to the drug administration base, and the drug administration conduit is internally connected with the drug administration base; The micro-dosing device is detachably connected to the drug delivery device, and the micro-dosing device can be connected to a catheter and inserted into the inside of the drug delivery base to inject medicine to treat inner ear diseases; Before implantation, use a power drill to remove part of the mastoid bone to expose any one of the three semicircular canals: the lateral semicircular canal, the anterior semicircular canal, and the posterior semicircular canal. Part of the bone in the semicircular canal is removed to open a window to form a window, exposing the membranous semicircular canal and the window. Set at a position close to the ampulla of the semicircular canal; at the window, a microscopic needle opens the membranous semicircular canal to place the drug catheter; during insertion, insert the drug catheter away from the ampulla of the semicircular canal to avoid irritation to the inner ear receptors; the drug administration The length of the catheter inserted into the semicircular canal is 8-16 mm; the diameter of the drug administration catheter is between 0.1-0.3 mm; the drug administration catheter is made of soft material, and the front end of the drug administration catheter is set in a smooth shape; An enlarged portion is provided 10mm away from the front end of the drug catheter for being stuck at the window of the semicircular canal; the diameter of the enlarged portion is larger than the diameter of the semicircular canal window; The total length of the drug delivery conduit is set to 150mm, and the infusion tube is coiled in the mastoid cavity; the interior of the drug delivery base is hollow, and a soft material is provided on the upper part of the drug delivery base, and the puncture needle can be inserted into the patient's skin and penetrated through the soft material. Materials, drugs can be injected into the drug delivery base and flow through the semicircular canals through the drug delivery catheter to achieve the therapeutic effect; The micro-administerer includes a syringe, an injection part and a syringe; the inside of the syringe is hollow, the injection part is arranged inside the syringe, the injection part is movably connected to the syringe, and the syringe is arranged on The front end of the syringe barrel, the syringe tube and the syringe barrel are detachably connected; the inner volume of the syringe barrel is 30-50 microliters. 2. The subcutaneous implantable trans-semicircular canal intraaural repeated drug administration device according to claim 1, characterized in that the transmission structure includes a drive motor, a lead screw, a fixed plate and a moving block; the fixed plate includes a first fixed plate and a second fixed plate; the driving motor is fixedly connected to the screw, the fixed plates are arranged on both sides of the screw, the screw is rotationally connected to the fixed plate, and the moving block is arranged between the first fixed plate and the second fixed plate. Between the two fixed plates, the moving block is movably connected to the lead screw; a mounting plate is provided at the bottom of the driving motor, and at least two fixing holes are provided on the mounting plate. The driving motor is fixed on the inside of the bottom of the drug delivery device shell. A hole matching the fixing hole is provided on the inside of the bottom of the device shell; the length of the screw is greater than the distance between the first fixing plate and the second fixing plate. 3. The subcutaneously implantable trans-semicircular canal inner ear repeated drug administration device according to claim 2, characterized in that a through hole is provided in the center of the first fixed plate and the second fixed plate, and the diameter of the through hole is larger than that of the lead screw. diameter, the through holes are equipped with bearings inside, the screw is installed on the bearing, the second end of the screw extends out of the through hole of the second fixed plate and is fixedly connected to the drive motor; the first fixed plate and the second fixed plate are At least one polished rod is set between the first fixed plate and the second fixed plate; two polished rods are set between the first fixed plate and the second fixed plate; a threaded hole is set in the center of the moving block, the threaded hole is adapted to the thread on the screw, and the polished rod is set on the moving block. Adapted through holes; the moving block is arranged between the first fixed plate and the second fixed plate, the screw passes through the threaded hole, and the polished rod passes through the through hole. 4. The subcutaneous implantable trans-semicircular canal intraaural repeated drug administration device according to claim 2, characterized in that a connecting rod is provided on one side of the moving block close to the front side of the drug drug casing, and the rear end of the connecting rod A spraying block is provided, a T-shaped groove is provided on the side of the spraying block, and the T-shaped groove penetrates the spraying block; a groove-shaped through hole is provided on the front side of the housing of the drug delivery device, and the length of the groove-shaped through hole is set to be equal to The length of the movement range of the moving block is the same; an arc-shaped groove is provided on the side of the channel-shaped through hole on the front side of the shell of the drug delivery device, and the curvature of the arc-shaped groove is 120-180 degrees. A circular groove is provided at the through-hole connection, and the circular groove is perpendicular to the front side of the housing of the drug delivery device. 5. The subcutaneous implantable trans-semicircular canal intraaural repeated drug delivery device according to claim 1, characterized in that a blocking structure is provided on the lower side of the arc-shaped groove of the housing of the drug delivery device, and the blocking structure includes a cylinder. Rod and blocking block; the blocking block is in the shape of a long strip, a round hole is provided on either side of the blocking block, the blocking block is arranged on the cylindrical rod, and the blocking block can rotate along the cylindrical rod ; There is friction between the stuck block and the cylindrical rod. 6. The subcutaneously implantable trans-semicircular canal intraaural repeated drug delivery device according to claim 1, characterized in that a display screen is provided on the upper front side of the drug delivery device casing, and a switch and at least one switch are provided on any side of the display screen. There are two adjustment buttons, which can adjust the dosage and speed of the micro-dosing device; a control system is provided inside the housing of the drug delivery device, which can control the speed and rotation time of the drive motor. 7. The subcutaneous implantable trans-semicircular canal inner ear repeated drug administration device according to claim 5, characterized in that the front end of the syringe barrel is provided with an injection port, and the rear end of the syringe barrel is provided with a hand-held part, and the hand-held part can be inserted into a circular tube. In the shaped groove, the middle part of the syringe barrel can be placed in the arc-shaped groove, and the blocking structure can fix the syringe barrel; the injection part includes a piston, a connecting rod and a pressing part, and the first end of the connecting rod Fixedly connected to the piston, the second end of the connecting rod is fixedly connected to the pressing part, the inner diameter of the piston and the injection barrel is the same; the first end of the injection tube is adapted to the injection port, and the second end of the injection tube is provided with a puncture needle.