CN116035800A - A subcutaneous implantable repeat drug delivery device through the semicircular canal inner ear - Google Patents

Abstract

The invention relates to a subcutaneously implanted repeat drug delivery device through the semicircular canal inner ear, which includes: a drug delivery device for precisely pushing a micro-dosing device for precise drug delivery, which includes a drug delivery device housing and a transmission structure, the transmission The structure is arranged inside the shell of the drug delivery device; the micro-dosing device is used to absorb the therapeutic drug and eject the drug, and inject the drug into the patient's subcutaneous drug delivery device; the drug delivery device; it includes a drug delivery base and a drug delivery catheter , the drug administration base is buried behind the patient's ear, the drug delivery catheter is arranged inside the patient's mastoid, the end of the drug delivery catheter is inserted into the semicircular canal, the drug delivery catheter is fixedly connected to the drug delivery base, and the drug delivery catheter is connected to the inside of the drug delivery base. Communication; the micro-dosing device is detachably connected to the drug delivery device, and the micro-dosing device can be connected to a catheter and inserted into the interior of the drug delivery base to inject medicine to it, which can treat inner ear diseases.

Description

A subcutaneous implantable repeat drug delivery device through the semicircular canal inner ear

technical field

The invention belongs to the technical field of medical devices, and in particular relates to a subcutaneous implanted repeat drug delivery device through the semicircular canal inner ear.

Background technique

The inner ear, also known as the labyrinth, includes the semicircular canals (outer semicircular canal, anterior semicircular canal, and posterior semicircular canal), vestibule, and cochlea. The labyrinth is divided into two parts by a membranous structure, and the outer side is the gap between the bony and membranous structures, called The bony labyrinth is filled with perilymph, and the membranous labyrinth is inside the membranous structure, which is filled with endolymph. The volume of endolymph is about 34 microliters. The receptors of the inner ear are located in the membranous labyrinth, and the microenvironment around it is the endolymph. The inner ear receptors include the ampulla located in the semicircular canal, the utricle and sacculus located in the vestibule, and the hair cells located in the cochlea. The inner ear receptors mainly sense linear and angular acceleration, gravity and sound. Lesions and injuries of the inner ear can lead to dizziness, tinnitus and deafness. Since there is no effective drug delivery route and drug delivery device for the inner ear, oral, intravenous and middle ear drug methods are often used clinically for treatment. Due to the side effects of drugs, oral and The dose of intravenous administration is often difficult to reach the effective inner ear drug concentration, and patients with underlying diseases (hypertension, diabetes, kidney disease, etc.) are greatly restricted by oral and intravenous administration. Although middle ear administration can achieve the purpose of local administration, because the middle ear cavity and nasopharynx communicate through the Eustachian tube, the liquid often flows out of the middle ear cavity quickly through the Eustachian tube, and middle ear administration needs to pass through the round window membrane Infiltration, and the infiltrated medicinal liquid can only reach the outer lymph of the inner ear, but the receptors of the inner ear are located in the endolymph, so the medicinal liquid needs to cross the membrane structure barrier between the perilymph and endolymph, and it is difficult to reach the inner ear. Effective drug concentration in lymph fluid. Although the cochlear implant electrode can be implanted through the round window at present, and the inner ear drug delivery can be realized through the side hole of the electrode, but this kind of drug delivery also releases the drug solution into the perilymph. inflammatory response, etc. With the development of biomedical technology, gene therapy, stem cell therapy and biological targeted therapy will be more applied to inner ear diseases, and it is urgent to develop a safe, effective and repeatable inner ear drug delivery device.

Aiming at the above problems, the present invention provides a subcutaneously implanted repeat drug delivery device through the semicircular canal inner ear.

Contents of the invention

In order to overcome the problems proposed in the background technology, the present invention adopts the following technical solutions:

A subcutaneous implantable repeat drug delivery device through the semicircular canal inner ear, which includes:

The drug delivery device is used to accurately push the micro-dosing device for precise drug delivery; it includes a drug delivery device housing and a transmission structure, and the transmission structure is arranged inside the drug delivery device housing;

Micro-dosing device, which is used to absorb therapeutic drugs and eject the drugs, and inject the drugs into the patient's subcutaneous drug delivery device;

Drug delivery device; it includes a drug delivery base and a drug delivery catheter, the drug delivery base is buried behind the patient's ear, the drug delivery guide is arranged inside the patient's ear, and the end of the drug delivery guide is inserted into the semicircular canal, and the drug delivery guide is connected to the patient's ear. The base is fixedly connected, and the drug delivery catheter communicates with the inside of the drug delivery base;

The micro-dosing device is detachably connected with the drug delivery device, and the micro-dosing device can be connected with a catheter and inserted into the drug delivery base to inject medicine to it, so as to treat inner ear diseases.

Further, the transmission structure includes a driving motor, a lead screw, a fixed plate and a moving block; the fixed plate includes a first fixed plate and a second fixed plate; the drive motor is fixedly connected to the lead screw, and the fixed plate is arranged on On both sides of the lead screw, the lead screw is rotatably connected to the fixed plate, the moving block is arranged between the first fixed plate and the second fixed plate, and the moving block is movably connected to the lead screw.

Further, a mounting plate is provided at the bottom of the driving motor, and at least two fixing holes are provided on the mounting plate, the driving motor is fixed on the inner side of the bottom of the drug delivery device housing, and the inner side of the bottom of the drug delivery device housing is provided with a hole adapted to the fixing hole .

Further, the length of the lead screw is greater than the distance between the first fixing plate and the second fixing plate.

Further, a through hole is provided in the center of the first fixing plate and the second fixing plate, the diameter of the through hole is larger than the diameter of the lead screw, and bearings are arranged inside the through holes, the lead screw is installed on the bearing, and the second end of the lead screw The through hole protruding from the second fixing plate is fixedly connected with the driving motor.

Further, at least one polished rod is arranged between the first fixed plate and the second fixed plate; optionally, two polished rods are arranged between the first fixed plate and the second fixed plate.

Further, a threaded hole is provided in the center of the moving block, and the threaded hole is adapted to the thread on the lead screw, and a through hole adapted to the polished rod is provided on the moving block; the moving block is arranged between the first fixed plate and the second fixed plate Between them, the lead screw passes through the threaded hole, and the polished rod passes through the through hole; the above arrangement ensures that the moving block can move between the first fixed plate and the second fixed plate when the lead screw rotates.

Further, a connecting rod is provided on the side of the moving block close to the front side of the drug delivery device housing, a spraying block is provided at the rear end of the connecting rod, a T-shaped slot is provided on the side of the spraying block, and the T-shaped slot runs through the spraying block. piece.

Further, a slot-shaped through hole is provided on the front side of the housing of the drug delivery device, and the length of the slot-shaped through hole is set to be the same as the length of the movement range of the moving block.

Further, an arc-shaped groove is arranged on the side of the slot-shaped through hole on the front side of the drug delivery device housing, and the arc-shaped groove has an arc of 120-180 degrees. shaped groove, the circular groove is perpendicular to the front side of the drug delivery device housing; optionally, the arc of the arc-shaped groove is set to 180 degrees.

Further, a locking structure is provided on the lower side of the arc-shaped groove of the housing of the drug delivery device, and the locking structure includes a cylindrical rod and a locking block; the locking block is elongated, and any of the locking blocks A round hole is set on one side, the stuck block is set on the cylindrical rod, and the blocked block can rotate along the cylindrical rod; there is friction between the stuck block and the cylindrical rod, which will not occur in non-human operation relative rotation.

Further, a display screen is provided on the upper front side of the housing of the drug delivery device, and a switch and at least two adjustment buttons are arranged on any side of the display screen, and the adjustment buttons can adjust the dosage and speed of the micro-dosing device. .

Furthermore, a control system is set inside the housing of the drug delivery device, which can control the rotation speed and rotation time of the driving motor, and the control system can be selected from existing technologies.

Further, a power cord is provided at the rear end of the housing of the drug delivery device to supply power to each component.

Further, the micro-doser includes a syringe, an injection part and an injection tube; the interior of the syringe is hollow, the injection part is arranged inside the syringe, the injection part is movably connected with the syringe, and the injection tube It is arranged at the front end of the syringe, and the syringe is detachably connected with the syringe. The inner volume of the syringe is 30-50 microliters.

Further, the front end of the syringe is provided with an injection port, and the rear end of the syringe is provided with a handle, the handle can be placed in a circular groove, the middle part of the syringe can be placed in an arc-shaped groove, and is stuck. The structure can fix the syringe to prevent the syringe from falling out in the arc-shaped groove when injecting medicine.

Further, the injection part includes a piston, a connecting rod and a pressing part, the first end of the connecting rod is fixedly connected to the piston, the second end of the connecting rod is fixedly connected to the pressing part, the inner diameter of the piston is the same as that of the syringe, The above arrangement ensures that the drug in the syringe can be pushed out by pushing the pressing part.

Further, the first end of the injection tube is adapted to the injection port, and the second end of the injection tube is provided with a puncture needle.

Further, the inside of the drug delivery base is hollow, and a soft material is provided on the upper part of the drug delivery base. The soft material can be made of silica gel. The puncture needle can be pierced into the patient's skin and pass through the soft material. The drug delivery catheter flows through the semicircular canal to achieve the therapeutic effect.

Further, the length of the insertion of the drug delivery catheter into the semicircular canal is 8-16mm; it can ensure that the drug delivery catheter is inserted deeper when the drug delivery catheter is inserted into the semicircular canal, and it is not easy to come out; optionally, the length of the drug delivery catheter inserted into the semicircular canal is 10mm.

Further, the diameter of the drug delivery catheter is between 0.1-0.3 mm, which can ensure that the diameter of the drug delivery catheter is smaller than that of the semicircular canal, and the drug delivery catheter can be inserted into the semicircular canal normally.

Further, the drug delivery catheter is made of a soft material, and the front end of the drug delivery catheter is set in a smooth shape to prevent the front end of the drug delivery catheter from inserting the semicircular canal from puncturing the semicircular canal again, causing the drug to be injected into the perilymph, which cannot reach the desired effect. The role of treatment.

Further, before inserting the drug delivery catheter, open a window in any one of the three semicircular canals, the window is set at a position close to the ampulla of the semicircular canal, and when the drug delivery catheter is inserted into the semicircular canal, the direction of catheter insertion is away from the semicircular canal ampulla.

Further, an enlarged part is set at 10 mm from the front end of the drug delivery catheter, and the diameter of the enlarged part is larger than the diameter of the opening of the semicircular canal; the above setting ensures that the enlarged part can be stuck at the opening of the semicircular canal after the drug delivery catheter is inserted, preventing internal The leakage of lymph fluid can also prevent the drug delivery catheter from slipping in the semicircular canal, so that the disturbance to the internal receptors of the ampulla is minimal.

Furthermore, during implantation, part of the mastoid bone needs to be removed with a power drill to expose any of the three semicircular canals, the outer semicircular canal, the anterior semicircular canal, and the posterior semicircular canal. At the fenestration of the first semicircular canal, a microscopic sharp needle picks open the semicircular canal. In order to avoid stimulation to the inner ear receptors, it should be inserted away from the direction of the ampulla; Coiled.

Beneficial effects of the present invention: the present invention can perform repeatable and accurate micro-dose to the inner ear of patients by setting the drug delivery device, and provides a reliable drug delivery route for the drug treatment of inner ear diseases.

Description of drawings

Fig. 1 is the overall structural representation of the present invention;

Fig. 2 is a structural schematic diagram of the coordination of the drug delivery device and the micro-dosing device of the present invention;

3 is a schematic structural view of the drug delivery device of the present invention;

Fig. 4 is a schematic cross-sectional structural view of the micro-dosing device of the present invention when it is installed on the drug delivery device;

5 is a schematic cross-sectional structural view of the drug delivery device of the present invention;

Fig. 6 is a schematic structural diagram of a moving block of the present invention;

Fig. 7 is a schematic structural view of the micro-dosing device of the present invention;

Figure 8 is a schematic structural view of the drug delivery device of the present invention;

9 is a schematic cross-sectional structural view of the drug delivery device of the present invention;

Fig. 10 is a schematic structural view of the drug delivery device of the present invention after it is placed under the skin;

In the figure, 1. Drug delivery device shell; 2. Micro-dosing device; 3. Drug delivery base; 4. Drug delivery catheter; 5. Driving motor; 6. Lead screw; 7. Fixed plate; 8. Moving block; 9 1. Polished rod; 10. Threaded hole; 11. Connecting rod; 12. Spraying block; 13. Groove through hole; 14. Arc groove; 15. Circular groove; 16. Cylindrical rod; 17. Blocking block; 18. Display screen; 19. Switch; 20. Adjustment button; 21. Power cord; 22. Injection barrel; 24. T-shaped slot; 25. Injection tube; 26. Handpiece; 27. Piston; 28. Connecting rod; 29 , compression part; 30, puncture needle; 31, ampulla; 32, semicircular canal.

Detailed ways

The technical solutions in the embodiments of the present invention are clearly and completely described below through specific specific embodiments. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all embodiments. Those skilled in the art can learn from this Other advantages and functions of the present invention can be easily understood from the contents disclosed in the specification. The present invention can also be implemented or applied through other different specific implementation modes. In the case of no conflict, the following embodiments and the features in the embodiments can be combined with each other. Based on the embodiments of the present invention, those of ordinary skill in the art will All other embodiments obtained under the premise of no creative work belong to the protection scope of the present invention.

Example 1

Please refer to Fig. 1-10, a kind of subcutaneous implantable inner ear repetitive drug delivery device through the semicircular canal 32 in this embodiment, which includes:

The drug delivery device is used to accurately push the micro-dosing device 2 for precise drug delivery; it includes a drug delivery device housing 1 and a transmission structure, and the transmission structure is arranged inside the drug delivery device housing 1 .

The micro-dosing device 2 is used to draw the therapeutic medicine and eject the medicine, and inject the medicine into the subcutaneous administration device of the patient.

Drug delivery device; it includes a drug delivery base 3 and a drug delivery catheter 4, the drug delivery base 3 is buried behind the patient's ear, the drug delivery guide 4 is arranged inside the patient's ear, the end of the drug delivery guide 4 is inserted into the semicircular canal 32, and the drug delivery guide 4 It is fixedly connected with the dosing base 3, and the dosing conduit 4 communicates with the inside of the dosing base 3.

The micro-dosing device 2 is detachably connected with the drug delivery device, and the micro-dosing device 2 can be connected to a catheter and inserted into the drug delivery base 3 to dispense medicine to it, which can treat inner ear diseases.

Example 2

Please refer to Figures 1-6, on the basis of Embodiment 1, this embodiment adds the following technical features: (The structure of the drug delivery device is specifically set as follows): the transmission structure includes a drive motor 5, a lead screw 6, and a fixed plate 7 and the moving block 8; the fixed plate 7 includes a first fixed plate and a second fixed plate; the driving motor 5 is fixedly connected with the leading screw 6, the fixed plate 7 is arranged on both sides of the leading screw 6, and the leading screw 6 is connected with the fixed plate 7 in rotation, The moving block 8 is arranged between the first fixing plate and the second fixing plate, and the moving block 8 is movably connected with the lead screw 6 .

A mounting plate is provided at the bottom of the drive motor 5, and at least two fixing holes are provided on the mounting plate. The drive motor 5 is fixed on the inside of the bottom of the drug delivery device housing 1, and the inside of the bottom of the drug delivery device housing 1 is provided with a hole adapted to the fixing holes.

The length of the lead screw 6 is greater than the distance between the first fixing plate and the second fixing plate.

The center of the first fixed plate and the second fixed plate is provided with a through hole, the diameter of the through hole is greater than the diameter of the screw 6, and the inside of the through hole is equipped with a bearing, the screw 6 is installed on the bearing, and the second end of the screw 6 extends out of the second fixed The through hole of the plate is fixedly connected with the drive motor 5 .

At least one polished rod 9 is arranged between the first fixed plate and the second fixed plate; optionally, two polished rods 9 are arranged between the first fixed plate and the second fixed plate.

A threaded hole 10 is set in the center of the moving block 8, and the threaded hole 10 is adapted to the thread on the lead screw 6, and a through hole adapted to the polished rod 9 is set on the moving block 8; the moving block 8 is arranged on the first fixed plate and the second fixed plate Between them, the lead screw 6 passes through the threaded hole 10, and the polished rod 9 passes through the through hole; the above arrangement ensures that the lead screw 6 rotates, and the moving block 8 can move between the first fixed plate and the second fixed plate.

A connecting rod 11 is arranged on the side of the moving block 8 close to the front side of the drug delivery device housing 1, a spraying block 12 is arranged at the rear end of the connecting rod 11, and a T-shaped groove 24 is arranged on the side of the spraying block 12, and the T-shaped groove 24 runs through the spraying block 12 .

A slot-shaped through hole 13 is provided on the front side of the drug delivery device housing 1 , and the length of the slot-shaped through hole 13 is set to the range of movement of the moving block 8 .

An arc-shaped groove 14 is arranged on the side of the slot-shaped through hole 13 on the front side of the drug delivery device housing 1. The arc of the arc-shaped groove 14 is 120-180 degrees. A circular groove 15, the circular groove 15 is perpendicular to the front side of the drug delivery device housing 1; optionally, the radian of the arc-shaped groove 14 is set to 180 degrees.

A locking structure is arranged on the lower side of the arc-shaped groove 14 of the drug delivery device housing 1, and the locking structure includes a cylindrical rod 16 and a locking block 17; Round hole, the stuck block 17 is arranged on the cylindrical rod 16, and the blocked block 17 can rotate along the cylindrical rod 16; there is friction between the stuck block 17 and the cylindrical rod 16, and there will be no relative rotation during non-human operation .

A display screen 18 is arranged on the top of the front side of the drug delivery device housing 1, and any side of the display screen 18 is provided with a switch 19 and at least two adjustment buttons 20.

A control system is arranged inside the drug delivery device housing 1, which can control the rotational speed and rotation time of the drive motor 5, and the control system can be selected from the prior art.

The rear end of the drug delivery device housing 1 is provided with a power cord 21, which can supply power to each component.

Example 3

Please refer to Figures 1-2, 4, and 7. On the basis of Embodiment 1-2, this embodiment adds the following technical features (the following specific settings are made to the structure of the micro-doser 2): the micro-doser 2 includes injection Cylinder 22, injection part and injection tube 25; The inside of the injection tube 22 is hollow, the injection part is arranged inside the injection tube 22, the injection part is movably connected with the injection tube 22, the injection tube 25 is arranged at the front end of the injection tube 22, and the injection tube 25 is connected with the injection tube 22. The cartridge 22 is detachably attached. The inner volume of the syringe 22 is 30-50 microliters, and the inner ear receptors are soaked in the endolymph, and the total amount of the endolymph is about 34 microliters.

The front end of the syringe 22 is provided with an injection port, and the rear end of the syringe 22 is provided with a handle 26. The handle 26 can be placed in the circular groove 15, and the middle part of the syringe 22 can be placed in the arc groove 14. The syringe 22 can be fixed to prevent the syringe 22 from falling out of the arc groove 14 when injecting medicine.

The injection part includes a piston 27, a connecting rod 28 and a pressing part 29. The first end of the connecting rod 28 is fixedly connected to the piston 27, the second end of the connecting rod 28 is fixedly connected to the pressing part 29, and the inner diameter of the piston 27 is the same as that of the injection cylinder 22. The arrangement ensures that pushing the pressing part 29 can push out the medicine in the syringe 22 .

The first end of the injection tube 25 is adapted to the injection port, and the second end of the injection tube 25 is provided with a puncture needle 30 .

Example 4

Please refer to Fig. 1, 8-10, on the basis of embodiment 1-3, this embodiment adds the following technical features (the structure of the drug delivery device is specifically set as follows): the inside of the drug delivery base 3 is hollow, and the drug delivery base 3 The upper part is provided with a soft material, the soft material can be made of silica gel, the puncture needle 30 can be pierced into the patient's skin and pass through the soft material, and the medicine can be injected into the drug delivery base. .

The length of the drug delivery catheter 4 inserted into the semicircular canal 32 is 8-16mm; when the drug delivery catheter 4 is inserted into the semicircular canal 32, the drug delivery catheter 4 is inserted deeply, and it is not easy to come out; optionally, the drug delivery catheter 4 is inserted into the semicircular canal 32. 10mm.

The diameter of the drug delivery catheter 4 is between 0.1-0.3mm, which can ensure that the diameter of the drug delivery catheter 4 is smaller than the diameter of the semicircular canal 32, and the drug delivery catheter 4 can be inserted into the semicircular canal 32 normally.

The drug delivery catheter 4 is made of soft material, and the front end of the drug delivery catheter 4 is set in a smooth shape to prevent the front end of the drug delivery catheter 4 from inserting into the semicircular canal 32 to puncture the semicircular canal 32 again, causing the medicine to be injected into the perilymph, thus failing to achieve treatment role.

Before inserting the drug delivery catheter 4, open a window in any one of the three semicircular canals 32, the window is set near the ampulla 31 of the semicircular canal 32, when the drug delivery catheter 4 is inserted into the semicircular canal 32, the direction of catheter insertion deviates from the semicircular canal 32 of the ampulla 31; preferably, the best selection of the outer semicircular canal, the other two semicircular canals 32 are relatively difficult to expose during surgery.

A swollen part is set at 10 mm from the front end of the drug delivery catheter 4, and the diameter of the swollen part is greater than the diameter of the opening of the semicircular canal 32; 4 slips within the semicircular canal 32 so that disturbance of the internal receptors of the ampulla 31 is minimal.

When the drug delivery catheter 4 is implanted, use a power drill to grind away part of the mastoid bone, expose any one of the three semicircular canals 32 of the outer semicircular canal, anterior semicircular canal, and posterior semicircular canal, and grind away part of the semicircular canal 32 to open a window to expose the membranous semicircular canal 32. At the window openings of the three semicircular canals 32, the microscopic sharp needle picks open the membrane semicircular canals 32. In order to avoid stimulation to the inner ear receptors, the drug delivery catheter 4 should be inserted in the direction away from the ampulla 31 of the semicircular canal 32; the total length of the drug delivery catheter 4 is set 150mm, the infusion tube can be coiled in the mastoid cavity.

After the drug delivery device is installed and fixed under the skin, the drug delivery catheter 4 is implanted inside the semicircular canal 32, and after the micro-dosing device 2 draws in the medicine, the micro-dosing device 2 is connected to the subcutaneous drug delivery device, and the drug injection device can be adjusted Dosing amount, after adjusting the dosing amount, pierce the puncture needle 30 at the rear end of the microneedle applicator into the skin behind the ear of the patient, and pierce into the drug delivery device.

The above descriptions of the embodiments are only for the understanding of the present invention. It should be pointed out that those skilled in the art can make some improvements to the present invention without departing from the principles of the present invention, and these improvements will also fall within the protection scope of the claims of the present invention.

Claims (10)

1. A subcutaneously implantable semi-structured inner ear repeat administration device comprising:

the drug delivery device is used for accurately pushing the micro drug delivery device to accurately deliver drugs; the drug delivery device comprises a drug delivery device shell and a transmission structure, wherein the transmission structure is arranged inside the drug delivery device shell;

a micro-drug delivery device for sucking therapeutic drug and delivering the drug out, and delivering the drug into subcutaneous drug delivery device of patient;

a drug delivery device; the device comprises a drug delivery base and a drug delivery catheter, wherein the drug delivery catheter is arranged inside the ear of a patient after the drug delivery base is buried in the ear of the patient, the tail end of the drug delivery catheter is inserted into a semicircular canal, the drug delivery catheter is fixedly connected with the drug delivery base, and the drug delivery catheter is communicated with the inside of the drug delivery base;

the micro-drug delivery device is detachably connected with the drug delivery device, and can be connected with a catheter to be pricked into the drug delivery base to deliver drugs to the drug delivery base, so that inner ear diseases can be treated.

2. The subcutaneously implantable semi-regulated in-canal re-administration device according to claim 1, wherein the transmission structure comprises a driving motor, a screw, a fixed plate and a moving block; the fixing plate comprises a first fixing plate and a second fixing plate; the driving motor is fixedly connected with the screw rod, the fixed plates are arranged on two sides of the screw rod, the screw rod is rotationally connected with the fixed plates, the moving block is arranged between the first fixed plate and the second fixed plate, and the moving block is movably connected with the screw rod; the bottom of the driving motor is provided with a mounting plate, the mounting plate is provided with at least two fixing holes, the driving motor is fixed on the inner side of the bottom of the shell of the drug delivery device, and the inner side of the bottom of the shell of the drug delivery device is provided with a hole matched with the fixing hole; the length of the screw rod is longer than the distance between the first fixing plate and the second fixing plate.

3. The subcutaneous implantable through-semicircular canal inner ear repeated administration device according to claim 2, wherein the centers of the first fixing plate and the second fixing plate are provided with through holes, the diameter of each through hole is larger than that of a lead screw, bearings are arranged in the through holes, the lead screws are arranged on the bearings, and the through holes, extending out of the second fixing plate, of the second ends of the lead screws are fixedly connected with a driving motor; at least one polish rod is arranged between the first fixing plate and the second fixing plate; two polish rods are arranged between the first fixing plate and the second fixing plate; the center of the moving block is provided with a threaded hole which is matched with the threads on the screw rod, and the moving block is provided with a through hole which is matched with the polish rod; the movable block is arranged between the first fixed plate and the second fixed plate, the screw rod penetrates through the threaded hole, and the polish rod penetrates through the through hole.

4. The subcutaneous implantable semi-structured inner ear repeated administration device according to claim 2, wherein a connecting rod is arranged on one side of the movable block, which is close to the front side surface of the administration device shell, a medicine beating block is arranged at the rear end of the connecting rod, a T-shaped groove is arranged on the side surface of the medicine beating block, and the T-shaped groove penetrates through the medicine beating block; the front side surface of the shell of the drug delivery device is provided with a groove-shaped through hole, and the length of the groove-shaped through hole is equal to the length of the movement range of the moving block; the side of the groove-type through hole on the front side of the shell of the drug delivery device is provided with an arc-shaped groove, the radian of the arc-shaped groove is 120-180 degrees, the joint of the arc-shaped groove and the groove-type through hole is provided with a circular groove, and the circular groove is perpendicular to the front side of the shell of the drug delivery device.

5. The subcutaneous implantable semi-structured inner ear repeat drug delivery device according to claim 1, wherein a locking structure is arranged at the lower side of the arc-shaped groove of the drug delivery device shell, and the locking structure comprises a cylindrical rod and a locking block; the clamping block is in a strip shape, a round hole is formed in any side of the clamping block, the clamping block is arranged on the cylindrical rod, and the clamping block can rotate along the cylindrical rod; friction is arranged between the clamping block and the cylindrical rod.

6. The subcutaneous implantable semi-structured inner ear repeated administration device according to claim 1, wherein a display screen is provided at the upper part of the front side of the administration device housing, a switch and at least two adjusting buttons are provided at either side of the display screen, and the adjusting buttons can adjust the administration amount and the administration speed of the microdose; the medicine feeding device is characterized in that a control system is arranged in the casing of the medicine feeding device, and the rotating speed and the rotating time of the driving motor can be controlled.

7. The subcutaneously implantable semi-structured inner ear repeat administration device according to claim 5, wherein the microdose comprises a syringe, an injection section and a syringe; the injection part is arranged in the injection cylinder, the injection part is movably connected with the injection cylinder, the injection pipe is arranged at the front end of the injection cylinder, and the injection pipe is detachably connected with the injection cylinder; the volume of the injection tube is 30-50 microliters; the front end of the injection tube is provided with an injection port, the rear end of the injection tube is provided with a hand-held part, the hand-held part can be placed in the circular groove, the middle part of the injection tube can be placed in the arc groove, and the injection tube can be fixed by the clamping structure; the injection part comprises a piston, a connecting rod and a pressing part, wherein the first end of the connecting rod is fixedly connected with the piston, the second end of the connecting rod is fixedly connected with the pressing part, and the inner diameter of the piston is the same as that of the injection cylinder; the first end of the injection tube is matched with the injection port, and the second end of the injection tube is provided with a puncture needle.

8. The subcutaneous implantable device for repeated administration of a substance through the inner ear of a semicircular canal according to claim 1, wherein a power drill is used for removing part of mastoid bone during implantation, any one of the three semicircular canals of the outer semicircular canal, the front semicircular canal and the rear semicircular canal is exposed, and the semicircular canal is removed for windowing, the membrane semicircular canal is exposed, and a microtip is used for picking up the membrane semicircular canal and inserting the administration catheter away from the ampulla direction of the semicircular canal; the total length of the administration catheter is set to be 150mm, and the infusion tube can be coiled in the mastoid cavity.

9. The subcutaneous implantable device for repeated administration of a medicament through a semicircular canal according to claim 7, wherein the interior of the administration base is hollow, a soft material is arranged at the upper part of the administration base, the puncture needle can be inserted into the skin of a patient to pass through the soft material, and the medicament can be injected into the administration base to flow through the semicircular canal through the administration catheter, so that the therapeutic effect is achieved; the length of the administration catheter insertion semicircular canal is 8-16mm; the diameter of the administration conduit is between 0.1 and 0.3 mm; the administration catheter is made of soft materials, and the front end of the administration catheter is smooth.

10. The subcutaneous implantable device for repeated administration via the inner ear of a semicircular canal according to any one of claims 1 to 9, wherein a window is formed in any one of the three semicircular canals before the administration line is placed, the window is disposed at a position close to the ampulla of the semicircular canal, and an enlarged portion having a diameter larger than that of the opening of the semicircular canal is disposed at a position 10mm from the front end of the administration line.

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