CN115996697A - Cosmetic composition for improved penetration - Google Patents

Abstract

A cosmetic composition for improving penetration of skin active agents comprising about 0.1-about 10 wt.% C-glycoside; about 0.1-about 5 wt.% polyglyceryl-3 methylglucose distearate; about 0.1-about 5 wt.% sodium polyacrylate; and water, wherein the cosmetic composition is an oil-in-water emulsion, and all weight percentages are based on the total weight of the cosmetic composition. Also disclosed is a method of treating damaged skin with a cosmetic composition.

Description

Cosmetic composition with improved penetration

Cross References to Related Applications

This application claims the benefit of US Application Serial No. 16/916,569, filed June 30, 2020, and French Patent Application No. 2009056, filed September 7, 2020, which are hereby incorporated by reference in their entirety.

public domain

The present disclosure relates to cosmetic compositions that provide improved penetration, and in particular, to cosmetic compositions that provide improved penetration without the use of conventional penetration enhancers. Additionally, aspects of the present disclosure relate to methods of treating damaged skin with cosmetic compositions.

public background

The skin acts as a natural barrier between the internal environment and the external environment, and thus plays an important role in important biological functions such as defense against mechanical and chemical damage, microorganisms, and UV damage. However, the health and appearance of the skin can be deteriorated due to environmental factors, genetic makeup, nutrition and sun exposure.

The environmental pollution situation is rapidly deteriorating and becoming more evident in the daily lives of consumers around the world. The damage of pollution to human skin is also becoming more and more obvious. Human skin is also subject to a wide variety of damage from external factors such as ultraviolet (UV) radiation, environmental pollution, wind, heat, infrared radiation, low humidity, harsh surfactants, abrasives, and the like. Recent research suggests that, in addition to UV radiation, other environmental factors (especially air pollution) contribute to the development of sun spots. These factors eventually lead to visible signs of skin damage, including small brown spots on the skin, especially in older adults.

Typical skin lesions include fine lines, wrinkles, hyperpigmentation, sallowness, sagging, dark under-eye circles, puffy eyes, enlarged pores, visible dead skin, ie, flaking, peeling ( scaling), dry and rough. Consumers want to slow down skin damage and reduce the effects of aging, especially on the face and around the eyes. Radiant and clear skin looks youthful and is a sign of good health and vitality. Accordingly, there is a continuing need for new and improved formulations that improve the health and visual appearance of the skin.

public overview

The present disclosure is directed to cosmetic compositions that provide improved penetration of desired skin active agents into adult skin. The inventors have discovered that certain amounts and combinations of ingredients enable cosmetic compositions to provide improved penetration of desired skin active agents without the use of conventional penetration enhancers.

Cosmetic compositions according to one aspect of the present disclosure generally include:

(a) about 0.1 to about 10 wt.% C-glycoside;

(b) about 0.1 to about 5 wt.% polyglyceryl-3 methylglucose distearate;

(c) about 0.1 to about 5 wt.% sodium polyacrylate; and

(d) water,

Wherein the cosmetic composition is an oil-in-water emulsion, and all weight percentages are based on the total weight of the cosmetic composition.

Suitable C-glycosides that may be incorporated into cosmetic compositions include those selected from the group consisting of: C-β-D-xylopyranoside-n-propan-2-one, C-α-D-xylopyranoside-n- Propan-2-one, C-β-D-xylopyranoside-2-hydroxypropane, C-α-D-xylopyranoside-2-hydroxypropane, 1-(C-β-D-pyranoside Alcoside) propan-2-one, 1-(C-α-D-fucopyranoside) propan-2-one, 1-(C-β-L-fucopyranoside) propan-2-one , 1-(C-α-L-fucopyranoside) propan-2-one, 1-(C-β-D-fucopyranoside)-2-hydroxypropane, 1-(C-α- D-fucopyranoside)-2-hydroxypropane, 1-(C-β-L-fucopyranoside)-2-hydroxypropane, 1-(C-α-L-fucopyranoside) -2-hydroxypropane, 1-(C-β-D-glucopyranosyl)-2-hydroxypropane, 1-(C-α-D-glucopyranosyl)-2-hydroxypropane, 1-(C -β-D-galactopyranosyl)-2-hydroxypropane, 1-(C-α-D-galactopyranosyl)-2-hydroxypropane, 1-(C-β-D-fucofuran Glycosyl)propan-2-one, 1-(C-α-D-funofuranosyl)propan-2-one, 1-(C-β-L-fucofuranosyl)propan-2-one , 1-(C-α-L-fucofuranosyl)propan-2-one, C-β-D-maltopyranoside-n-propan-2-one, C-α-D-maltopyranoside - n-propan-2-one, C-β-D-maltopyranoside-2-hydroxypropane, C-α-D-maltopyranoside-2-hydroxypropane, isomers thereof, mixtures thereof, and combination. In at least some embodiments, the C-glycoside comprises at least one of C-β-D-xylopyranoside-2-hydroxypropane and C-α-D-xylopyranoside-2-hydroxypropane. In at least one instance, the C-glycoside is C-β-D-xylopyranoside-2-hydroxypropane.

The cosmetic composition may further include about 1 to about 30 wt.% of a polyol. Suitable polyols may include those selected from the group consisting of ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, pentylene glycol, diethylene glycol, dipropylene glycol, caprylyl glycol, 1,3-propanediol, glycerol , diglycerol, polyethylene glycol, and mixtures thereof.

In some cases, the cosmetic composition includes from about 0.1 to about 10 wt. % of a degreasing agent. The degreasing agent may be aluminum starch octenyl succinate. Additionally or alternatively, the cosmetic composition may include from about 0.5 to about 10 wt.% oil. The oil may be silicone and/or may be selected from coconut oil, soybean oil, canola oil, canola oil, corn oil, cottonseed oil, olive oil, palm oil, peanut oil, safflower oil, sesame oil, sunflower oil , linseed oil, palm kernel oil, tung oil, jatropha oil, mustard oil, camelina oil, galanga oil, castor oil, wheat germ oil, almond oil, pistachio oil, poppy oil, pine oil, crocodile Pear Oil, Hazelnut Oil, Grapeseed Oil, Canola Oil, Juniper Oil, Peach Kernel Oil, Coffee Bean Oil, Jojoba Oil, and mixtures thereof.

The cosmetic composition may include from about 0.05 to about 5 wt. % of a thickener other than sodium polyacrylate. In some cases, the thickener other than sodium polyacrylate is selected from ammonium polyacryloyldimethyltaurate, ammonium acryloyldimethyltaurate/VP copolymer, sodium polyacrylate, acrylate copolymer, polyacryloyldimethyltaurate Acrylamide, Carbomer, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Acrylates/Beheneth-25 Methacrylate Copolymer, and mixtures thereof.

Skin active agents may be included in cosmetic compositions in amounts of about 0.05 to about 5 wt.%. Non-limiting examples of skin active agents include hyaluronic acid, lanolin, niacinamide, citric acid, malic acid, lactic acid, tartaric acid, salicylic acid, caprylyl salicylic acid, retinoids, retinal, retinol , adenosine, sodium hyaluronate, retinoic acid, carotenoids, panthenol, amino acids, proteins, enzymes, coenzymes, or mixtures thereof.

In some cases, the cosmetic composition includes from about 0.1 to about 20 wt. % of a fatty ester other than polyglyceryl-3 methylglucose distearate. Fatty esters other than polyglyceryl-3 methylglucose distearate can include isononyl isononanoate, caprylic/capric triglyceride, or mixtures thereof.

public details

The present disclosure is directed to cosmetic compositions that provide improved penetration of desired skin active agents into adult skin. As mentioned above, the inventors have discovered that certain amounts and combinations of ingredients enable cosmetic compositions to provide improved penetration of desired skin active agents without the use of conventional penetration enhancers.

Cosmetic compositions according to one aspect of the present disclosure generally include:

(a) about 0.1 to about 10 wt.% C-glycoside;

(b) about 0.1 to about 5 wt.% polyglyceryl-3 methylglucose distearate;

(c) about 0.1 to about 5 wt.% sodium polyacrylate; and

(d) water,

Wherein the cosmetic composition is an oil-in-water emulsion, and all weight percentages are based on the total weight of the cosmetic composition.

In some cases, the cosmetic composition achieves improved penetration of skin active agents into adult skin. For example, cosmetic compositions can achieve penetration of skin active agents into the epidermis and dermis of the skin. In some cases, the cosmetic composition achieves about 2 μg/cm ² or more, 2.1 μg/cm ² or more, 2.2 μg/cm ² or more, 2.3 μg/cm ^{2 or} more in the epidermis and dermis of human skin. More, 2.4 μg/ ^cm2 or more, 2.5 μg/ ^cm2 or more, 2.6 μg/ ^cm2 or more, 2.7 μg/ ^cm2 or more, 2.8 μg/ ^cm2 or more, 2.9 μg /cm ² or more, 3 μg/cm ² or more skin active agent. In certain embodiments, cosmetic compositions achieve improved penetration of skin active agents without the use of penetration enhancers.

酮)、吡咯烷酮(例如2-吡咯烷酮，2P)、醇和烷醇(乙醇或癸醇)、表面活性剂(还常见于剂型中)和萜烯。一些渗透增强剂能够嵌在双层的疏水尾之间，因此干扰其堆积(packing)，增加其流动性，并且随后导致脂质样渗透剂的更容易扩散。发明人出人意料地发现，根据本公开的某些化妆品组合物提供皮肤活性剂进入成人皮肤的改善的渗透而不必要使用某些渗透增强剂。然而，在一些情况中，可合意的是，包括渗透增强剂，例如本文中讨论的那些。Some therapeutic or cosmetic compositions achieve epidermal penetration through the use of carriers or vehicles that enhance skin penetration. Such carriers or vehicles, which are compounds or mixtures of compounds, are often described as "penetration enhancers" or "skin enhancers". Typical penetration enhancers (which can optionally be excluded from cosmetic compositions) include sulfoxides (e.g. dimethyl sulfoxide, DMSO), azones (e.g. lauryl azone

ketones), pyrrolidones (such as 2-pyrrolidone, 2P), alcohols and alkanols (ethanol or decanol), surfactants (also commonly found in dosage forms), and terpenes. Some penetration enhancers are able to become embedded between the hydrophobic tails of the bilayer, thus interfering with its packing, increasing its fluidity, and subsequently leading to easier diffusion of lipid-like penetrants. The inventors have surprisingly discovered that certain cosmetic compositions according to the present disclosure provide improved penetration of skin active agents into adult skin without the necessity of using certain penetration enhancers. In some cases, however, it may be desirable to include penetration enhancers, such as those discussed herein.

In some cases, the cosmetic composition has 5 wt.% or less, 4 wt.% or less, 3 wt.% or less, 2 wt.% or less, or 1 wt.% or less of the aforementioned penetration enhancers any kind. In at least one instance, the cosmetic composition is free or substantially free of any of the foregoing penetration enhancers. Additionally or alternatively, the cosmetic composition may have a total amount of about 5 wt.% or less, 4 wt.% or less, 3 wt.% or less, 2 wt.% or less, or 1 wt.% or less penetration enhancer. For example, a cosmetic composition may be free or substantially free of penetration enhancers.

Cosmetic compositions are usually formulated as emulsions. Typically, cosmetic compositions are formulated as oil-in-water emulsions, having a fatty phase emulsified in a hydrophilic phase. In some cases, however, cosmetic compositions may be formulated to have a hydrophilic phase (eg, alcohol, diol, polyol, etc.) emulsified in a fatty phase. In some cases, the cosmetic composition may be formulated as a lotion, serum, cream, spray, or any other suitable product form.

Additionally, the present disclosure relates to methods of treating skin comprising applying to the skin a cosmetic composition of the present disclosure. The cosmetic compositions are additionally useful in methods of treating and/or repairing skin damage due to photoaging and reducing wrinkles, dark spots and uneven skin texture. The foregoing methods may be non-therapeutic.

Suitable components, such as those listed below, may be included or excluded from the formulation for the cosmetic composition, depending on the particular combination of other components, the form of the cosmetic composition, and/or Or the use of the formulation (such as lotion, essence, gel, cream, spray, etc.).

C-glycoside

Cosmetic compositions typically include C-glycosides in an amount of about 0.1 to about 10 wt.%, based on the total weight of the cosmetic composition. For example, based on the total weight of the cosmetic composition, the amount of C-glycoside present in the cosmetic composition can be about 0.1 to about 10 wt.%, about 0.1 to about 9 wt.%, about 0.1 to about 8 wt.%, about 0.1-about 7wt.%, about 0.1-about 6wt.%, about 0.1-about 5wt.%, about 0.1-about 4wt.%; about 1-about 10wt.%, about 1-about 9wt.%, about 1- About 8wt.%, about 1-about 7wt.%, about 1-about 6wt.%, about 1-about 5wt.%, about 1-about 4wt.%; about 2-about 10wt.%, about 2-about 9wt.% .%, about 2-about 8wt.%, about 2-about 7wt.%, about 2-about 6wt.%, about 2-about 5wt.%, about 2-about 4wt.%; about 3-about 10wt.% , about 3-about 9wt.%, about 3-about 8wt.%, about 3-about 7wt.%, about 3-about 6wt.%, about 3-about 5wt.% or about 3-about 4wt.% (including ranges and subranges in between).

Cosmetic compositions may comprise one or more C-glycosides having a structure according to general formula (I), as well as their physiologically acceptable salts, their solvates (eg hydrates), and their optical Isomers and Geometric Isomers:

in:

-R represents a saturated C ₁ -C ₁₀ (especially C ₁ -C ₄ ) hydrocarbon group, which may be optionally substituted by at least one group selected from OH, COOH or COOR" ₂ , wherein R" ₂ is a saturated C ₁ -C ₄ Hydrocarbyl,

-S represents a monosaccharide or a polysaccharide comprising up to 20 sugar units (especially up to 6 sugar units), in the form of pyranose and/or furanose and in the L and/or D series, said monosaccharide or polysaccharide having may be substituted with necessarily free hydroxyl groups, and optionally with one or more optionally protected amine functions, and

-X represents a group selected from -CO-, -CH(OH)-, -CH(NH ₂ )-, -CH(NHCH ₂ CH ₂ CH ₂ OH)-, -CH(NHPh)- and -CH(CH ₃ )-, and in particular the group -CO-, -CH(OH)- or -CH(NH ₂ )-, and more particularly the group -CH(OH)-,

Wherein the S-CH2-X bond represents a bond with C-anomeric nature, which can be α or β.

The C-glycosides of formula (I) preferably have a structure in which R represents a saturated linear C ₁ -C ₆ (in particular C ₁ -C ₄ , preferably C ₁ -C ₂ ) hydrocarbon group, and more preferably a methyl group. Particular mention may be made of the following alkyl groups for C-glycosides (eg R): methyl, ethyl, isopropyl, n-propyl, n-butyl, tert-butyl, isobutyl, sec-butyl, pentyl , n-hexyl, cyclopropyl, cyclopentyl and cyclohexyl.

According to at least one embodiment, it is possible to use C-glycoside compounds corresponding to formula (I), wherein S represents a monosaccharide or a polysaccharide comprising up to 6 sugar units, for example in the form of pyranose and/or furanose and is L and/or type D (chimericseries). The monosaccharide or polysaccharide exhibits at least one free hydroxyl function and/or optionally one or more protected amine functions, otherwise X and R retain all the definitions given above.

Advantageously, the monosaccharides of the present invention may be selected from D-glucose, D-galactose, D-mannose, D-xylose, D-lyxose or L-fucose, L-arabinose, L-murine Lise, D-glucuronic acid, D-galacturonic acid, D-iduronic acid, N-acetyl-D-glucosamine or N-acetyl-D-galactosamine, and advantageously represent D-glucose, D-xylose, N-acetyl-D-glucosamine, L-fucose, and mixtures thereof. In one instance, the monosaccharide is D-xylose.

More particularly, the polysaccharides of the present invention comprising up to 6 sugar units may be selected from D-maltose, D-lactose, D-cellobiose, D-maltotriose; the combination is selected from D-iduronic acid or D - the combination of uronic acid of glucuronic acid and hexosamine selected from D-galactosamine, D-glucosamine, N-acetyl-D-galactosamine and N-acetyl-D-glucosamine Disaccharides; oligosaccharides comprising at least one xylose, which may advantageously be selected from the group consisting of xylobiose, methyl-β-xylobioside, xylotriose, xylotetraose, xylopentaose and xylohexaose, and mixture. Preferably, the oligosaccharide is xylobiose, which consists of two xylose molecules linked via a 1-4 bond. More particularly, S may represent a monosaccharide selected from D-glucose, D-xylose, L-fucose, D-galactose, D-maltose, and mixtures thereof. In some cases, the monosaccharide is D-xylose.

Preferably, the C-glycoside may be a derivative of formula (I), wherein:

-R represents unsubstituted straight chain C ₁ -C ₄ (especially C ₁ -C ₂ ) alkyl, especially methyl;

-S represents a monosaccharide as described above, and is in particular selected from D-glucose, D-xylose, N-acetyl-D-glucosamine or L-fucose, and especially D-xylose; and

-X represents a group selected from -CO-, -CH(OH)- or -CH(NH ₂ )-, and is preferably the group -CH(OH)-.

The compounds described herein may be in the form of salts. Acceptable salts of the compounds described in this disclosure include conventional non-toxic salts of the compounds, such as those formed from organic or inorganic acids. By way of example, mention may be made of salts of mineral acids such as sulfuric acid or hydrochloric acid. Mention may also be made of salts of organic acids, which may contain one or more carboxylic acid, sulfate or phosphoric acid groups. Particular mention may be made of propionic, acetic, terephthalic, citric and tartaric acids.

When the compound of formula (I) contains an acid group, an inorganic base or an organic base can be used to neutralize the acid group, such as LiOH, NaOH, KOH, Ca(OH) ₂ , NH ₄ OH, Mg(OH ) ₂ or Zn(OH) ₂ , the organic base is, for example, primary alkylamine, secondary alkylamine or tertiary alkylamine. For example triethylamine or butylamine can be used to neutralize the compound of formula (I). The primary, secondary or tertiary alkylamine may contain one or more nitrogen and/or oxygen atoms, and may contain, for example, one or more alcohol functional groups. Mention may be made of 2-amino-2-methylpropanol, triethanolamine, 2-(dimethylamino)propanol or 2-amino-2-(hydroxymethyl)-1,3-propanediol. Mention may also be made of lysine or 3-(dimethylamino)propylamine.

Non-limiting examples of solvates that can be used in the cosmetic composition include conventional solvates such as those formed due to the presence of solvents during the final stages of preparation of the compounds. By way of example, mention may be made of solvates due to the presence of water or linear or branched alcohols, such as ethanol or isopropanol. Of course, according to the present disclosure, the C-glycoside derivatives corresponding to formula (I) can be used alone or as mixtures with other C-glycoside derivatives and in any proportion.

C-glycoside derivatives suitable for use in the present invention are obtainable in particular by the synthetic methods described in document WO 02/051828 (which document is hereby incorporated in its entirety for all purposes).

Non-limiting examples of C-glycoside compounds that may be suitable for use in cosmetic compositions include:

-C-β-D-xylopyranoside-n-propan-2-one,

-C-α-D-xylopyranoside-n-propan-2-one,

-C-β-D-xylopyranoside-2-hydroxypropane,

-C-α-D-xylopyranoside-2-hydroxypropane,

-1-(C-β-D-fucopyranoside) propan-2-one,

-1-(C-α-D-fucopyranoside) propan-2-one,

-1-(C-β-L-fucopyranoside) propan-2-one,

-1-(C-α-L-fucopyranoside) propan-2-one,

-1-(C-β-D-fucopyranoside)-2-hydroxypropane,

-1-(C-α-D-fucopyranoside)-2-hydroxypropane,

-1-(C-β-L-fucopyranoside)-2-hydroxypropane,

-1-(C-α-L-fucopyranoside)-2-hydroxypropane,

-1-(C-β-D-glucopyranosyl)-2-hydroxypropane,

-1-(C-α-D-glucopyranosyl)-2-hydroxypropane,

-1-(C-β-D-galactopyranosyl)-2-hydroxypropane,

-1-(C-α-D-galactopyranosyl)-2-hydroxypropane,

-1-(C-β-D-fucofuranosyl)propan-2-one,

-1-(C-α-D-fucofuranosyl)propan-2-one,

-1-(C-β-L-fucofuranosyl)propan-2-one,

-1-(C-α-L-fucofuranosyl)propan-2-one,

-C-β-D-maltopyranoside-n-propan-2-one,

-C-α-D-maltopyranoside-n-propan-2-one,

-C-β-D-maltopyranoside-2-hydroxypropane,

-C-α-D-maltopyranoside-2-hydroxypropane, isomers thereof, and/or mixtures thereof.

The cosmetic composition may preferably comprise a C-glycoside selected from C-β-D-xylopyranoside-2-hydroxypropane, C-α-D-xylopyranoside-2-hydroxypropane, and mixtures thereof. In some instances, the C-glycoside is C-β-D-xylopyranoside-2-hydroxypropane. According to at least one embodiment, the C-glycoside compound may be C-beta-D-pyranylwood provided in the form of a solution containing 30% by weight of active material in a water/propylene glycol (60% by weight/40% by weight) mixture Glycoside - 2-hydroxypropane (or hydroxypropyltetrahydropyrantriol).

Polyglyceryl-3 Methyl Glucose Distearate

The cosmetic composition includes polyglyceryl-3 methylglucose distearate in an amount that can vary, but is typically present in an amount of about 0.1 to about 5 wt.%, based on the total weight of the cosmetic composition. In some cases, based on the total weight of the cosmetic composition, the amount of polyglyceryl-3 methylglucose distearate in the cosmetic composition is about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1-about 3wt.%, about 0.1-about 2wt.%, about 0.1-about 1wt.%; about 0.25-about 5wt.%, about 0.25-about 4wt.%, about 0.25-about 3wt.%, about 0.25- About 2wt.%, about 0.25-about 1wt.%, about 0.5-about 5wt.%, about 0.5-about 4wt.%, about 0.5-about 3wt.%, about 0.5-about 2wt.%, about 0.5-about 1wt.% .%; about 0.75-about 5wt.%, about 0.75-about 4wt.%, about 0.75-about 3wt.%, about 0.75-about 2wt.%; about 1-about 5wt.%, about 1-about 4wt.% , about 1 to about 3 wt.%, or about 1 to about 2 wt.% (including ranges and subranges therebetween).

Sodium polyacrylate

Cosmetic compositions include sodium polyacrylate, generally in an amount of about 0.1 to about 5 wt.%, based on the total weight of the cosmetic composition. For example, based on the total weight of the cosmetic composition, the amount of sodium polyacrylate present in the cosmetic composition may be about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1-about 2wt.%, about 0.1-about 1wt.%; about 0.3-about 5wt.%, about 0.3-about 4wt.%, about 0.3-about 3wt.%, about 0.3-about 2wt.%, about 0.3- About 1wt.%; about 0.5-about 5wt.%, about 0.5-about 4wt.%, about 0.5-about 3wt.%, about 0.5-about 2wt.%, about 0.5-about 1wt.%; about 0.75-about 5wt.% .%, about 0.75-about 4wt.%, about 0.75-about 3wt.%, about 0.75-about 2wt.%; about 1-about 5wt.%, about 1-about 4wt.%, about 1-about 3wt.% , about 1-about 2wt.%; about 1.25-about 5wt.%, about 1.25-about 4wt.%, about 1.25-about 3wt.%, about 1.25-about 2wt.% (including each range and subranges therebetween) .

In general, sodium polyacrylate can be present in the composition in particulate or non-particulate form. When the sodium polyacrylate is present in particulate form, their average size in the hydrated state is preferably less than or equal to 10 μm, and even more preferably less than or equal to 5 μm. Their average size in the unhydrated state is preferably less than or equal to 2 μm, preferably less than or equal to 1 μm.

Non-limiting examples of commercially available sodium polyacrylates include those sold by Avecia under the names Octacare X100, X110, and RM100; those sold by SNF under the names Flocare GB300 and Flosorb 500; those sold by BASF under the names Luquasorb 1003, Luquasorb 1010 , Luquasorb 1280, and Luquasorb 1100; those sold by Grain Processing under the names Water Lock G400 and G430 (INCI name: Acrylamide/Sodium Acrylate Copolymer); under the names Aqua Keep 10SH NF, Aqua Keep 10SH NFC (Sodium Acrylate Crosslinked Polymer-2, those sold by Sumitomo Seika); and/or those sold by Sanyo Chemical Industries under the names Sanfresh ST-100C, ST100MC and IM-300MC (INCI name: Sodium Starch Polyacrylate).

Polyol

Cosmetic compositions may include one or more polyols. The amount of polyol (if present) in the cosmetic composition can range from about 1 to about 30 wt.%, based on the total weight of the cosmetic composition. For example, based on the total weight of the cosmetic composition, the cosmetic composition may include the following amounts of water-soluble solvents: about 1-about 30 wt.%, about 1-about 25 wt.%, about 1-about 20 wt.%, about 1- About 18wt.%, about 1-about 16wt.%, about 1-about 14wt.%, about 1-about 12wt.%, about 1-about 10wt.%; about 5-about 30wt.%, about 5-about 25wt.% .%, about 5-about 20wt.%, about 5-about 18wt.%, about 5-about 16wt.%, about 5-about 14wt.%, about 5-about 12wt.%, about 5-about 10wt.% about 10-about 30wt.%, about 10-about 25wt.%, about 10-about 20wt.%, about 10-about 18wt.%, about 10-about 16wt.%, about 10-about 14wt.%; 12-about 30wt.%, about 12-about 25wt.%, about 12-about 20wt.%, about 12-about 18wt.%, about 12-about 16wt.%; about 14-about 30wt.%, about 14- About 25wt.%, about 14-about 20wt.%, about 14-about 18wt.%; about 16-about 30wt.%, about 16-about 25wt.%, about 16-about 20wt.%; about 18-about 30wt.% %, about 18 to about 25 wt.%, about 18 to about 20 wt.% (including ranges and subranges thereof).

Polyols are useful. The term "polyol" is understood within the meaning of the present disclosure to mean an organic molecule comprising at least two free hydroxyl groups. The polyol of the cosmetic composition may be a diol or a compound having numerous hydroxyl groups. In some cases, the one or more polyols are selected from C ₂ -C ₃₂ polyols. The one or more polyols may be liquid at ambient temperature (25°C). The one or more polyols can have 2-32 carbon atoms, 3-16 carbon atoms, or 3-12 carbon atoms.

Non-limiting examples of polyols that may optionally be included in cosmetic compositions include and/or may be selected from alkanediols such as glycerol, 1,2,6-hexanetriol, trimethylolpropane, ethylene glycol, Alcohol, propylene glycol, butylene glycol, pentylene glycol, hexanediol, diethylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, 2-butene-1,4-diol, 2 -Ethyl-1,3-hexanediol, 2-methyl-2,4-pentanediol, caprylyl glycol, 1,2-hexanediol, 1,2-pentanediol and 4-methyl-1 ,2-Pentanediol; glycol ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monomethyl ether acetate, diethylene glycol Monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol mono-n-propyl ether, ethylene glycol monoisopropyl ether, diethylene glycol monoisopropyl ether, ethylene glycol mono-n-butyl ether, ethyl Glycol mono-tert-butyl ether, diethylene glycol mono-tert-butyl ether, 1-methyl-1-methoxybutanol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol mono-tert-butyl ether, propylene glycol Mono-n-propyl ether, Propylene glycol monoisopropyl ether, Dipropylene glycol monomethyl ether, Dipropylene glycol monoethyl ether, Dipropylene glycol mono-n-propyl ether, Dipropylene glycol monoisopropyl ether , sorbitol, sorbitan, triacetin, and mixtures thereof. The one or more polyols may optionally be glycols or glycol ethers such as monomethyl, monoethyl and monobutyl ethers of ethylene glycol, propylene glycol or ethers thereof, such as propylene glycol, butylene glycol , hexanediol, monomethyl ether of dipropylene glycol; and alkyl ethers of diethylene glycol, such as monoethyl ether or monobutyl ether of diethylene glycol.

In some cases, polyols include glycerin, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1,3-butanediol, 2,3-butanediol, 1,4-butanediol, 3-methyl-1,3-butanediol, 1,5-pentanediol, tetraethylene glycol, 1,6-hexanediol, 2-methyl-2,4- Pentylene glycol, polyethylene glycol, 1,2,4-butanetriol, 1,2,6-hexanetriol, and mixtures thereof. Polyol compounds can also be used. Non-limiting examples include aliphatic diols such as 2-ethyl-2-methyl-1,3-propanediol, 3,3-dimethyl-1,2-butanediol, 2,2-diethyl -1,3-propanediol, 2-methyl-2-propyl-1,3-propanediol, 2,4-dimethyl-2,4-pentanediol, 2,5-dimethyl-2,5 - hexanediol, 5-hexyl-1,2-diol and 2-ethyl-1,3-hexanediol, and mixtures thereof.

In some cases, the polyhydric alcohol is selected from the group consisting of ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, pentylene glycol, diethylene glycol, dipropylene glycol, caprylyl glycol, 1,3-propanediol, glycerol, Diglycerol, polyethylene glycol, and mixtures thereof.

degreaser

Cosmetic compositions of the present disclosure may include a degreasing agent. Based on the total weight of the cosmetic composition, the amount of degreasing agent in the cosmetic composition can be, for example, about 0.1 to about 10 wt.%, about 0.1 to about 8 wt.%, about 0.1 to about 6 wt.%, about 0.1 to about 5 wt. .%, about 0.1-about 4wt.%, about 0.1-about 3wt.%, about 0.1-about 2wt.%, about 0.1-about 1wt.%; about 0.25-about 10wt.%, about 0.25-about 8wt.% , about 0.25-about 6wt.%, about 0.25-about 5wt.%, about 0.25-about 4wt.%, about 0.25-about 3wt.%, about 0.25-about 2wt.%, about 0.25-about 1wt.%; about 0.5-about 10wt.%, about 0.5-about 8wt.%, about 0.5-about 6wt.%, about 0.5-about 5wt.%, about 0.5-about 4wt.%, about 0.5-about 3wt.%, about 0.5- About 2wt.%, about 0.5-about 1wt.%, about 0.75-about 10wt.%, about 0.75-about 8wt.%, about 0.75-about 6wt.%, about 0.75-about 5wt.%, about 0.75-about 4wt.% .%, about 0.75-about 3wt.%, about 0.75-about 2wt.%; about 1-about 10wt.%, about 1-about 8wt.%, about 1-about 6wt.%, about 1-about 5wt.% , about 1 to about 4 wt.%, about 1 to about 3 wt.%, or about 1 to about 2 wt.% (including ranges and subranges therebetween).

Degreasing agents (also known as "degreasing fillers") refer to materials that impart a clearer and hazy effect to the complexion and provide the skin with a natural and desirable appearance without giving it a greasy, shimmery and shiny appearance. For this purpose, these materials are usually absorbent fillers, such as talc, silica, kaolin, or fillers with light-scattering optical properties known under the name of the "soft focus" effect. In addition to reducing shine or greasiness, degreasing agents can contribute to the overall texture and thickness of the cosmetic composition. Degreasing agents are usually, but not always, particulate materials or powders.

Cosmetic compositions containing degreasing agents can be characterized by means of the following protocol. The test composition is spread at a rate of 2 mg/cm ² over a control card (Prufkarte type 24/5-250 cm ² sold by the company Erichsen) using a mechanical film spreader. The composition was then dried overnight at a temperature of 37° C., after which its reflection was measured using a gonior reflectometer sold by the company Micromodule. Measure the specular reflection intensity at 30° (R) and the scattering intensity at 90° (D) in sequence. The result obtained is the ratio R between specular and diffuse reflection. Proportionally the smaller the value of R, the greater the de-greasing effect provided by the filler. A value of R less than or equal to 2 generally indicates a degreasing effect. The degreasing agents according to the present disclosure include those which give R values of less than 1.5 and preferably less than 1, preferably at a level of 5% in the cosmetic composition.

Non-limiting examples of degreasing agents include: silica, clays, silicate derivatives, hydrophobic silica airgel particles, porous silica microparticles, such as Silica Beads SB150 with an average size of 5 microns from Miyoshi and SB700; Sunsphere H series products from Asahi Glass, such as Sunsphere H33, H51, and H53, with respective sizes of 3 μm, 5 μm, and 5 μm; polytetrafluoroethylene powder, such as PTFE Ceridust 9205F from Clariant, with an average size of 8 μm; silicon Ketone resin powders such as silicone resin Tospearl 145A from GE Silicone with an average size of 4.5 microns; hollow hemispherical silicone particles such as NLK500, NLK 506 and NLK 510 from Takemoto Oil and Fat; acrylic copolymer powders (especially Polymethyl(meth)acrylate powder), such as PMMA particles Jurymer MBI from Nihon Junyoki with an average size of 8 micrometers; hollow PMMA spheres sold under the name Covabead LH 85 by the company Wackher, and metachloride sold under the name Expancel Ethylene/acrylonitrile/methylene methacrylate expanded microspheres; wax powders, such as MicroEase 114S paraffin wax particles from MicroPowders, with an average size of 7 microns; polyethylene powders, especially containing at least one ethylene /acrylic acid copolymers, and especially consisting of ethylene/acrylic acid copolymers, such as Flobeads EA 209 particles from Sumitomo (average size 10 microns); coated with silicone resins (especially silsesquioxane resins) ) of crosslinked elastomeric organopolysiloxane powders, as described, for example, in patent US Pat. No. 5,538,793. Such elastomer powders are marketed by the company Shin-Etsu under the names KSP-100, KSP-101, KSP-102, KSP-103, KSP-104 and KSP-105; polyamide (nylon. RTM.) powders, e.g. from Atofina Orgasol type nylon 12 particles with an average size of 10 microns; polymethylmethacrylate (PMMA) type powder; talc; silica/ _TiO2 or silica/zinc oxide composites, styrene/acrylic copolymers powders; and mixtures thereof.

Among the clays, mention may be made of clays of the smectite family, such as laponite; clays of the kaolinite family, such as kaolinite, dickite or perlite; halloysite, dombese dombassite, antigorite, berthierine or pyrophyllite family, montmorillonite, beiderite, vermiculite, talc, stevensite, hectorite, saponite, chlorite Optionally modified clays of chrysene, sepiolite and illite (family).

Clays include products described, for example, in the publication Mineralogie des argiles [Clay Mineralogy] (S. Caillere, S. Henin, M. Rautureau, 2nd ed., 1982, Masson), which publication is incorporated by reference in its entirety Incorporated into this article. Natural clays are sedimentary rocks composed largely of specific minerals, usually silicates of aluminium. Kaolin is a natural clay. Clays can also be synthetic. Clays can also be chemically modified with various compounds such as acrylic acid, polysaccharides (eg carboxymethylcellulose) or organic cations. In some cases, the cosmetic compositions of the present disclosure include a clay selected from the group consisting of kaolinite, montmorillonite, saponite, hectorite, hectorite (including disteardimethylammonium hectorite) and illite.

Silica derivatives that may be mentioned include silica powders such as porous silica microspheres sold under the name SILICABEADS SB-700 by the company Miyoshi; the products SUNSPHERE H51, SUNSPHERE H33 and SUNSPHERE H53 sold by the company Asahi Glass; Dimethicone-coated amorphous silica microspheres sold under the names SA SUNSPHERE H-33 and SASUNSPHERE H-53 by the company Asahi Glass; silica microspheres, for example sold under the name SB150 by the company Miyoshi of those.

In some cases, the cosmetic composition includes one or more degreasing agents selected from the group consisting of methyl methacrylate/ethylene glycol dimethacrylate crosspolymer, vinyl dimethicone Alkane/Methicone Silsesquioxane Crosspolymer, Methyl Methacrylate Crosspolymer, Nylon-12, Polyamide, Polyethylene, Talc, Titanium Dioxide, Silica, Starch Octenyl Aluminum succinate, clays (eg, hectorite clays, including disteardimethylammonium hectorite), silica, polymethylsilsesquioxanes, and mixtures thereof. Preferably, the degreasing agent, if present, is aluminum starch octenyl succinate.

Oil

Cosmetic compositions comprise one or more oils, such as silicone oils, fluoro oils, hydrocarbon-based oils, and the like. In some cases, the cosmetic composition includes an oil, which is a vegetable-based oil or a vegetable-based oil. Based on the total weight of the cosmetic composition, the oil and/or vegetable-based oil or vegetable-based oil may be present in the cosmetic composition in an amount of about 0.1 to about 10 wt.%, about 0.1 to about 8 wt.%, about 0.1-about 7wt.%, about 0.1-about 6wt.%, about 0.1-about 5wt.%; about 0.5-about 10wt.%, about 0.5-about 8wt.%, about 0.5-about 7wt.%, about 0.5- About 6wt.%, about 0.5-about 5wt.%, about 1-about 10wt.%, about 1-about 8wt.%, about 1-about 7wt.%, about 1-about 6wt.%, about 1-about 5wt.% .%; about 2-about 10wt.%, about 2-about 8wt.%, about 2-about 7wt.%, about 2-about 6wt.%, about 2-about 5wt.%; about 3-about 10wt.% , about 3-about 8wt.%, about 3-about 7wt.%, about 3-about 6wt.%, about 3-about 5wt.%; about 4-about 10wt.%, about 4-about 8wt.% or about 4 to about 7 wt.% (including all ranges and subranges therebetween).

Additionally and/or alternatively, the cosmetic composition may exclude synthetic oils. In some cases, the cosmetic composition may exclude oils other than plant-based and vegetable-based oils. For example, based on the total weight of the cosmetic composition, the amount of synthetic oil and/or oils other than vegetable-based and vegetable-based oils may be about 5 wt.% or less, about 4 wt.% or less, About 3 wt.% or less, about 2 wt.% or less, about 1 wt.% or less, or about 0.5 wt.% or less. In at least one embodiment, the cosmetic composition is free or substantially free of synthetic oils and/or oils other than vegetable-based and vegetable-based oils.

The term "oil" means any fatty substance in liquid form at room temperature (20-25° C.) and atmospheric pressure (760 mmHg). Typically, at least one of the oils in the cosmetic composition is part of the oily phase. "Oil phase" is a phase comprising at least one oil which may include additional fat-soluble and lipophilic components and fatty substances. Oils suitable for use herein can be volatile or nonvolatile. The term "volatile oil" relates to an oil capable of evaporating on contact with the skin or keratin fibers in less than one hour at room temperature and atmospheric pressure. Volatile oils are liquid at room temperature and have a non-zero vapor pressure at room temperature and atmospheric pressure, especially in the range of 0.13 Pa to 40000 Pa (10 ⁻³ to 300 mmHg). The term "non-volatile oil" relates to oils that remain on the skin or keratin fibers for at least several hours at room temperature and atmospheric pressure, and in particular have a vapor pressure of less than 10 ⁻³ mmHg (0.13 Pa).

The term "silicone oil" relates to an oil comprising at least one silicon atom, and especially at least one Si-O group. The term "fluoro oil" relates to an oil comprising at least one fluorine atom. The term "hydrocarbon-based oil" relates to an oil mainly comprising hydrogen and carbon atoms. The hydrocarbon based oil may be a hydrocarbon based animal oil, a hydrocarbon based vegetable oil, a hydrocarbon based mineral oil or a hydrocarbon based synthetic oil. Furthermore, suitable oils may be hydrocarbon-based mineral oils, hydrocarbon-based vegetable oils or hydrocarbon-based synthetic oils.

silicone oil

The cosmetic compositions described herein may comprise one or more silicone oils. Non-limiting examples of silicone oils include dimethicone, cyclomethicone, polysilicone-11, phenyl trimethicone, trimethylsilyl amomethicone Trimethylsilylamodimethicone and stearoxytrimethylsilane. In some cases, the cosmetic composition includes dimethicone; and optionally additional oils, including additional silicone oils. Typically, the one or more silicone oils are non-volatile silicone oils. In some embodiments, the silicone oil is polydimethylsiloxane (PDMS); polydimethylsiloxane comprising alkyl or alkoxy groups pendant and/or at the end of the silicone chain, said groups each containing 2 to 24 carbon atoms; or phenyl silicones such as phenyl trimethicone, phenyl dimethicone, phenyl(trimethylsiloxy)diphenyl diphenyl dimethicone, diphenyl(methyldiphenyl)trisiloxane or (2-phenylethyl)trimethylsiloxysilicate.

Other examples of silicone oils that may be mentioned include volatile linear or cyclic silicone oils, especially those having a viscosity of 8 centistokes (8×10 ⁶ m ² /s) and especially containing 2 to 7 silicon atoms, any of which An alkyl or alkoxy group containing 1-10 carbon atoms is selected. As volatile silicone oils which can be used in the present invention, mention may especially be made of octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, heptamethylhexyltrisiloxane oxane, heptamethyloctyltrisiloxane, hexamethyldisiloxane, octamethyltrisiloxane, decamethyltetrasiloxane, dodecamethylpentasiloxane, and mixtures thereof.

Fluorine oil

The cosmetic compositions described herein may comprise one or more fluoro oils. For example, one or more fluoro oils may be selected from perfluoromethylcyclopentane, perfluoro-1,3-dimethylcyclohexane, dodecafluoropentane, tetrafluorohexane, bromoperfluoro Octyl, nonafluoromethoxybutane, nonafluoroethoxyisobutane and 4-trifluoromethylperfluoromorpholine. Volatile fluoro oils such as nonafluoromethoxybutane, decafluoropentane, tetradecafluorohexane, dodecafluoropentane can also be used.

hydrocarbon based oil

The cosmetic compositions described herein may comprise one or more hydrocarbon-based oils. For example, hydrocarbon-based oils can be saturated hydrocarbons, unsaturated hydrocarbons, lipids, triglycerides, natural oils and/or synthetic oils. In some embodiments, the composition includes a synthetic oil selected from hydrogenated polyisobutene and/or hydrogenated polydecene.

The hydrocarbon based oil may be a non-volatile hydrocarbon based oil such as:

(i) Hydrocarbon-based oils of vegetable origin, such as triglycerides, which are generally triesters of fatty acids and glycerol, the fatty acids of which can have varying chain lengths from _C4 to _C24 , which chains may be saturated or unsaturated and linear or branched; these oils are especially wheat germ oil, sunflower oil, grapeseed oil, sesame oil, corn oil, apricot oil, castor oil, shea butter, avocado oil, olive oil, soybean oil, sweet almond Oil, Palm Oil, Canola Oil, Cottonseed Oil, Hazelnut Oil, Macadamia Oil, Jojoba Oil, Alfalfa Oil, Poppy Oil, Pumpkin Seed Oil, Zucchini Oil, Black Currant Oil, Evening Primrose Oil, Millet Oil, Barley oil, quinoa oil, rye oil, safflower oil, candelilla oil, passionflower oil and musk rose oil.

(ii) synthetic ethers containing 10-40 carbon atoms;

(iii) straight-chain or branched-chain hydrocarbons of mineral or synthetic origin, such as petrolatum, polydecene, hydrogenated polyisobutene (such as Parleam) and 40 squalane;

或Witconol

销售的产品或者由EvonikGoldschmidt以商品名Tegosoft

销售的产品；苯甲酸2-乙基苯酯，例如由ISP以名称X-Tend 226销售的商品；羊毛脂酸异丙酯、月桂酸己酯、己二酸二异丙酯、异壬酸异壬酯、芥酸油醇酯、棕榈酸2-乙基己酯、异硬脂酸异硬脂酯；癸二酸二异丙酯，例如由StearinerieDubois以名称“Dub Dis”销售的产品；醇或多元醇的辛酸酯、癸酸酯或蓖麻油酸酯，例如二辛酸丙二醇酯；羟基化酯，例如乳酸异硬脂酯或苹果酸二异硬脂酯；和季戊四醇酯；柠檬酸酯或酒石酸酯，例如酒石酸二(直链C₁₂-C₁₃烷基)酯，例如由Enichem Augusta Industriale以名称Cosmacol

销售的那些；以及酒石酸二(直链C₁₄-C₁₅烷基)酯，例如由同一公司以名称Cosmacol

销售的那些；或乙酸酯；(iv) synthetic esters, such as oils of the formula RCOOR', wherein R represents a straight or branched fatty acid residue containing 1 to 40 carbon atoms, and R' represents a particularly branched hydrocarbon-based chain containing 1 -40 carbon atoms, provided that R+R'≥10, such as Purcellin oil (cetearyl caprylate), isopropyl myristate, isopropyl palmitate; benzoic acid C ₁₂ -C ₁₅ Alkyl esters, for example by Witco under the trade name Finsolv

or Witconol

products sold by EvonikGoldschmidt or under the trade name Tegosoft

Products sold; 2-ethylphenyl benzoate, such as that sold by ISP under the name X-Tend 226; Isopropyl lanolate, Hexyl laurate, Diisopropyl adipate, Iso-nononanoate Nonyl, oleyl erucate, 2-ethylhexyl palmitate, isostearyl isostearate; diisopropyl sebacate, such as the product sold under the name "Dub Dis" by Stearinerie Dubois; alcohol or Caprylic, capric, or ricinoleic acid esters of polyols, such as propylene glycol dicaprylate; hydroxylated esters, such as isostearyl lactate or diisostearyl malate; and pentaerythritol esters; citrates or tartaric acid Esters, such as bis(linear C ₁₂ -C ₁₃ alkyl) tartrates, for example by Enichem Augusta Industriale under the name Cosmacol

and those sold under the _{name Cosmacol}

those sold; or acetates;

(v) fatty alcohols containing branched and/or unsaturated carbon-based chains having 12 to 26 carbon atoms which are liquid at room temperature, such as octyldodecanol, isostearyl alcohol, oleyl alcohol, 2-Hexyldecanol, 2-Butyloctanol or 2-Undecylpentadecanol;

(vi) higher fatty acids, such as oleic acid, linoleic acid or linolenic acid;

销售的产品；(vii) Carbonates, such as dioctyl carbonate, for example by Cognis under the name Cetiol

Products on sale;

销售的产品；和(viii) Fatty amides, such as isopropyl N-lauroyl sarcosinate, such as Eldew® from Ajinomoto under the trade name Eldew

products sold; and

(ix) Essential oils selected from the group consisting of sunflower oil, sesame oil, peppermint oil, macadamia oil, tea tree oil, evening primrose oil, sage oil, rosemary oil, coriander oil, thyme oil, pimento berry oil, rose oil , Anise Oil, Balsam Oil, Bergamot Oil, Rosewood Oil, Cedarwood Oil, Chamomile Oil, Clary Sage Oil, Clary Sage Oil, Clove Oil, Cypress Oil, Eucalyptus Oil, Cumin Oil, Sea Fennel Oil, Milk Sesame Oil, Geranium Oil, Ginger Oil, Grapefruit Oil, Jasmine Oil, Juniper Oil, Lavender Oil, Lemon Oil, Lemongrass Oil, Pearberry Oil, Tangerine Oil, Margana Oil, Myrrh Oil, Neroli Oil , Orange Oil, Patchouli Oil, Pepper Oil, Black Pepper Oil, Orange Leaf Oil, Pine Oil, Rose Otto Oil, Rosemary Oil, Sandalwood Oil, Spearmint Oil, Nardine Oil, Vetiver Oil, Wintergreen Oil, and Elephant Oil Lan Ylang (oil).

In some cases, the non-volatile hydrocarbon-based oils are triglycerides, and especially caprylic/capric triglycerides; synthetic esters, and especially isononyl isononanoate, oleyl erucate, benzoic acid C ₁₂ -C ₁₅ alkyl esters, 2-ethylphenyl benzoate; and fatty alcohols such as octyldodecanol.

As volatile hydrocarbon-based oils, mention is made of hydrocarbon-based oils containing 8 to 16 carbon atoms, and in particular branched C ₈ -C ₁₆ alkanes, such as C ₈ -C ₁₆ isoalkanes of petroleum origin (also known as isoparaffins) such as isododecane (also known as 2,2,4,4,6-pentamethylheptane), isodecane, or isohexadecane; sold under the trade names Isopar or Permethyl oils; branched _C8 - _C16 esters; and isohexyl pivalate.

Preferably, the oil is selected from vegetable-based or vegetable-based oils, such as coconut oil, soybean oil, canola oil, rapeseed oil, corn oil, cottonseed oil, olive oil, palm oil, peanut oil, safflower oil, sesame oil, sunflower oil, linseed oil, palm kernel oil, tung oil, jatropha oil, mustard oil, camelina oil, galica oil, castor oil, wheat germ oil, almond oil, pistachio oil, poppy oil, pine oil, avocado oil, hazelnut oil, grapeseed oil, canola oil, juniper oil, peach kernel oil, coffee bean oil, jojoba oil, and mixtures thereof.

Thickeners other than sodium polyacrylate

The cosmetic compositions described herein may optionally include thickeners other than sodium polyacrylate. Based on the total weight of the cosmetic composition, the amount of thickeners other than sodium polyacrylate can be about 0.01wt.% to about 5wt.%, about 0.01wt.% to about 4wt.%, about 0.01wt.% to About 3wt.%, about 0.01wt.% - about 2wt.%, about 0.01wt.% - about 1wt.%; 0.05wt.% - about 3wt.%, about 0.05wt.% - about 2wt.%, about 0.05 wt.% - about 1wt.%; about 0.1wt.% - about 5wt.%, about 0.1wt.% - about 4wt.%, about 0.1wt.% - about 3wt.%, about 0.1wt.% - about 2wt.% .%, about 0.1wt.% - about 1wt.%; about 0.2wt.% - about 5wt.%, about 0.2wt.% - about 4wt.%, about 0.2wt.% - about 3wt.%, about 0.2wt.% .%-about 2wt.%, about 0.2wt.%-about 1wt.%; about 0.3wt.%-about 5wt.%, about 0.3wt.%-about 4wt.%, about 0.3wt.%-about 3wt.% %, about 0.3 wt.% to about 2 wt.%, or about 0.3 wt.% to about 1 wt.% (including ranges and subranges thereof). In addition, based on the total weight of the cosmetic composition, the amount of the thickener can be 0.1wt.%, 0.2wt.%, 0.3wt.%, 0.4wt.%, 0.5wt.%, 0.6wt.%, 0.7wt. %, 0.8 wt.%, 0.9 wt.%, 1.0 wt.% or 1.5 wt.% to 2 wt.%, 3 wt.%, 4 wt.% or 5 wt.% (including each range and its subranges).

Many thickeners are water-soluble and increase the viscosity of water or form a hydrogel when the cosmetic composition of the present invention is dispersed/dissolved in water. The aqueous solution may be heated and cooled, or neutralized, for gel formation, if necessary. Thickeners other than sodium polyacrylate may be dispersed/dissolved in an aqueous solvent soluble in water (for example, ethanol when dispersed/dissolved in water).

Thickeners may be referred to as "thickeners" or "viscosity modifiers". Thickeners are usually included to increase the viscosity of the composition. In some cases, however, certain thickeners provide additional unexpected benefits to the composition. Non-limiting examples of thickeners include polyacrylate crosslinked polymers (other than sodium polyacrylate) or crosslinked polyacrylate polymers (other than crosslinked sodium polyacrylate), cationic acrylate copolymers, anionic acrylic polymers or carboxylic acid polymers, polyacrylamide polymers, polysaccharides (e.g. cellulose derivatives), gums, polyquaternium salts, vinylpyrrolidone homopolymers/copolymers, C8-24 hydroxyl substituted aliphatic acids, C8-24 conjugated aliphatic acids, sugar fatty esters, polyglycerol esters, and mixtures thereof. Suitable thickeners other than sodium polyacrylate can be found in US Patent Application Serial No. 16/731,654 (which application is hereby incorporated in its entirety for all purposes).

Thickeners other than sodium polyacrylate may be selected from xanthan gum, guar gum, biosugar gum, cellulose, acacia seneca gum, sclerotinia, agarose, pectin, gellan gum , Hyaluronic Acid. Additionally, thickeners other than sodium polyacrylate may include polymeric thickeners selected from the group consisting of ammonium polyacryloyldimethyltaurate, ammonium acryloyldimethyltaurate/VP copolymer, acrylates Copolymers, polyacrylamides, carbomers and acrylates/C10-30 alkyl acrylate crosspolymers.

Particular types of thickeners that may be mentioned include the following thickeners:

Homopolymers or copolymers based on carboxylic acids or carboxylates, which may be linear or crosslinked:

These polymers contain one or more monomers derived from acrylic acid, substituted acrylic acids, and salts and esters of these acrylic acids (acrylates) and substituted acrylic acids. Commercially available polymers include those sold under the tradenames CARBOPOL, ACRYSOL, POLYGEL, SOKALAN, CARBOPOL ULTREZ, and POLYGEL. Examples of commercially available carboxylic acid polymers include carbomers, which are homopolymers of acrylic acid crosslinked with sucrose or allyl ethers of pentaerythritol. Carbomers are available as CARBOPOL 900 series (eg CARBOPOL 954) from B.F. Goodrich. Additionally, other suitable carboxylic acid polymer reagents include ULTREZ 10 (B.F. Goodrich) and a combination of a C10-30 alkyl acrylate and one of acrylic acid, methacrylic acid, or their short chain (i.e., C1-4 alcohol) esters. A copolymer of one or more monomers, wherein the crosslinking agent is allyl ether of sucrose or pentaerythritol. These copolymers are known as acrylates/C10-C30 alkyl acrylate crosspolymers and are commercially available from B.F. Goodrich as CARBOPOL 1342, CARBOPOL 1382, PEMULEN TR-1, and PEMULEN TR-2.

Other suitable carboxylic acid or carboxylate polymer agents include copolymers of acrylic acid and C5-C10 alkyl acrylates, copolymers of acrylic acid and maleic anhydride, and polyacrylate crosspolymer-6. Polyacrylate Crosspolymer-6 is available from Seppic under the material known as SEPIMAXZEN.

Another suitable carboxylic acid or carboxylate polymer reagent includes acrylamidopropyltrimethylammonium chloride/acrylate copolymer, which is a cationic acrylate copolymer (or quaternary ammonium compound) available as SIMULQUAT HC The starting material known under the trade name of 305 was obtained from Seppic.

In certain embodiments, carboxylic acid or carboxylate polymer thickeners useful herein are those selected from the group consisting of carbomers, acrylates/C10-C30 alkyl acrylate crosspolymers, polyacrylic acid Ester Crosspolymer-6, Acrylamidopropyltrimethylammonium Chloride/Acrylates Copolymer, and mixtures thereof.

polyquaternium compound

Non-limiting examples include Polyquaternium-1, Polyquaternium-2, Polyquaternium-3, Polyquaternium-4, Polyquaternium-5, Polyquaternium-6, Polyquaternium Salt-7, Polyquaternium-8, Polyquaternium-9, Polyquaternium-10, Polyquaternium-11, Polyquaternium-12, Polyquaternium-13, Polyquaternium -14, Polyquaternium-15, Polyquaternium-16, Polyquaternium-17, Polyquaternium-18, Polyquaternium-19, Polyquaternium-20, Polyquaternium- 21. Polyquaternium-22, Polyquaternium-23, Polyquaternium-24, Polyquaternium-25, Polyquaternium-26, Polyquaternium-27, Polyquaternium-28 , Polyquaternium-29, Polyquaternium-30, Polyquaternium-40, Polyquaternium-41, Polyquaternium-42, Polyquaternium-43, Polyquaternium-44, Polyquaternium-45, Polyquaternium-46, Polyquaternium-47, Polyquaternium-48, Polyquaternium-49, Polyquaternium-50, Polyquaternium-51, Polyquaternium Quaternium-52, Polyquaternium-53, Polyquaternium-54, Polyquaternium-55, Polyquaternium-56, Polyquaternium-57, Polyquaternium-58, Polyquaternium Ammonium-59, Polyquaternium-60, Polyquaternium-61, Polyquaternium-62, Polyquaternium-63, Polyquaternium-64, Polyquaternium-65, Polyquaternium Salt-66, polyquaternium-67, etc. In some cases, preferred polyquaternium compounds include polyquaternium-10, polyquaternium-11, polyquaternium-67, and mixtures thereof. In some cases, the cosmetic composition includes polyquaternium-10, polyquaternium-11, polyquaternium-67, or mixtures thereof.

Cellulose

Non-limiting examples of cellulose include cellulose, carboxymethyl hydroxyethyl cellulose, cellulose acetate propionate carboxylate, hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl cellulose Methylcellulose, methylhydroxyethylcellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof. In some cases, the cellulose is selected from water-soluble cellulose derivatives (e.g., carboxymethylcellulose, methylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, cellulose sodium sulfate). Furthermore, in some cases the cellulose is preferably hydroxypropyl cellulose (HPC). In some cases, the cosmetic composition includes one or more cellulosic thickeners (eg, microcrystalline cellulose, carboxymethylcellulose, hydroxymethylcellulose, and hydroxypropylcellulose).

Polyvinylpyrrolidone (PVP) and Copolymers

Non-limiting examples include polyvinylpyrrolidone (PVP), polyvinylpyrrolidone ((PVP)/vinyl acetate copolymer (PVP/VA copolymer), polyvinylpyrrolidone (PVP)/eicosene copolymer, PVP/hexadecene copolymers, etc. Commercially available polyvinylpyrrolidones include LUVISKOL K30, K85, K90 available from BASF. Commercially available copolymers of vinylpyrrolidone and vinyl acetate include those available from LUVISKOL VA37, VA64 from BASF; copolymers of vinylpyrrolidone, methacrylamide and vinylimidazole (INCI: VP/methacrylamide/vinylimidazole copolymer) are commercially available from BASF as LUVISET. In some In this case, PVP and PVP/VA copolymers are preferred.

Sucrose esters

Non-limiting examples include sucrose palmitate, sucrose cocoate, sucrose monocaprylate, sucrose monocaprate, sucrose monolaurate or sucrose dilaurate, sucrose monomyristate, sucrose monopalmitate sucrose dipalmitate, sucrose monostearate and sucrose distearate, sucrose monooleate, sucrose dioleate or sucrose trioleate, sucrose monolinoleate or sucrose dioleate Linoleate, sucrose pentaoleate, sucrose hexaoleate, sucrose heptaoleate or sucrose octaoleate, mixed esters thereof (e.g. sucrose palmitate/sucrose stearate), and mixtures thereof .

Polyglycerides

Non-limiting polyglycerol esters (polyglycerol esters) of fatty acids include those having the formula:

Wherein n is 2-20 or 2-10 or 2-5, or is 2, 3, 4, 5, 6, 7, 8, 9 or 10, and each of R ¹ , R ² and R ³ can independently be a fatty acid moiety or hydrogen, with the proviso that at least one of R ¹ , R ² and R ³ is a fatty acid moiety. For example R ¹ , R ² and R ³ can be saturated or unsaturated, linear or branched, and have C ₁ -C ₄₀ , C ₁ -C ₃₀ , C ₁ -C ₂₅ , or C ₁ -C ₂₀ , C ₁ -C ₁₆ or C ₁ -C ₁₀ length. Additionally, non-limiting examples of polyglyceryl esters of nonionic fatty acids include polyglyceryl-4 caprylate/caprate, polyglyceryl-10 caprylate/caprate, polyglyceryl-4 caprate, polyglyceryl -10 Caprate, Polyglyceryl-4 Laurate, Polyglyceryl-5 Laurate, Polyglyceryl-6 Laurate, Polyglyceryl-10 Laurate, Polyglyceryl-10 Cocoate, Polyglyceryl- 10 Myristate, Polyglyceryl-10 Oleate, Polyglyceryl-10 Stearate, and mixtures thereof.

C8-24 hydroxyl substituted aliphatic acids and C8-24 conjugated aliphatic acids

Non-limiting examples include conjugated linoleic acid, cis-stearatetraenoic acid, trans-7-octadecenoic acid, cis-5,8,11,14,17-eicosapentaene acid, cis-4,7,10,13,16,19-docosahexaenoic acid, columbian acid, elandoleic acid, ricinoleic acid, stearidonic acid, 2 -Hydroxystearic acid, α-linolenic acid, arachidonic acid, cis-11,14-eicosadienoic acid, elaidic acid, monopetroselinic acid, petroselinic acid, ricinoleic acid, trans -Vericoleic acid, cis-11,14,17-eicosatrienoic acid, cis-5-eicosatrienoic acid, cis-8,11,14-eicosatrienoic acid, hexadecyl Carbatrienoic acid, palmitoleic acid, trans petroselinic acid, trans-farnesol, cis-13,16-docosadienoic acid, cis-isooleic acid, cis-11-dienoic acid Decenoic acid, cis-13,16,19-docosatrienoic acid, cis-13-octadecenoic acid, cis-15-octadecanoic acid, cis-7,10, 13,16-Docosatetraenoic acid, elaidic acid, gamma-linolenic acid, geranic acid, geranyl geranoic acid, linoleic acid, oleic acid, pinolenic acid, trans-13 - octadecenoic acid. More preferably, the aliphatic acid includes 12-hydroxystearic acid, conjugated linoleic acid, or mixtures thereof.

glue

Non-limiting examples of gums include acacia, tragacanth, karaya, guar, gellan, tara, locust bean, tamarind, xanthan, locust bean, acacia (Seneca gum), Sclerotinia gum, etc.

skin active agent

Cosmetic compositions may optionally include one or more skin active agents, such as anti-aging agents, anti-wrinkle actives, antioxidants, moisturizers, moisturizing ingredients, depigmenting agents, and/or agents to treat oily skin, and the like. The skin active agent may be included in the composition in an amount ranging from greater than 0 to about 10 wt.%, based on the total weight of the cosmetic composition. For example, the total amount of skin active agents can be greater than 0 to about 9 wt.%, greater than 0 to about 8 wt.%, greater than 0 to about 7 wt.%, greater than 0 to about 6 wt.%, based on the total weight of the cosmetic composition , greater than 0-about 5wt.%, greater than 0-about 4wt.%, greater than 0-about 3wt.%, greater than 0-about 2wt.%; about 10ppm-about 10wt.% (100,000ppm), about 10ppm-about 5wt .% (50,000ppm), about 10ppm-about 2.5wt.% (25,000ppm), about 10ppm-about 1wt.% (10,000ppm), about 10ppm-about 0.5wt.% (5,000ppm), about 10ppm-about 0.3 wt.% (3,000ppm), about 10ppm-about 0.2wt.% (2,000ppm), about 10ppm-about 0.1wt.% (1,000ppm), about 10ppm-500ppm; about 0.05-about 10wt.%, about 0.05- About 5wt.%, about 0.05-about 2.5wt.%, about 0.05-about 1wt.%, about 0.05-about 0.5wt.%; about 0.1-about 10wt.%, about 0.1-about 5wt.%, about 0.1- About 2.5wt.%, about 0.1-about 1wt.%, about 0.1-about 0.5wt.%; about 1-about 10wt.%, about 1-about 8wt.%, about 1-about 6wt.%, about 1- About 5wt.%, about 1-about 4wt.%, about 1-about 3wt.%; about 2-about 10wt.%, about 2-about 8wt.%, about 2-about 6wt.%, about 2-about 5wt.% .%, about 2-about 4wt.%; about 3-about 10wt.%, about 3-about 8wt.%, about 3-about 6wt.%, about 3-about 5wt.%; about 4-about 10wt.% , about 4 to about 8 wt.%, about 4 to about 6 wt.% (including ranges and subranges therebetween).

The following provides a non-limiting discussion of skin active agents that may be included in cosmetic compositions in some cases:

humectants and/or humectants

Examples of humectants and/or humectants include glycerin and its derivatives; urea and its derivatives, especially Hydrovance sold by National Starch; lactic acid; hyaluronic acid; AHA; BHA; ; sodium lactate; ectoine and its derivatives; chitosan and its derivatives; collagen; plankton; Imperata cylindra extract sold under the name Moist24 by Sederma; Beta-glucans, and especially sodium carboxymethyl beta-glucan (Mibelle-AG-Biochemistry); Passiflora oil, apricot oil, corn oil and rice bran oil sold under the name NutraLipids by Nestle Mixtures; C-glycoside derivatives, in particular C-13-D-xylopyranoside-2-hydroxypropane, in the form of a 30% by weight solution of the active material in a water/propylene glycol mixture (60/40% by weight), as A product produced under the trade name "Mexoryl SBB" by the company Chimex; rosehip oil sold by Nestle; a zinc-rich microalgae extract Prophyridium cruentum sold under the name Algualane Zinc by Vincience; sold by the company Engelhard Lyon Collagen and chondroitin sulfate spheres of marine origin sold under the name Marine Filling Spheres (Atelocollagen); hyaluronic acid spheres such as those sold by Engelhard Lyon; and arginine.

decolorizer

Depigmenting agents that may be incorporated into cosmetic compositions include those selected from the group consisting of alpha arbutin and beta arbutin; ferulic acid; lucinol and its derivatives; kojic acid; resorcinol and its derivatives; Toxic acid and its derivatives; gentisic acid; homogentisic acid; methyl gentisate or homogentisic acid methyl ester; dioic acid; calcium D pantetheine sulfonate ( D pantheteine calcium sulphonate); lipoic acid; ellagic acid; vitamin B3; linoleic acid and its derivatives; obtained from sources such as chamomile, bearberry, aloe family (aloe vera, aloe vera, aloe vera), mulberry, skullcap Certain compounds of plants such as (skullcap); kiwi fruit (Actinidia chinensis) water marketed by Gattefosse; extracts of roots of peony (Paeonia suffruticosa), e.g. by IchimaruPharcos under the name Liquid Botanpi Be Of the kind marketed; extracts of brown sugar (Saccharum officinarum), such as molasses extracts marketed under the name Liquid Molasses by Taiyo Kagaku, this list is not exhaustive. Specific depigmenting agents include alpha arbutin and beta arbutin; ferulic acid; kojic acid; resorcinol and its derivatives; calcium D-pantetheinate; lipoic acid; ellagic acid; vitamin B3; Kiwi fruit (Actinidia chinensis) water sold by Gattefosse; extract of peony (Paeonia suffruticosa) root, such as that sold under the name Botanpi Liquid B by the company Ichimaru Pharcos.

Anti-Wrinkle Actives

Cosmetic compositions may include one or more anti-wrinkle actives. The term "anti-wrinkle active agent" refers to a natural or synthetic compound which, when in contact with a wrinkled area of skin, produces a biological effect, such as an increase in the synthesis and/or activity of certain enzymes, which has the effect of reducing the appearance of wrinkles and/or fine lines Effect. Exemplary anti-wrinkle active agents may be selected from: peeling agents, anti-glycation agents, inhibitors of NO synthase, agents that stimulate the synthesis of dermal or epidermal macromolecules and/or prevent their degradation, for stimulating fibroblasts and/or Or an agent for keratinocyte proliferation or a reducing agent for stimulating keratinocyte differentiation, a muscle relaxant and/or a dermo-decontracting agent, an anti-free radical agent, and a mixture thereof. Examples of such compounds are: adenosine and its derivatives and retinoids (such as retinyl palmitate and retinol); ascorbic acid and its derivatives, such as magnesium ascorbyl phosphate and ascorbyl glucoside; niacin and Its precursors, such as nicotinamide; ubiquinone; glutathione and its precursors, such as L-2-oxothiazolidine-4-carboxylic acid; compounds C-glycosides and its Derivatives, such as C-β-D-xylopyranoside-2-hydroxypropane as described inter alia in EP-1345919; plant extracts, including extracts of sea fennel and olive leaves; and plants and their hydrolysates, such as Rice protein hydrolyzate or soybean protein; Algal extracts, and especially Laminaria (extracts); Bacterial extracts; Saponins, such as diosgenin and plants of the genus Dioscorea (especially wild yam ) containing: a-hydroxy acids; f3-hydroxy acids; such as salicylic acid and n-octanoyl-5-salicylic acid oligopeptides and pseudodipeptides, and their acyl derivatives, especially the acid {2- [Acetyl-(3-trifluoromethyl-phenyl)-amino]-3-methyl-}acetic acid and lipopeptides (sold under the trade names Matrixyl 500 and Matrixyl 3000 by the company SEDERMA); lycopene; manganese salts and magnesium salts (especially gluconate); and mixtures thereof. In at least one case, the cosmetic composition comprises an adenosine derivative, such as a non-phosphate derivative of adenosine, such as in particular 2'-deoxyadenosine, 2',3'-isopropylideneadenosine; Adderamycin, 1-methyladenosine, N-6-methyladenosine; adenosine N-oxide, 6-methylmercaptopurine nucleoside, and 6-chloropurine nucleoside. Other derivatives include adenosine receptor agonists such as phenylisopropyladenosine ("PIA"), 1-methylisoguanosine, N6-cyclohexyladenosine (CHA), N6-cyclopentyladenosine (CPA), 2-chloro-N6-cyclopentyladenosine, 2-chloroadenosine, N6-phenyladenosine, 2-phenylaminoadenosine, MECA, N 6-phenylethyladenosine, 2- p-(2-Carboxy-ethyl)phenethyl-amino-5'-N-ethylcarboxamidoadenosine (CGS-21680), N-ethylcarboxamido-adenosine (NECA), 5' (N-cyclopropyl)-carboxamidoadenosine, DPMA (PD 129.944) and adenosyldil.

Dermoactive Agents for Oily Skin

Cosmetic compositions may optionally include skin active agents for oily skin. These agents may be sebum-regulating or anti-seborrhea agents capable of modulating the activity of the sebaceous glands. Exemplary skin actives for oily skin include: retinoic acid, retinol, benzoyl peroxide, sulfur, vitamin B6 (or pyridoxine) chloride, selenium, salicornia-cinnamon extract co- Mixtures, tea leaves and caprylglycine, eg - 15 Sepicontrol A5 TEA from Seppic; mixtures of cinnamon, sarcosine and caprylglycine - especially sold under the trade name Sepicontrol A5 by Seppic; - zinc salts, eg Zinc Gluconate, Zinc Pyrrolidone Carboxylate (or Zinc Piruvate), Zinc Lactate, Zinc Aspartate, Zinc Carboxylate, Zinc Salicylate 20, Zinc Cysteate; --Derivative substances, especially copper and copper pyruvate, as Cuivridone Solabia; -- extracts from the following plants: Arnica montana, Cinchona succirubra, Clove (Eugenia caryophyllata), Hops (Humulus lupulus ), Hypericum perforatum (Hypericum perforatum), peppermint (Mentha pipenta)25, rosemary (Rosmarinus officinalis), sage (Salvia officinalis) and thymus (Thymus vulgaris), all sold for example by Maruzen; -- Spiraea (Spiraea ulmaria), such as that sold under the name Sebonormine by Silab; - an extract of Laminaria saccharina, such as that sold under the name Phlorogine 30 by Biotechmarine; - root extract of burnet mixture (Sanguisorba officinalis/Poterium officinale), rhizome of ginger (Zingiber officinalis) and bark of cinnamon (Cinnamomum cassia) e.g. - that sold under the name Sebustop by Solabia; - an extract of linseed, such as that sold under the name Linumine by Lucas Meyer; - an extract of Phellodendron, such as by Maruzen under the name Phellodendron extract BG or by Ichimaru Pharcos Those marketed under the name Oubaku liquid B; - a mixture of argan oil, Serenoa serrulata (saw palmetto) extract and sesame seed extract, such as that sold under the name Regu SEB by Pentapharm ;--a mixture of extracts of willow lily, Terminalia chebula, nasturtium and bioavailable zinc (microalgae), such as that sold under the name Seborilys Green Tech;--Pygeum afrianum Extracts of Saw palmetto (Serenoa serrulata), such as those sold under the name Viapure Sabal by Actives International, and those sold by the company Euromed ;--extract of plantain blend, extract of Berberis aquifolium (Berberis aquifolium) and sodium salicylate 20, such as that sold under the name Seboclear Rahn;--extract of clove, such as that sold by Maruzen under the name - the kind sold by Clove extract powder; -- Argan oil, such as that sold under the name Lipofructyl Laboratories Serobiologiques; 25 -- milk protein filtrates (lactic protein filtrates), such as that sold by Sederma under the name Normaseb; -- Seaweed Laminaria extract, such as that sold under the name Laminarghane by Biotechmarine; - the oligosaccharide seaweed Laminaria digitata, such as that sold under the name Phycosaccharide 30AC by the company Codif; - an extract of sugar cane , such as that sold under the name Policosanol by the company Sabinsa; sulfonated shale oils, such as that sold under the name Ichtyol Pale by Ichthyol; - an extract of Spiraea (Spiraea ulmaria), Such as that sold by societeLibiol under the name Cytobiol Ulmaire; - sebacic acid, especially sold by Sederma under the name Sebosoft in the form of sodium polyacrylate gel; - extracted from konjac tubers and modified with alkylsulfonate chains Glucomannan, such as that sold under the name Biopol Beta by Arch Chemical; - extracts of Sophora angustifolia, such as those sold under the name Sophorapowder or Sophora extract by Bioland; Extract, such as that sold under the name Red Bark HS by Alban Muller; - an extract of Quillaja saponaria, such as that sold under the name 15 Panamawood HS by Alban Muller; - grafted to undecene Glycine on the chain, such as that sold under the name Lipacide UGOR by SEPPIC; a mixture of oleanolic acid and nordihydroguaiaretic acid, such as that sold in gel form by Sederma under the name AC.Net species; 20 -- phthalimidoperoxycaproic acid; -- tris(C12-C13) citrate, sold by Sasol under the name COSMACOL.RTM.ECI; tris(C14-C15) alkyl citrate , sold under the name COSMACOL.RTM.ECL by Sasol; -- 10-Hydroxydecanoic acid, including the mixture hydroxydecanoic acid October 25, sebacic acid and 1,10-decanediol, such as that sold under the name Acnacidol BG by Vinscience species; and mixtures thereof.

Antioxidants

Vitamin C and derivatives may be used, including ascorbic acid, sodium ascorbate, and the fat-soluble esters tetrahexyldecyl ascorbate and ascorbyl palmitate, magnesium ascorbyl phosphate, ascorbyl glucoside, glucosamine ascorbate, ascorbyl acetate, and the like. In addition, extracts from plants rich in vitamin C such as camu camu (Myrciaria dubia), acerola, emblica officinalis; Flavonoids, including water-soluble bioflavonoids such as hesperidin methylchalcone.

Sesamum indicum or sesame lignans can also be added. Sesame and its lignans (fibrous compounds related to sesame) act as antioxidants. Sesame seed lignans significantly enhanced vitamin E activity.

Other antioxidants include tocopherols (e.g. d-alpha-tocopherol, d-beta-tocopherol, d-gamma-tocopherol, d-delta-tocopherol), tocotrienols (e.g. d-alpha-tocotriene phenol, d-beta-tocotrienol, d-gamma-tocotrienol, d-delta-tocotrienol) and vitamin E (alpha-tocopheryl acetate). These compounds may be isolated from natural sources, prepared by synthetic means, or mixtures thereof. Tocotrienol-enriched vitamin E preparations can be obtained by fractionating the vitamin E preparation to remove a portion of the tocopherols and recover a more highly concentrated tocotrienol preparation. Useful tocotrienols are natural products isolated, for example, from wheat germ oil, corn oil or palm oil using high performance liquid chromatography or from barley, distillers grains or oats by alcohol extraction and/or molecular distillation. The term "tocotrienol" as used herein includes tocotrienol-rich fractions as well as pure compounds obtained from these natural products. Increased glutathione peroxidase activity protects skin from oxidative damage.

Additionally, carotenoids, especially the lutein type, are also useful antioxidants that can be used. Lutein-type carotenoids include molecules such as lutein, canthaxantin, cryptoxanthin, zeaxanthin, and astaxanthin. Luteinoids protect compounds such as vitamin A, vitamin E and other carotenoids.

flavonoids

The active agent may be an antioxidant selected from flavonoids. In some instances, the flavonoid is a flavanone (a derivative of 2,3-dihydro-2-phenylchromen-4-one). Flavonoids include: erionthidrin, eriodiction, hesperetin, hesperidin, homoeloutin, isosakuratin, naringenin, naringin, pinesin, poncirin, sakuratin, Saranin and 7-O-methyl eriodictyol (Sterubin). The flavonoid may be dihydroflavonol (a derivative of 3-hydroxy-2,3-dihydro-2-phenylchromen-4-one). Flavanols include: Taxifolin, Aromadedrin, Chrysandroside A, Chrysandroside B, Xeractinol, Astilbin, and Ayrin. The flavonoids may be flavones (derivatives of 2-phenylbenzopyran-4-one). Flavones include: apigenin, luteolin, citrus flavonoids, chrysin, baicalein, scutellarein, wogonin, and synthetic flavones: diosmin and flavoxate. The flavonoids may be flavonols (derivatives of 3-hydroxy-2-phenylbenzopyran-4-one). Flavonols include: 3-hydroxyflavone, rhododendron, fisetin, galangin, gossin, kaempferol, kaempferol, isorhamnetin, morin, myricetin, naringenin, ageratum Flavonol (Pachypodol), quercetin, rhamnatin, rhamnetin, rhododendron, hyperoside, isoquercitrin, kaempferin, myricitrin, quercetin, acacia, rutin, embroidered thread Inulin, reshamnetin, dehydrophellodendron, icariin, and troxerutin. The flavonoid may be a flavan-3-ol (a derivative of 2-phenyl-3,4-dihydro-2H-chromen-3-ol). Flavan-3-ols include: catechin, epicatechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate, epiafzelechin, Fisetinol, Guibourtinidol, Mesquitol, and Robinetinidol. The flavonoid may be a flavan-4-ol (a derivative of 2-phenylchroman-4-ol). Flavan-4-ols include: Apiforol and Luteoforol. The flavonoids may be isoflavones (derivatives of 3-phenylbenzopyran-4-one). Isoflavones include: genistein, daidzein, biochanin A, formononetin, and equol metabolites from daidzein.

Antioxidants may be anthocyanins (derivatives of 2-phenylbenzopyrylium cations). Anthocyanins include: Aurantinidin, cyanidin, delphinidin, Europinidin, Luteolinidin, Pelargonidin, Malvidin, Peonidin, Petunidin, Rosinidin and Xanthone.

The antioxidant may be dihydrochalcone (a derivative of 1,3-diphenyl-1-propanone). Dihydrochalcones include: Phloretin, Dihydrochalcone Phloretin, Phloridin, Aspalathin, Naringin Dihydrochalcone, Neohesperidin Dihydrochalcone and Nothofagin. Without limiting the mode of action of the present invention, dihydrochalcone can exert antioxidant effects by reducing active free radicals (such as active oxygen species and active nitrogen species).

The antioxidant may be anthocyanins. Anthocyanins and their derivatives are antioxidants. Anthocyanins encompass a class of flavonoid compounds responsible for the red, purple and blue colors of many fruits, vegetables, grains and flowers, which are naturally occurring water-soluble compounds. In addition, anthocyanins are collagenase inhibitors. The inhibition of collagenase helps to prevent and reduce wrinkles caused by the reduction of skin collagen, increase skin elasticity, etc. Anthocyanins can be obtained from any part of various plant sources, such as fruits, flowers, stems, leaves, roots, bark or seeds. Those skilled in the art will appreciate that certain parts of the plant may contain higher natural levels of anthocyanins, and thus use these parts to obtain the desired anthocyanins. In some instances, the antioxidant may include one or more betacyanins. Beta-anthocyanins (similar to anthocyanins) are available from natural sources and are antioxidants.

Antioxidants may be phenylpropanoids (derivatives of cinnamic acid). Phenylpropanoids include: cinnamic acid, caffeic acid, ferulic acid, trans-ferulic acid (including its antioxidant pharmacore 2,6-dihydroxyacetophenome), 5-hydroxyalkanoate Fullic acid, sinapic acid, coumaryl alcohol, coniferyl alcohol, sinapyl alcohol, eugenol, chavicol, safrole, p-coumaric acid, and sinapic acid. Without limiting the mode of action of the invention, phenylpropanoids neutralize free radicals.

The antioxidant may be chalcone (a derivative of 1,3-diphenyl-2-propen-1-one). Chalcones include: Butein, Coreopsis Chalcone, Safflowerin, Maritin, Griscenone, Xanthohumol, Flavokvain A, Flavokavain B, Flavokavin C, and synthetic Safalcone.

Antioxidants may be curcuminoids. Curcuminoids include: curcumin, demethoxycurcuminoids, bisdemethoxycurcuminoids, tetrahydrocurcuminoids, and tetrahydrocurcuminoids. Curcuminoids and tetrahydrocurcuminoids can be obtained from the rhizome of Curcuma longa. Tetrahydrocurcumin (a metabolite of curcumin) has been found to be a more potent antioxidant and more stable than curcumin.

Antioxidants can be tannins. Tannins include: Tannin, Terflavin B, Glucogallin, Dgallic acid and Quercitannic acid.

Antioxidants may be stilbenoids. Stilbene compounds include: resveratrol, pterostilbene and piceatanol. Resveratrol may include, but is not limited to, 3,5,4'-trihydroxystilbene, 3,4,3',5'-tetrahydroxystilbene (picetanol), 2,3',4,5'- Tetrahydroxystilbene (oxidized resveratrol), 4,4'-dihydroxystilbene and their alpha- and beta-glucoside, galactoside and mannoside derivatives.

The antioxidant may be coumarin (a derivative of 2H-chromen-2-one). The coumarins include: 4-hydroxycoumarin, umbelliferone, terperetin, deenteridin, hesperetin, and dicoumarol.

Antioxidants may be carotenoids. Carotenoids include: β-carotene, α-carotene, γ-carotene, β-cryptoxanthin, lycopene, lutein and idebenone. Sesamumindicum or sesame lignans may also be added. Sesame and its lignans (fibrous compounds related to sesame) act as antioxidants. Sesame seed lignans significantly enhanced vitamin E activity.

Antioxidants can be xanthone, butylated hydroxytoluene, 2,6-di-tert-butylphenol, 2,4-dimethyl-6-tert-butylphenol, gallic acid, eugenol, uric acid, alpha-sulfur Caprylic Acid, Ellagic Acid, Chichoric Acid, Chlorogenic Acid, Rosmarinic Acid, Salicylic Acid, Acetylcysteine, S-Allylcysteine, Barbigerone, Myrobalin, Edaravone, Ethoxyquin, Glutathione, Hydroxytyrosol, Idebenone, Melatonin, N-Acetyl Serotonin, Nordihydroguaiaretic Acid, Olive Oil Stimulated Aldehyde (Oleocanthal) , Oleuropein, Paradol, Picetanol, Probucol, Propyl Gallate, Protocatechuic Acid, Pyritinol, Rutin, Semoisolaricol Diglucose, Sesamin, Sesamol, silybin, silymarin, theaflavins, theaflavin digallate, Thmoquinone, Trolox, tyrosol, polyunsaturated fatty acids; and sulfur-based antioxidants such as methionine or lipoic acid.

Fatty esters other than polyglyceryl-3 methylglucose distearate

Cosmetic compositions may include fatty esters other than polyglyceryl-3 methylglucose distearate, in amounts that vary, but generally range from about 0.1 to 20 wt.%, about 0.1 to about 18wt.%, about 0.1-about 16wt.%, about 0.1-about 14wt.%, about 0.1-about 12wt.%, about 0.1-about 10wt.%, about 0.1-about 8wt.%, about 0.1-about 7wt. %, about 0.1-about 6wt.%, about 0.1-about 5wt.%; about 0.5to 20wt.%, about 0.5-about 18wt.%, about 0.5-about 16wt.%, about 0.5-about 14wt.%, about 0.5-about 12wt.%, about 0.5-about 10wt.%, about 0.5-about 8wt.%, about 0.5-about 7wt.%, about 0.5-about 6wt.%, about 0.5-about 5wt.%; about 1- About 20wt.%, about 1-about 18wt.%, about 1-about 16wt.%, about 1-about 14wt.%, about 1-about 12wt.%, about 1-about 10wt.%, about 1-about 8wt.% .%, about 1-about 7wt.%, about 1-about 6wt.%, about 1-about 5wt.%; about 2-about 20wt.%, about 2-about 18wt.%, about 2-about 16wt.% , about 2-about 14wt.%, about 2-about 12wt.%, about 2-about 10wt.%, about 2-about 8wt.%, about 2-about 7wt.%, about 2-about 6wt.%, about 2-about 5wt.%; about 3-about 20wt.%, about 3-about 18wt.%, about 3-about 16wt.%, about 3-about 14wt.%, about 3-about 12wt.%, about 3- About 10wt.%, about 3-about 8wt.%, about 3-about 7wt.%, about 3-about 6wt.%, about 3-about 5wt.%; about 4-about 20wt.%, about 4-about 18wt.% .%, about 4-about 16wt.%, about 4-about 14wt.%, about 4-about 12wt.%, about 4-about 10wt.%, about 4-about 8wt.% or about 4-about 7wt.% (including all ranges and subranges in between).

The fatty esters other than polyglyceryl-3 methylglucose distearate may be glycerin fatty esters, sorbitan fatty esters, ethoxylated fatty esters, synthetic esters, and the like. A discussion of fatty esters other than polyglyceryl-3 methylglucose distearate that can be included in cosmetic compositions is provided below.

Glycerin Fatty Esters

Fatty esters of glycerol useful as nonionic amphipathic lipids may in particular be selected from esters formed from at least one acid comprising a saturated linear alkyl chain having 16-22 carbon atoms and 1-10 glycerol units. One or more of these fatty glycerides may be used in the emulsions of the present disclosure.

Sorbitan Fatty Ester

Sorbitan fatty esters useful as nonionic amphiphilic lipids are chosen in particular from esters of C16-C22 fatty acids with sorbitan and oxyethylated esters of C16-C22 fatty acids with sorbitan. They are formed from at least one fatty acid comprising at least one saturated linear alkyl chain each having 16 to 22 carbon atoms and sorbitol or ethoxylated sorbitol. Oxyethylenated esters generally contain 1-100 ethylene oxide units, and preferably 2-40 ethylene oxide (EO) units.

These esters may in particular be chosen from stearates, behenates, arachidates, palmitates and mixtures thereof. Preference is given to using stearates and palmitates.

As examples of sorbitan fatty esters and oxyethylenated sorbitan fatty esters, mention may be made of sorbitan monostearate sold under the name Span 60 by the company ICI (CTFA name: anhydrous Sorbitan Stearate); Sorbitan Monopalmitate (CTFA name: Sorbitan Palmitate) sold under the name Span 40 by the ICI Corporation; or Tween 65 by the ICI Corporation Sorbitan Tristearate 20EO (CTFA name: Polysorbate 65).

Ethoxylated Fatty Esters

Ethoxylated fatty esters useful as nonionic amphipathic lipids are esters consisting of 1-100 ethylene oxide units and at least one fatty acid chain containing 16-22 carbon atoms. The fatty chain of the ester may in particular be selected from stearate, behenate, arachidate and palmitate units, and mixtures thereof. As examples of ethoxylated fatty esters, mention may be made of esters of stearic acid comprising 40 ethylene oxide units, such as the product sold under the name Myrj 52 by the company ICI (CTFA name: PEG-40 stearate); Also esters of behenic acid comprising 8 ethylene oxide units (CTFA designation: PEG-8 behenate), such as the product sold under the name Compritol HD5 ATO by the company Gattefosse.

synthetic ester

或Witconol

销售的产品或由EvonikGoldschmidt以商品名Tegosoft

销售的产品；苯甲酸2-乙基苯酯，例如由ISP以名称X-Tend 226销售的商品；羊毛脂酸异丙酯、月桂酸己酯、己二酸二异丙酯、异壬酸异壬酯、芥酸油醇酯、棕榈酸2-乙基己酯、异硬脂酸异硬脂酯；癸二酸二异丙酯，例如由StearinerieDubois以名称"Dub Dis"销售的产品；醇或多元醇的辛酸酯、癸酸酯或蓖麻油酸酯，例如二辛酸丙二醇酯；羟基化酯，例如乳酸异硬脂酯或苹果酸二异硬脂酯；以及季戊四醇酯；柠檬酸酯或酒石酸酯，例如酒石酸二(直链C12-C13烷基)酯，例如由Enichem AugustaIndustriale以名称Cosmacol

销售的那些；以及酒石酸二(直链C14-C15烷基)酯，例如由同一公司以名称Cosmacol

销售的那些；或乙酸酯。Synthetic esters, such as oils of the formula RCOOR', wherein R represents a straight-chain or branched chain fatty acid residue containing 1-40 carbon atoms, and R' represents a particularly branched hydrocarbon-based residue containing 1-40 carbon atoms Chain, provided that R+R'≥10, such as purcellin oil (cetearyl caprylate), isopropyl myristate, isopropyl palmitate; C12-C15 alkyl benzoate Esters, such as those sold by Witco under the trade name Finsolv

or Witconol

products sold by EvonikGoldschmidt or under the trade name Tegosoft

Products sold; 2-ethylphenyl benzoate, such as that sold by ISP under the name X-Tend 226; Isopropyl lanolate, Hexyl laurate, Diisopropyl adipate, Iso-nononanoate Nonyl, oleyl erucate, 2-ethylhexyl palmitate, isostearyl isostearate; diisopropyl sebacate, such as the product sold under the name "Dub Dis" by Stearinerie Dubois; alcohol or Caprylic, capric, or ricinoleic acid esters of polyols, such as propylene glycol dicaprylate; hydroxylated esters, such as isostearyl lactate or diisostearyl malate; and pentaerythritol esters; citrates or tartaric acid Esters, such as bis(linear C12-C13 alkyl) tartrates, for example by Enichem Augusta Industriale under the name Cosmacol

those sold; and bis(linear C14-C15 alkyl) tartrates, for example by the same company under the name Cosmacol

those sold; or acetate.

Nonionic emulsifiers other than polyglyceryl-3 methylglucose distearate

In some cases, the cosmetic composition may include a nonionic emulsifier in addition to polyglyceryl-3 methylglucose distearate. Based on the total weight of the cosmetic composition, the amount of nonionic emulsifiers other than polyglyceryl-3 methylglucose distearate can be about 0.1-20 wt.%, about 0.1-about 18 wt.%, about 0.1- About 16wt.%, about 0.1-about 14wt.%, about 0.1-about 12wt.%, about 0.1-about 10wt.%, about 0.1-about 8wt.%, about 0.1-about 7wt.%, about 0.1-about 6wt.% .%, about 0.1-about 5wt.%; about 1-about 20wt.%, about 1-about 18wt.%, about 1-about 16wt.%, about 1-about 14wt.%, about 1-about 12wt.% , about 1-about 10wt.%, about 1-about 8wt.%, about 1-about 7wt.%, about 1-about 6wt.%, about 1-about 5wt.%; about 4-about 20wt.%, about 4-about 18wt.%, about 4-about 16wt.%, about 4-about 14wt.%, about 4-about 12wt.%, about 4-about 10wt.%, about 4-about 8wt.% or about 4- About 7 wt.% (including all ranges and subranges therebetween).

Emulsifiers are commonly used to incorporate oils and/or fatty compounds into hydrophilic media (eg, aqueous media) to form oil-in-water emulsions. In some cases, however, emulsifiers can be used to incorporate a hydrophilic phase (eg, an aqueous medium) into an oil or fatty phase to form a water-in-oil emulsion. Cosmetic compositions include one or more nonionic emulsifiers. However, further emulsifiers may also be included (or excluded), for example amphoteric, anionic and/or cationic emulsifiers.

As regards O/W emulsions, examples of emulsifiers that may be mentioned include nonionic emulsifiers such as oxyalkylenated (more especially polyoxyethylenated) fatty acid esters of glycerol; oxyalkylenated fatty acids of sorbitan Esters; oxyalkylenated (oxyethylenated and/or oxypropylenelated) fatty acid esters; oxyalkylenated (oxyethylenated and/or oxypropylenelated) fatty alcohol ethers; sugar esters such as sucrose stearate; and mixtures thereof . A more exhaustive but non-limiting list of useful nonionic emulsifiers is provided below under the heading "Nonionic Emulsifiers".

In some cases, natural oil-containing cosmetic compositions include two or more nonionic emulsifiers. In particular, one or more nonionic emulsifiers with an HLB of 10 or higher and one or more nonionic emulsifiers with an HLB of 5 or lower. The total amount of these emulsifiers is such that the final HLB of the hair treatment composition is within +/- 0.5 of the HLB of the natural oil in the cosmetic composition. This generally results in a final HLB of the emulsified natural oil in the hair treatment composition in the range of about 6 to about 8.

Examples of emulsifiers that may be mentioned include nonionic emulsifiers such as oxyalkylenated (more particularly polyoxyethylenated) fatty acid esters of glycerol; oxyalkylenated fatty acid esters of sorbitan; Ethylenelated and/or oxypropylenelated) fatty acid esters; oxyalkylenated (oxyethylenelated and/or oxypropylenelated) fatty alcohol ethers; sugar esters, such as sucrose stearate; and mixtures thereof.

Non-limiting examples of nonionic emulsifiers include polyglycerol-based emulsifiers, polyol esters, glycerol ethers, oxyethylenated ethers, oxypropylenelated ethers, glycol polymers, sorbitan esters, polysorbate , and mixtures thereof. In some cases, the one or more nonionic emulsifiers are selected from polyglyceryl-10-stearate, polyglyceryl-3-caprate, polyglyceryl-3-diisostearate, polyglycerol -3 Methylglucose distearate, or a mixture thereof.

pH regulator

Cosmetic compositions may include one or more pH adjusting agents to increase or decrease the overall pH of the cosmetic composition. For example, one or more acids may be included to lower the pH of the cosmetic composition. Examples of suitable acids for lowering the pH of cosmetic compositions include, but are not limited to, citric acid, acetic acid, and the like. Cosmetic compositions may include one or more bases (eg, sodium hydroxide, potassium hydroxide, etc.) to lower the pH of the cosmetic composition. Additional or alternative acids and bases suitable for adjusting the pH of cosmetic compositions are readily known to those of ordinary skill in the art.

Cosmetic compositions may desirably have a pH of from about 4 to about 7, preferably from about 4.5 to about 6.5 or from about 5.5 to about 6.5. In one instance, the pH of the cosmetic composition is at or about 6. The amount of pH adjuster in the cosmetic composition can be based on the desired pH of the final cosmetic composition and/or product. For example, the total amount of pH adjuster can range from about 0.05 to about 20 wt.%, based on the total weight of the composition. In some cases, based on the total weight of the composition, the total amount of the pH adjuster is about 0.05 to about 15 wt.%, about 0.5 to about 10 wt.%, about 1 to about 5 wt.%, about 1.5 to about 4 wt.%. % or about 2.0 to about 3 wt.% (including ranges and subranges therebetween).

water

The total amount of water in the cosmetic composition can vary, but typically ranges from about 50 to about 95 wt.%, based on the total weight of the cosmetic composition. In some cases, the total amount of water is about 50 to about 90 wt.%, about 50 to about 85 wt.%, about 50 to about 80 wt.%, based on the total weight of the cosmetic composition; about 55 to about 95 wt.%. , about 55-about 90wt.%, about 55-about 85wt.%, about 55-about 80wt.%; about 60-about 95wt.%, about 60-about 90wt.%, about 60-about 85wt.%, about 60-about 80wt.%; about 65-about 95wt.%, about 65-about 90wt.%, about 65-about 85wt.% or about 65-about 80wt.%; about 70-about 95wt.%, about 70- About 90 wt.%, about 70 to about 85 wt.%, about 70 to about 80 wt.% (including ranges and subranges therebetween).

production method

The present disclosure also relates to methods or processes of preparing/manufacturing the cosmetic compositions described herein. It also covers products prepared by these methods or processes.

The process of making certain embodiments of the cosmetic composition includes forming an oily phase and forming a separate aqueous phase (containing water), heating the two phases and combining while warming. The phases may be heated to the same temperature or may be heated to different temperatures.

Thickeners may be added to the aqueous phase of the cosmetic composition. In some cases, however, one or more emulsifiers and/or thickeners are added to the oil phase. Additionally or alternatively, a thickener may be added after emulsification, for example ammonium polyacryldimethyl taurate may be added after emulsification.

After combining the oily and aqueous phases to form the emulsion, the composition is generally allowed to cool. Additional components may be added during or after the emulsification time. For example, certain fragrances, colorants, exfoliants, active ingredients, etc. may be added to the aqueous phase, the fatty phase, or after emulsification.

Instructions

The present disclosure also relates to methods of using the cosmetic compositions described herein. For example, the cosmetic composition can be used in a method comprising applying the cosmetic composition to human skin. In some instances, the compositions are applied to the face. Furthermore, the cosmetic compositions can be used in methods for treating and/or repairing damage to the skin, such as damage from photoaging, and in methods for reducing the appearance of wrinkles, dark spots, and uneven skin texture of the skin. The foregoing methods are non-therapeutic.

The cosmetic composition may be applied once a day, twice a day, or more than once or twice a day. In some instances, the composition is administered at night before bed. In other cases, the composition is administered in the morning. In still other cases, the composition can be applied immediately after washing the skin. The composition can be used once or over a series of days, weeks or months. For example, the composition can be used daily for 1 week or 1 month, 2 weeks or 2 months, 3 weeks or 3 months, 4 weeks or 4 months, 5 weeks or 5 months, 6 weeks or 6 months , 7 weeks or 7 months, 8 weeks or 8 months or more for a period of weeks or more months.

implementation plan

In certain embodiments, the cosmetic compositions of the present disclosure generally include:

- about 0.1 to about 10 wt.%, preferably about 1 to about 10 wt.%, more preferably about 2 to about 9 wt.% of C-glycosides, for example selected from C-β-D-xylopyranoside-2-hydroxypropane , C-alpha-D-xylopyranoside-2-hydroxypropane, and mixtures thereof;

- about 0.1 to about 5 wt.%, preferably about 0.25 to about 5 wt.%, more preferably about 0.5 to about 4 wt.% of polyglyceryl-3 methylglucose distearate;

- about 0.1 to about 5 wt.%, preferably about 0.25 to about 5 wt.%, more preferably about 0.5 to about 4 wt.% of sodium polyacrylate; and

- Water, preferably about 50 to about 95 wt.% water, more preferably about 60 to about 95 wt.% water, wherein the cosmetic composition is an oil-in-water emulsion, and all weight percentages are based on the total weight of the cosmetic composition.

In a further embodiment, there is provided a cosmetic composition comprising:

- about 0.1 to about 10 wt.%, preferably about 1 to about 10 wt.%, more preferably about 2 to about 9 wt.% of C-glycosides, for example selected from C-β-D-xylopyranoside-2-hydroxypropane , C-alpha-D-xylopyranoside-2-hydroxypropane, and mixtures thereof;

- about 0.1 to about 5 wt.%, preferably about 0.25 to about 5 wt.%, more preferably about 0.5 to about 4 wt.% of polyglyceryl-3 methylglucose distearate;

- about 0.1 to about 5 wt.%, preferably about 0.25 to about 5 wt.%, more preferably about 0.5 to about 4 wt.% of sodium polyacrylate;

- water, preferably about 50 to about 95 wt.% water, more preferably about 60 to about 95 wt.% water;

- optionally from about 1 to about 30 wt.%, preferably from about 5 to about 25 wt.%, more preferably from about 10 to about 20 wt.%, of polyhydric alcohols, including for example ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, Pentylene glycol, diethylene glycol, dipropylene glycol, caprylyl glycol, 1,3-propanediol, glycerin, diglycerol, polyethylene glycol, or mixtures thereof;

- optionally from about 0.1 to about 10 wt.%, preferably from about 0.25 to about 8 wt.%, more preferably from about 0.5 to about 6 wt.%, of a degreasing agent, such as aluminum starch octenyl succinate;

- optionally from about 0.5 to about 10 wt.%, preferably from about 1 to about 10 wt.%, more preferably from about 1 to about 6 wt.%, of oils such as silicone, coconut oil, soybean oil, canola oil, Rapeseed oil, corn oil, cottonseed oil, olive oil, palm oil, peanut oil, safflower oil, sesame oil, sunflower oil, linseed oil, palm kernel oil, tung oil, jatropha oil, mustard oil, camelina oil, safflower oil Oil, Castor Oil, Wheat Germ Oil, Almond Oil, Pistachio Oil, Poppy Oil, Pine Oil, Avocado Oil, Hazelnut Oil, Grape Seed Oil, Rapeseed Oil, Juniper Oil, Peach Kernel Oil, Coffee Bean Oil, Jojoba oil, or a mixture thereof;

- optionally from about 0.01 to about 5 wt.%, preferably from about 0.01 wt.% to about 4 wt.%, more preferably from about 0.05 wt.% to about 4 wt.%, of a thickener other than sodium polyacrylate, for example selected from Those of: Ammonium Polyacryloyldimethyltaurate, Ammonium Acryloyldimethyltaurate/VP Copolymer, Sodium Polyacrylate, Acrylates Copolymer, Polyacrylamide, Carbomer, Acrylates/Acrylic C10 -30 Alkyl Ester Crosspolymer, Acrylates/Beheneth-25 Methacrylate Copolymer, and mixtures thereof;

- optionally up to about 5 wt.%, preferably from about 0.05 to about 5 wt.%, more preferably from about 0.1 to about 4 wt.%, of skin active agents, such as those selected from the group consisting of hyaluronic acid, lanolin, niacinamide, Citric Acid, Malic Acid, Lactic Acid, Tartaric Acid, Salicylic Acid, Caprylyl Salicylic Acid, Retinoids, Retinaldehyde, Retinol, Adenosine, Sodium Hyaluronate, Retinoic Acid, Carotenoids, Panthenol , amino acids, proteins, enzymes, coenzymes, and mixtures thereof; and

- optionally from about 1 to about 30 wt.%, preferably from about 0.5 to about 16 wt.%, more preferably from about 1 to about 8 wt.%, of a fatty ester other than polyglyceryl-3 methylglucose distearate, wherein the Fatty esters include isononyl isononanoate, caprylic/capric triglycerides, or mixtures thereof, wherein the cosmetic composition is an oil-in-water emulsion, and all weight percents are based on the total weight of the cosmetic composition.

Example

The following examples are provided primarily for the purpose of illustrating the benefits achieved by embodiments of the present disclosure. The examples are intended to illustrate the technology and are not necessarily limiting in nature.

Example 1

Example 2

The penetration of Example Composition A was evaluated in vitro by applying a sample of Example Composition A to a Glass Franz diffusion cell. Samples of Example Composition A were applied to 3 pig skin samples from 3 different donors. Pig skin samples were full thickness pig skin obtained from the flank. Approximately 5 mg/cm ² of Example Composition A was applied to a 2 cm ² surface area of each pig skin sample. The diffusion cell was filled with 3 mL of receptor fluid, which was saline solution containing 0.9 wt.% NaCl. Pig skin samples from the diffusion cell were kept at a temperature of 32°C for 16 hours.

Pigskin samples from the diffusion cell were washed with 0.6 mL of a solution containing 5 wt.% lauryl ether sulfate and gently massaged for 30 seconds using half a cotton swab. Subsequently, the pigskin sample was washed with 0.6 mL of a solution containing 5 wt.% of lauryl ether sulfate by aspirating with a pipette and dispensing the solution several times. Pig skin samples were then washed three times by aspirating with a pipette and dispensing 0.6 mL of water. After each preceding washing step, the corresponding solution or water was removed using a pipette. After the washing step was complete, the pigskin samples were dried using two half cotton swabs.

Tape peeling was then performed on the porcine skin samples using DSquame ^™ adhesive tape (which is commercially available from Clinical & Derm). Specifically, 30 sheets of tape were stripped (10 sheets were obtained from each donor of pigskin samples). The amount of Example Composition A that penetrated into the epidermis, dermis (epd) was determined to be an average amount of hydroxypropyltetrahydropyrantriol of about 2.2 μg/ ^cm2 using LC-MSMS equipment and receptor fluid.

The term "INCI" is an acronym for International Nomenclature of Cosmetic Ingredients, which is provided by the International Nomenclature Committee of the Personal Care Products Council to describe personal care products. Nomenclature of ingredients.

All provided ranges as used herein are meant to include each specific range within the given range, as well as combinations of subranges between the given ranges. Thus, a range of 1-5 specifically includes 1, 2, 3, 4, and 5, and subranges such as 2-5, 3-5, 2-3, 2-4, 1-4, and the like.

All components and elements positively stated in the present disclosure can be negatively excluded from the claims. In other words, the cosmetic compositions of the present disclosure may be free or substantially free of all components and elements positively described throughout the present disclosure.

In some cases, the cosmetic compositions of the present disclosure may be substantially free of, in non-incidental amounts, the ingredients or compounds described herein. A non-incidental amount of an ingredient or compound is the amount of that ingredient or compound itself that is added to the cosmetic composition. For example, a cosmetic composition may be substantially free of ingredients or compounds in non-incidental amounts, although such ingredients or compounds may be present as part of raw materials included as a blend of two or more compounds .

Some of the various classes of components identified may overlap. In such cases where overlap is possible and the composition includes two components (or the composition includes more than two overlapping components), overlapping compounds do not represent more than one component. For example, tocopherol can be characterized as both a skin active agent and a preservative. If a particular composition includes both a skin active agent and a preservative, Steareth-20 will act only as a skin active agent or only as a preservative (tocopherol will not act as both a skin active agent and a preservative).

All publications and patent applications cited in this specification are herein incorporated by reference for any and all purposes as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference. In the event of any inconsistency between this disclosure and any publication or patent application incorporated herein by reference, the present disclosure controls.

As used herein, the terms "comprising," "having," and "including" are used in their open, non-limiting sense.

The terms "a" and "the" are understood to cover the plural as well as the singular. Accordingly, the term "a mixture thereof" also relates to "mixtures thereof". Throughout this disclosure, the term "mixture thereof" is used after a list of elements, as shown in the following examples, where the letters A-F represent elements: "An or more elements". The term "a mixture thereof" does not require that the mixture include all of A, B, C, D, E, and F (although all of A, B, C, D, E, and F may be included). Rather, it indicates that a mixture of any two or more of A, B, C, D, E and F may be included. In other words, it is equivalent to the phrase "chosen from A, B, C, D, E, F; and any mixture of any two or more of A, B, C, D, E, and F or more elements".

The expression "one or more" means "at least one" and thus includes individual components as well as mixtures/combinations.

Except in the working examples or where otherwise indicated, all numerical values expressing amounts of ingredients and/or reaction conditions may in all cases be modified by the term "about", which means within +/- 5% of the indicated numerical value within.

The term "treatment" (and grammatical variants thereof) as used herein refers to the application of the compositions of the present disclosure to the surface of a keratinous substrate such as hair on the user's head and/or body.

As used herein, the term "substantially free" or "essentially free" means that less than about 2% by weight of a particular material is added to the composition, based on the total weight of the composition. However, the composition may include less than about 1 wt.%, less than about 0.5 wt.%, less than about 0.1 wt.%, or no specified material. All components set forth herein can be optionally included in or excluded from the composition/method/kit. When excluded, the composition/method/kit can be free or substantially free of that component. For example, a particular composition may be free or substantially free of silicone.

Claims (20)

1. A cosmetic composition comprising:

(a) About 0.1 to about 10wt.% of a C-glycoside;

(b) About 0.1 to about 5wt.% polyglycerol-3 methyl glucose distearate;

(c) About 0.1 to about 5wt.% sodium polyacrylate; and

(d) Water and its preparation method

Wherein the cosmetic composition is an oil-in-water emulsion and all weight percentages are based on the total weight of the cosmetic composition.

2. The cosmetic composition of claim 1, further comprising:

(e) About 1 to about 30wt.% of a polyol.

3. The cosmetic composition of claim 2 wherein the polyhydric alcohol is selected from the group consisting of ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, pentylene glycol, diethylene glycol, dipropylene glycol, octylene glycol, 1, 3-propanediol, glycerol, diglycerol, polyethylene glycol, and mixtures thereof.

4. The cosmetic composition of any one of claims 1-3, further comprising:

(f) About 0.1 to about 10wt.% of a polish remover.

5. The cosmetic composition of claim 4, wherein the degreasing agent comprises aluminum starch octenyl succinate.

6. The cosmetic composition of any one of claims 1-3, further comprising:

(g) About 0.5 to about 10wt.% oil.

7. The cosmetic composition of claim 6, wherein the oil is silicone.

8. The cosmetic composition of claim 6, wherein the oil is selected from the group consisting of coconut oil, soybean oil, canola oil, rapeseed oil, corn oil, cottonseed oil, olive oil, palm oil, peanut oil, safflower oil, sesame oil, sunflower oil, linseed oil, palm kernel oil, tung oil, jatropha oil, mustard oil, camelina oil, pennycress oil, castor oil, wheat germ oil, almond oil, pistachio oil, poppy oil, pine oil, avocado oil, hazelnut oil, grapeseed oil, vegetable oil, juniper oil, peach seed oil, coffee bean oil, jojoba oil, and mixtures thereof.

9. The cosmetic composition of any one of claims 1-3, further comprising:

(h) About 0.01 to about 5wt.% of a thickener other than sodium polyacrylate.

10. The cosmetic composition of claim 9 wherein the thickener other than sodium polyacrylate is selected from the group consisting of ammonium polyacryl dimethyl taurate, ammonium acryl dimethyl taurate/VP copolymer, sodium polyacrylate, acrylate copolymer, polyacrylamide, carbomer, acrylate/C10-30 alkyl acrylate cross-linked polymer, acrylate/behenate-25 methacrylate copolymer, and mixtures thereof.

11. The cosmetic composition of any one of claims 1-3, further comprising:

(i) About 0.05 to about 5wt.% of a skin active agent.

12. The cosmetic composition of claim 11, wherein the skin active agent is selected from the group consisting of hyaluronic acid, lanolin, nicotinamide, citric acid, malic acid, lactic acid, tartaric acid, salicylic acid, octanoylsalicylic acid, retinoids, retinaldehyde, retinol, adenosine, sodium hyaluronate, retinoic acid, carotenoids, panthenol, amino acids, proteins, enzymes, coenzymes, and mixtures thereof.

13. The cosmetic composition of any one of claims 1-3, further comprising:

(j) About 0.1 to about 20wt.% of a fatty ester other than polyglycerol-3 methyl glucose distearate.

14. The cosmetic composition of claim 13, wherein the fatty ester that is not polyglycerol-3 methyl glucose distearate comprises isononyl isononanoate, caprylic/capric triglyceride, or mixtures thereof.

15. A cosmetic composition according to any one of claims 1-3, wherein the C-glycoside is selected from the group consisting of C- β -D-xylopyranoside-n-propan-2-one, C- α -D-xylopyranoside-n-propan-2-one, C- β -D-xylopyranoside-2-hydroxypropane, C- α -D-xylopyranoside-2-hydroxypropane, 1- (C- β -D-fucopyranoside) propan-2-one, 1- (C- α -D-fucopyranoside) propan-2-one, 1- (C- β -L-fucopyranoside) propan-2-one, 1- (C- β -D-fucopyranoside) -2-hydroxypropane, 1- (C- α -D-fucopyranoside) -2-hydroxypropane, 1- (C- β -L-fucopyranoside) -2-hydroxypropane, 1- (C- α -L-fucopyranoside) -2-hydroxypropane, 1- (C- β -L-fucopyranoside) -2-hydroxypropane, 1- (C-L-fucopyranoside) propan-2-one, 1- (C- β -L-fucopyranoside) propan-2-one, 1- (C-L-glucopyranoside) 1- (C- α -D-glucopyranosyl) -2-hydroxypropane, 1- (C- β -D-galactopyranosyl) -2-hydroxypropane, 1- (C- α -D-galactopyranosyl) -2-hydroxypropane, 1- (C- β -D-fucopyranosyl) propan-2-one, 1- (C- α -D-fucopyranosyl) propan-2-one, 1- (C- β -L-fucopyranosyl) propan-2-one, C- β -D-maltopyranoside-n-propan-2-one, C- β -D-maltopyranoside-2-hydroxypropane, C- α -D-maltopyranoside-2-hydroxypropane, isomers thereof, mixtures thereof, and combinations thereof.

16. The cosmetic composition of any one of claims 1-3, wherein the C-glycoside comprises at least one of C- β -D-xylopyranoside-2-hydroxypropane and C- α -D-xylopyranoside-2-hydroxypropane.

17. A cosmetic composition according to any one of claims 1 to 3, wherein the C-glycoside is C- β -D-xylopyranoside-2-hydroxypropane.

18. A cosmetic composition consisting of the following components:

(a) About 0.1 to about 10wt.% of a C-glycoside;

(b) About 0.1 to about 5wt.% polyglycerol-3 methyl glucose distearate;

(c) About 0.1 to about 5wt.% sodium polyacrylate;

(d) Water;

(e) Optionally about 1 to about 30wt.% of a polyol;

(f) Optionally about 0.1 to about 10wt.% of a gloss reducing agent;

(g) Optionally about 0.5 to about 10wt.% oil;

(h) Optionally about 0.01 to about 5wt.% of a thickener other than sodium polyacrylate;

(i) Optionally, a skin active agent in an amount up to about 5 wt.%; and

(j) Optionally about 1 to about 30wt.% of a fatty ester other than polyglycerol-3 methyl glucose distearate,

wherein the cosmetic composition is an oil-in-water emulsion and all weight percentages are based on the total weight of the cosmetic composition.

19. The cosmetic composition of claim 18, wherein the C-glycoside is selected from the group consisting of C- β -D-xylopyranoside-n-propan-2-one, C- α -D-xylopyranoside-n-propan-2-one, C- β -D-xylopyranoside-2-hydroxypropane, C- α -D-xylopyranoside-2-hydroxypropane, 1- (C- β -D-fucopyranoside) propan-2-one, 1- (C- α -D-fucopyranoside) propan-2-one, 1- (C- β -L-fucopyranoside) propan-2-one, 1- (C- α -L-fucopyranoside) propan-2-one, 1- (C- β -D-fucopyranoside) -2-hydroxypropane, 1- (C- β -L-fucopyranoside) -2-hydroxypropane, 1- (C- α -L-fucopyranoside) -2-hydroxypropane, 1- (C- β -L-fucopyranoside) propan-2-one, 1- (C- β -L-glucopyranoside) 1- (C- β -D-galactopyranosyl) -2-hydroxypropane, 1- (C- α -D-galactopyranosyl) -2-hydroxypropane, 1- (C- β -D-fucopyranosyl) propan-2-one, 1- (C- α -D-fucopyranosyl) propan-2-one, 1- (C- β -L-fucofuranosyl) propan-2-one, 1- (C- α -L-fucofuranosyl) propan-2-one, C- β -D-maltopyranoside-n-propan-2-one, C- α -D-maltopyranoside-n-propan-2-one, C- β -D-maltopyranoside-2-hydroxypropane, isomers thereof, mixtures thereof, and combinations thereof.

20. The cosmetic composition of claim 18, wherein the C-glycoside comprises at least one of C- β -D-xylopyranoside-2-hydroxypropane and C- α -D-xylopyranoside-2-hydroxypropane.