CN100339135C

CN100339135C - Antibiotic aerogel dressing of hollow acetate fiber and its prepn

Info

Publication number: CN100339135C
Application number: CNB200510040001XA
Authority: CN
Inventors: 褚省吾
Original assignee: Individual
Current assignee: Taizhou Roosin Medical Product Co ltd
Priority date: 2005-05-13
Filing date: 2005-05-13
Publication date: 2007-09-26
Anticipated expiration: 2025-05-13
Also published as: CN1706503A

Abstract

The present invention discloses an antibacterial hollow cellulose acetate hydrogel dressing and a preparation method thereof. In the preparation method for the hydrogel dressing, a calcium alginate fiber and chitosan fiber are mixed and are cut into short fibers A; polyethyleneglycol and agar are added in an initial material of polyvinyl alcohol, and the obtained mixture is dissolved in physiological saline to be heated into a homogeneous solution; then water-soluble carboxymethyl chitosan powder and nanometer silver ions are added in the homogeneous solution to be uniformly mixed into hydrogel B which is then coated on a hollow cellulose acetate hydroentangling non-woven fabric with negative static charges; the fibers A are uniformly sprayed on the hydrogel B by a wind spraying method, and then an isolating film is covered on the hydrogel B. The hydrogel B is mainly prepared from the following raw materials: 80 to 120 of polyvinyl alcohol, 10 to 40 of polyethyleneglycol and 5 to 20 of agar. The antibacterial hollow cellulose acetate hydrogel dressing has favorable humidity keeping properties, is completely separated from a wound, has the functions of inflammation relief, bacteriostasis, hemostasis and growth promotion of cells and is suitable for treating burns, scalds and bedsore.

Description

A kind of hollow acetate fiber antibiotic aerogel dressing and preparation thereof

Technical field

The present invention relates to a kind of hollow acetate fiber antibiotic aerogel dressing and preparation thereof that is applied to burn wound's treatment.

Background technology

The effective method of treatment large-area burns at present, scald wound is an epidermization, adopts epidermization to treat and protect wound.Adopting gel to cover be the better protect method, therefore should provide possess simultaneously permeable, ventilative, antibiotic, certain mechanical strength and elasticity are arranged, material self physics and stable chemical performance, easily preservation.

Summary of the invention

The invention provides a kind of hollow acetate fiber antibiotic aerogel dressing and preparation thereof that is applied to burn wound's treatment.

A kind of hollow acetate fiber of the present invention antibiotic aerogel dressing, being coated with polyvinyl alcohol, Polyethylene Glycol and agar on the hollow acetate fiber spun-laced nonwoven fabric that contains negative electrostatic charge is the hydrogel B that primary raw material is formed, the weight of each component consists of polyvinyl alcohol: Polyethylene Glycol: agar=80-120: 10-40: 5-20, on hydrogel B, be covered with calcium alginate fibre and chitin fiber mixing short fiber A, the weight ratio of calcium alginate fibre and chitin fiber is 60: 40, covers isolating membrane on mixing short fiber A.

Described isolating membrane is a hyaline membrane.The length of short fiber A is 20-50mm.

A kind of hollow acetate fiber of the present invention antibiotic aerogel dressing preparation method is to mix and cut into short fiber A at 60: 40 with calcium alginate fibre and chitin fiber by weight; In expecting, polyvinyl alcohol first add Polyethylene Glycol and agar, its weight consists of polyvinyl alcohol: Polyethylene Glycol: agar=80-120: 10-40: 5-20, and it is dissolved in the normal saline, heating makes it become homogeneous solution, add water-soluble carboxymethyl chitosan powder and nano-silver ionic again, mix homogeneously is hydrogel B, after hydrogel B is coated on the hollow acetate fiber spun-laced nonwoven fabric of the negative electrostatic charge of band, hydrogel B goes up the method for drenching with wind fiber A is drenched uniformly on hollow acetate fiber spun-laced nonwoven fabric, covers then and goes up isolating membrane.

The use of Polyethylene Glycol can make hydrogel have moisture retention preferably; The hollow acetate fiber plays skeleton and water retention, has weak acidic medium simultaneously and prevents the bacterial growth breeding; Calcium alginate fibre and chitin fiber provide antiinflammatory, antibacterial, hemostasis, promote the growth of wound tissue's cell for it, skin and wound there are good biocompatibility and degradability, easily be absorbed by the body, because wound is moistening, dressing and wound keep peeling off fully state, fiber is not stayed on the wound surface, and prevents that teleneuron is dead and expose, and reduces when changing the damage to the wound surface.Nontoxic, non-stimulated, no sensitization.The hollow acetate fiber has the breeding of pH value 5-6 weak acidic medium bacteria growing inhibiting, and nanometer silver has stronger bactericidal action.

Description of drawings

Fig. 1 is dressing structure figure of the present invention.

The specific embodiment

A kind of hollow acetate fiber of the present invention antibiotic aerogel dressing preparation method, it is that 20-50mm is short fiber A that calcium alginate fibre was mixed and cut into length with chitin fiber by weight 60: 40.In expecting, polyvinyl alcohol first add Polyethylene Glycol and agar, its weight consists of polyvinyl alcohol: Polyethylene Glycol: agar=8-120: 10-40: 5-20, and it is dissolved in the normal saline, Material control concentration is less than 10%, adding thermic makes it become homogeneous solution for 60 ℃, add water-soluble carboxymethyl chitosan powder and nano-silver ionic again, mix homogeneously is hydrogel B, after hydrogel B is coated on the hollow acetate fiber spun-laced nonwoven fabric of the negative electrostatic charge of band, hydrogel thickness is controlled at 4-5mm, and hydrogel viscosity is controlled at 12000 centipoises-20000 centipoise, with the method that wind drenches fiber A is drenched on hydrogel B uniformly, the short fiber A of every square metre of wind pouring is controlled at the 20-30 gram, and it is compressed, cover the polyester transparent isolating membrane then, be cut into required bulk, packing is also carried out crosslinking with radiation, plays the effect of sterilization simultaneously.

Claims

1. A hollow cellulose acetate antibacterial hydrogel dressing, which is coated with polyvinyl alcohol, polyethylene glycol and agar as the main raw materials on the hollow acetate spunlace non-woven fabric containing negative electrostatic charges. , the weight composition of each component is polyvinyl alcohol: polyethylene glycol: agar=80-120: 10-40: 5-20, on hydrogel B, calcium alginate fiber and chitosan fiber are mixed short For fiber A, the weight ratio of calcium alginate fiber to chitosan fiber is 60:40, and the mixed short fiber A is covered with an isolation film.

2. The dressing according to claim 1, wherein the barrier film is a transparent film.

3. The dressing according to claim 1 or 2, characterized in that the short fibers A have a length of 20-50 mm.

4. A method for preparing a hollow acetate fiber antibacterial hydrogel dressing, mixing calcium alginate fiber and chitosan fiber in a weight ratio of 60:40 and cutting them into short fibers A; adding polyvinyl alcohol to the initial material Polyethylene glycol and agar, its weight composition is polyvinyl alcohol: polyethylene glycol: agar=80-120: 10-40: 5-20, and it is dissolved in normal saline, and heating makes it become uniform solution, again Add water-soluble carboxymethyl chitosan powder and nano-silver ions, mix evenly to form hydrogel B, and then apply hydrogel B to negatively charged hollow acetate spunlace non-woven fabric, the hydrogel Spray fiber A evenly on hollow acetate fiber spunlaced non-woven fabric by air shower on B, and then cover with isolation film.