CN109156692A - A kind of effervescent tablet and preparation method thereof mixing natural products - Google Patents
A kind of effervescent tablet and preparation method thereof mixing natural products Download PDFInfo
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- CN109156692A CN109156692A CN201810806515.9A CN201810806515A CN109156692A CN 109156692 A CN109156692 A CN 109156692A CN 201810806515 A CN201810806515 A CN 201810806515A CN 109156692 A CN109156692 A CN 109156692A
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- natural products
- effervescent tablet
- effervescent
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- 229930014626 natural product Natural products 0.000 title claims abstract description 48
- 239000007938 effervescent tablet Substances 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 238000002156 mixing Methods 0.000 title claims description 31
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 22
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 15
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 13
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 13
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims abstract description 12
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims abstract description 12
- 235000021283 resveratrol Nutrition 0.000 claims abstract description 12
- 229940016667 resveratrol Drugs 0.000 claims abstract description 12
- 229930186301 urolithin Natural products 0.000 claims abstract description 12
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 11
- 239000000194 fatty acid Substances 0.000 claims abstract description 11
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 11
- 239000011718 vitamin C Substances 0.000 claims abstract description 11
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 9
- 239000003765 sweetening agent Substances 0.000 claims abstract description 9
- 239000000853 adhesive Substances 0.000 claims abstract description 8
- 230000001070 adhesive effect Effects 0.000 claims abstract description 8
- 239000000314 lubricant Substances 0.000 claims abstract description 7
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 13
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 13
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 13
- 239000000845 maltitol Substances 0.000 claims description 11
- 235000010449 maltitol Nutrition 0.000 claims description 11
- 244000269722 Thea sinensis Species 0.000 claims description 10
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 9
- 229940035436 maltitol Drugs 0.000 claims description 9
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 7
- 235000019359 magnesium stearate Nutrition 0.000 claims description 7
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 6
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 6
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 6
- -1 hydroxyl isomaltulose Chemical compound 0.000 claims description 6
- 239000001630 malic acid Substances 0.000 claims description 6
- 235000011090 malic acid Nutrition 0.000 claims description 6
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 6
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 6
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 229920001100 Polydextrose Polymers 0.000 claims description 5
- 235000013856 polydextrose Nutrition 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 4
- 239000011975 tartaric acid Substances 0.000 claims description 4
- 235000002906 tartaric acid Nutrition 0.000 claims description 4
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims description 3
- 239000008116 calcium stearate Substances 0.000 claims description 3
- 235000013539 calcium stearate Nutrition 0.000 claims description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 claims description 2
- 230000006835 compression Effects 0.000 claims description 2
- 238000007906 compression Methods 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 239000011736 potassium bicarbonate Substances 0.000 claims description 2
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 235000005979 Citrus limon Nutrition 0.000 claims 2
- 244000131522 Citrus pyriformis Species 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 210000002966 serum Anatomy 0.000 abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 10
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 8
- 230000004060 metabolic process Effects 0.000 abstract description 4
- 230000003647 oxidation Effects 0.000 abstract description 4
- 238000007254 oxidation reaction Methods 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 3
- 150000001875 compounds Chemical group 0.000 abstract description 2
- 238000011031 large-scale manufacturing process Methods 0.000 abstract description 2
- 241001122767 Theaceae Species 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 16
- 238000002474 experimental method Methods 0.000 description 8
- 241000699670 Mus sp. Species 0.000 description 7
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000003963 antioxidant agent Substances 0.000 description 5
- 230000003078 antioxidant effect Effects 0.000 description 5
- 235000006708 antioxidants Nutrition 0.000 description 5
- 235000013361 beverage Nutrition 0.000 description 5
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 5
- 239000003826 tablet Substances 0.000 description 5
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 229960004106 citric acid Drugs 0.000 description 4
- 235000015165 citric acid Nutrition 0.000 description 4
- 210000002381 plasma Anatomy 0.000 description 4
- 239000013641 positive control Substances 0.000 description 4
- 239000001259 polydextrose Substances 0.000 description 3
- 229940035035 polydextrose Drugs 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 206010014025 Ear swelling Diseases 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 229960004543 anhydrous citric acid Drugs 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 230000003471 anti-radiation Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 229960003180 glutathione Drugs 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000001603 reducing effect Effects 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 102000016938 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 102000006587 Glutathione peroxidase Human genes 0.000 description 1
- 108700016172 Glutathione peroxidases Proteins 0.000 description 1
- UWIULCYKVGIOPW-UHFFFAOYSA-N Glycolone Natural products CCOC1=C(CC=CC)C(=O)N(C)c2c(O)cccc12 UWIULCYKVGIOPW-UHFFFAOYSA-N 0.000 description 1
- XEUCQOBUZPQUMQ-UHFFFAOYSA-N Glycolone Chemical compound COC1=C(CC=C(C)C)C(=O)NC2=C1C=CC=C2OC XEUCQOBUZPQUMQ-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000003777 Interleukin-1 beta Human genes 0.000 description 1
- 108090000193 Interleukin-1 beta Proteins 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- WSMYVTOQOOLQHP-UHFFFAOYSA-N Malondialdehyde Chemical compound O=CCC=O WSMYVTOQOOLQHP-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 244000294611 Punica granatum Species 0.000 description 1
- 235000014360 Punica granatum Nutrition 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 150000002525 isomaltoses Chemical class 0.000 description 1
- 229940099690 malic acid Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 229960001367 tartaric acid Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
- A23L2/395—Dry compositions in a particular shape or form
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/40—Effervescence-generating compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Botany (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to health drink manufacture fields, particularly with regard to a kind of using a variety of natural products as compound function effervescent tablet of primary raw material and preparation method thereof.The effervescent tablet is made of following components and its parts by weight: mixotrophism element, and 30 ~ 60 parts；Sweetener, 30 ~ 50 parts；Disintegrating agent, 8 ~ 15 parts；Help stream lubricant, 1 ~ 3 part；Adhesive, 0 ~ 0.04 part；Effervescent agent, 0 ~ 15 part；Surplus is water；Wherein, the mixotrophism element is tea polyphenols, resveratrol, urolithin, vitamin C and omega-fatty acid.The effervescent tablet of the method for the present invention preparation is easy to drink, is more received by consumer, and at the same time having the function of anti-inflammatory containing there are many natural products, improving oxidation resistance in serum, remove Radical Metabolism product in serum.Preparation method is simple, convenient for large-scale production.
Description
Technical field
The invention belongs to health drink manufacture fields, particularly with regard to a kind of using a variety of natural products as primary raw material
Compound function effervescent tablet and preparation method thereof.
Background technique
Natural products generally has plurality of health care functions, such as anti-oxidant, anti-inflammatory, anti-radiation, reducing blood lipid, anti-aging etc.,
It is the primary raw material of functional mass and health care product important in plant.The source of different natural products is different, major function acts on
Also different, main cause is that the protein molecular target spot that different natural products act in body is not quite similar.Such as tea polyphenols master
Tealeaves is derived from, primary healthcare function is anti-oxidant, anti-inflammatory, anti-radiation and reducing blood lipid；Resveratrol is mainly derived from Portugal
Grape wine, primary healthcare function are anti-oxidant and anti-inflammatory；Urolithin is mainly derived from pomegranate, and primary healthcare function is antioxygen
Change, anti-inflammatory and anti-aging.Currently, the use for natural products generally remains in single natural products health-caring capsule or single
On natural products beverage, and health-caring capsule audient's narrow range, and the production method of beverage generallys use high temperature extraction, is extremely easy
Natural products is destroyed, its health effect is significantly reduced.On the other hand, studies have pointed out that there is collaboration effect between natural products
It answers, more protein molecular target spots can be acted on simultaneously, and then make up the deficiency in each comfortable effect, reach optimal health care function
Effect.But different natural products sources is different, is difficult to eat the food containing these natural products simultaneously.Therefore, urgent at present
It needs to provide a kind of health drink of composite natral product conveniently drunk, preferably to play health-care efficacy, and is benefited more
Extensive consumer demographics.
Summary of the invention
The object of the present invention is to provide a kind of easy to drink, more received by consumer, and at the same time containing being produced there are many natural
The drinks of object, specifically it is a kind of mix natural products effervescent tablet and preparation method thereof.
The present invention is achieved by the following technical solutions:
A kind of effervescent tablet mixing natural products, is made of following components and its weight percentage:
Mixotrophism element, 30 ~ 60 parts；
Sweetener, 30 ~ 50 parts；
Disintegrating agent, 8 ~ 15 parts；
Help stream lubricant, 1 ~ 3 part；
Adhesive, 0 ~ 0.04 part；
Effervescent agent, 0 ~ 15 part；
Wherein, the mixotrophism element is tea polyphenols, resveratrol, urolithin, vitamin C and omega-fatty acid.
Preferably, the weight percent of the mixotrophism element is respectively as follows:
Tea polyphenols, 10 ~ 50 parts；Resveratrol, 10 ~ 30 parts；Urolithin, 3 ~ 20 parts；Vitamin C, 3 ~ 10 parts；Omega-fatty acid, 2
~ 10 parts.
Preferably, the sweetener is the mixed of one or more of polydextrose, maltitol, hydroxyl isomaltulose
Close object.
Preferably, the sweetener includes 10 ~ 15 parts of polydextroses, 10 ~ 20 parts of maltitols and 10 ~ 20 portions of isomaltoses
The mixture of alcohol.
Preferably, the disintegrating agent is one or more of citric acid, malic acid, tartaric acid or microcrystalline cellulose
Mixture.
Preferably, described to help stream lubricant in magnesium stearate, calcium stearate, lauryl sodium sulfate or polyethylene glycol
One or more kinds of mixtures.
Preferably, described adhesive is the ethanol solution of the polyvinylpyrrolidone containing 2wt%.
Preferably, the effervescent agent is citric acid, malic acid, Na2CO3、Na2HCO3、KHCO3One or more of
Mixture.
A kind of preparation method of the effervescent tablet of the mixing natural products, comprising the following steps:
(1) it weighs mixotrophism element, sweetener, disintegrating agent, help stream lubricant, adhesive, effervescent agent, pulverize and sieve, stirring is mixed
Adhesive is added after even；
(2) after mixing being sufficiently stirred in above-mentioned substance, pH to 7.0 ~ 8.0 is adjusted；
(3) it is granulated using pelletizer, tabletting after drying.
Preferably, step (3) pelletizer is swing pelletizer.
Preferably, step (3) the tabletting mode is shape tabletting to be fixed according to compression mold, or utilize one-shot tabletting
Machine tabletting.
The beneficial effects of the present invention are:
The effervescent tablet of the method for the present invention preparation is easy to drink, is more received by consumer, and at the same time containing there are many natural products, tools
There is anti-inflammatory, improves oxidation resistance in serum, removes Radical Metabolism product in serum.Preparation method is simple,
Convenient for large-scale production.
Specific embodiment
To be best understood from the present invention, the present invention will be further described below with reference to examples, and following embodiment is only pair
The present invention is illustrated rather than is limited to it.
The effervescent tablet of the preparation mixing natural products of embodiment 1
| Mixotrophism element | 60g |
| Maltitol | 25g |
| Hydroxyl isomaltulose | 25g |
| Microcrystalline cellulose | 15g |
| Magnesium stearate | 2g |
| 2% polyvinylpyrrolidone (PVP) solution | 2mL |
The mixotrophism element are as follows: tea polyphenols, resveratrol, urolithin, vitamin C, omega-fatty acid.
The preparation method of the mixing natural products effervescent tablet is:
Weigh tea polyphenols 20g, resveratrol 20g, urolithin 8g, vitamin C 8g, omega-fatty acid 4g, maltitol 25g, different
Maltitol 25g, microcrystalline cellulose 15g, magnesium stearate 2g are crushed and are sieved with 100 mesh sieve, and 2% polyethylene pyrrole is added after stirring and evenly mixing
Pyrrolidone (PVP) solution 2mL, after mixing is sufficiently stirred, is granulated using swing pelletizer, then dries tabletting according to tabletting mould
Has fixed shape tabletting.
Gained effervescent tablet diameter is 12mm, thick 3mm, 1.4 ± 0.03g of average weight, and surfacing is fine and smooth.By a piece of mixing
Natural products effervescent tablet is put into 25 degrees Celsius of 300mL pure water, and tablet sinks under water rapidly, and is generated with a large amount of bubbles, 5
Disintegration rapidly in water, forms the green beverage of stable homogeneous in minute.
The effervescent tablet of the preparation mixing natural products of embodiment 2
| Mixotrophism element | 30g |
| Maltitol | 20g |
| Hydroxyl isomaltulose | 20g |
| Malic acid | 4g |
| Tartaric acid | 4g |
| Anhydrous citric acid | 8g |
| Anhydrous sodium bicarbonate | 7g |
| Calcium stearate | 1g |
| 2% polyvinylpyrrolidone (PVP) solution | 1.5mL |
The mixotrophism element are as follows: tea polyphenols, resveratrol, urolithin, vitamin C, omega-fatty acid.
The preparation method of the mixing natural products effervescent tablet is:
Weigh tea polyphenols 10g, resveratrol 8g, urolithin 2g, vitamin C 6g, omega-fatty acid 4g, maltitol 20g, different
Maltitol 20g, malic acid 4g, tartaric acid 4g, anhydrous citric acid 8g, anhydrous sodium bicarbonate 7g, magnesium stearate 21g is crushed and mistake
2% polyvinylpyrrolidone (PVP) solution 15mL is added in 100 meshes after stirring and evenly mixing, after mixing is sufficiently stirred, utilization is swing
Pelletizer is granulated, and is then dried, is utilized single-punch tablet press tabletting.
Gained effervescent tablet diameter is 12mm, thick 3mm, 1.4 ± 0.08g of average weight, and surfacing is fine and smooth.By a piece of mixing
Natural products effervescent tablet is put into 25 degrees Celsius of 300ml pure water, and tablet sinks under water rapidly, and is generated with a large amount of bubbles, 4
Disintegration rapidly in water, forms the green beverage of stable homogeneous in minute, and disintegration rate is better than embodiment 1.
The effervescent tablet of the preparation mixing natural products of embodiment 3
| Mixotrophism element | 40g |
| Polydextrose | 15g |
| Hydroxyl isomaltulose | 15g |
| Citric acid | 4g |
| Microcrystalline cellulose | 8g |
| Magnesium stearate | 2g |
| Polyethylene glycol | 1g |
| Na2HCO3 | 2g |
| Na2CO3 | 2g |
| 2% polyvinylpyrrolidone (PVP) solution | 2mL |
The mixotrophism element are as follows: tea polyphenols, resveratrol, urolithin, vitamin C, omega-fatty acid.
The preparation method of the mixing natural products effervescent tablet is:
Weigh tea polyphenols 15g, resveratrol 10g, urolithin 4g, vitamin C 5g, omega-fatty acid 6g, polydextrose 15g, different
Maltitol 15g, citric acid 4g, microcrystalline cellulose 8g, magnesium stearate 2g, polyethylene glycol 1g, Na2HCO32g and Na2CO32g powder
It is broken and sieve with 100 mesh sieve, 2% polyvinylpyrrolidone (PVP) solution 2mL is added after stirring and evenly mixing, after mixing is sufficiently stirred, utilizes
Swing pelletizer is granulated, and is then dried, is utilized single-punch tablet press tabletting.
Gained effervescent tablet diameter is 12mm, and thick 3mm, 1.3 ± 0.12g of average weight, surface smoothness is inadequate, there is obvious color
Damp difference.A piece of mixing natural products effervescent tablet being put into 25 degrees Celsius of 300ml pure water, tablet sinks under water rapidly, and
It is generated with a large amount of bubbles, disintegration rapidly in water, forms the green beverage of stable homogeneous in 3 minutes.
Embodiment 4 mixes influence of the natural products effervescent tablet to mouse corrosion disease and anti-oxidation function
Mouse selection and grouping: selecting KM mouse, and 6~8 week old, 18~22g is male, and every group 10~15.
Dosage grouping and given the test agent give the time: the formula that embodiment 1 is chosen in experiment sets basic, normal, high three dosage groups
(0.1,0.5,1.0g/kg/d), 1 blank control group and 1 positive controls (1.0g/kg/d tea polyphenols).Wherein, middle dose
Amount group is the human body recommended amounts intake of the mixing natural products effervescent tablet, and effervescent tablet is made according to formula described in embodiment 1,
The orally administration animal subject by way of drinking-water, test period are 30 days, and each group feeds chow diet in experimental period.Examination
The detection of anti-inflammatory and Antioxidant Indexes is carried out after testing, as a result as follows:
TableMix influence of the natural products effervescent tablet to inflammation index in experiment mice serum
| Group | Ear swelling (mg) | - 1 β concentration (pg/mL) of plasma IL | - 2 concentration of plasma IL (pg/mL) | - 6 concentration of plasma IL (pg/mL) |
| Blank control group | 3.81±2.12 | 152.12±31.53 | 161.04±38.52 | 198.36±88.14 |
| Positive controls | 1.41±1.37* | 101.13±34.11* | 78.16±31.21** | 129.81±61.88* |
| Low dose group | 1.79±1.11 | 118.38±29.69* | 125.45±35.69* | 148.12±69.87 |
| Middle dose group | 1.51±1.46* | 79.47±32.51** | 86.74±30.25** | 131.41±57.23* |
| High dose group | 1.21±1.09** | 44.23±22.89*** | 55.23±27.69*** | 121.73±63.14** |
Note: compared with blank group, P < 0.001 * P < 0.05, * * P < 0.01, * * *, data are shown as mean+SD.
Experimental result shows that the natural products effervescent tablet can eliminate the effect of experiment mice ear swelling, and reduces blood plasma
The concentration (table 1) of middle inflammatory factor IL-1 β, IL-2 and IL-6 show that the natural products effervescent tablet has the work of anti-inflammatory diligent
Energy.
Table 2 mixes influence of the natural products effervescent tablet to anti-SOD, GSH-Px, CAT, T-AOC in experiment mice serum
| Group | Superoxide dismutase SOD(U/ml) | Glutathione peroxidase GSH-Px(U/ml) | Cat catalase (U/ml) | Total antioxidant capacity T-AOC (U/ml) |
| Blank control group | 117.58±10.83 | 81.43±3.21 | 2.23±0.33 | 7.04±0.33 |
| Positive controls | 179.14±11.31 | 121.05±2.58** | 3.64±0.21** | 8.87±0.12** |
| Low dose group | 151.97±14.03* | 62.97±4.32 | 2.06±0.27 | 4.87±0.29 |
| Middle dose group | 182.14±16.33* | 92.49±1.34 | 2.73±0.25* | 5.18±0.11 |
| High dose group | 243.62±3.26** | 110.05±2.58* | 3.97±0.36** | 7.81±0.12* |
Note: compared with blank group, P < 0.001 * P < 0.05, * * P < 0.01, * * *, data are shown as mean+SD.
In table 2 data show the natural products effervescent tablet be remarkably improved SOD, GSH-Px in experiment mice serum,
CAT, T-AOC activity level (P < 0.05).Show that the natural products effervescent tablet has the work for improving oxidation resistance in serum
With.
Table 3 mixes influence of the natural products effervescent tablet to MDA, GSH in experiment mice serum
| Group | Malonaldehyde MDA(nmol/L) | Reduced glutathione GSH(mg/L) |
| Blank control group | 11.11±0.47 | 122.17±10.40 |
| Positive controls | 3.41±0.35*** | 207.46±9.83** |
| Low dose group | 8.47±1.41* | 129.41±6.39 |
| Middle dose group | 6.05±0.15* | 185.44±7.47* |
| High dose group | 4.82±0.23** | 217.80±6.91* |
Note: compared with blank group, P < 0.001 * P < 0.05, * * P < 0.01, * * *, data are shown as mean+SD.
Data show that the natural products effervescent tablet makes Radical Metabolism product MDA content in experiment mice serum in table 3
It significantly reduces (P < 0.05), while significantly improving G-SH activity level (P < 0.05) in experiment mice serum.Show the day
Right product effervescent tablet has the function of removing Radical Metabolism product in serum and improves oxidation resistance in serum.
Embodiment described above is only that preferred embodiments of the present invention will be described, not to model of the invention
It encloses and is defined, without departing from the spirit of the design of the present invention, those of ordinary skill in the art are to technical side of the invention
The various changes and improvements that case is made, should fall within the scope of protection determined by the claims of the present invention.
Claims (10)
1. a kind of effervescent tablet for mixing natural products, which is characterized in that be made of following components and its parts by weight:
Mixotrophism element, 30 ~ 60 parts；
Sweetener, 30 ~ 50 parts；
Disintegrating agent, 8 ~ 15 parts；
Help stream lubricant, 1 ~ 3 part；
Adhesive, 0 ~ 0.04 part；
Effervescent agent, 0 ~ 15 part；
Wherein, the mixotrophism element is tea polyphenols, resveratrol, urolithin, vitamin C and omega-fatty acid.
2. a kind of effervescent tablet for mixing natural products according to claim 1, which is characterized in that the mixotrophism element
Parts by weight are respectively as follows:
Tea polyphenols, 10 ~ 50 parts；Resveratrol, 10 ~ 30 parts；Urolithin, 3 ~ 20 parts；Vitamin C, 3 ~ 10 parts；Omega-fatty acid, 2
~ 10 parts.
3. a kind of effervescent tablet for mixing natural products according to claim 1, it is characterised in that: the sweetener is poly- Portugal
The mixture of one or more of grape sugar, maltitol, hydroxyl isomaltulose.
4. a kind of effervescent tablet for mixing natural products according to claim 3, it is characterised in that: the sweetener includes 10
The mixture of ~ 15 parts of polydextroses, 10 ~ 20 parts of maltitols and 10 ~ 20 parts of hydroxyl isomaltuloses.
5. a kind of effervescent tablet for mixing natural products according to claim 1, it is characterised in that: the disintegrating agent is lemon
The mixture of one or more of acid, malic acid, tartaric acid or microcrystalline cellulose.
6. it is according to claim 1 it is a kind of mix natural products effervescent tablet, it is characterised in that: it is described help stream lubricant be
The mixture of one or more of magnesium stearate, calcium stearate, lauryl sodium sulfate or polyethylene glycol.
7. it is according to claim 1 it is a kind of mix natural products effervescent tablet, it is characterised in that: described adhesive be containing
The ethanol solution of 2wt% polyvinylpyrrolidone.
8. a kind of effervescent tablet for mixing natural products according to claim 1, it is characterised in that: the effervescent agent is lemon
Acid, malic acid, Na2CO3、Na2HCO3、KHCO3One or more of mixture.
9. a kind of preparation method of the effervescent tablet of the described in any item mixing natural products of claim 1 ~ 8, which is characterized in that packet
Include following steps:
(1) it weighs mixotrophism element, sweetener, disintegrating agent, help stream lubricant, effervescent agent, pulverize and sieve, be added after stirring and evenly mixing
Adhesive；
(2) after mixing being sufficiently stirred in above-mentioned substance, pH to 7.0 ~ 8.0 is adjusted；
(3) it is granulated using pelletizer, tabletting after drying.
10. a kind of preparation method of effervescent tablet for mixing natural products according to claim 9, it is characterised in that: step
(3) pelletizer is swing pelletizer；The tabletting mode is shape tabletting to be fixed according to compression mold, or utilize list
Stamping machine tabletting.
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| WO2024029580A1 (en) * | 2022-08-02 | 2024-02-08 | 株式会社ダイセル | Autophagy-activation-accelerating composition |
| WO2025078652A1 (en) * | 2023-10-13 | 2025-04-17 | L'oreal | Use of a urolithin to prevent/slow down hair getting finer |
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