CN107703467A - Acquisition method, device, equipment and the storage medium of Three-Dimensional Dynamic magnetic resonance imaging - Google Patents
Acquisition method, device, equipment and the storage medium of Three-Dimensional Dynamic magnetic resonance imaging Download PDFInfo
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Abstract
本发明适用于动态核磁共振成像技术领域,提供了一种三维动态磁共振成像的采集方法、装置、设备以及存储介质,该方法包括:在磁共振成像系统的三维k空间中建立球坐标系,根据该球坐标系,构建当前采集次数对应的圆锥面,在圆锥面中构建螺旋轨迹,并沿着螺旋轨迹,通过磁共振成像系统采集k空间数据,当当前采集次数达到预设阈值时,停止k空间数据的采集并输出,否则跳转至构建圆锥面的步骤,从而实现了三维动态磁共振成像中三维k空间数据的连续采集,使得任一时间窗采集到的数据在三维球形的k空间中近似均匀分布,使得后续图像重建数据的选择更为自由,提高了三维动态磁共振成像的数据采集效率、三维动态磁共振图像的时间分辨率。
The present invention is applicable to the technical field of dynamic nuclear magnetic resonance imaging, and provides a three-dimensional dynamic magnetic resonance imaging acquisition method, device, equipment, and storage medium. The method includes: establishing a spherical coordinate system in the three-dimensional k-space of the magnetic resonance imaging system, According to the spherical coordinate system, construct the conical surface corresponding to the current acquisition times, construct the spiral trajectory in the conical surface, and collect k-space data through the magnetic resonance imaging system along the spiral trajectory, and stop when the current acquisition times reach the preset threshold Acquisition and output of k-space data, otherwise jump to the step of constructing the conical surface, thereby realizing the continuous acquisition of three-dimensional k-space data in three-dimensional dynamic magnetic resonance imaging, so that the data collected in any time window can be in the three-dimensional spherical k-space The approximate uniform distribution in the center makes the selection of subsequent image reconstruction data more free, and improves the data acquisition efficiency of the three-dimensional dynamic magnetic resonance imaging and the time resolution of the three-dimensional dynamic magnetic resonance image.
Description
技术领域technical field
本发明属于动态核磁共振成像技术领域,尤其涉及一种三维动态磁共振成像的采集方法、装置、设备及存储介质。The invention belongs to the technical field of dynamic nuclear magnetic resonance imaging, and in particular relates to an acquisition method, device, equipment and storage medium for three-dimensional dynamic magnetic resonance imaging.
背景技术Background technique
磁共振成像(Magnetic Resonance Imaging,MRI)具有无电离辐射,多对比度成像,软组织对比度高等优点,已经成为临床医学检查的一种重要工具。在磁共振成像过程中将采集到的磁共振模拟信号转换为数字信号,并填充到k空间中,再对k空间数据进行重建可得到磁共振图像。k空间也称为傅里叶空间,是带有空间定位编码信息的磁共振信息原始数字数据的填充空间。Magnetic resonance imaging (Magnetic Resonance Imaging, MRI) has the advantages of no ionizing radiation, multi-contrast imaging, and high soft tissue contrast, and has become an important tool for clinical medical examination. During the magnetic resonance imaging process, the collected magnetic resonance analog signal is converted into a digital signal, and filled into the k-space, and then the k-space data is reconstructed to obtain a magnetic resonance image. K-space, also known as Fourier space, is the filling space of raw digital data of magnetic resonance information with spatially positioned encoding information.
三维动态磁共振成像是利用磁共振技术对人体组织器官的动态生理过程或者药物代谢过程进行跟踪成像的一种技术。三维动态磁共振成像的基本原理是通过重复地采集同一成像空间,生成一系列与时间相关的k空间数据,通过对这些数据重建可以得到与时间相关的磁共振图像,该组磁共振图像在一定程度上可以提供组织器官等动态生理过程(如心跳运动,药物代谢等)。通过对这些图像做数据分析可以获得一系列定量或半定量参数,这些参数反映了病变发生发展过程中的生物学和病理生理学信息,对研究和诊断都有重要价值。Three-dimensional dynamic magnetic resonance imaging is a technology that uses magnetic resonance technology to track and image the dynamic physiological process or drug metabolism process of human tissues and organs. The basic principle of 3D dynamic magnetic resonance imaging is to generate a series of time-correlated k-space data by repeatedly collecting the same imaging space, and to obtain time-correlated magnetic resonance images by reconstructing these data. To a certain extent, it can provide dynamic physiological processes such as tissues and organs (such as heartbeat movement, drug metabolism, etc.). A series of quantitative or semi-quantitative parameters can be obtained through data analysis of these images, which reflect the biological and pathophysiological information during the development of lesions, and are of great value to research and diagnosis.
目前,三维动态磁共振成像的采集方法主要包括三维笛卡尔采集、三维径向采集、径向与笛卡尔相结合的混合采集等,这些采集方法都是基于重复采集部分或者全部k空间数据实现动态成像。在三维笛卡尔采集中,通过选层梯度、相位编码梯度和频率编码梯度完成k空间三个方向上的编码,实现三维k空间数据的填充。三维径向采集方法通过对k空间三个方向同时施加适当的梯度实现三维球形k空间的填充。这两种方法重建一组三维图像都需要采集全部k空间数据,导致获得的三维动态磁共振图像的时间分辨率很低。径向与笛卡尔相结合的混合采集方法一般在二维面内采用基于黄金比例角的径向轨迹的采集方式,在第三个维度上采用笛卡尔采集,该方法通过结合回顾性重建技术可以在一定程度上提高时间分辨率,但需要进行多次重复的采集才能实现,增加了扫描时间,动态图像的连续性也不高,而且由于受到第三个维度上的采集时间限制,该方法的时间分辨率难以进一步提高。At present, the acquisition methods of 3D dynamic MRI mainly include 3D Cartesian acquisition, 3D radial acquisition, hybrid acquisition combining radial and Cartesian, etc. These acquisition methods are based on repeated acquisition of part or all of k-space data to achieve dynamic imaging. In the three-dimensional Cartesian acquisition, the encoding in the three directions of the k-space is completed through the layer selection gradient, the phase encoding gradient and the frequency encoding gradient, so as to realize the filling of the three-dimensional k-space data. The three-dimensional radial acquisition method realizes the filling of the three-dimensional spherical k-space by applying appropriate gradients to the three directions of the k-space at the same time. These two methods need to collect all the k-space data to reconstruct a set of 3D images, resulting in very low temporal resolution of the obtained 3D dynamic MRI images. The hybrid acquisition method combining radial and Cartesian generally adopts the radial trajectory acquisition method based on the golden ratio angle in the two-dimensional plane, and adopts Cartesian acquisition in the third dimension. This method can be combined with retrospective reconstruction technology. To a certain extent, the time resolution can be improved, but it needs repeated acquisitions to achieve it, which increases the scanning time, and the continuity of the dynamic image is not high, and due to the limitation of the acquisition time in the third dimension, the method’s The time resolution is difficult to further improve.
发明内容Contents of the invention
本发明的目的在于提供一种三维动态磁共振成像的采集方法、装置、设备及存储介质,旨在解决由于现有的三维动态磁共振成像的采集方法需要重复采集全部的三维k空间数据、或多次重复采集全部或部分的三维k空间,导致三维动态磁共振成像的数据采集效率较低的问题。The purpose of the present invention is to provide a three-dimensional dynamic magnetic resonance imaging acquisition method, device, equipment and storage medium, aiming to solve the problem that the existing three-dimensional dynamic magnetic resonance imaging acquisition method needs to repeatedly acquire all three-dimensional k-space data, or Repeated acquisition of all or part of the three-dimensional k-space many times leads to the problem of low data acquisition efficiency of the three-dimensional dynamic magnetic resonance imaging.
一方面,本发明提供了一种三维动态磁共振成像的采集方法,所述方法包括下述步骤:On the one hand, the present invention provides a kind of acquisition method of three-dimensional dynamic magnetic resonance imaging, and described method comprises the following steps:
在预设的磁共振成像系统的三维k空间中建立球坐标系,根据所述球坐标系,构建当前采集次数对应的圆锥面;Establishing a spherical coordinate system in the three-dimensional k-space of the preset magnetic resonance imaging system, and constructing a conical surface corresponding to the current number of acquisitions according to the spherical coordinate system;
根据预设的螺旋轨迹函数,在所述圆锥面中构建螺旋轨迹,并沿着所述螺旋轨迹,通过所述磁共振成像系统采集k空间数据;Constructing a spiral trajectory in the conical surface according to a preset spiral trajectory function, and collecting k-space data through the magnetic resonance imaging system along the spiral trajectory;
当检测到所述当前采集次数达到预设阈值时,停止所述k空间数据的采集,输出采集的所述k空间数据,否则,对所述当前采集次数进行加一操作,并跳转至所述构建当前采集次数对应的圆锥面的步骤。When it is detected that the current acquisition times reach the preset threshold, stop the acquisition of the k-space data, and output the collected k-space data; otherwise, add one to the current acquisition times, and jump to the Describe the steps of constructing the conical surface corresponding to the current collection times.
另一方面,本发明提供了一种三维动态磁共振成像的采集装置,所述装置包括:In another aspect, the present invention provides an acquisition device for three-dimensional dynamic magnetic resonance imaging, the device comprising:
圆锥面构建单元,用于在预设的磁共振成像系统的k空间中建立球坐标系,根据所述球坐标系,构建当前采集次数对应的圆锥面;A conical surface construction unit, configured to establish a spherical coordinate system in the preset k-space of the magnetic resonance imaging system, and construct a conical surface corresponding to the current number of acquisitions according to the spherical coordinate system;
螺旋采集单元,用于根据预设的螺旋轨迹函数,在所述圆锥面中构建螺旋轨迹,并沿着所述螺旋轨迹,通过所述磁共振成像系统采集k空间数据;以及a spiral acquisition unit, configured to construct a spiral trajectory in the conical surface according to a preset spiral trajectory function, and collect k-space data through the magnetic resonance imaging system along the spiral trajectory; and
采集数据输出单元,用于当检测到所述当前采集次数达到预设阈值时,停止所述k空间数据的采集,输出采集的所述k空间数据,否则,对所述当前采集次数进行加一操作,并触发所述圆锥面构建单元执行构建所述当前采集次数对应的圆锥面的操作。A collection data output unit, configured to stop the collection of the k-space data and output the collected k-space data when it is detected that the current collection times reach a preset threshold, otherwise, add one to the current collection times operation, and trigger the conical surface construction unit to execute the operation of constructing the conical surface corresponding to the current acquisition times.
另一方面,本发明还提供了一种医疗设备,包括存储器、处理器以及存储在所述存储器中并可在所述处理器上运行的计算机程序,所述处理器执行所述计算机程序时实现如上述一种三维动态磁共振成像的采集方法所述的步骤。On the other hand, the present invention also provides a medical device, comprising a memory, a processor, and a computer program stored in the memory and operable on the processor, when the processor executes the computer program, the The steps described in the above-mentioned acquisition method of a three-dimensional dynamic magnetic resonance imaging.
另一方面,本发明还提供了一种计算机可读存储介质,所述计算机可读存储介质存储有计算机程序,所述计算机程序被处理器执行时实现如上述一种三维动态磁共振成像的采集方法所述的步骤。On the other hand, the present invention also provides a computer-readable storage medium, the computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the acquisition of the above-mentioned three-dimensional dynamic magnetic resonance imaging is realized. steps described in the method.
本发明在预设的三维动态磁共振成像系统的k空间中,建立球坐标系,根据球坐标系,构建当前采集次数对应的圆锥面,根据螺旋轨迹函数,在圆锥面中构建螺旋轨迹,并通过磁共振成像系统沿着该螺旋轨迹采集k空间数据,当检测道当前采集次数达到预设阈值时,停止k空间数据的采集,输出采集的k空间数据,否则跳转至构建圆锥面的步骤,继续k空间数据的采集,从而通过球坐标、圆锥面以及螺旋轨迹实现k空间数据的连续采集,在任一采集时间窗内都可以得到近似均匀的k空间数据分布,使得后续图像重建数据的选择更为自由,有效地提高了三维动态磁共振成像的数据采集效率、以及后续重建得到的三维动态磁共振图像的时间分辨率。The present invention establishes a spherical coordinate system in the preset k-space of the three-dimensional dynamic magnetic resonance imaging system, constructs a conical surface corresponding to the current acquisition times according to the spherical coordinate system, constructs a spiral trajectory in the conical surface according to the spiral trajectory function, and Collect k-space data along the spiral trajectory through the magnetic resonance imaging system. When the current collection times of the detection track reach the preset threshold, stop the collection of k-space data and output the collected k-space data, otherwise jump to the step of constructing the conical surface , continue the acquisition of k-space data, so that the continuous acquisition of k-space data can be realized through spherical coordinates, conical surfaces and spiral trajectories, and an approximately uniform distribution of k-space data can be obtained in any acquisition time window, making the selection of subsequent image reconstruction data It is more free and effectively improves the data acquisition efficiency of the three-dimensional dynamic magnetic resonance imaging and the time resolution of the three-dimensional dynamic magnetic resonance image obtained by subsequent reconstruction.
附图说明Description of drawings
图1是本发明实施例一提供的三维动态磁共振成像的采集方法的实现流程图;Fig. 1 is a flow chart of the implementation of the three-dimensional dynamic magnetic resonance imaging acquisition method provided by Embodiment 1 of the present invention;
图2是本发明实施例一提供的三维动态磁共振成像的采集方法中球坐标系中圆锥面的仰角、螺旋轨迹的初始方位角的示例图;2 is an example diagram of the elevation angle of the conical surface in the spherical coordinate system and the initial azimuth angle of the helical trajectory in the acquisition method of the three-dimensional dynamic magnetic resonance imaging provided by Embodiment 1 of the present invention;
图3是本发明实施例一提供的三维动态磁共振成像的采集方法中连续采集3次的螺旋轨迹和连续采集300次的螺旋轨迹分别在球坐标系中的分布示例图;Fig. 3 is an exemplary diagram of the distribution of spiral trajectories acquired continuously for 3 times and spiral trajectories acquired continuously for 300 times in the spherical coordinate system in the three-dimensional dynamic magnetic resonance imaging acquisition method provided by Embodiment 1 of the present invention;
图4是本发明实施例一提供的三维动态磁共振成像的采集方法中连续采集500次后,螺旋轨迹末端在虚拟球面上的点分布的示例图;4 is an example diagram of the point distribution of the end of the spiral trajectory on the virtual spherical surface after 500 consecutive acquisitions in the acquisition method of the three-dimensional dynamic magnetic resonance imaging provided by Embodiment 1 of the present invention;
图5是本发明实施例一提供的三维动态磁共振成像的采集方法中分别在不同采集次数、不同时间窗、不同时间组合下,螺旋轨迹末端在虚拟球面上的点分布的示例图;Fig. 5 is an example diagram of the point distribution of the end of the spiral trajectory on the virtual spherical surface under different acquisition times, different time windows, and different time combinations in the acquisition method of the three-dimensional dynamic magnetic resonance imaging provided by Embodiment 1 of the present invention;
图6是本发明实施例二提供的三维动态磁共振成像的采集装置的优选结构示意图;FIG. 6 is a schematic diagram of an optimal structure of a three-dimensional dynamic magnetic resonance imaging acquisition device provided in Embodiment 2 of the present invention;
图7是本发明实施例二提供的三维动态磁共振成像的采集装置的优选结构示意图;以及FIG. 7 is a schematic diagram of a preferred structure of a three-dimensional dynamic magnetic resonance imaging acquisition device provided by Embodiment 2 of the present invention; and
图8是本发明实施例三提供的医疗设备的结构示意图。Fig. 8 is a schematic structural diagram of a medical device provided by Embodiment 3 of the present invention.
具体实施方式detailed description
为了使本发明的目的、技术方案及优点更加清楚明白,以下结合附图及实施例,对本发明进行进一步详细说明。应当理解,此处所描述的具体实施例仅仅用以解释本发明,并不用于限定本发明。In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.
以下结合具体实施例对本发明的具体实现进行详细描述:The specific realization of the present invention is described in detail below in conjunction with specific embodiment:
实施例一:Embodiment one:
图1示出了本发明实施例一提供的三维动态磁共振成像的采集方法的实现流程,为了便于说明,仅示出了与本发明实施例相关的部分,详述如下:Fig. 1 shows the implementation process of the three-dimensional dynamic magnetic resonance imaging acquisition method provided by the first embodiment of the present invention. For the convenience of description, only the parts related to the embodiment of the present invention are shown, and the details are as follows:
在步骤S101中,在预设的磁共振成像系统的三维k空间中建立球坐标系。In step S101, a spherical coordinate system is established in a preset three-dimensional k-space of the magnetic resonance imaging system.
在步骤S102中,根据建立的球坐标系,构建当前采集次数对应的圆锥面。In step S102, according to the established spherical coordinate system, a conical surface corresponding to the current number of acquisitions is constructed.
在本发明实施例中,磁共振成像系统在这里可称为三维动态磁共振成像系统,三维的k空间为磁共振成像系统采集的原始数据的填充空间。在磁共振成像系统采集k空间数据前(即采集用来填充k空间的原始数据),在三维的k空间中建立球坐标系,以便在三维球形的k空间中进行k空间数据的采集。In the embodiment of the present invention, the magnetic resonance imaging system may be referred to as a three-dimensional dynamic magnetic resonance imaging system here, and the three-dimensional k-space is a space filled with raw data collected by the magnetic resonance imaging system. Before the MRI system acquires k-space data (that is, collects the original data used to fill the k-space), a spherical coordinate system is established in the three-dimensional k-space, so as to collect the k-space data in the three-dimensional spherical k-space.
在本发明实施例中,在进行k空间数据采集时,先在该球坐标系中建立当前采集次数对应的圆锥面,具体地,可根据预设的二维黄金分割比例系数,计算当前采集次数对应的圆锥面在该球坐标系中的仰角,再根据该仰角,并以球坐标系的原点为圆锥面的顶点,构建当前采集次数对应的圆锥面。其中,圆锥面在该球坐标系中的仰角的计算公式可为:In the embodiment of the present invention, when collecting k-space data, the conical surface corresponding to the current acquisition times is first established in the spherical coordinate system. Specifically, the current acquisition times can be calculated according to the preset two-dimensional golden section ratio coefficient The elevation angle of the corresponding conical surface in the spherical coordinate system, and then according to the elevation angle, and with the origin of the spherical coordinate system as the apex of the conical surface, construct the conical surface corresponding to the current acquisition times. Wherein, the calculation formula of the elevation angle of the conical surface in the spherical coordinate system can be:
θn=arcsin(2mod(n1γ1,1)-1),其中,n1=n+i,n为当前采集次数,n为大于等于1的正整数,θn为当当前采集次数为n时,圆锥面在球坐标系中的仰角,i为预设参数,i的值可为任意自然数,γ1为二维黄金分割比例系数之一且γ1=0.6823。θ n =arcsin(2mod(n 1 γ 1 ,1)-1), where n 1 =n+i, n is the current collection times, n is a positive integer greater than or equal to 1, θ n is when the current collection times is n, the elevation angle of the conical surface in the spherical coordinate system, i is a preset parameter, the value of i can be any natural number, γ 1 is one of the two-dimensional golden ratio coefficients and γ 1 =0.6823.
在步骤S103中,根据预设的螺旋轨迹函数,在圆锥面中构建螺旋轨迹,并沿着螺旋轨迹,通过磁共振成像系统采集k空间数据。In step S103, a spiral trajectory is constructed on the conical surface according to a preset spiral trajectory function, and k-space data is collected through a magnetic resonance imaging system along the spiral trajectory.
在本发明实施例中,在构建好当前采集次数对应的圆锥面后,可根据预设的螺旋轨迹函数,在该圆锥面上构建螺旋轨迹,具体地,先根据二维黄金分割比例系数,计算圆锥面中的螺旋轨迹在球坐标系中的初始方位角,再根据该初始方位角和螺旋轨迹函数,在圆锥面上构建(或绘制)该螺旋轨迹。其中,螺旋轨迹在球坐标系中的初始方位角的计算公式为:In the embodiment of the present invention, after constructing the conical surface corresponding to the current collection times, the spiral trajectory can be constructed on the conical surface according to the preset spiral trajectory function. Specifically, firstly, according to the two-dimensional golden section ratio coefficient, calculate The initial azimuth angle of the helical trajectory in the conical surface in the spherical coordinate system, and then construct (or draw) the helical trajectory on the conical surface according to the initial azimuth angle and the helical trajectory function. Among them, the calculation formula of the initial azimuth angle of the spiral trajectory in the spherical coordinate system is:
其中,为当当前采集次数为n时,螺旋轨迹在球坐标系中的初始方位角,γ2为二维黄金分割比例系数之一且γ2=0.4656。在构建螺旋轨迹的同时,由磁选共振成像系统沿着该螺旋轨迹,进行k空间数据的采集,从而完成k空间数据的一次采集。螺旋轨迹函数在此不进行限定,可根据实际条件和需求采用适用于圆锥面采集的三维螺旋轨迹曲线函数。 in, is the initial azimuth angle of the spiral trajectory in the spherical coordinate system when the current number of acquisitions is n, γ 2 is one of the two-dimensional golden section ratio coefficients and γ 2 =0.4656. While constructing the helical trajectory, the magnetic separation resonance imaging system collects the k-space data along the helical trajectory, thereby completing one acquisition of the k-space data. The spiral trajectory function is not limited here, and a three-dimensional spiral trajectory curve function suitable for conical surface acquisition can be used according to actual conditions and requirements.
作为示例地,图2中给出了圆锥面在球坐标系中的仰角θn、圆锥面上的螺旋轨迹在球坐标系上的初始方位角kx ky kz表示球坐标系,虚线部分为虚拟的球体,以便于更清晰地表示出仰角与初始方位角。As an example, Figure 2 shows the elevation angle θ n of the conical surface in the spherical coordinate system, and the initial azimuth angle of the helical trajectory on the conical surface in the spherical coordinate system k x k y k z represents the spherical coordinate system, and the dotted line part is a virtual sphere, so as to express the elevation angle and the initial azimuth angle more clearly.
在步骤S104中,检测当前采集次数是否达到预设阈值。In step S104, it is detected whether the current number of acquisitions reaches a preset threshold.
在本发明实施例中,当检测到当前采集次数达到预设阈值时,可认为已完成k空间数据的采集,执行步骤S104,否则,执行步骤S105。In the embodiment of the present invention, when it is detected that the current number of acquisitions reaches the preset threshold, it may be considered that the acquisition of k-space data has been completed, and step S104 is performed; otherwise, step S105 is performed.
在步骤S105中,停止k空间数据的采集,输出采集的k空间数据。In step S105, the collection of k-space data is stopped, and the collected k-space data is output.
在本发明实施例中,当前可认为已完成k空间数据的采集,输出采集的k空间数据,已采集到的k空间数据可用来重建三维动态磁共振图像,例如,将第一次到第二十次采集的k空间数据用于第一帧三维磁共振图像的重建,将第二十一次到三十次采集的k空间数据用于第二帧三维磁共振图像的重建,如此推算,即可完成三维动态磁共振图像的重建,从而通过k空间数据的连续采集,提高了重建后三维动态磁共振图像的连续性。In the embodiment of the present invention, it can be considered that the acquisition of k-space data has been completed at present, and the acquired k-space data can be output. The acquired k-space data can be used to reconstruct a three-dimensional dynamic magnetic resonance image. For example, the first to second The k-space data collected ten times are used for the reconstruction of the first frame of 3D magnetic resonance image, and the k-space data collected for the 21st to 30th time are used for the reconstruction of the second frame of 3D magnetic resonance image. The reconstruction of the three-dimensional dynamic magnetic resonance image can be completed, thereby improving the continuity of the reconstructed three-dimensional dynamic magnetic resonance image through continuous acquisition of k-space data.
作为示例地,图3左边的a为连续采集3次的螺旋轨迹、右边的b为连续采集300次的螺旋轨迹,虚线部分为虚拟的球体(用来表示三维球形k空间)。图4为连续采集500次后,螺旋轨迹末端在虚拟球面上的点分布,从图4可看出,采集到的k空间数据在三维球体的k空间中近似均匀分布。图5中分别为不同采集次数、不同时间窗、不同时间组合下,螺旋轨迹末端在虚拟球面上的点分布,从图5可以看出,任意长度时间内(即任意采集次数)采集到的k空间数据在三维球体的k空间中近似均匀分布,任意位置时间窗内采集到的k空间数据在三维球体的k空间中近似均匀分布,任意组合时间窗内采集到的k空间数据在三维球体的k空间中近似均匀分布,从而使得后续进行图像重建时数据的选择更为自由,有效地提高了三维动态磁共振成像的数据采集效率、三维动态磁共振图像的时间分辨率。As an example, a on the left of Fig. 3 is a spiral trajectory collected 3 times continuously, b on the right is a spiral trajectory collected 300 times continuously, and the dotted line part is a virtual sphere (used to represent a three-dimensional spherical k-space). Figure 4 shows the distribution of points on the virtual spherical surface at the end of the spiral trajectory after 500 consecutive acquisitions. It can be seen from Figure 4 that the collected k-space data are approximately uniformly distributed in the k-space of the three-dimensional sphere. Figure 5 shows the distribution of points on the virtual spherical surface at the end of the spiral trajectory under different acquisition times, different time windows, and different time combinations. It can be seen from Figure 5 that k The spatial data are distributed approximately uniformly in the k-space of the three-dimensional sphere, and the k-space data collected in the time window of any position are approximately uniformly distributed in the k-space of the three-dimensional sphere. The k-space is approximately uniformly distributed, so that the selection of data in the subsequent image reconstruction is more free, and the data acquisition efficiency of the three-dimensional dynamic magnetic resonance imaging and the time resolution of the three-dimensional dynamic magnetic resonance image are effectively improved.
在步骤S106中,对当前采集次数进行加一操作,并跳转至步骤S102。In step S106, add one to the current number of acquisitions, and jump to step S102.
在本发明实施例中,当当前采集次数未达到预设阈值时,可对当前采集次数进行加一操作,并跳转至步骤S102中,继续进行当前采集次数对应的圆锥面、螺旋轨迹的构建和k空间数据的采集。In the embodiment of the present invention, when the current number of acquisition times does not reach the preset threshold, the current number of acquisition times can be increased by one, and jump to step S102, and continue to construct the conical surface and spiral trajectory corresponding to the current number of acquisition times and k-space data acquisition.
在本发明实施例中,在磁共振成像系统的三维k空间中建立球坐标系,在球坐标系中根据二维黄金分割比例系数,建立圆锥面并构建圆锥面上的螺旋轨迹,通过磁共振成像系统沿着螺旋轨迹进行k空间数据的采集,当当前采集次数达到预设阈值时,停止k空间数据的采集,并输出采集的k空间数据,否则对当前采集次数进行加一操作,继续圆锥面、螺旋轨迹的构建以及k空间数据的采集,从而实现了三维动态磁共振成像中三维k空间数据的连续采集,使得任一时间窗采集到的数据在三维球形的k空间中近似均匀分布,进而使得后续图像重建数据的选择更为自由,有效地提高了三维动态磁共振成像的数据采集效率、三维动态磁共振图像的时间分辨率。In the embodiment of the present invention, a spherical coordinate system is established in the three-dimensional k-space of the magnetic resonance imaging system. In the spherical coordinate system, according to the two-dimensional golden section ratio coefficient, a conical surface is established and a spiral trajectory on the conical surface is constructed. The imaging system collects k-space data along the helical trajectory. When the current acquisition times reach the preset threshold, stop the k-space data acquisition and output the collected k-space data, otherwise, add one to the current acquisition times and continue the conic The construction of surface and spiral trajectory and the acquisition of k-space data realize the continuous acquisition of three-dimensional k-space data in three-dimensional dynamic magnetic resonance imaging, so that the data collected in any time window are approximately uniformly distributed in the three-dimensional spherical k-space, Further, the selection of subsequent image reconstruction data is more free, and the data acquisition efficiency of the three-dimensional dynamic magnetic resonance imaging and the time resolution of the three-dimensional dynamic magnetic resonance image are effectively improved.
实施例二:Embodiment two:
图6示出了本发明实施例二提供的三维动态磁共振成像的采集装置的结构,为了便于说明,仅示出了与本发明实施例相关的部分,其中包括:Fig. 6 shows the structure of the three-dimensional dynamic magnetic resonance imaging acquisition device provided by the second embodiment of the present invention. For the convenience of description, only the parts related to the embodiment of the present invention are shown, including:
圆锥面构建单元61,用于在预设的磁共振成像系统的三维k空间中建立球坐标系,根据球坐标系,构建当前采集次数对应的圆锥面。The conical surface construction unit 61 is configured to establish a spherical coordinate system in the preset three-dimensional k-space of the magnetic resonance imaging system, and construct a conical surface corresponding to the current number of acquisitions according to the spherical coordinate system.
在本发明实施例中,在磁共振成像系统采集k空间数据前在三维的k空间中建立球坐标系,在该球坐标系中建立当前采集次数对应的圆锥面,具体地,可根据预设的二维黄金分割比例系数,计算当前采集次数对应的圆锥面在该球坐标系中的仰角,再根据该仰角,以球坐标系的原点为圆锥面的顶点,构建当前采集次数对应的圆锥面。In the embodiment of the present invention, before the magnetic resonance imaging system acquires k-space data, a spherical coordinate system is established in the three-dimensional k-space, and a conical surface corresponding to the current acquisition times is established in the spherical coordinate system. Specifically, according to preset Calculate the elevation angle of the conical surface corresponding to the current acquisition times in the spherical coordinate system, and then use the origin of the spherical coordinate system as the apex of the conical surface according to the elevation angle to construct the conical surface corresponding to the current acquisition times .
在本发明实施例中,圆锥面在该球坐标系中的仰角的计算公式可为:In the embodiment of the present invention, the formula for calculating the elevation angle of the conical surface in the spherical coordinate system can be:
θn=arcsin(2mod(n1γ1,1)-1),其中,n1=n+i,n为当前采集次数,n为大于等于1的正整数,θn为当当前采集次数为n时,圆锥面在球坐标系中的仰角,i为预设参数,i的值可为任意自然数,γ1为二维黄金分割比例系数之一且γ1=0.6823。θ n =arcsin(2mod(n 1 γ 1 ,1)-1), where n 1 =n+i, n is the current collection times, n is a positive integer greater than or equal to 1, θ n is when the current collection times is n, the elevation angle of the conical surface in the spherical coordinate system, i is a preset parameter, the value of i can be any natural number, γ 1 is one of the two-dimensional golden ratio coefficients and γ 1 =0.6823.
螺旋采集单元62,用于根据预设的螺旋轨迹函数,在圆锥面中构建螺旋轨迹,并沿着螺旋轨迹,通过磁共振成像系统采集k空间数据。The helical acquisition unit 62 is configured to construct a helical trajectory in the conical surface according to a preset helical trajectory function, and collect k-space data along the helical trajectory through the magnetic resonance imaging system.
在本发明实施例中,在构建好当前采集次数对应的圆锥面后,可根据预设的螺旋轨迹函数,在该圆锥面上构建螺旋轨迹,具体地,先根据二维黄金分割比例系数,计算圆锥面中的螺旋轨迹在球坐标系中的初始方位角,再根据该初始方位角和螺旋轨迹函数,在圆锥面上构建(或绘制)该螺旋轨迹。其中,螺旋轨迹在球坐标系中的初始方位角的计算公式为:In the embodiment of the present invention, after constructing the conical surface corresponding to the current collection times, the spiral trajectory can be constructed on the conical surface according to the preset spiral trajectory function. Specifically, firstly, according to the two-dimensional golden section ratio coefficient, calculate The initial azimuth angle of the helical trajectory in the conical surface in the spherical coordinate system, and then construct (or draw) the helical trajectory on the conical surface according to the initial azimuth angle and the helical trajectory function. Among them, the calculation formula of the initial azimuth angle of the spiral trajectory in the spherical coordinate system is:
其中,为当当前采集次数为n时,螺旋轨迹在球坐标系中的初始方位角,γ2为二维黄金分割比例系数之一且γ2=0.4656。在构建螺旋轨迹的同时,由磁选共振成像系统沿着该螺旋轨迹,进行k空间数据的采集,从而完成k空间数据的一次采集。螺旋轨迹函数在此不进行限定,可根据实际条件和需求采用适用于圆锥面采集的三维螺旋轨迹曲线函数。 in, is the initial azimuth angle of the spiral trajectory in the spherical coordinate system when the current number of acquisitions is n, γ 2 is one of the two-dimensional golden section ratio coefficients and γ 2 =0.4656. While constructing the helical trajectory, the magnetic separation resonance imaging system collects the k-space data along the helical trajectory, thereby completing one acquisition of the k-space data. The spiral trajectory function is not limited here, and a three-dimensional spiral trajectory curve function suitable for conical surface acquisition can be used according to actual conditions and requirements.
采集数据输出单元63,用于当检测到当前采集次数达到预设阈值时,停止k空间数据的采集,输出采集的k空间数据,否则,对当前采集次数进行加一操作,并触发圆锥面构建单元61执行构建当前采集次数对应的圆锥面的操作。The collected data output unit 63 is used to stop the collection of k-space data and output the collected k-space data when it is detected that the current collection times reach the preset threshold, otherwise, add one to the current collection times and trigger the construction of the conical surface Unit 61 executes the operation of constructing the conical surface corresponding to the current collection times.
在本发明实施例中,当检测到当前采集次数达到预设阈值时,可认为已完成k空间数据的采集,已采集到的k空间数据可用来重建三维动态磁共振图像,例如,将第一次到第二十次采集的k空间数据用于第一帧三维磁共振图像的重建,将第二十一次到三十次采集的k空间数据用于第二帧三维磁共振图像的重建,如此推算,即可完成三维动态磁共振图像的重建,从而通过k空间数据的连续采集,提高了重建后三维动态磁共振图像的连续性。In the embodiment of the present invention, when it is detected that the current number of acquisitions reaches the preset threshold, it can be considered that the acquisition of k-space data has been completed, and the acquired k-space data can be used to reconstruct a three-dimensional dynamic magnetic resonance image, for example, the first The k-space data collected for the second to the twentieth time are used for the reconstruction of the first frame of the three-dimensional magnetic resonance image, and the k-space data collected for the twenty-first to the thirty times are used for the reconstruction of the second frame of the three-dimensional magnetic resonance image, In this way, the reconstruction of the three-dimensional dynamic magnetic resonance image can be completed, so that the continuity of the reconstructed three-dimensional dynamic magnetic resonance image is improved through the continuous acquisition of k-space data.
在本发明实施例中,在当前采集次数达到采集阈值时,采集到的k空间数据在三维球体的k空间中近似均匀分布,且任意长度时间内(即任意采集次数)、任意位置时间窗内、或者任意组合时间窗内采集到的k空间数据在三维球体的k空间中都近似均匀分布,从而使得后续进行图像重建时数据的选择更为自由,有效地提高了三维动态磁共振成像的数据采集效率、三维动态磁共振图像的时间分辨率。In the embodiment of the present invention, when the current number of acquisitions reaches the acquisition threshold, the collected k-space data are approximately uniformly distributed in the k-space of the three-dimensional sphere, and within any length of time (that is, any number of acquisitions) and within the time window of any position , or any combination of time windows, the k-space data collected in the three-dimensional spherical k-space are approximately uniformly distributed, which makes the data selection more free for subsequent image reconstruction, and effectively improves the data quality of three-dimensional dynamic magnetic resonance imaging. Acquisition efficiency, temporal resolution of 3D dynamic MRI images.
在本发明实施例中,当当前采集次数未达到预设阈值时,可对当前采集次数进行加一操作,并触发圆锥面构建单元61进行当前采集次数对应的圆锥面、构建。In the embodiment of the present invention, when the current collection times do not reach the preset threshold, the current collection times can be incremented by one, and the conical surface construction unit 61 is triggered to construct the conical surface corresponding to the current collection times.
优选地,如图7所示,圆锥面构建单元61包括:Preferably, as shown in Figure 7, the conical surface construction unit 61 includes:
仰角计算单元711,用于根据预设的二维黄金分割比例系数,计算当前采集次数对应的圆锥面在球坐标系中的仰角;以及The elevation angle calculation unit 711 is used to calculate the elevation angle of the conical surface corresponding to the current number of acquisitions in the spherical coordinate system according to the preset two-dimensional golden section ratio coefficient; and
圆锥面构建子单元712,用于根据圆锥面在球坐标系中的仰角,以球坐标系的原点为顶点,构建圆锥面。The conical surface constructing subunit 712 is configured to construct the conical surface according to the elevation angle of the conical surface in the spherical coordinate system, with the origin of the spherical coordinate system as the apex.
优选地,螺旋采集单元62包括:Preferably, the spiral collection unit 62 includes:
方位角计算单元721,用于根据二维黄金分割比例系数,计算圆锥面中螺旋轨迹在球坐标系中的初始方位角;以及The azimuth calculation unit 721 is used to calculate the initial azimuth of the spiral trajectory in the conical surface in the spherical coordinate system according to the two-dimensional golden section ratio coefficient; and
轨迹构建单元722,用于根据螺旋轨迹在球坐标系中的初始方位角和螺旋轨迹函数,构建螺旋轨迹。The trajectory construction unit 722 is configured to construct the spiral trajectory according to the initial azimuth angle of the spiral trajectory in the spherical coordinate system and the spiral trajectory function.
在本发明实施例中,在磁共振成像系统的三维k空间中建立球坐标系,在球坐标系中根据二维黄金分割比例系数,建立圆锥面并构建圆锥面上的螺旋轨迹,通过磁共振成像系统沿着螺旋轨迹进行k空间数据的采集,当当前采集次数达到预设阈值时,停止k空间数据的采集,并输出采集的k空间数据,否则对当前采集次数进行加一操作,继续圆锥面、螺旋轨迹的构建以及k空间数据的采集,从而实现了三维动态磁共振成像中三维k空间数据的连续采集,使得任一时间窗采集到的数据在三维球形的k空间中近似均匀分布,进而使得后续图像重建数据的选择更为自由,有效地提高了三维动态磁共振成像的数据采集效率、三维动态磁共振图像的时间分辨率。In the embodiment of the present invention, a spherical coordinate system is established in the three-dimensional k-space of the magnetic resonance imaging system. In the spherical coordinate system, according to the two-dimensional golden section ratio coefficient, a conical surface is established and a spiral trajectory on the conical surface is constructed. The imaging system collects k-space data along the helical trajectory. When the current acquisition times reach the preset threshold, stop the k-space data acquisition and output the collected k-space data, otherwise, add one to the current acquisition times and continue the conic The construction of surface and spiral trajectory and the acquisition of k-space data realize the continuous acquisition of three-dimensional k-space data in three-dimensional dynamic magnetic resonance imaging, so that the data collected in any time window are approximately uniformly distributed in the three-dimensional spherical k-space, Further, the selection of subsequent image reconstruction data is more free, and the data acquisition efficiency of the three-dimensional dynamic magnetic resonance imaging and the time resolution of the three-dimensional dynamic magnetic resonance image are effectively improved.
在本发明实施例中,三维动态磁共振成像的采集装置的各单元可由相应的硬件或软件单元实现,各单元可以为独立的软、硬件单元,也可以集成为一个软、硬件单元,在此不用以限制本发明。In the embodiment of the present invention, each unit of the three-dimensional dynamic magnetic resonance imaging acquisition device can be realized by corresponding hardware or software units, and each unit can be an independent software and hardware unit, or can be integrated into a software and hardware unit, here It is not intended to limit the invention.
实施例三:Embodiment three:
图8示出了本发明实施例三提供的医疗设备的结构,为了便于说明,仅示出了与本发明实施例相关的部分。Fig. 8 shows the structure of the medical device provided by Embodiment 3 of the present invention. For convenience of description, only the parts related to the embodiment of the present invention are shown.
本发明实施例的医疗设备8包括处理器80、存储器81以及存储在存储器81中并可在处理器80上运行的计算机程序82。该处理器80执行计算机程序82时实现上述方法实施例中的步骤,例如图1所示的步骤S101至S106。或者,处理器80执行计算机程序82时实现上述装置实施例中各单元的功能,例如图6所示单元61至63的功能。The medical device 8 of the embodiment of the present invention includes a processor 80 , a memory 81 and a computer program 82 stored in the memory 81 and operable on the processor 80 . When the processor 80 executes the computer program 82, the steps in the above method embodiments are implemented, for example, steps S101 to S106 shown in FIG. 1 . Alternatively, when the processor 80 executes the computer program 82, the functions of the units in the above device embodiments are realized, for example, the functions of the units 61 to 63 shown in FIG. 6 .
在本发明实施例中,在预设的三维动态磁共振成像系统的k空间中建立球坐标系,根据球坐标系,构建当前采集次数对应的圆锥面,根据螺旋轨迹函数,在圆锥面中构建螺旋轨迹,并通过磁共振成像系统沿着该螺旋轨迹采集k空间数据,当检测道当前采集次数达到预设阈值时,停止k空间数据的采集,并输出采集到的k空间数据,否则跳转至构建圆锥面的步骤,继续k空间数据的采集,从而通过球坐标、圆锥面以及螺旋轨迹实现k空间数据的连续采集,在任一采集时间窗内都可以得到近似均匀的k空间数据分布,使得后续图像重建数据的选择更为自由,有效地提高了三维动态磁共振成像的数据采集效率、以及后续重建得到的三维动态磁共振图像的时间分辨率。In the embodiment of the present invention, the spherical coordinate system is established in the k-space of the preset three-dimensional dynamic magnetic resonance imaging system, and the conical surface corresponding to the current acquisition times is constructed according to the spherical coordinate system, and the conical surface is constructed according to the spiral trajectory function. Helical trajectory, and collect k-space data along the spiral trajectory through the magnetic resonance imaging system. When the current acquisition times of the detection track reach the preset threshold, stop the acquisition of k-space data, and output the collected k-space data, otherwise jump Up to the step of constructing the conical surface, continue the collection of k-space data, so that the continuous collection of k-space data can be realized through spherical coordinates, conical surface and spiral trajectory, and an approximately uniform distribution of k-space data can be obtained in any collection time window, so that The selection of subsequent image reconstruction data is more free, which effectively improves the data acquisition efficiency of three-dimensional dynamic magnetic resonance imaging and the time resolution of three-dimensional dynamic magnetic resonance images obtained by subsequent reconstruction.
实施例四:Embodiment four:
在本发明实施例中,提供了一种计算机可读存储介质,该计算机可读存储介质存储有计算机程序,该计算机程序被处理器执行时实现上述方法实施例中的步骤,例如,图1所示的步骤S101至S106。或者,该计算机程序被处理器执行时实现上述装置实施例中各单元的功能,例如图6所示单元61至63的功能。In an embodiment of the present invention, a computer-readable storage medium is provided, the computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the steps in the above-mentioned method embodiments are implemented, for example, as shown in FIG. 1 Steps S101 to S106 shown. Alternatively, when the computer program is executed by the processor, the functions of the units in the above device embodiments are implemented, for example, the functions of the units 61 to 63 shown in FIG. 6 .
在本发明实施例中,本发明在预设的三维动态磁共振成像系统的k空间中建立球坐标系,根据球坐标系,构建当前采集次数对应的圆锥面,根据螺旋轨迹函数,在圆锥面中构建螺旋轨迹,并通过磁共振成像系统沿着该螺旋轨迹采集k空间数据,当检测道当前采集次数达到预设阈值时,停止k空间数据的采集,并输出采集的k空间数据,否则跳转至构建圆锥面的步骤,继续k空间数据的采集,从而通过球坐标、圆锥面以及螺旋轨迹实现k空间数据的连续采集,在任一采集时间窗内都可以得到近似均匀的k空间数据分布,使得后续图像重建数据的选择更为自由,有效地提高了三维动态磁共振成像的数据采集效率、以及后续重建得到的三维动态磁共振图像的时间分辨率。In the embodiment of the present invention, the present invention establishes a spherical coordinate system in the k-space of the preset three-dimensional dynamic magnetic resonance imaging system. According to the spherical coordinate system, the conical surface corresponding to the current acquisition times is constructed. According to the spiral trajectory function, the Construct a spiral trajectory in the system, and collect k-space data along the spiral trajectory through the magnetic resonance imaging system. When the current collection times of the detection track reach the preset threshold, stop the collection of k-space data and output the collected k-space data, otherwise skip Go to the step of constructing the conical surface and continue the collection of k-space data, so that the continuous collection of k-space data can be realized through spherical coordinates, conical surface and spiral trajectory, and an approximately uniform distribution of k-space data can be obtained in any collection time window. The selection of subsequent image reconstruction data is more free, and the data acquisition efficiency of three-dimensional dynamic magnetic resonance imaging and the time resolution of three-dimensional dynamic magnetic resonance images obtained by subsequent reconstruction are effectively improved.
本发明实施例的计算机可读存储介质可以包括能够携带计算机程序代码的任何实体或装置、记录介质,例如,ROM/RAM、磁盘、光盘、闪存等存储器。The computer-readable storage medium in the embodiments of the present invention may include any entity or device or recording medium capable of carrying computer program codes, such as ROM/RAM, magnetic disk, optical disk, flash memory and other memories.
以上所述仅为本发明的较佳实施例而已,并不用以限制本发明,凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等,均应包含在本发明的保护范围之内。The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalent replacements and improvements made within the spirit and principles of the present invention should be included in the protection of the present invention. within range.
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