CN106727012A - A kind of acne-eliminating cosmetic composition - Google Patents
A kind of acne-eliminating cosmetic composition Download PDFInfo
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- CN106727012A CN106727012A CN201710007077.5A CN201710007077A CN106727012A CN 106727012 A CN106727012 A CN 106727012A CN 201710007077 A CN201710007077 A CN 201710007077A CN 106727012 A CN106727012 A CN 106727012A
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- acne
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- eliminating
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- 229960004889 salicylic acid Drugs 0.000 description 1
- NWMIYTWHUDFRPL-UHFFFAOYSA-N sapogenin Natural products COC(=O)C1(CO)C(O)CCC2(C)C1CCC3(C)C2CC=C4C5C(C)(O)C(C)CCC5(CCC34C)C(=O)O NWMIYTWHUDFRPL-UHFFFAOYSA-N 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 201000010153 skin papilloma Diseases 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 150000005856 steroid saponins Chemical class 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
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- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical group N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides a kind of acne-eliminating cosmetic composition, is mainly prepared by the natural woody plant raw material of following weight：2 20 parts of American aloe, 4 18 parts of cotton rose, white pond lily spend 29 parts, 5 20 parts of the stem of noble dendrobium.In the natural herbs raw material of the active component of acne-eliminating cosmetic composition of the present invention, American aloe can ease pain, and inhibiting bacteria and diminishing inflammation controls acne；Cotton rose can be clearing heat and detoxicating, cooling blood and hemostasis；White pond lily spends relieving heat toxin, and dry the wind that disappears, and controls wet sore；Stem of noble dendrobium enriching yin disappears heat, and inhibiting bacteria and diminishing inflammation is anti-oxidant, anti-aging, this is several with inhibiting bacteria and diminishing inflammation, and clearing heat and detoxicating natural herbs are combined, serve the effect of synergy, and active component is completely pure natural, do not stimulate gently, pro-skin sense is good, injured skin can be repaired, promote skin revitalization, while there is good inhibiting bacteria and diminishing inflammation to act on, so as to reach good anti-acne effect.
Description
Technical field
The present invention is cosmetic field, and in particular to a kind of acne-eliminating cosmetic composition.
Background technology
Acne is a kind of chronic inflammatory skin that inflammation is triggered due to hair follicle and sebum adenemphraxis.Easily betide
In hebetic teenager, but due to environmental pollution, urban life pressure increase etc. reasons it is now increasing into
Year, people had acne to perplex, and repeatability is broken out, and is influenceed attractive in appearance.Although increasing product for resolving poxes occurs, due to acne
Cause and trigger mechanism it is complicated, this causes that acne is difficult radical cure.
At present, anti-acne method on the market is a variety of, and 1, the method for such as laser therapy whelk, it can rapid damage propionic acid
Whelk bacillus, effectively suppresses bacterial reproduction, eliminates its stimulation and destruction to organizing, but the effect of laser therapy is too
By force, and simply physical method, it is impossible to tackle the problem at its root；2nd, using some west such as salicylic acid, Bo Nisong, dexamethasone
Medicine anti-acne, the side effect of Western medicine is strong, high cost；3rd, the compositions such as hormone, antibiotic, vitamin A acid are added in product, excitant is big, holds
Easily cause skin to the drug resistance of Propiobacterium, its security is constantly under suspicion.
The content of the invention
A kind of acne-eliminating cosmetic composition that the present invention is provided, the active component of the cosmetic composition is planted with natural herb
Thing is extracted for primary raw material, and macroreticular resin isolates and purifies preparation, has functions that antibacterial and anti-inflammatory.
A kind of acne-eliminating cosmetic composition that the present invention is provided, the active component of described acne-eliminating cosmetic composition is under
The natural woody plant raw material for stating weight is prepared：American aloe 2-20 parts, cotton rose 4-18 parts, white pond lily flower 2-9
Part, stem of noble dendrobium 5-20 parts.
A kind of acne-eliminating cosmetic composition that the present invention is provided, the weight of described natural herbs raw material
It is：American aloe 3-10 parts, cotton rose 5-10 parts, 4-8 parts, stem of noble dendrobium 8-15 parts of white pond lily flower.
A kind of acne-eliminating cosmetic composition that the present invention is provided, the active component of the cosmetic composition refers to from natural
By mixing extraction in herbaceous plant raw material American aloe, cotton rose, white pond lily flower, the stem of noble dendrobium, extract solution separates pure through macroreticular resin
The combined extracts that change is prepared, the content of general flavone and polysaccharide is more than 18% in the active component.
A kind of acne-eliminating cosmetic composition that the present invention is provided, in the composition of the cosmetic composition, cosmetic combinations
The relative content of the active component of thing is 0.3-5%, and remaining is the conventional matrix of cosmetics exterior-applied formulation.
A kind of acne-eliminating cosmetic composition that the present invention is provided, described cosmetics exterior-applied formulation is anti-acne facial cleanser, dispels
Acne frost, anti-acne or acne removing water.
The natural herbs raw material of the active component of cosmetic composition of the present invention is prepared, with following effect and spy
Point：
American aloe is Agavaceae perennial herb, and sweet micro-pungent is put down, nontoxic.Its extract contain abundant steroid sapogenin,
The material such as steroid saponin and levulan, the glucosides containing hecogenin and Tigogenin, sugar chain is generally connected to the 3 of aglycon
Position, the sugar into glycosides has four kinds of glucose, xylose, galactolipin and rhamnose, and can suppress capillary permeability increases and connective
Hyperblastosis, and with preferable analgesic activity, with desinsection, anti-inflammation and active anticancer.For treat pain, lump,
The human body diseases such as inflammation, spasm, hyperthyroidism, acne.
Cotton rose is Malvaceae rose of Sharon platymiscium, and flavonoid glycoside, such as Iso quercitins, golden Silk peaches are mainly contained in its extract
Glycosides, rutin sophorin etc., with clearing heat and detoxicating, detumescence and apocenosis, the effects such as cooling blood and hemostasis.For treating cough with lung heat, controlling carbuncle swells boil,
Mastitis, lymphnoditis, parotitis, burn and scald, venomous snake bite, traumatic injury.
White pond lily flower belongs to the perennial aquatic herbaceous plant of Nymphaeceae.Bitter sweet, temperature contains abundant sweet-scented osmanthus in its extract
Various flavonoids such as careless element glycoside, Kaempferol, Kaempferol-Galactose Glucose glucoside, Kaempferol-diglucoside.
《Book on Chinese herbal medicine is new again》：" enter the heart, the warp of liver two." function is cured mainly：Promoting blood circulation and hemostasis, dry the wind that disappears, and controls and falls damage spitting blood, day bubble wet sore.《Solar corona
Sub- book on Chinese herbal medicine》：" relieving palpitation, beneficial color is preserved youthful looks."《Daily book on Chinese herbal medicine》：" puckery vital essence."《The southern regions of the Yunnan Province book on Chinese herbal medicine》：" control the inverse stupor of married woman's blood."《Book on Chinese herbal medicine
It is new again》：" clear away heart-fire cool blood, and relieving heat toxin controls frightened epilepsy, disappear it is wet remove wind, control sore scabies."《Hebei medicinal material》：" broken patch pyogenic infections is rubbed, promotees abscess
Absorption."《Shandong Chinese medicine》：" promoting blood circulation." spitting blood is controlled, pendant falls hematocele, and heart stomach spitting blood is more than.Control acne.
The stem of noble dendrobium is the perennial herbaceous plant that grows nonparasitically upon another plant of orchid family Dendrobium.Gan Han, returns stomach kidney channel, reinforcing stomach reg fluid, nourishing Yin and clearing heat, profit
Lung kidney-nourishing, for impairment of yin body fluid deficiency, dry polydipsia.Except main polysaccharide, alkaloid, amino acid and micro unit in Herba Dendrobii extract
Outside element, the also various active composition such as phenols, luxuriant and rich with fragrance class, stilbene class, sesquiterpenoids.Modern study is to dendrobium candidum volatile ingredient
It is analyzed, respectively is isolated by monomeric compound 72, including flavonoids, phenols, stilbene class etc. and esters, alcohols olefines etc.,
Wherein content alpha, beta-lonone higher has the effect for suppressing tumour growth, in addition, also anti-oxidant well, resists
Inflammation, the effect of anti-aging.
Beneficial effects of the present invention：(1) natural herbs of the active component of acne-eliminating cosmetic composition of the present invention are former
In material, American aloe extract can increase and connective tissue proliferation, inhibiting bacteria and diminishing inflammation, can control acne；Cotton rose extract can heat-clearing solution
Poison, cooling blood and hemostasis；White pond lily flower extract relieving heat toxin, dry the wind that disappears, and can control wet sore；Herba Dendrobii extract enriching yin disappears heat, antibacterial to disappear
Inflammation, anti-oxidant, anti-aging, this is several with inhibiting bacteria and diminishing inflammation, and clearing heat and detoxicating natural herbs are combined, and serve increasing
The effect of effect, and active component is completely pure natural, does not stimulate gently, and pro-skin sense is good, can repair injured skin, promotes skin new
It is raw, while there is good inhibiting bacteria and diminishing inflammation to act on, so as to reach good anti-acne effect；(2) through experiment, Four Plants natural component
Compounding, the content of general flavone and polysaccharide is easily absorbed by the skin more than 18% in active component, increases skin collagen fine
Dimension, further enhancing the ability that skin tackles environmental stimuli, make that skin is more flexible, smooth, exquisiteness；(3) cotton rose and stone
Flavones in dry measure used in former times extract can effectively suppress oozing out for inflammatory biology enzyme, accelerate to damage skin healing, effectively alleviate lump, inflammation
Disease, polysaccharide anti-oxidative, delay skin aging in American aloe, white pond lily flower and Herba Dendrobii extract, promoting blood circulation, detumescence dispel purulence,
Play a part of to protect biomembrane, composition to complement each other, realize more preferable anti-acne effect.
Specific embodiment
A part of specific embodiment is set forth below, and the present invention will be described, it is necessary to it is pointed out here that be real in detail below
Apply example and be served only for that the invention will be further described, do not represent limiting the scope of the invention.Other people are according to the present invention
Some the nonessential modifications and adjustment made still fall within protection scope of the present invention.
The following component title occurred in text is INCI (Internation Nomenclaure Cosmetic
Ingredent, i.e. international cosmetic raw material name) institute to regulation title：Dimethiconol/DBSA
TEA salt, dimethyl silicone polymer/methyl polysilicone alkyl copolymer, stearine/PEG-100 stearates, double (hydroxyl first
Base) imidazolidinyl urea/iodine propilolic alcohol butyl mephenesin Carbamate, glycerine polymethacrylates/propane diols/Gantrez AN-119,1,
2- hexylene glycols/pungent glycol, methylisothiazolinone/iodine propilolic alcohol butyl mephenesin Carbamate.
Embodiment 1
Take 20 parts of American aloe, 4 parts of cotton rose, white pond lily and spend 5 parts, 20 parts of the stem of noble dendrobium；1 part be set to 50g, i.e. American aloe 1000g,
Follow these steps to for above-mentioned raw materials to be prepared into anti-acne facial cleanser by cotton rose 200g, white pond lily flower 250g, stem of noble dendrobium 1000g：
After American aloe, cotton rose, white pond lily flower, the stem of noble dendrobium are boiled into extract solution concentration through water, ethanol precipitation is added, stood, mistake
Filter, filtrate recycling ethanol obtains Chinese herbal medicine concentrate to without alcohol taste.Macroporous resin column on concentrate, washing, ethanol elution are received
Collection eluent, eluent reclaims ethanol, and concentration is dried, and obtains composition extract.
Anti-acne facial cleanser
The component and its relative content for constituting above-mentioned anti-acne facial cleanser product be:
Embodiment 2
Take 10 parts of American aloe, 18 parts of cotton rose, white pond lily and spend 9 parts, 10 parts of the stem of noble dendrobium, portion is set to 50g, i.e. American aloe
Follow these steps to for above-mentioned raw materials to be prepared into acne eliminating cream by 500g, cotton rose 900g, white pond lily flower 450g, stem of noble dendrobium 500g：
After American aloe, cotton rose, white pond lily flower, the stem of noble dendrobium are boiled into extract solution concentration through water, ethanol precipitation is added, stood, mistake
Filter, filtrate recycling ethanol obtains Chinese herbal medicine concentrate to without alcohol taste.Macroporous resin column on concentrate, washing, ethanol elution are received
Collection eluent, eluent reclaims ethanol, and concentration is dried, and obtains composition extract.
Anti-acne acne eliminating cream
The component and its relative content for constituting above-mentioned acne eliminating cream product be:
Embodiment 3
Take 2 parts of American aloe, 4 parts of cotton rose, white pond lily and spend 2 parts, 5 parts of the stem of noble dendrobium, portion is 25g, i.e. American aloe 50g, wooden cottonrose hibiscus
Rong 80g, white pond lily flower 50g, stem of noble dendrobium 125g.
Above-mentioned raw materials are follow these steps to be prepared into acne removing water：
After American aloe, cotton rose, white pond lily flower, the stem of noble dendrobium are boiled into extract solution concentration through water, ethanol precipitation is added, stood, mistake
Filter, filtrate recycling ethanol obtains Chinese herbal medicine concentrate to without alcohol taste.Macroporous resin column on concentrate, washing, ethanol elution are received
Collection eluent, eluent reclaims ethanol, and concentration is dried, and obtains composition extract.
Acne removing water
The component and its relative content for constituting above-mentioned anti-acne aquatic products be:
Embodiment 4
Take 7 parts of American aloe, 5 parts of cotton rose, white pond lily and spend 8 parts, 9 parts of the stem of noble dendrobium；1 part is set to 50g, i.e. American aloe 350g, wood
Follow these steps to for above-mentioned raw materials to be prepared into anti-acne facial cleanser by lotus 250g, white pond lily flower 400g, stem of noble dendrobium 450g：
After American aloe, cotton rose, white pond lily flower, the stem of noble dendrobium are boiled into extract solution concentration through water, ethanol precipitation is added, stood, mistake
Filter, filtrate recycling ethanol obtains Chinese herbal medicine concentrate to without alcohol taste.Macroporous resin column on concentrate, washing, ethanol elution are received
Collection eluent, eluent reclaims ethanol, and concentration is dried, and obtains combined extracts.
Anti-acne facial cleanser
The component and its relative content for constituting above-mentioned anti-acne facial cleanser product be:
Comparative example 1
It is that its plant composition is cotton rose extract, other preparation conditions and method and implementation with the difference of embodiment 1
Example 1 is identical.
Comparative example 2
It is that its plant composition is white pond lily extract, other preparation conditions and method and implementation with the difference of embodiment 1
Example 1 is identical.
Comparative example 3
It is that its plant composition is American aloe extract, other preparation conditions and method and implementation with the difference of embodiment 1
Example 1 is identical.
Comparative example 4
It is that its plant composition is Herba Dendrobii extract, other preparation conditions and method and embodiment 1 with the difference of embodiment 1
It is identical.
Comparative example 5
It is not add American aloe extract in its plant composition with the difference of embodiment 1, other preparation conditions and method
It is same as Example 1.
Suppression experiment to propionibacterium acnes
The generation of acne is mainly blocked with hypersteatosis, pilosebaceous duct, bacterium infection and inflammatory reaction etc.
Factor is closely related.The level of androgen particularly testosterone in descendant's body that adolesces is raised rapidly, promotes sebaceous glands development
And produce a large amount of sebums.The dyskeratosis of pilosebaceous duct causes catheter blockage simultaneously, and dyssebacia forms cutin
Bolt is micro mist thorn.Multiple-microorganism especially propionibacterium acnes amount reproduction in hair follicle, the lipase that propionibacterium acnes is produced
Sebum generation free fatty is decomposed, while chemotactic inflammatory cell and medium, finally induce and aggravate inflammatory reaction.Thus may be used
See, propionibacterium acnes amount reproduction is a key factor for inducing whelk and causing whelk deterioration, therefore, it is right to study
The inhibitory action of propionibacterium acnes is one of important method of evaluation sample anti-acne action effect.
(1) test specimen：Natural herbs acne-removing composition, cotton rose extract, the acne propionic acid of the gained of embodiment 1
3 groups of bacillus strain (isolated at patients with acne skin damaged)；
(2) test method：
1. culture, separation, the identification of anaerobic bacteria：THl0 cultures will be inoculated at patients with acne skin damaged by isolated sample
In base, airbag method is used, be placed in 37 DEG C of culture 72h in anaerobic jar, indicator is made with methylene blue, palladium grain is pierced for catalysis.
2. the separation of anaerobic bacteria
Picking single bacterium colony, turns 2 pieces of flat boards, and one piece is placed in anaerobic jar, the lower 37 DEG C of pure cultures of anaerobic condition；Another piece with
37 DEG C of aerobic cultures；Result is observed after 48h.
3. the identification of anaerobic bacteria
Without bacterial growth under aerobic culture；
Occur homogeneous form, canescence, tiny, diameter about 1.O mm raised circle, edge on the flat board of Anaerobic culturel
Slightly neat bacterium colony, microscopy is made by bacterium colony, visible chromabacterium biolaceum under mirror.It is micro-bend in bar-shaped or shaft-like, can one end blunt circle, one end becomes
Carefully, coloring is not deep, and cell is single, and it is the shapes such as " people ", " v " that can in pairs arrange or arrange.Again through oxytolerant experiment, catalase test,
Indole test, biochemical series test for identification are propionibacterium acnes.
4. anaerobism drug sensitive test
Inoculation：1 colony inoculation in the bacterium colony more than picking cultivated on LB plating mediums, 37 DEG C of aerobic trainings
24h is supported, aerobic culture 24h propionibacterium acneses are rinsed with SPSS, flushing liquor is put into sterile test tube；Using wheat
Family name's turbidimetry need to shake 12 times than turbid before opacity tube, first than turbid to 3 × 108/mL, then with normal saline dilution to 106/mL
It is standby.
LB plating mediums are inoculated with：The swab stick of sterilizing is dipped into bacterium solution, unnecessary bacterium solution is gone in being squeezed on tube wall, in the training of LB flat boards
Even spread on base is supported, and a circle is swept along plate edge ring, cover plate, dry 2min.Aseptic steel bowl (a diameter of 6mm) is light
It is put on plating medium, fills it up with the natural herbs acne-removing composition of the gained of embodiment 1, is put into 37 DEG C of aerobic culture 24h,
It was found that without bacterial growth in plate, seeing there is inhibition zone to be formed after continuing 37 DEG C of aerobic culture 24h.Antibacterial circle diameter is surveyed, by 3 groups of suppressions
Bacterium loop diameter value is averaged.
Result of the test：
It is experimental group with the natural herb acne-removing composition group for adding the gained of embodiment 1, is replaced with cotton rose extract real
The composition extract of example 1 is applied for control group 1, is control group 2 with the white pond lily flower extract substitution composition extract of embodiment 1,
It is control group 3 with the American aloe extract substitution composition extract of embodiment 1, the composition of embodiment 1 is replaced with Herba Dendrobii extract
Extract is control group 4, and the composition extract of embodiment 1 is replaced with the composition extract of white pond lily flower, cotton rose and the stem of noble dendrobium
It is control group 5.Chinese medicine antibacterial susceptibility grade classification, with reference to corresponding antibiotic standard ".Inhibition zone diameter>20mm is Gao Min, 10~
20mm is quick in being,<10mm is resistance, and specific observation result is as shown in table 1.
Table 1
Efficacy assessments：
Natural herbs acne-removing composition of the invention and cotton rose extract, dragon are can be seen that from above result of the test
Tongue orchid extract, white lotus flower extract, Herba Dendrobii extract and white pond lily flower, the composition extract of cotton rose and the stem of noble dendrobium all have
Suppress the effect of propionibacterium acnes, and natural herb acne-removing composition has quick effect (inhibition zone high to propionibacterium acnes
Diameter>20mm)；Cotton rose extract group, American aloe extract, white lotus flower extract, Herba Dendrobii extract and white pond lily flower, wooden cottonrose hibiscus
The composition extract of Rong and the stem of noble dendrobium quick effect (antibacterial circle diameter is between 10~20mm) in having to propionibacterium acnes, thus
Cotton rose is cooperateed with by sharing to have with other natural herbs in can be seen that natural herbs acne-removing composition of the present invention
The effect of synergy.
Acne-removing is verified
Subjects：
300 26-35 Sui long the volunteer of whelk, and volunteer's facial area has papule, redness, skin greasing, pore
Thick, inflammatory reaction substantially, the warts symptom such as continuous repeatedly.
Selection standard:Glucocorticoid, dimension A classes medicine, antibiotic etc. are taken in clinical observation the last fortnight, and in the observation period
Between do not use said medicine；No drinking during observation, excessively pungent stimulation group food is not eaten.
500 people are randomly divided into 10 groups, every group of 50 people correspond to embodiment 1~4 respectively, and the comparative example 6 of comparative example 1~6 is certain
Commercially available anti-acne emulsion.Be evenly coated on the face the clean rear appropriate face cleaning dew that will be provided of Irrigation then sooner or later daily by patient
Clean up, continuing more than 30d must not be interrupted.
Criterion of therapeutical effect：
Criterion of therapeutical effect is worked out with reference to the guideline of clinical investigations of new Chinese medicine treatment acne vulgaris.1) it is almost recovered:It is scorching
Property fash all disappear, pigmentation is only stayed, without new fash；2) it is effective:Inflammatory deflorescence more than 70%, new fash is less than 5
It is individual；3) effectively:More than inflammatory deflorescence 30%-60%, new fash is less than 10；4) it is invalid:Inflammatory deflorescence is not enough
29% or without significant change, or even add severe one.
Clinical efficacy result is as shown in table 3 after 30d：
Table 3
By the average cure rate and effective efficiency of the visible embodiment 1~4 of table three for 36.5% and 98.5% far above contrast
The cure rate and effective percentage of example 1~5, it was demonstrated that anti-acne make-up composition cotton rose extract group of the present invention, American aloe extract, white
Flos Nelumbinis extract, Herba Dendrobii extract and white pond lily the flower extract Synergistic on anti-acne effect.The cure rate of comparative example 6 and effectively
Rate is 30% and 84%, hence it is evident that less than embodiment 1~5, the present invention has remarkable result in terms of anti-acne.
Volunteer has no that obvious stimulation is reacted in process of the test, and 98% without pockmark residual, follow-up in the volunteer of recovery from illness
6 middle of the month, there are not relapse indications.
As can be seen from the above data, Chinese medicinal anti-acne composition of the invention is non-stimulated to skin safe, and it is used as work(
Can not only play a part of anti-acne in property additive addition cosmetics series, pockmark be repaired, while curative effect stabilization, can prevent
Whelk recurrent exerbation.
Above example only illustrates embodiment of the present invention, does not there is any formal limitation to the present invention；Appoint
What is engaged in professional and technical personnel, all has the ability to make some changes using the technology contents for disclosing or modifies, as equivalent
The Equivalent embodiments of change, according to the technology of the present invention essence, simply modification, equivalent variations and modification are carried out to the present invention, are belonged to
In the range of technical solution of the present invention.
Claims (5)
1. a kind of acne-eliminating cosmetic composition, it is characterised in that the active component of the cosmetic composition is matched somebody with somebody by following weight parts
The natural woody plant raw material of ratio is prepared：American aloe 2-20 parts, cotton rose 4-18 parts, white pond lily flower 2-9 parts, stem of noble dendrobium 5-20
Part.
2. a kind of acne-eliminating cosmetic composition according to claim 1, it is characterised in that described natural herbs are former
The weight of material is：American aloe 3-10 parts, cotton rose 5-10 parts, 4-8 parts, stem of noble dendrobium 8-15 parts of white pond lily flower.
3. a kind of acne-eliminating cosmetic composition according to claim 1 and 2, it is characterised in that the cosmetic composition
Active component refers to, by mixing extraction, to extract from natural herbs raw material American aloe, cotton rose, white pond lily flower, the stem of noble dendrobium
Liquid isolates and purifies the combined extracts for preparing through macroreticular resin, and the content of general flavone and polysaccharide exists in the active component
More than 18%.
4. a kind of acne-eliminating cosmetic composition according to claim 3, it is characterised in that the composition of the cosmetic composition
In, the relative content of the active component of cosmetic composition is 0.3-5%, and remaining is the conventional base of cosmetics exterior-applied formulation
Matter.
5. a kind of acne-eliminating cosmetic composition according to claim 4, it is characterised in that described cosmetics exterior-applied formulation
It is anti-acne facial cleanser, acne eliminating cream, anti-acne or acne removing water.
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| CN201710007077.5A CN106727012A (en) | 2017-01-04 | 2017-01-04 | A kind of acne-eliminating cosmetic composition |
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| CN201710007077.5A CN106727012A (en) | 2017-01-04 | 2017-01-04 | A kind of acne-eliminating cosmetic composition |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107510628A (en) * | 2017-08-16 | 2017-12-26 | 佛山市三水区嘉信农业技术研究院（普通合伙） | It is a kind of with the plant residue composition of anti-inflammatory efficacy and its application |
| CN109394666A (en) * | 2018-12-06 | 2019-03-01 | 广州市诺兰精细化工有限公司 | A kind of face mask of traditional Chinese medicine and preparation method for scytitis |
| CN116407475A (en) * | 2023-04-18 | 2023-07-11 | 广州奥蓓斯化妆品有限公司 | Facial cleanser and preparation method thereof |
| US11786451B2 (en) | 2019-06-28 | 2023-10-17 | The Procter & Gamble Company | Skin care composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105943430A (en) * | 2016-05-05 | 2016-09-21 | 广州丹奇日用化工厂有限公司 | Cosmetic composition having function of removing acne |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105943430A (en) * | 2016-05-05 | 2016-09-21 | 广州丹奇日用化工厂有限公司 | Cosmetic composition having function of removing acne |
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| 王建新: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107510628A (en) * | 2017-08-16 | 2017-12-26 | 佛山市三水区嘉信农业技术研究院（普通合伙） | It is a kind of with the plant residue composition of anti-inflammatory efficacy and its application |
| CN109394666A (en) * | 2018-12-06 | 2019-03-01 | 广州市诺兰精细化工有限公司 | A kind of face mask of traditional Chinese medicine and preparation method for scytitis |
| US11786451B2 (en) | 2019-06-28 | 2023-10-17 | The Procter & Gamble Company | Skin care composition |
| US12102707B2 (en) | 2019-06-28 | 2024-10-01 | The Procter & Gamble Company | Skin care composition |
| CN116407475A (en) * | 2023-04-18 | 2023-07-11 | 广州奥蓓斯化妆品有限公司 | Facial cleanser and preparation method thereof |
| CN116407475B (en) * | 2023-04-18 | 2024-06-25 | 广州奥蓓斯化妆品有限公司 | Facial cleanser and preparation method thereof |
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Application publication date: 20170531 |