CN106619380A - Anti-acne essence - Google Patents
Anti-acne essence Download PDFInfo
- Publication number
- CN106619380A CN106619380A CN201611240873.5A CN201611240873A CN106619380A CN 106619380 A CN106619380 A CN 106619380A CN 201611240873 A CN201611240873 A CN 201611240873A CN 106619380 A CN106619380 A CN 106619380A
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- CN
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- Prior art keywords
- extract
- parts
- caulis bambusae
- acne
- taenia
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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Abstract
The invention discloses an anti-acne essence. The essence is prepared from 0.02-1.1 parts of cortex dictamni extracts, 0.01-1.5 parts of paper mulberry bark extracts, 0.02-1.2 parts of bamboo shavings extract, 0.2-0.5 part of thickening agent, 5-15 parts of moisturizing agent, 0.005-0.01 part of preservative and the balance deionized water. The essence is high in safety and good in skin permeability, effective ingredients are easily absorbed, bacterium inhibition and skin care are achieved at the same time, the inflammatory reaction of skin with acne can be alleviated, the pore environment can be improved, acne marks can be faded, the skin barrier function is restored, and the excellent anti-acne effect can be achieved.
Description
Technical field
The present invention relates to cosmetic field, and in particular to a kind of anti-acne essence.
Background technology
Acne, is commonly called as whelk, also known as dark sore or acne, be it is a kind of generation in pilosebaceous follicle and its inflammation of surrounding tissue
Disease pathology, occurs more universal in various people especially young man.Show according to investigations, the patient of 14-19 year accounts for total morbidity
Account for 43.0%, 25-29 year 20.1%, 20-24 the year of number and account for 13.6%, 30-39 year and account for 13.6%, 40-45 year and account for 1.9%,
Obviously 20-24 year be acne Gao Fa Nian Ling, this age bracket is in the youth and rebels the phase, and the presence of whelk can affect blue or green few
The self-confidence in year and communication, so anti-acne is necessary.In recent years, the amount of consumption of anti-acne class cosmetics rose year by year, perhaps
Many Management of Cosmetics Enterprises are proposed miscellaneous product for resolving poxes.The species and content of active ingredient not only decide in product for resolving poxes
The quality of anti-acne effect, and also have certain impact on the health of consumer, it is desirable to it will also while anti-acne effect is reached
Using safety, it is impossible to produce obvious stimulation and damage to site of administration, any resistance to the action of a drug can not be produced.Compared with medicine, change
The security requirement of cosmetic is higher.
Anti-acne class cosmetics species is various in China market, announces only on the total board web of state food pharmaceuticals administration
Import anti-acne class cosmetics are just up to kind more than 1500.Except finding metronidazole and chlorine in national cosmetics supervised sample in 2012
Outside mycin, it was found that addition clindamycin, lincomycin, Ofloxacin, Sulfamethoxazole, Tinidazole, Enoxacin etc. are various
Prohibit the situation of regulated substance, or even there are various phenomenons for limiting and being added with material mixing；There is also regulated substance such as salicylic acid
Deng the exceeded phenomenon such as use of material.Therefore, a safety of research and development is natural, and the significant product for resolving poxes of effect, is trend of the times, is also
One of Research Emphasis of cosmetic field.
Patent Office of the People's Republic of China discloses a kind of anti-acne formula of liquid (CN104435786A), by speciality corn wine, erythromycin, first nitre
Azoles etc. is into being grouped into.The quick anti-acne of invention energy, but, meeting injured skin big to the excitant of skin, there is certain side effect.
At present, on the market product for resolving poxes security is low, and anti-acne effect is not obvious.
The content of the invention
For the problems referred to above, the technical problem to be solved in the present invention is：There is provided one kind can load Cortex Dictamni extract, paper mulberry
Bark extract, the anti-acne essence with anti-acne effect of Caulis Bambusae In Taenia extract, targetedly from keys such as anti-acne, foster skin, moisturizings
Link is set about, the bactericidal antiphlogistic factor such as flavones, cumarin, alkaloid for being contained using extract, is effectively treated acne.
To reach effect described above, the present invention adopts following scheme：
A kind of anti-acne essence includes Cortex Dictamni extract, paper mulberry bark extract, Caulis Bambusae In Taenia extract, wherein the root bark of shaggy-fruited dittany
Extract, paper mulberry bark extract, the weight ratio of Caulis Bambusae In Taenia extract is (0.01-1.2)：(0.01-2)：(0.01-1.5).
Preferably, the Cortex Dictamni extract, paper mulberry bark extract, the parts by weight of Caulis Bambusae In Taenia extract are：The root bark of shaggy-fruited dittany is carried
Take thing 0.02-1.1 parts, paper mulberry bark extract 0.01-1.5 parts, Caulis Bambusae In Taenia extract 0.02-1.2 parts.
Preferably, the Cortex Dictamni extract, paper mulberry bark extract, the parts by weight of Caulis Bambusae In Taenia extract are：The root bark of shaggy-fruited dittany is carried
Take thing 0.04-0.8 parts, paper mulberry bark extract 0.02-1.2 parts, Caulis Bambusae In Taenia extract 0.05-1.0 parts.
The extract of the present invention can be obtained by conventional preparation method, and the preparation method of preferred Cortex Dictamni extract is：
Take shaggy-fruited dittany root is dried epidermis, with 1：The solid-liquid ratio of 8-12 immerses the ethanol of 70-80%, 50-60 DEG C of refluxing extraction 3-5 time,
Every time 1-2h, merges extract, reduced pressure concentration；8000-9000r/min is centrifuged, and takes supernatant, and supernatant is injected into macroporous absorption
Resin column, with 25-50% ethanol elution impurity, then uses 60-85% ethanol elutions, reclaims eluent, is spray-dried, and obtains described white
Fresh hide extract.
It is preferred that the preparation method of paper mulberry bark extract is：The ethanol solution of 75-90% will be added after tapa clean dry
In, solid-liquid ratio (g：Ml it is) 1:(15-20)；Refluxing extraction 2-6h under the conditions of 50-100 DEG C, is repeated 2 times, merging filtrate；By gained
Standing 10-24h takes supernatant and obtains final product the paper mulberry bark extract under the conditions of -5-10 DEG C of filtrate.
It is preferred that the preparation method of Caulis Bambusae In Taenia extract is：Take caulis bambusae in taenian plus deionized water refluxing extraction, solid-liquid ratio (g:Ml it is) 1:
15-20, temperature 50-80 DEG C is extracted 2-3 time, merges filtering and collecting filter liquid, and it is 1.13-1.16 to be concentrated into relative density, must be soaked
Cream；Above-mentioned medicinal extract is taken, plus 4-6 times is measured 90% ethanol solution and is stirred, it is closed to stand overnight；Take above-mentioned overnight feed liquid decompression to take out
Filter, filtrate recycling ethanol is to without alcohol taste, 0-4 DEG C of refrigeration 24h；By above-mentioned feed liquid filtration under diminished pressure, the concentration of filtrate normal pressure, obtain caulis bambusae in taenian and carry
Take thing.
A kind of anti-acne essence is consisted of the following composition：Cortex Dictamni extract 0.02-1.1 parts, paper mulberry bark extract 0.01-
1.5 parts, Caulis Bambusae In Taenia extract 0.02-1.2 parts, thickener 0.2-0.5 parts, NMF 5-15 parts, preservative 0.005-0.01 parts, go
Ionized water is to 100 parts.
The thickener is at least one in hydroxyethyl cellulose, xanthans；The NMF be glycerine, propane diols,
At least one in sorbierite, polyethylene glycol, hyaluronic acid；The preservative is Phenoxyethanol, methyl hydroxybenzoate, the different thiophene of methyl
At least one in oxazoline ketone.
A kind of preparation method of anti-acne essence that the present invention is provided is comprised the following steps：
(1) thickener, NMF and deionized water are added together in agitated kettle, is heated to 80-85 DEG C, stirred to dissolving
Completely；
(2) 40-45 DEG C is cooled to, sequentially adds Cortex Dictamni extract, paper mulberry bark extract, Caulis Bambusae In Taenia extract, preservative,
Stirring discharges completely.
Following introduction is made to the plant extracts of the present invention：
The root bark of shaggy-fruited dittany is the dry root skin of Rutaceae shaggy-fruited dittany platymiscium shaggy-fruited dittany, is mainly distributed on the northeast, Henan, Xinjiang of China
Etc. ground, be China's Chinese traditional herbs.Root bark of shaggy-fruited dittany major function has heat-clearing and damp-drying drug, wind-dispelling removing toxic substances, for treating eczema, rubella, Huang
Subcutaneous ulcer is urinated red etc..In recent years, with the research that solution is extracted to the root bark of shaggy-fruited dittany, it has been found that the separated identification from Cortex Dictamni extract
The chemical composition for going out mainly includes limonin, alkaloid, flavonoids, lactone, sequiterpene and its glycoside etc., makes the root bark of shaggy-fruited dittany
Extract has the biologically actives such as antibacterial, anti-inflammatory, desinsection, anticancer.
Paper mulberry belongs to arbor for Moraceae structure, there is significant bacteriostasis.《Compendium of Materia Medica》Cloud " curing rheumatism swelling, tinea sore ".Structure
Bark also known as paper mulberry bark, property sweet taste, energy wind-dispelling, promoting blood circulation, diuresis can be used to treat arthralgia due to wind-dampness, traumatic injury, puffiness, skin
Inflammation etc..The chemical composition of paper mulberry bark extract is mainly flavonoids, diphenyl propane class compound and cumarin, terpene, biology
Alkali, fat oil etc., with anti-oxidant, anti-platelet aggregation, step-down, it is antitumor, strengthen the effect such as immune and antibacterial.
Caulis bambusae in taenian is dried intermediate layer for the stalk of grass bambusa breviflora Munro, major part allusion quotation bamboo or henon bamboo, with clearing heat and eliminating phlegm,
Relieving restlessness, effect of preventing or arresting vomiting.Caulis Bambusae In Taenia extract contains suberone, pentacyclic triterpenoid and terpene.What Caulis Bambusae In Taenia extract contained
Hydroxyl is combined with water with hydrogen bond formation, formed water lock film, prevent the loss of moisture of skin, can play moistening skin, greasy skin,
Protection and the effect of softening skin；Caulis Bambusae In Taenia extract has abundant raw material sources, the safety in utilization of height, market potential
Greatly.
The device have the advantages that as follows：(1) Cortex Dictamni extract and paper mulberry bark extract have significant antibacterial
Anti-inflammatory effect, with reference to the strong Caulis Bambusae In Taenia extract of water conservation water lock power, antibacterial and maintenance one, the inflammation for alleviating long acne skin is anti-
Should；Through repetition test, the inhibiting bacteria and diminishing inflammation effect of the compounded combination of three kinds of natural components is imitated than the inhibiting bacteria and diminishing inflammation of single extract
Fruit is more preferable, so that the present invention reaches excellent anti-acne effect；(2) adopt hydrophilic material anti-acne essence of the invention more,
The good penetrability on skin, active ingredient is readily absorbed by, and has anti-acne and nutrition concurrently, can improve pore environment, desalinates acne print, extensive
Multiple skin barrier function；(3) present invention adopts the thickener of food-grade, non-toxic to skin；Using NMF all have it is good
Good water conservation, promotes skin water sorption, gentle moisturizing；Using the antibacterial sterilization effect of preservative it is good, making in the present invention
Consumption meets《Cosmetics health specification》(version in 2007)；Therefore, Essence each component of the invention collocation, safe, makes
The not cutaneous physiological action with after；(4) Essence preparation process is simple of the invention, product quality is stable, can scale
Industrial production.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
The anti-acne essence formula of the present invention of the embodiment of the present invention 1～5 is shown in Table one
The preparation method of Cortex Dictamni extract is：Take shaggy-fruited dittany root is dried epidermis, with 1：The solid-liquid ratio immersion 70- of 8-12
80% ethanol, 50-60 DEG C of refluxing extraction 3-5 time, each 1-2h merges extract, reduced pressure concentration；8000-9000r/min from
The heart, takes supernatant, and supernatant is injected into large pore resin absorption column, with 25-50% ethanol elution impurity, then uses 60-85% ethanol
Wash-out, reclaims eluent, is spray-dried, and obtains the Cortex Dictamni extract.
The preparation method of paper mulberry bark extract is：By in the ethanol solution that 75-90% is added after tapa clean dry, expect
Liquor ratio (g：Ml it is) 1:(15-20)；Refluxing extraction 2-6h under the conditions of 50-100 DEG C, is repeated 2 times, merging filtrate；By gained filtrate-
Standing 10-24h takes supernatant and obtains final product the paper mulberry bark extract under the conditions of 5-10 DEG C.
The preparation method of Caulis Bambusae In Taenia extract is：Take Caulis Bambusae In Taenia extract plus deionized water refluxing extraction, solid-liquid ratio (g:Ml) it is
1:15-20, temperature 50-80 DEG C is extracted 2-3 time, merges filtering and collecting filter liquid, and it is 1.13-1.16 to be concentrated into relative density, is obtained
Medicinal extract；Above-mentioned medicinal extract is taken, plus 4-6 times is measured 90% ethanol solution and is stirred, it is closed to stand overnight；Take above-mentioned overnight feed liquid decompression
Suction filtration, filtrate recycling ethanol is to without alcohol taste, 0-4 DEG C of refrigeration 24h；By above-mentioned feed liquid filtration under diminished pressure, the concentration of filtrate normal pressure, caulis bambusae in taenian is obtained
Extract.
The method of anti-acne essence, it is characterised in that the preparation method is comprised the following steps：
(1) thickener, NMF and deionized water are added together in agitated kettle, is heated to 80-85 DEG C, stirred to dissolving
Completely；
(2) 40-45 DEG C is cooled to, sequentially adds Cortex Dictamni extract, paper mulberry bark extract, Caulis Bambusae In Taenia extract, preservative,
Stirring discharges completely.
The preparation method of anti-acne essence is comprised the following steps：
(1) thickener, NMF and deionized water are added together in agitated kettle, is heated to 80-85 DEG C, stirred to dissolving
Completely；
(2) 40-45 DEG C is cooled to, sequentially adds Cortex Dictamni extract, paper mulberry bark extract, Caulis Bambusae In Taenia extract, preservative,
Stirring discharges completely.
Comparative example 1
It is not add Iceland's lichens extract with the difference of embodiment 1, other preparation conditions and method and the phase of embodiment 1
Together.
Comparative example 2
It is not add paper mulberry bark extract with the difference of embodiment 1, other preparation conditions and method are same as Example 1.
Comparative example 3
It is not add Caulis Bambusae In Taenia extract with the difference of embodiment 1, other preparation conditions and method are same as Example 1.
Comparative example 4
It is not add vegetable composition with the difference of embodiment 1, other preparation conditions and method are same as Example 1.
Suppression to propionibacterium acnes is tested
The generation of acne is mainly blocked with hypersteatosis, pilosebaceous duct, bacterium infection and inflammatory reaction etc.
Factor is closely related.The androgen in descendant's body that adolesces is particularly the level of testosterone and raises rapidly, promotes sebaceous glands development
And produce a large amount of sebums.Simultaneously the dyskeratosis of pilosebaceous duct causes catheter blockage, dyssebacia to form cutin
Bolt is micro mist thorn.Multiple-microorganism especially propionibacterium acnes amount reproduction in hair follicle, the lipase that propionibacterium acnes is produced
Decompose sebum and generate free fatty, while chemotactic inflammatory cell and medium, finally induce and increase inflammatory reaction.Thus may be used
See, propionibacterium acnes amount reproduction is a key factor for inducing whelk and causing whelk deterioration, therefore, it is right to study
The inhibitory action of propionibacterium acnes is one of important method of evaluation sample anti-acne action effect.
(1) test specimen：Vegetable composition, Cortex Dictamni extract, paper mulberry bark extract, caulis bambusae in taenian in embodiment 1 is extracted
The composition of thing, paper mulberry bark extract and Caulis Bambusae In Taenia extract, 5 groups of propionibacterium acnes bacterial strain (is separated at patients with acne skin damaged
To)；
(2) test method：
1. culture, separation, the identification of anaerobic bacteria：THl0 cultures will be inoculated at patients with acne skin damaged by isolated sample
In base, airbag method is used, be placed in 37 DEG C of culture 72h in anaerobic jar, indicator is made with methylene blue, palladium grain is catalysis thorn.
2. the separation of anaerobic bacteria
Picking single bacterium colony, turns 2 pieces of flat boards, and one piece is placed in anaerobic jar, the lower 37 DEG C of pure cultures of anaerobic condition；Another piece with
37 DEG C of aerobic cultures；Result is observed after 48h.
3. the identification of anaerobic bacteria
Without bacterial growth under aerobic culture；
Occur homogeneous form, canescence, tiny, diameter about 1.Omm raised circle, edge on the flat board of Anaerobic culturel slightly
Neat bacterium colony, by bacterium colony microscopy is made, visible chromabacterium biolaceum under mirror.It is micro-bend in bar-shaped or shaft-like, can one end blunt circle, one end attenuates,
Coloring is not deep, and cell is single, can in pairs arrange or arrange as shapes such as " people ", " v ".And the test of Jing oxytolerants, catalase test, indoles
Test, biochemical series test for identification are propionibacterium acnes.
4. anaerobism drug sensitive test
Inoculation：It is more than picking cultivate bacterium colony in 1 colony inoculation on LB plating mediums, the aerobic trainings of 370C
Foster 24h, aerobic culture 24h propionibacterium acneses are rinsed with SPSS, and flushing liquor is put in sterile test tube；Using wheat
Family name's turbidimetry need to shake 12 times than turbid before opacity tube, first than turbid to 3 × 108/mL, then with normal saline dilution to 106/mL
It is standby.
LB plating mediums are inoculated with：The swab stick of sterilizing is dipped into bacterium solution, is squeezed on tube wall and is gone unnecessary bacterium solution, in the training of LB flat boards
Even spread on foster base, and a circle is swept along plate edge ring, plate is covered, it is dried 2min.Aseptic steel bowl (a diameter of 6mm) is light
It is put on plating medium, fills it up with the vegetable composition of the gained of embodiment 1, be put into 37 DEG C of aerobic culture 24h, finds nothing in plate
Bacterial growth, continues to see have inhibition zone to be formed after 37 DEG C of aerobic culture 24h.Antibacterial circle diameter is surveyed, 3 groups of antibacterial circle diameter values are taken
Mean value.
Result of the test：To add the vegetable composition group of the gained of embodiment 1 as experimental group, replaced with Cortex Dictamni extract real
It is control group 1 to apply the composition extract of example 1, and the composition extract of embodiment 1 is replaced as control group 2 with paper mulberry bark extract, with
It is control group 3 that Caulis Bambusae In Taenia extract replaces the composition extract of embodiment 1, is replaced with paper mulberry bark extract and Caulis Bambusae In Taenia extract and is implemented
The composition extract of example 1 is control group 4.Chinese medicine antibacterial susceptibility grade classification, with reference to corresponding antibiotic standard ".Inhibition zone diameter>
20mm is Gao Min, and 10～20mm is quick in being,<10mm is resistance, and concrete observation result is as shown in Table 2.
Table two
Efficacy assessments：
From above result of the test can be seen that the present invention vegetable composition and Cortex Dictamni extract, paper mulberry bark extract,
The composition of Caulis Bambusae In Taenia extract, paper mulberry bark extract and Caulis Bambusae In Taenia extract all has the effect for suppressing propionibacterium acnes, and plants
Compositions have high quick effect (antibacterial circle diameter to propionibacterium acnes>20mm)；Cortex Dictamni extract, tapa are extracted
Quick effect is (antibacterial during the composition of thing, Caulis Bambusae In Taenia extract, paper mulberry bark extract and Caulis Bambusae In Taenia extract has to propionibacterium acnes
Loop diameter is between 10～20mm), it can thus be seen that Cortex Dictamni extract, paper mulberry bark extract, bamboo in vegetable composition of the present invention
Eat the effect that extract has Synergistic.
Acne-removing is verified
Choose homeliness type acne patient 200, male patient 108, female patient 92, the age (20 ± 1) year, the course of disease
(20.1 ± 18.4) individual month.All patient's voluntary participation clinical observations, sign Informed Consent Form, and on request using dispelling for providing
Acne face cleaning is revealed.
Selection standard:Glucocorticoid, dimension A class medicines, antibiotic etc. are taken in clinical observation the last fortnight, and in the observation period
Between do not use said medicine；No drinking during observation, does not eat excessively pungent stimulation group food.
200 people are randomly divided into into 10 groups, per group of 20 people correspond to respectively embodiment 1～5, comparative example 1～5, and comparative example 5 is
Certain excellent commercially available anti-acne essence of anti-acne effect.Patient is daily sooner or later by the clean rear appropriate face cleaning that will be provided of Irrigation
Dew is evenly coated on the face and then cleans up, and continuing more than 28d must not be interrupted.
After patient uses front and use the 7th, 14, respectively observation once, is carried out 28d to extent according to level Four scoring
Scoring, while observing and recording bad reaction, draws skin repair effect.
Respectively inquire that patient adapts to impression using the 7th after front and use, 14,28d in patient.
Degree is improved according to skin damaged, course for the treatment of index is calculated, curative effect is judged.Therapeutic index is (long-pending after integration-curative effect before curative effect
Point) × 100% is integrated before/curative effect.It is almost recovered：Therapeutic index ＞ 75%, effective (remarkable result)：Therapeutic index be 50～
75%, effectively：Therapeutic index is 20～50%, invalid：Therapeutic index ＜ 20%.
Using embodiment 1～5, there is not bad reaction, the trouble of correspondence embodiment 1～3 in comparative example 1～5, patient
Person, very well, all patients complete experiment to reaction effect.
Repair result and see the table below three
Table three
More contrasted apparently higher than the same period with effective number by visible 7th day, the 15 days and 30 days base of embodiment 1～5 of table three
The base of example 1～5 is healed and effective number, it is seen that anti-acne essence of the present invention effect is significant in terms of anti-acne；Comparative example 1～3 and enforcement
The difference of example 1 does not respectively add Iceland's lichens extract, paper mulberry bark extract, Caulis Bambusae In Taenia extract, by comparative example 1～3 and in fact
Apply example 1 and contrast visible Iceland's lichens extract, paper mulberry bark extract, Caulis Bambusae In Taenia extract in anti-acne essence of the present invention in anti-acne
Aspect Synergistic.Comparative example 4 the 7th day, 15 days and 30 space-baseds more and effective number be significantly lower than with period other embodiment and
Comparative example, it is seen that vegetable composition is important active ingredient in anti-acne essence of the present invention.
Water conservation water lock efficacy validation
Experimental subjects：Above-mentioned 200 homeliness type acne patients, male patient 108, female patient 92 is randomly divided into
10 groups, embodiment 1～5, per group of 20 people of comparative example 1～5.
Test method：All volunteers carry out face cleaning process before sleeping every night, and everyone left face is smart using the anti-acne of place group
Magnificent liquid, right face does not use anti-acne essence.On probation one month by a definite date, at the 7th day, the 15th day, each statistics was once tried out within the 30th day
As a result.Effectively be expressed as trier or so face contrast face more add water it is tender flexible；Invalid representation be trier's skin texture without
Any change；Generally trier's skin quality makes moderate progress but effect is not notable, between effective and invalid.
Experimental result see the table below four
By visible 7th day, 15 days of table four and 30 days efficiently individual quantities of embodiment 1～5 apparently higher than same period comparative example 1～5
Number, it is seen that anti-acne essence of the present invention effect is significant in terms of water conservation water lock.Being contrasted by comparative example 1～3 and embodiment 1 can
See that Iceland's lichens extract, paper mulberry bark extract, Caulis Bambusae In Taenia extract are cooperateed with terms of moisturizing water lock in anti-acne essence of the present invention
Synergy.
Above example only illustrates embodiment of the present invention, does not there is any pro forma restriction to the present invention；Appoint
What is engaged in professional and technical personnel, all has the ability to make some changes using the technology contents for disclosing or modifies, and becomes equivalent
The Equivalent embodiments of change, according to the technology of the present invention essence, simply modification, equivalent variations and modification are carried out to the present invention, are belonged to
In the range of technical solution of the present invention.
Claims (9)
1. a kind of anti-acne essence, it is characterised in that the Essence includes Cortex Dictamni extract, paper mulberry bark extract, caulis bambusae in taenian
Extract, wherein the Cortex Dictamni extract, paper mulberry bark extract, the weight ratio of Caulis Bambusae In Taenia extract is (0.01-1.2)：
(0.01-2)：(0.01-1.5).
2. a kind of anti-acne essence according to claim 1, it is characterised in that the Cortex Dictamni extract, tapa is carried
Thing is taken, the parts by weight of Caulis Bambusae In Taenia extract are：
Cortex Dictamni extract 0.02-1.1 parts
Paper mulberry bark extract 0.01-1.5 parts
Caulis Bambusae In Taenia extract 0.02-1.2 parts.
3. a kind of anti-acne essence according to claim 1 and 2, it is characterised in that the Cortex Dictamni extract, tapa
Extract, the parts by weight of Caulis Bambusae In Taenia extract are：
Cortex Dictamni extract 0.04-0.8 parts
Paper mulberry bark extract 0.02-1.2 parts
Caulis Bambusae In Taenia extract 0.05-1.0 parts.
4. a kind of anti-acne essence according to claim 1, it is characterised in that the preparation method of the Cortex Dictamni extract
For：Take shaggy-fruited dittany root is dried epidermis, with 1：The solid-liquid ratio of 8-12 immerses the ethanol of 70-80%, 50-60 DEG C of refluxing extraction 3-5
Secondary, each 1-2h merges extract, reduced pressure concentration；8000-9000r/min is centrifuged, and takes supernatant, and supernatant is injected into macropore
Adsorption resin column, with 25-50% ethanol elution impurity, then uses 60-85% ethanol elutions, reclaims eluent, is spray-dried, and obtains institute
State Cortex Dictamni extract.
5. a kind of anti-acne essence according to claim 1, it is characterised in that the preparation method of the paper mulberry bark extract
For：By after tapa clean dry add 75-90% ethanol solution in, solid-liquid ratio (g：Ml it is) 1:(15-20)；50-100℃
Under the conditions of refluxing extraction 2-6h, be repeated 2 times, merging filtrate；Supernatant is taken by 10-24h is stood under the conditions of -5-10 DEG C of gained filtrate
Obtain final product the paper mulberry bark extract.
6. a kind of anti-acne essence according to claim 1, it is characterised in that the preparation method of the Caulis Bambusae In Taenia extract
For：Take caulis bambusae in taenian plus deionized water refluxing extraction, solid-liquid ratio (g:Ml it is) 1:15-20, temperature 50-80 DEG C is extracted 2-3 time, is merged
Filtering and collecting filter liquid, it is 1.13-1.16 to be concentrated into relative density, obtains medicinal extract；Above-mentioned medicinal extract is taken, plus 4-6 times is measured 90% ethanol
Solution stirs, closed to stand overnight；Above-mentioned overnight feed liquid decompression suction filtration is taken, filtrate recycling ethanol is to without alcohol taste, and 0-4 DEG C cold
Hide 24h；By above-mentioned feed liquid filtration under diminished pressure, the concentration of filtrate normal pressure, Caulis Bambusae In Taenia extract is obtained.
7. a kind of anti-acne essence as described in any one of claim 1-6, it is characterised in that described to consist of the following composition：
Cortex Dictamni extract 0.02-1.1 parts
Paper mulberry bark extract 0.01-1.5 parts
Caulis Bambusae In Taenia extract 0.02-1.2 parts
Thickener 0.2-0.5 parts
NMF 5-15 parts
Preservative 0.005-0.01 parts
Deionized water is to 100 parts.
8. a kind of anti-acne essence according to claim 7, it is characterised in that the thickener be hydroxyethyl cellulose,
At least one in xanthans；The NMF is at least in glycerine, propane diols, sorbierite, polyethylene glycol, hyaluronic acid
Kind；The preservative is at least one in Phenoxyethanol, methyl hydroxybenzoate, methylisothiazolinone.
9. a kind of method for preparing anti-acne essence as claimed in claim 7, it is characterised in that comprise the following steps：
(1) thickener, NMF and deionized water are added together in agitated kettle, is heated to 80-85 DEG C, stirred to having dissolved
Entirely；
(2) 40-45 DEG C is cooled to, sequentially adds Cortex Dictamni extract, paper mulberry bark extract, Caulis Bambusae In Taenia extract, preservative, stirred
Discharge completely.
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| CN201611240873.5A CN106619380A (en) | 2016-12-28 | 2016-12-28 | Anti-acne essence |
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Cited By (7)
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| CN106511189A (en) * | 2017-01-06 | 2017-03-22 | 广州聚澜健康产业研究院有限公司 | Composition with efficacies of inhibiting bacteria and diminishing inflammation |
| CN107028797A (en) * | 2017-06-12 | 2017-08-11 | 南京凯创协同纳米技术有限公司 | Anti-acne essence and preparation method thereof |
| CN107375110A (en) * | 2017-08-29 | 2017-11-24 | 宁波保税区攀峒信息科技有限公司 | A kind of loose structure cold cream and the usage food ointment chemical product ointment of physiotherapy containing skin care |
| CN107595666A (en) * | 2017-09-30 | 2018-01-19 | 惠州东慧新材料制品有限公司 | A kind of long-acting moisture-keeping essence |
| CN109431907A (en) * | 2018-12-26 | 2019-03-08 | 广州市藻谷生物科技有限公司 | A kind of acne-removing composition and preparation method and application containing Cortex Dictamni extract |
| JP2019038767A (en) * | 2017-08-24 | 2019-03-14 | 佐藤 隆 | Sebum production inhibitor |
| CN109528533A (en) * | 2018-12-25 | 2019-03-29 | 珠海中科先进技术研究院有限公司 | A kind of cosmetics and preparation method thereof containing choline cloves hydrochlorate |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511189A (en) * | 2017-01-06 | 2017-03-22 | 广州聚澜健康产业研究院有限公司 | Composition with efficacies of inhibiting bacteria and diminishing inflammation |
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| JP2019038767A (en) * | 2017-08-24 | 2019-03-14 | 佐藤 隆 | Sebum production inhibitor |
| JP2021181494A (en) * | 2017-08-24 | 2021-11-25 | 隆 佐藤 | Sebum production inhibitor |
| CN107375110A (en) * | 2017-08-29 | 2017-11-24 | 宁波保税区攀峒信息科技有限公司 | A kind of loose structure cold cream and the usage food ointment chemical product ointment of physiotherapy containing skin care |
| CN107595666A (en) * | 2017-09-30 | 2018-01-19 | 惠州东慧新材料制品有限公司 | A kind of long-acting moisture-keeping essence |
| CN109528533A (en) * | 2018-12-25 | 2019-03-29 | 珠海中科先进技术研究院有限公司 | A kind of cosmetics and preparation method thereof containing choline cloves hydrochlorate |
| CN109431907A (en) * | 2018-12-26 | 2019-03-08 | 广州市藻谷生物科技有限公司 | A kind of acne-removing composition and preparation method and application containing Cortex Dictamni extract |
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Application publication date: 20170510 |