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CL2019003892A1 - Nuevos derivados de azaquinolina. - Google Patents

Nuevos derivados de azaquinolina.

Info

Publication number
CL2019003892A1
CL2019003892A1 CL2019003892A CL2019003892A CL2019003892A1 CL 2019003892 A1 CL2019003892 A1 CL 2019003892A1 CL 2019003892 A CL2019003892 A CL 2019003892A CL 2019003892 A CL2019003892 A CL 2019003892A CL 2019003892 A1 CL2019003892 A1 CL 2019003892A1
Authority
CL
Chile
Prior art keywords
compounds
preparation
new
azaquinoline
pharmaceutical compositions
Prior art date
Application number
CL2019003892A
Other languages
English (en)
Inventor
Nils Griebenow
Wei Zhuang
Adeline Köhler
Daniel Kulke
Claudia Böhm
Kirsten Börngen
Thomas Ilg
Hans-Georg Schwarz
Werner Hallenbach
Ulrich Görgens
Walter Hübsch
Bernd Alig
Iring Heisler
Isa Jana Irina Janssen
Original Assignee
Bayer Animal Health Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Animal Health Gmbh filed Critical Bayer Animal Health Gmbh
Publication of CL2019003892A1 publication Critical patent/CL2019003892A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCIÓN ABARCA COMPUESTOS DE AZAQUINOLINA DE LA FÓRMULA GENERAL (I): EN LA CUAL T, R1, R2, R3, R4, R5, R6, Y Q SON COMO SE DEFINEN EN EL PRESENTE, PROCEDIMIENTOS PARA LA PREPARACIÓN DE DICHOS COMPUESTOS, COMPUESTOS INTERMEDIOS ÚTILES PARA LA PREPARACIÓN DE DICHOS COMPUESTOS, COMPOSICIONES FARMACÉUTICAS Y COMBINACIONES QUE COMPRENDEN DICHOS COMPUESTOS Y EL USO DE DICHOS COMPUESTOS PARA LA ELABORACIÓN DE COMPOSICIONES FARMACÉUTICAS PARA EL TRATAMIENTO, CONTROL Y/O PREVENCIÓN DE ENFERMEDADES, EN ESPECIAL DE INFECCIONES CON HELMINTOS, COMO UN ÚNICO AGENTE O EN COMBINACIÓN CON OTROS INGREDIENTES ACTIVOS.
CL2019003892A 2017-06-30 2019-12-30 Nuevos derivados de azaquinolina. CL2019003892A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17179149 2017-06-30

Publications (1)

Publication Number Publication Date
CL2019003892A1 true CL2019003892A1 (es) 2020-07-10

Family

ID=59269946

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019003892A CL2019003892A1 (es) 2017-06-30 2019-12-30 Nuevos derivados de azaquinolina.

Country Status (22)

Country Link
US (1) US11485733B2 (es)
EP (1) EP3615527B1 (es)
JP (1) JP7210483B2 (es)
KR (1) KR20200020911A (es)
CN (1) CN110770227B (es)
AR (1) AR112216A1 (es)
AU (1) AU2018293627B2 (es)
CA (1) CA3068350A1 (es)
CL (1) CL2019003892A1 (es)
CO (1) CO2019014484A2 (es)
CR (1) CR20190595A (es)
DK (1) DK3615527T3 (es)
ES (1) ES2984497T3 (es)
IL (1) IL271607B2 (es)
MX (1) MX2019015895A (es)
PE (1) PE20200608A1 (es)
PH (1) PH12019502851A1 (es)
PL (1) PL3615527T3 (es)
TW (1) TWI799429B (es)
UA (1) UA125800C2 (es)
UY (1) UY37789A (es)
WO (1) WO2019002132A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12312356B2 (en) 2020-05-29 2025-05-27 Boehringer Ingelheim Vetmedica Gmbh Anthelmintic heterocyclic compounds

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20211275A1 (es) * 2018-07-09 2021-07-19 Boehringer Ingelheim Animal Health Usa Inc Compuestos heterociclicos antihelminticos
AU2019405444B2 (en) 2018-12-18 2023-05-18 Elanco Tiergesundheit Ag Bicyclic derivatives
JP7304952B2 (ja) * 2018-12-18 2023-07-07 エランコ・ティアゲゾンタイト・アーゲー 二環式誘導体
KR20220002890A (ko) * 2019-03-19 2022-01-07 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 아자-벤조티오펜 및 아자-벤조푸란 화합물
EP3980414A1 (en) * 2019-06-07 2022-04-13 Elanco Tiergesundheit AG Bicyclic derivatives for treating endoparasites
TWI865563B (zh) * 2019-07-30 2024-12-11 德商拜耳動物保健有限公司 新穎異喹啉衍生物
JP7644121B2 (ja) * 2019-12-18 2025-03-11 インターベット インターナショナル ベー． フェー． アザインドール構造を含む駆虫剤化合物
EP4132911A1 (en) 2020-04-09 2023-02-15 Bayer Animal Health GmbH Substituted condensed azines as anthelmintic compounds
US20240059680A1 (en) 2020-11-18 2024-02-22 Elanco Tiergesundheit Ag N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections
CN116685584A (zh) * 2020-11-18 2023-09-01 礼蓝动物保健有限公司 用于治疗心丝虫感染的n-(2,3-二氢-1,4-苯并噁嗪-4-基)-3-异丙基-7-(2,3,5-三氟苯基)苯并噻吩-2-甲酰胺衍生物和类似化合物
CN116888124A (zh) * 2020-12-04 2023-10-13 礼蓝动物保健有限公司 二环衍生物
TW202237600A (zh) 2020-12-04 2022-10-01 瑞士商禮藍動物保健股份有限公司 雙環衍生物
EP4148052A1 (en) * 2021-09-09 2023-03-15 Bayer Animal Health GmbH New quinoline derivatives
PE20250675A1 (es) 2021-11-01 2025-03-04 Boehringer Ingelheim Vetmedica Gmbh Compuestos de pirrolopiridazina como antihelminticos
WO2024213752A1 (en) 2023-04-14 2024-10-17 Elanco Animal Health Gmbh Long-term prevention and/or treatment of a disease by slo-1 inhibitors
WO2025027117A1 (en) 2023-08-02 2025-02-06 Intervet International B.V. Carboxamide-4-quinoline compounds with anthelmintic activity

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4479955A (en) 1983-01-10 1984-10-30 Ciba-Geigy Corporation Heterocycle-fused pyrazolo[3,4-d]pyridin-3-ones as benzodiazepine receptor modulators
DE3639877A1 (de) 1986-11-21 1988-05-26 Bayer Ag Hetarylalkyl substituierte 5- und 6-ringheterocyclen
KR0169813B1 (ko) 1995-07-12 1999-01-15 김종인 4-아미노-3-아실나프티리딘 유도체
JP2001511813A (ja) 1997-02-18 2001-08-14 ニューロクライン バイオサイエンシーズ，インコーポレイテッド Ｃｒｆレセプターアンタゴニストおよびそれらに関連する方法
DE19858253A1 (de) * 1998-12-17 2000-06-21 Aventis Pharma Gmbh Verwendung von Inhibitoren des KQt1-Kanals zur Herstellung eines Medikaments zur Behandlung von Krankheiten, die durch Helminthen und Ektoparasiten hervorgerufen werden
EP1254114A2 (en) * 2000-01-28 2002-11-06 Melacure Therapeutics AB Melanocortin receptor agonists and antagonists
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
GB0213715D0 (en) 2002-06-14 2002-07-24 Syngenta Ltd Chemical compounds
SE0202461D0 (sv) 2002-08-14 2002-08-14 Astrazeneca Ab Novel compounds
TWI312272B (en) 2003-05-12 2009-07-21 Sumitomo Chemical Co Pyrimidine compound and pests controlling composition containing the same
GB0414438D0 (en) 2004-06-28 2004-07-28 Syngenta Participations Ag Chemical compounds
CN101039922B (zh) 2004-10-20 2011-04-13 组合化学工业株式会社 3-三唑基苯基硫醚衍生物及含其作为有效成分的杀虫·杀螨·杀线虫剂
EP1844055A1 (en) * 2005-01-28 2007-10-17 Janssen Pharmaceutica N.V. Anthelmintic imidazol-thiazole derivatives
US7304074B2 (en) 2005-04-05 2007-12-04 Hoffmann-La Roche Inc. Substituted 1,5-naphthyridine azolinones
AU2006250987A1 (en) 2005-05-24 2006-11-30 Astrazeneca Ab Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
US7938851B2 (en) 2005-06-08 2011-05-10 Xtent, Inc. Devices and methods for operating and controlling interventional apparatus
JP4871290B2 (ja) 2005-10-06 2012-02-08 日本曹達株式会社 架橋環状アミン化合物および有害生物防除剤
US7465795B2 (en) * 2005-12-20 2008-12-16 Astrazeneca Ab Compounds and uses thereof
WO2007073283A1 (en) 2005-12-20 2007-06-28 Astrazeneca Ab Substituted cinnoline derivatives as gabaa-receptor modulators and method for their synthesis
SA08290245B1 (ar) * 2007-04-23 2012-02-12 استرازينيكا ايه بي مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم
AU2008245447C1 (en) 2007-04-30 2014-11-20 Genentech, Inc. Inhibitors of IAP
JP2010529145A (ja) 2007-06-08 2010-08-26 ヘリコン・セラピューティクス・インコーポレーテッド 治療用ピラゾロナフチリジン誘導体
AU2008298545B2 (en) 2007-09-14 2013-12-12 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
WO2009089263A2 (en) 2008-01-07 2009-07-16 Ardea Biosciences Inc. Novel compositions and methods of use
BRPI0908837A2 (pt) 2008-03-11 2015-07-21 Neurosearch As Derivado de triarila, composição farmacêutica, uso de um derivado de triarila, e, método para tratar, prevenir ou para o alívio de uma doença, um distúrbio ou uma condição de um corpo de animal vivo
JP5268461B2 (ja) 2008-07-14 2013-08-21 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 Ｐｆ１３６４物質、その製造方法、生産菌株、及び、それを有効成分とする農園芸用殺虫剤
CN101337940B (zh) 2008-08-12 2012-05-02 国家农药创制工程技术研究中心 具杀虫活性的含氮杂环二氯烯丙醚类化合物
CN101337937B (zh) 2008-08-12 2010-12-22 国家农药创制工程技术研究中心 具有杀虫活性的n-苯基-5-取代氨基吡唑类化合物
CN101715774A (zh) 2008-10-09 2010-06-02 浙江化工科技集团有限公司 一个具有杀虫活性化合物制备及用途
EP2184273A1 (de) 2008-11-05 2010-05-12 Bayer CropScience AG Halogen-substituierte Verbindungen als Pestizide
GB0820344D0 (en) 2008-11-06 2008-12-17 Syngenta Ltd Herbicidal compositions
AU2009313927A1 (en) * 2008-11-13 2010-05-20 Astrazeneca Ab Azaquinolinone derivatives and uses thereof
BRPI0922824B8 (pt) 2008-12-12 2021-10-19 Syngenta Ltd Compostos n-oxipiperidinas espiro-heterocíclicas como pesticidas, seu processo de preparação, composição pesticida que as contém e método de combater e controlar pestes
WO2011085575A1 (zh) 2010-01-15 2011-07-21 江苏省农药研究所股份有限公司 邻杂环甲酰苯胺类化合物及其合成方法和应用
AR081721A1 (es) 2010-02-25 2012-10-17 Nippon Soda Co Compuesto de amina ciclica y acaricida
CN102199152A (zh) 2010-03-25 2011-09-28 高大新 杂环咪唑类磷脂激酶抑制剂
BR112012030408A2 (pt) 2010-05-31 2015-09-29 Syngenta Participations Ag método de melhoramento de culturas
EP2959775A1 (en) * 2010-08-31 2015-12-30 Meiji Seika Pharma Co., Ltd. Pest control agent
CN101967139B (zh) 2010-09-14 2013-06-05 中化蓝天集团有限公司 一种含一氟甲氧基吡唑的邻甲酰氨基苯甲酰胺类化合物、其合成方法及应用
EP2675440B1 (en) 2011-02-14 2020-03-25 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
BR112013030095A2 (pt) 2011-05-23 2019-09-24 Elan Pharm Inc inibidores de atividade de lrrk2 cinase
WO2013050317A1 (en) 2011-10-03 2013-04-11 Syngenta Limited Polymorphs of an isoxazoline derivative
CN102391261A (zh) 2011-10-14 2012-03-28 上海交通大学 一种n-取代噁二嗪类化合物及其制备方法和应用
SG11201402664VA (en) * 2011-11-28 2014-06-27 Du Pont N- (4 -quinolinylmethyl) sulfonamide derivatives and their use as anthelmintics
TWI566701B (zh) 2012-02-01 2017-01-21 日本農藥股份有限公司 芳烷氧基嘧啶衍生物及包含該衍生物作為有效成分的農園藝用殺蟲劑及其使用方法
GEP201606560B (en) 2012-03-06 2016-10-25 Pfizer Macrocyclic derivatives for the treatment of proliferative diseases
WO2013148603A1 (en) 2012-03-27 2013-10-03 Takeda Pharmaceutical Company Limited Cinnoline derivatives as as btk inhibitors
US9334238B2 (en) 2012-03-30 2016-05-10 Basf Se N-substituted pyridinylidenes for combating animal pests
EP2647626A1 (en) 2012-04-03 2013-10-09 Syngenta Participations AG. 1-Aza-spiro[4.5]dec-3-ene and 1,8-diaza-spiro[4.5]dec-3-ene derivatives as pesticides
US9282739B2 (en) 2012-04-27 2016-03-15 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
MX2014013069A (es) 2012-04-27 2015-07-06 Dow Agrosciences Llc Composiciones plaguicidas y procesos relacionados.
CN103232431B (zh) 2013-01-25 2014-11-05 青岛科技大学 一种二卤代吡唑酰胺类化合物及其应用
CN103109816B (zh) 2013-01-25 2014-09-10 青岛科技大学 硫代苯甲酰胺类化合物及其应用
WO2014158644A1 (en) 2013-03-13 2014-10-02 Dow Agrosciences Llc Process for the preparation of triaryl rhamnose carbamates
WO2014143241A1 (en) 2013-03-15 2014-09-18 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
US20140336182A1 (en) 2013-05-13 2014-11-13 Amgen Inc. Aurora Kinase Modulators and Method of Use
US20160081342A1 (en) 2013-05-23 2016-03-24 Syngenta Participations Ag Tank-mix formulations
CN103265527B (zh) 2013-06-07 2014-08-13 江苏省农用激素工程技术研究中心有限公司 邻氨基苯甲酰胺化合物及其制备方法和应用
TWI529171B (zh) 2013-07-29 2016-04-11 赫孚孟拉羅股份公司 １，７－萘啶衍生物
CN103524422B (zh) 2013-10-11 2015-05-27 中国农业科学院植物保护研究所 苯并咪唑衍生物及其制备方法和用途
CN105636440A (zh) 2013-10-17 2016-06-01 美国陶氏益农公司 制备杀虫化合物的方法
MX2016004942A (es) 2013-10-17 2016-06-28 Dow Agrosciences Llc Procesos para la preparacion de compuestos plaguicidas.
EP3060557A1 (de) * 2013-10-23 2016-08-31 Bayer CropScience Aktiengesellschaft Substituierte chinoxalin-derivate als schädlingsbekämpfungsmittel
BR112016017996A2 (pt) * 2014-02-06 2017-08-08 Abbvie Inc 6-heteroariloxi- or 6-ariloxi-quinolina-2-carboxamidas e método de uso
WO2015144001A1 (zh) 2014-03-24 2015-10-01 南京明德新药研发股份有限公司 作为smo抑制剂的喹啉衍生物
TWI649307B (zh) 2014-05-07 2019-02-01 日商橘生藥品工業股份有限公司 Cyclohexylpyridine derivative
TW201613866A (en) 2014-07-07 2016-04-16 Bayer Cropscience Ag Process for preparing fluorinated iminopyridine compounds
UY36196A (es) * 2014-07-25 2016-02-29 Bayer Animal Health Gmbh Compuestos para usar en el tratamiento antihelmíntico
PL3259992T3 (pl) 2015-02-17 2019-05-31 Nippon Soda Co Kompozycja agrochemiczna
WO2016196961A1 (en) 2015-06-03 2016-12-08 Uwm Research Foundation, Inc. Ligands selective to alpha 6 subunit-containing gabaa receptors ans their methods of use
DK3538512T3 (da) 2016-11-11 2021-07-05 Bayer Animal Health Gmbh Nye anthelmintiske quinolin-3-carboxamid-derivater

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12312356B2 (en) 2020-05-29 2025-05-27 Boehringer Ingelheim Vetmedica Gmbh Anthelmintic heterocyclic compounds

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TWI799429B (zh) 2023-04-21
PL3615527T3 (pl) 2024-07-01
WO2019002132A1 (en) 2019-01-03
IL271607B1 (en) 2023-03-01
CA3068350A1 (en) 2019-01-03
PE20200608A1 (es) 2020-03-10
US20200131175A1 (en) 2020-04-30
CN110770227A (zh) 2020-02-07
CN110770227B (zh) 2024-03-01
BR112019028181A2 (pt) 2020-07-07
JP7210483B2 (ja) 2023-01-23
AU2018293627A1 (en) 2019-12-12
DK3615527T3 (da) 2024-05-06
JP2020525444A (ja) 2020-08-27
EP3615527A1 (en) 2020-03-04
TW201904961A (zh) 2019-02-01
IL271607A (en) 2020-02-27
UY37789A (es) 2019-01-31
NZ759633A (en) 2024-05-31
CR20190595A (es) 2020-03-03
AR112216A1 (es) 2019-10-02
AU2018293627B2 (en) 2022-07-21
PH12019502851A1 (en) 2020-10-19
US11485733B2 (en) 2022-11-01
EP3615527B1 (en) 2024-03-06
RU2020103733A (ru) 2021-07-30
ES2984497T3 (es) 2024-10-29
KR20200020911A (ko) 2020-02-26
CO2019014484A2 (es) 2020-01-17
IL271607B2 (en) 2023-07-01
UA125800C2 (uk) 2022-06-08
MX2019015895A (es) 2020-02-07
RU2020103733A3 (es) 2021-10-22

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