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CL2019003536A1 - Dominio de unión a antígeno anti trbc1. - Google Patents

Dominio de unión a antígeno anti trbc1.

Info

Publication number
CL2019003536A1
CL2019003536A1 CL2019003536A CL2019003536A CL2019003536A1 CL 2019003536 A1 CL2019003536 A1 CL 2019003536A1 CL 2019003536 A CL2019003536 A CL 2019003536A CL 2019003536 A CL2019003536 A CL 2019003536A CL 2019003536 A1 CL2019003536 A1 CL 2019003536A1
Authority
CL
Chile
Prior art keywords
seq
binding domain
trbc1
trbc1 antigen
antigen
Prior art date
Application number
CL2019003536A
Other languages
English (en)
Inventor
Shaun Cordoba
Simon Thomas
Shimobi Onuoha
Ram Jha
Wen Chean Lim
Original Assignee
Autolus Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Autolus Ltd filed Critical Autolus Ltd
Publication of CL2019003536A1 publication Critical patent/CL2019003536A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
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  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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Abstract

LA PRESENTE INVENCIÓN PROPORCIONA UN DOMINIO DE UNIÓN A ANTÍGENO ANTI-TRBC1 EL CUAL COMPRENDE: A) UN DOMINIO VH QUE TIENE UNA SECUENCIA DE AMINOÁCIDOS QUE SE SELECCIONA DE SEQ ID NO. 9, SEQ ID NO. 10, SEQ ID NO. 11, SEQ ID NO. 12, SEQ ID NO. 13, SEQ ID NO. 14, SEQ ID NO. 15, SEQ ID NO. 16, SEQ ID NO. 17 Y SEQ ID NO. 18; Y B) UN DOMINIO VL QUE TIENE UNA SECUENCIA DE AMINOÁCIDOS QUE SE SELECCIONA DE SEQ ID NO. 19, SEQ ID NO. 20, SEQ ID NO. 21, SEQ ID NO. 22, SEQ ID NO. 23, SEQ ID NO. 24, SEQ ID NO. 25, SEQ ID NO. 26, SEQ ID NO. 27, SEQ ID NO. 28, SEQ ID NO. 29, SEQ ID NO. 30, SEQ ID NO. 31, SEQ ID NO. 32, SEQ ID NO. 33, SEQ ID NO. 34.
CL2019003536A 2017-06-09 2019-12-04 Dominio de unión a antígeno anti trbc1. CL2019003536A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1709203.2A GB201709203D0 (en) 2017-06-09 2017-06-09 Antigen-binding domain

Publications (1)

Publication Number Publication Date
CL2019003536A1 true CL2019003536A1 (es) 2020-05-08

Family

ID=59358238

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019003536A CL2019003536A1 (es) 2017-06-09 2019-12-04 Dominio de unión a antígeno anti trbc1.

Country Status (19)

Country Link
US (3) US11440961B2 (es)
EP (1) EP3635006A1 (es)
JP (3) JP7177794B2 (es)
KR (1) KR102743539B1 (es)
CN (2) CN118480126A (es)
AU (1) AU2018282038B2 (es)
BR (1) BR112019025990A2 (es)
CA (1) CA3065006A1 (es)
CL (1) CL2019003536A1 (es)
CO (1) CO2019013614A2 (es)
CU (1) CU24663B1 (es)
GB (1) GB201709203D0 (es)
IL (1) IL270731B2 (es)
MX (1) MX2019013387A (es)
MY (1) MY205039A (es)
PE (1) PE20191717A1 (es)
PH (1) PH12019502785A1 (es)
WO (1) WO2018224844A1 (es)
ZA (1) ZA201907524B (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11385233B2 (en) 2015-03-05 2022-07-12 Autolus Limited Methods of depleting malignant T-cells
US11982672B2 (en) 2014-03-05 2024-05-14 Autolus Limited Methods
GB201709203D0 (en) * 2017-06-09 2017-07-26 Autolus Ltd Antigen-binding domain
GB201800298D0 (en) 2018-01-09 2018-02-21 Autolus Ltd Method
EP3737692A4 (en) 2018-01-09 2021-09-29 Elstar Therapeutics, Inc. CALRETICULIN AND MODIFIED T-LYMPHOCYTES BINDING CONSTRUCTIONS FOR THE TREATMENT OF DISEASES
US12152073B2 (en) 2018-03-14 2024-11-26 Marengo Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
AU2019297451A1 (en) 2018-07-03 2021-01-28 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof
GB201812650D0 (en) 2018-08-03 2018-09-19 Autolus Ltd Molecular assessment of TRBC usage
GB201817172D0 (en) 2018-10-22 2018-12-05 Autolus Ltd Antibody
GB201817822D0 (en) 2018-10-31 2018-12-19 Autolus Ltd Binding domain
EP3927747A1 (en) 2019-02-21 2021-12-29 Marengo Therapeutics, Inc. Antibody molecules that bind to nkp30 and uses thereof
CN119661722A (zh) * 2019-02-21 2025-03-21 马伦戈治疗公司 结合t细胞相关癌细胞的多功能分子及其用途
AU2020407235A1 (en) * 2019-12-20 2022-07-07 Poseida Therapeutics, Inc. Anti-MUC1 compositions and methods of use
GB2609554B (en) 2020-01-03 2025-08-20 Marengo Therapeutics Inc Anti-TCR antibody molecules and uses thereof
UY40280A (es) * 2020-03-13 2023-07-31 Janssen Biotech Inc Dominios de unión a antígeno que se unen a la proteina cd33 de la superficie de células mieloides
WO2021188454A1 (en) * 2020-03-16 2021-09-23 Marengo Therapeutics, Inc. Engineered cell compositions and methods of use thereof
GB202004263D0 (en) * 2020-03-24 2020-05-06 Autolus Ltd Antibody conjugate
GB202005216D0 (en) 2020-04-08 2020-05-20 Autolus Ltd Cell
KR20210131239A (ko) 2020-04-22 2021-11-02 스미또모 가가꾸 가부시키가이샤 염, 산 발생제, 레지스트 조성물 및 레지스트 패턴의 제조 방법
KR20230028242A (ko) * 2020-04-24 2023-02-28 마렝고 테라퓨틱스, 인크. T 세포 관련 암 세포에 결합하는 다중기능성 분자 및 그것의 용도
JP2022008152A (ja) 2020-06-25 2022-01-13 住友化学株式会社 塩、酸発生剤、レジスト組成物及びレジストパターンの製造方法
JP7758480B2 (ja) 2020-07-01 2025-10-22 住友化学株式会社 塩、酸発生剤、レジスト組成物及びレジストパターンの製造方法
CN111909277A (zh) * 2020-08-13 2020-11-10 上海市第一人民医院 一种靶向trbc1的人源化嵌合抗原受体、t细胞及用途
GB2616354A (en) * 2020-08-26 2023-09-06 Marengo Therapeutics Inc Methods of detecting TRBC1 or TRBC2
US20220291583A1 (en) 2021-02-12 2022-09-15 Sumitomo Chemical Company, Limited Salt, acid generator, resist composition and method for producing resist pattern
CA3211203A1 (en) * 2021-02-17 2022-08-25 The Johns Hopkins University Methods and materials for treating clonal t cell expansions
JP2022164583A (ja) 2021-04-15 2022-10-27 住友化学株式会社 塩、酸発生剤、レジスト組成物及びレジストパターンの製造方法
JP2022164585A (ja) 2021-04-15 2022-10-27 住友化学株式会社 塩、酸発生剤、レジスト組成物及びレジストパターンの製造方法
US20230004084A1 (en) 2021-05-06 2023-01-05 Sumitomo Chemical Company, Limited Salt, acid generator, resist composition and method for producing resist pattern
CN114181971A (zh) * 2021-11-22 2022-03-15 东莞市麦亘生物科技有限公司 一种靶向trbc1 car-t细胞的制备方法与应用
CN114853893A (zh) * 2022-02-23 2022-08-05 南京蓝盾生物科技有限公司 一种靶向gpc3嵌合抗原受体t细胞及其应用
WO2024085182A1 (ja) * 2022-10-18 2024-04-25 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 Ｔ細胞性腫瘍の治療剤
WO2024256823A1 (en) 2023-06-14 2024-12-19 Autolus Limited Treatment of trbc1-positive t cell malignancies
WO2025007013A2 (en) * 2023-06-28 2025-01-02 The Johns Hopkins University Trbc targeting antibody-drug conjugates
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof
CN119912570A (zh) * 2024-12-30 2025-05-02 武汉科技大学 一种抗trbc1纳米抗体及其制备方法与应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2484182A1 (en) 2002-04-29 2003-11-13 Genpat77 Pharmacogenetics Ag Novel antibody binding tcr and tirc7 and its use in therapy and diagnosis
RU2355703C2 (ru) 2002-10-09 2009-05-20 Медиджен Лимитед Одноцепочечные рекомбинантные т-клеточные рецепторы
GB0304068D0 (en) 2003-02-22 2003-03-26 Avidex Ltd Substances
US8518405B2 (en) * 2009-10-08 2013-08-27 The University Of North Carolina At Charlotte Tumor specific antibodies and uses therefor
WO2013074916A1 (en) 2011-11-18 2013-05-23 Board Of Regents, The University Of Texas System Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla
GB201206559D0 (en) 2012-04-13 2012-05-30 Ucl Business Plc Polypeptide
AU2013312838B2 (en) * 2012-09-04 2018-11-29 Cellectis Multi-chain chimeric antigen receptor and uses thereof
EP3241561B1 (en) * 2014-03-05 2025-04-30 Autolus Limited Conjugated antibody or bispecific t-cell engager which selectively binds either tcr beta constant region 1 (trbc1) or trbc2
US11385233B2 (en) 2015-03-05 2022-07-12 Autolus Limited Methods of depleting malignant T-cells
GB201405845D0 (en) 2014-04-01 2014-05-14 Ucl Business Plc Signalling system
KR20160145802A (ko) * 2014-04-23 2016-12-20 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 요법에 사용하기 위한 키메라 항원 수용체 (car) 및 이의 제조 방법
WO2016016343A1 (en) * 2014-07-31 2016-02-04 Cellectis Ror1 specific multi-chain chimeric antigen receptor
GB201415347D0 (en) 2014-08-29 2014-10-15 Ucl Business Plc Signalling system
GB201501936D0 (en) 2015-02-05 2015-03-25 Ucl Business Plc Signalling system
GB201503133D0 (en) 2015-02-24 2015-04-08 Ucl Business Plc And Syncona Partners Llp Chimeric protein
GB201709203D0 (en) * 2017-06-09 2017-07-26 Autolus Ltd Antigen-binding domain
GB201800298D0 (en) 2018-01-09 2018-02-21 Autolus Ltd Method

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