CL2019002777A1 - Compuestos que inhiben la proteína mcl-1. - Google Patents
Compuestos que inhiben la proteína mcl-1.Info
- Publication number
- CL2019002777A1 CL2019002777A1 CL2019002777A CL2019002777A CL2019002777A1 CL 2019002777 A1 CL2019002777 A1 CL 2019002777A1 CL 2019002777 A CL2019002777 A CL 2019002777A CL 2019002777 A CL2019002777 A CL 2019002777A CL 2019002777 A1 CL2019002777 A1 CL 2019002777A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds
- mcl
- inhibit
- protein
- methods
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 title 1
- 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000000066 myeloid cell Anatomy 0.000 abstract 1
- 229940121649 protein inhibitor Drugs 0.000 abstract 1
- 239000012268 protein inhibitor Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
EN LA PRESENTE SE PROVEEN INHIBIDORES DE LA PROTEÍNA LEUCEMIA DE CÉLULAS MIELOIDES 1 (MCL- 1), MÉTODOS PARA SU PREPARACIÓN, COMPOSICIONES FARMACÉUTICAS RELACIONADAS, Y MÉTODOS DE USO DE ESTO. POR EJEMPLO, EN LA PRESENTE SE PROVEEN COMPUESTOS DE FÓRMULA 1, O UN ESTEREOISOMERO DE ESTOS; Y SALES FARMACÉUTICAMENTE ACEPTABLES DE ESTOS Y COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN LOS COMPUESTOS. LOS COMPUESTOS Y COMPOSICIONES PROVISTAS EN LA PRESENTE PUEDEN USARSE, POR EJEMPLO, EN EL TRATAMIENTO DE ENFERMEDADES O AFECCIONES, COMO CÁNCER.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762479230P | 2017-03-30 | 2017-03-30 | |
| US201762479171P | 2017-03-30 | 2017-03-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2019002777A1 true CL2019002777A1 (es) | 2019-12-20 |
Family
ID=61972255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2019002777A CL2019002777A1 (es) | 2017-03-30 | 2019-09-27 | Compuestos que inhiben la proteína mcl-1. |
Country Status (35)
| Country | Link |
|---|---|
| US (5) | US10300075B2 (es) |
| EP (1) | EP3601297B9 (es) |
| JP (2) | JP6453507B2 (es) |
| KR (1) | KR102372322B1 (es) |
| CN (1) | CN110691784B (es) |
| AU (2) | AU2018244349B2 (es) |
| BR (1) | BR112019020459B1 (es) |
| CA (1) | CA3057882A1 (es) |
| CL (1) | CL2019002777A1 (es) |
| CO (1) | CO2019011762A2 (es) |
| CR (1) | CR20190489A (es) |
| DK (1) | DK3601297T5 (es) |
| ES (1) | ES2940641T3 (es) |
| FI (1) | FI3601297T3 (es) |
| HR (1) | HRP20221412T2 (es) |
| HU (1) | HUE060919T2 (es) |
| IL (1) | IL269603B (es) |
| JO (1) | JOP20190229B1 (es) |
| LT (1) | LT3601297T (es) |
| MX (1) | MX389487B (es) |
| MY (1) | MY204294A (es) |
| NZ (1) | NZ757606A (es) |
| PE (1) | PE20200335A1 (es) |
| PH (1) | PH12019502245A1 (es) |
| PL (1) | PL3601297T3 (es) |
| PT (1) | PT3601297T (es) |
| RS (1) | RS63892B9 (es) |
| SA (1) | SA519410222B1 (es) |
| SG (1) | SG11201908945RA (es) |
| SI (1) | SI3601297T1 (es) |
| SM (1) | SMT202300122T1 (es) |
| TW (1) | TWI685493B (es) |
| UA (1) | UA124784C2 (es) |
| UY (1) | UY37656A (es) |
| WO (1) | WO2018183418A1 (es) |
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| JP6786892B2 (ja) | 2016-06-09 | 2020-11-18 | 富士ゼロックス株式会社 | サーバ装置、情報処理システム及びプログラム |
| JP6453507B2 (ja) | 2017-03-30 | 2019-01-16 | アムジエン・インコーポレーテツド | Ｍｃｌ−１タンパク質を阻害する化合物 |
| EP3668878B1 (en) | 2017-08-18 | 2025-05-21 | Amgen Inc. | Compounds that inhibit mcl-1 protein |
| MA50033A (fr) | 2017-08-29 | 2020-07-08 | Amgen Inc | Composés macrocycliques permettant d'inhiber la protéine mcl-1 |
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2018
- 2018-03-27 JP JP2018059341A patent/JP6453507B2/ja active Active
- 2018-03-28 NZ NZ757606A patent/NZ757606A/en unknown
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- 2018-03-28 MX MX2019011693A patent/MX389487B/es unknown
- 2018-03-28 SI SI201830809T patent/SI3601297T1/sl unknown
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- 2018-03-28 US US15/938,001 patent/US10300075B2/en active Active
- 2018-03-28 HU HUE18717811A patent/HUE060919T2/hu unknown
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- 2018-03-28 PT PT187178116T patent/PT3601297T/pt unknown
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- 2018-03-28 JO JOP/2019/0229A patent/JOP20190229B1/ar active
- 2018-03-28 WO PCT/US2018/024723 patent/WO2018183418A1/en not_active Ceased
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- 2018-03-28 MY MYPI2019005626A patent/MY204294A/en unknown
- 2018-03-28 RS RS20230036A patent/RS63892B9/sr unknown
- 2018-03-28 SG SG11201908945R patent/SG11201908945RA/en unknown
- 2018-03-28 BR BR112019020459-8A patent/BR112019020459B1/pt active IP Right Grant
- 2018-03-28 UA UAA201910703A patent/UA124784C2/uk unknown
- 2018-03-28 AU AU2018244349A patent/AU2018244349B2/en active Active
- 2018-03-28 CA CA3057882A patent/CA3057882A1/en active Pending
- 2018-03-28 PE PE2019001963A patent/PE20200335A1/es unknown
- 2018-03-28 LT LTEPPCT/US2018/024723T patent/LT3601297T/lt unknown
- 2018-03-28 HR HRP20221412TT patent/HRP20221412T2/hr unknown
- 2018-03-28 EP EP18717811.6A patent/EP3601297B9/en active Active
- 2018-03-30 TW TW107111110A patent/TWI685493B/zh active
- 2018-04-02 UY UY0001037656A patent/UY37656A/es not_active Application Discontinuation
- 2018-12-11 JP JP2018231352A patent/JP6629419B2/ja active Active
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2019
- 2019-03-11 US US16/297,904 patent/US10500213B2/en active Active
- 2019-08-22 US US16/547,747 patent/US10632128B2/en active Active
- 2019-09-24 IL IL269603A patent/IL269603B/en unknown
- 2019-09-27 CL CL2019002777A patent/CL2019002777A1/es unknown
- 2019-09-27 PH PH12019502245A patent/PH12019502245A1/en unknown
- 2019-09-30 SA SA519410222A patent/SA519410222B1/ar unknown
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2020
- 2020-02-06 US US16/783,269 patent/US10821115B2/en active Active
- 2020-09-23 US US17/029,249 patent/US11224601B1/en active Active
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2021
- 2021-01-15 AU AU2021200233A patent/AU2021200233A1/en not_active Abandoned
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