MA50033A - Composés macrocycliques permettant d'inhiber la protéine mcl-1 - Google Patents
Composés macrocycliques permettant d'inhiber la protéine mcl-1Info
- Publication number
- MA50033A MA50033A MA050033A MA50033A MA50033A MA 50033 A MA50033 A MA 50033A MA 050033 A MA050033 A MA 050033A MA 50033 A MA50033 A MA 50033A MA 50033 A MA50033 A MA 50033A
- Authority
- MA
- Morocco
- Prior art keywords
- protein
- macrocyclic compounds
- inhibit mcl
- mcl
- inhibit
- Prior art date
Links
- 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 title 1
- 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 title 1
- 150000002678 macrocyclic compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762551718P | 2017-08-29 | 2017-08-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA50033A true MA50033A (fr) | 2020-07-08 |
Family
ID=63528919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA050033A MA50033A (fr) | 2017-08-29 | 2018-08-27 | Composés macrocycliques permettant d'inhiber la protéine mcl-1 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US11279712B2 (fr) |
| EP (1) | EP3676270A1 (fr) |
| MA (1) | MA50033A (fr) |
| WO (1) | WO2019046150A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6453507B2 (ja) | 2017-03-30 | 2019-01-16 | アムジエン・インコーポレーテツド | Ｍｃｌ−１タンパク質を阻害する化合物 |
| EP3668878B1 (fr) | 2017-08-18 | 2025-05-21 | Amgen Inc. | Composés inhibant la protéine mcl-1 |
| US11274105B2 (en) | 2018-03-05 | 2022-03-15 | Amgen Inc. | Alpha-hydroxy phenylacetic acid pharmacophore or bioisostere Mcl-1 protein antagonists |
| PE20210004A1 (es) | 2018-05-14 | 2021-01-05 | Gilead Sciences Inc | Inhibidores de mcl-1 |
| TWI745836B (zh) | 2019-01-18 | 2021-11-11 | 大陸商蘇州亞盛藥業有限公司 | 作為mcl-1抑製劑的大螺環醚 |
| ES2987630T3 (es) | 2019-07-09 | 2024-11-15 | Janssen Pharmaceutica Nv | Derivados de espirociclos macrocíclicos como inhibidores de MCL-1 |
| TWI778443B (zh) | 2019-11-12 | 2022-09-21 | 美商基利科學股份有限公司 | Mcl1抑制劑 |
| AU2020391106B2 (en) | 2019-11-26 | 2024-03-21 | Gilead Sciences, Inc. | Processes and intermediates for preparing MCL1 inhibitors |
| US20230219906A1 (en) | 2020-06-10 | 2023-07-13 | Janssen Pharmaceutica Nv | Macrocyclic-2-amino-3-fluoro-but-3-enamides as inhibitors of mcl-1 |
| CA3201943A1 (fr) | 2020-11-19 | 2022-05-27 | Gilead Sciences, Inc. | Procedes et intermediaires pour la preparation d'inhibiteurs de mcl1 macrocycliques |
| CA3200704A1 (fr) | 2020-12-17 | 2023-06-23 | Meng-Yang HSIAO | 3-fluoro-but-3-enamides ramifies macrocycliques utilises comme inhibiteurs de mcl-1 |
| BR112023020877A2 (pt) | 2021-04-26 | 2023-12-12 | Janssen Pharmaceutica Nv | 2-aliltetra-hidrofuranos macrocíclicos como inibidores de mcl-1 |
| WO2022261310A1 (fr) | 2021-06-11 | 2022-12-15 | Gilead Sciences, Inc. | Inhibiteurs de mcl-1 en combinaison avec des conjugués anti-corps-médicament |
| EP4351564A1 (fr) | 2021-06-11 | 2024-04-17 | Gilead Sciences, Inc. | Inhibiteurs de mcl-1 en combinaison avec des agents anticancéreux |
| JP2024544570A (ja) | 2021-11-16 | 2024-12-03 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｍｃｌ－１阻害剤としての大環状２－アミノ－ブト－３－エナミド |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| US6042820A (en) | 1996-12-20 | 2000-03-28 | Connaught Laboratories Limited | Biodegradable copolymer containing α-hydroxy acid and α-amino acid units |
| US6472375B1 (en) | 1998-04-16 | 2002-10-29 | John Wayne Cancer Institute | DNA vaccine and methods for its use |
| JP5496877B2 (ja) | 2007-04-16 | 2014-05-21 | アッヴィ・インコーポレイテッド | ７−置換インドールＭｃｌ−１阻害薬 |
| EP2528893B1 (fr) | 2010-01-29 | 2018-10-10 | Dana-Farber Cancer Institute, Inc. | Petites molécules pour la modulation de mcl-1 et procédés de modulation de la mort cellulaire, la division cellulaire, la différenciation cellulaire et procédés de traitement de troubles |
| US9486422B2 (en) | 2011-10-06 | 2016-11-08 | The Regents Of The University Of Michigan | Small molecule inhibitors of Mcl-1 and the uses of thereof |
| ES2657649T3 (es) | 2012-03-29 | 2018-03-06 | The Regents Of The University Of Michigan | Inhibidores de Mcl-1 de molécula pequeña y sus usos |
| JO3474B1 (ar) | 2014-08-29 | 2020-07-05 | Amgen Inc | مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1 |
| US11306107B2 (en) * | 2016-02-25 | 2022-04-19 | Amgen Inc. | Compounds that inhibit MCL-1 protein |
| JP6453507B2 (ja) | 2017-03-30 | 2019-01-16 | アムジエン・インコーポレーテツド | Ｍｃｌ−１タンパク質を阻害する化合物 |
| EP3668878B1 (fr) | 2017-08-18 | 2025-05-21 | Amgen Inc. | Composés inhibant la protéine mcl-1 |
| US11274105B2 (en) | 2018-03-05 | 2022-03-15 | Amgen Inc. | Alpha-hydroxy phenylacetic acid pharmacophore or bioisostere Mcl-1 protein antagonists |
-
2018
- 2018-08-27 MA MA050033A patent/MA50033A/fr unknown
- 2018-08-27 EP EP18766453.7A patent/EP3676270A1/fr active Pending
- 2018-08-27 WO PCT/US2018/048058 patent/WO2019046150A1/fr not_active Ceased
- 2018-08-27 US US16/642,441 patent/US11279712B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3676270A1 (fr) | 2020-07-08 |
| US11279712B2 (en) | 2022-03-22 |
| WO2019046150A1 (fr) | 2019-03-07 |
| US20200247821A1 (en) | 2020-08-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA50033A (fr) | Composés macrocycliques permettant d'inhiber la protéine mcl-1 | |
| FI3601297T3 (fi) | Mcl-1-proteiinia estäviä yhdisteitä | |
| PL3761790T3 (pl) | Pikolinoamidy jako fungicydy | |
| LT3810602T (lt) | Junginiai | |
| EP3692489A4 (fr) | Chaîne de blocs à l'épreuve des attaques quantiques | |
| EP3592149A4 (fr) | Combinaisons fongicides | |
| MA49908A (fr) | Composés inhibant la protéine mcl-1 | |
| EP3609871A4 (fr) | Composés d'amide aryl cyclopropyl-amino-isoquinolinyl | |
| DK3612519T3 (da) | Phenyl-2-hydroxy-acetylamino-2-methyl-phenyl forbindelser | |
| EP3773566A4 (fr) | Composés ox2r | |
| IL279620B1 (en) | Compounds | |
| EP3758510A4 (fr) | Ingrédient | |
| EP3614845A4 (fr) | Combinaisons fongicides | |
| LT3867247T (lt) | Naujieji junginiai | |
| EP3444345A4 (fr) | Dérivé d'arnmicro-143 | |
| DK3672941T3 (da) | Pyridylpyridonforbindelser | |
| DK3445766T3 (da) | Ny antimikrobiel forbindelse | |
| HUE056928T2 (hu) | Új vegyületek | |
| DK3672962T3 (da) | Morpholinylpyridonforbindelser | |
| EP3428104C0 (fr) | Fauteuil monte-escalier | |
| EP3575284A4 (fr) | Composé de prolineamide substitué par un phényldifluorométhyle | |
| EP3410854A4 (fr) | Composition microbicide | |
| LT3898613T (lt) | Priešvėžiniai junginiai | |
| PL3867333T3 (pl) | Dipodstawione związki diaryloksybenzoheterodiazolowe | |
| LT3668853T (lt) | Nauji junginiai |