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DK3612519T3 - Phenyl-2-hydroxy-acetylamino-2-methyl-phenyl forbindelser - Google Patents

Phenyl-2-hydroxy-acetylamino-2-methyl-phenyl forbindelser Download PDF

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Publication number
DK3612519T3
DK3612519T3 DK18718570.7T DK18718570T DK3612519T3 DK 3612519 T3 DK3612519 T3 DK 3612519T3 DK 18718570 T DK18718570 T DK 18718570T DK 3612519 T3 DK3612519 T3 DK 3612519T3
Authority
DK
Denmark
Prior art keywords
phenyl
acetylamino
hydroxy
methyl
compounds
Prior art date
Application number
DK18718570.7T
Other languages
English (en)
Inventor
Marta Maria Cifuentes-Garcia
Maria Cristina Garcia-Paredes
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK3612519T3 publication Critical patent/DK3612519T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK18718570.7T 2017-04-18 2018-04-11 Phenyl-2-hydroxy-acetylamino-2-methyl-phenyl forbindelser DK3612519T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17382207 2017-04-18
PCT/US2018/027005 WO2018194885A1 (en) 2017-04-18 2018-04-11 Phenyl-2-hydroxy-acetylamino-2-methyl-phenyl compounds

Publications (1)

Publication Number Publication Date
DK3612519T3 true DK3612519T3 (da) 2022-03-07

Family

ID=58606227

Family Applications (2)

Application Number Title Priority Date Filing Date
DK18718570.7T DK3612519T3 (da) 2017-04-18 2018-04-11 Phenyl-2-hydroxy-acetylamino-2-methyl-phenyl forbindelser
DK21211015.9T DK4039675T3 (da) 2017-04-18 2018-04-11 Phenyl-2-hydroxy-acetylamino-2-methyl-phenyl forbindelser

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK21211015.9T DK4039675T3 (da) 2017-04-18 2018-04-11 Phenyl-2-hydroxy-acetylamino-2-methyl-phenyl forbindelser

Country Status (31)

Country Link
US (2) US11655214B2 (da)
EP (2) EP3612519B1 (da)
JP (2) JP7110232B2 (da)
KR (2) KR20230129627A (da)
CN (2) CN110831927B (da)
AU (2) AU2018255191B2 (da)
BR (1) BR112019021867A2 (da)
CA (1) CA3060564A1 (da)
CO (1) CO2019012767A2 (da)
CR (1) CR20190519A (da)
CY (1) CY1125150T1 (da)
DK (2) DK3612519T3 (da)
ES (2) ES2906847T3 (da)
FI (1) FI4039675T3 (da)
HR (2) HRP20220263T1 (da)
HU (2) HUE068023T2 (da)
IL (2) IL270005B (da)
LT (2) LT3612519T (da)
MX (2) MX389724B (da)
MY (1) MY199442A (da)
NZ (1) NZ758291A (da)
PH (1) PH12019502363B1 (da)
PL (2) PL4039675T3 (da)
PT (2) PT3612519T (da)
RS (2) RS65914B1 (da)
SA (1) SA519410320B1 (da)
SG (1) SG11201909680UA (da)
SI (2) SI3612519T1 (da)
SM (2) SMT202400357T1 (da)
WO (1) WO2018194885A1 (da)
ZA (1) ZA201906811B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230129627A (ko) * 2017-04-18 2023-09-08 일라이 릴리 앤드 캄파니 페닐-2-히드록시-아세틸아미노-2-메틸-페닐 화합물
AU2019243443B2 (en) * 2018-03-26 2025-05-22 Icahn School Of Medicine At Mount Sinai Methods of treating minimal residual cancer
US12331054B2 (en) 2019-08-29 2025-06-17 Hibercell, Inc. Perk inhibiting imidazolopyrazine compounds
US20220348584A1 (en) 2019-08-29 2022-11-03 Hibercell, Inc. Perk inhibiting indolinyl compounds
CN114585606A (zh) * 2019-08-29 2022-06-03 希伯塞尔股份有限公司 抑制perk的化合物
KR20220066290A (ko) * 2019-08-29 2022-05-24 히버셀, 인크. Perk 억제 피롤로피리미딘 화합물
WO2021231782A1 (en) * 2020-05-13 2021-11-18 Hibercell, Inc. Perk inhibitors for treating viral infections
WO2021231788A1 (en) * 2020-05-13 2021-11-18 Hibercell, Inc. Perk inhibiting pyrrolopyrimidine compounds to treat viral infections
CN113234029B (zh) * 2021-05-25 2022-03-22 白银康寓信生物科技有限公司 一种2-氨基-3,5-二卤代吡嗪的合成方法
WO2024206890A1 (en) * 2023-03-30 2024-10-03 Hibercell, Inc. Crystalline forms of (r)-2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-n-isopropylnicotinamide and methods for using the same

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2283961A1 (en) 1997-03-19 1998-09-24 Basf Aktiengesellschaft Pyrrolo[2,3d]pyrimidines and their use as tyrosine kinase inhibitors
US7863444B2 (en) 1997-03-19 2011-01-04 Abbott Laboratories 4-aminopyrrolopyrimidines as kinase inhibitors
TW200306819A (en) * 2002-01-25 2003-12-01 Vertex Pharma Indazole compounds useful as protein kinase inhibitors
WO2003093297A2 (en) 2002-05-03 2003-11-13 Exelixis, Inc. Protein kinase modulators and methods of use
UA84156C2 (ru) 2003-07-23 2008-09-25 Байер Фармасьютикалс Корпорейшн Фторозамещённая омега-карбоксиарилдифенилмочевина для лечения и профилактики болезней и состояний
PE20070335A1 (es) * 2005-08-30 2007-04-21 Novartis Ag Benzimidazoles sustituidos y metodos para su preparacion
CA2620818A1 (en) * 2005-09-02 2007-03-08 Astellas Pharma Inc. Amide derivatives as rock inhibitors
CN103399144B (zh) 2008-02-25 2015-10-28 雀巢产品技术援助有限公司 用抗体阵列选择乳腺癌治疗药物
WO2010080992A1 (en) 2009-01-09 2010-07-15 The Trustees Of The University Of Pennsylvania Regulators of the interferon-alpha receptor 1 (ifnar1) chain of the interferon receptor
BR112012024380A2 (pt) 2010-03-25 2015-09-15 Glaxosmithkline Llc compostos químicos
WO2014170706A1 (en) 2013-04-15 2014-10-23 Università Degli Studi Di Bari Galloyl benzamide-based compounds as jnk modulators
WO2015056180A1 (en) 2013-10-15 2015-04-23 Glaxosmithkline Intellectual Property (No.2) Limited Indoline derivatives as inhibitors of perk
US9586967B2 (en) 2013-11-08 2017-03-07 Ono Pharmaceutical Co., Ltd. Pyrrolo pyrimidine derivative
JP2017507967A (ja) * 2014-03-11 2017-03-23 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ Ｐｅｒｋ阻害剤として作用する化合物
WO2016004254A1 (en) 2014-07-01 2016-01-07 The Regents Of The University Of California Combined modulation of ire1
EA039885B1 (ru) 2014-11-14 2022-03-23 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Производные 6-амино-7-бицикло-7-деазапурина в качестве ингибиторов протеинкиназы
GB201508747D0 (en) 2015-05-21 2015-07-01 Univ Edinburgh Compounds
CA2994819A1 (en) * 2015-07-24 2017-02-02 Blueprint Medicines Corporation Compounds useful for treating disorders related to kit and pdgfr
CN109153680B (zh) 2016-07-07 2021-04-23 株式会社大熊制药 4-氨基吡唑并[3,4-d]嘧啶基氮杂双环衍生物及含其的药物组合物
BR112019001136A2 (pt) 2016-07-20 2019-04-30 Glaxosmithkline Ip Dev Ltd compostos químicos
CN106748989B (zh) 2016-11-14 2020-03-17 西安交通大学 一种具有抗肿瘤活性的二芳基脲类化合物及其制备方法和应用
EP3656382A1 (en) 2017-01-30 2020-05-27 Université de Liège Perk and ire-1a inhibitors against neurodevelopmental disorders
KR20230129627A (ko) 2017-04-18 2023-09-08 일라이 릴리 앤드 캄파니 페닐-2-히드록시-아세틸아미노-2-메틸-페닐 화합물
WO2019099564A1 (en) 2017-11-14 2019-05-23 Children's Medical Center Corporation Novel imidazopyrimidine compounds and uses thereof
EP3492454A1 (en) 2017-11-30 2019-06-05 Step Pharma S.A.S. Compounds
AU2019243443B2 (en) 2018-03-26 2025-05-22 Icahn School Of Medicine At Mount Sinai Methods of treating minimal residual cancer
AU2019297428C1 (en) 2018-07-06 2023-03-23 Gilead Sciences, Inc. Therapeutic heterocyclic compounds
US20220040183A1 (en) 2018-10-01 2022-02-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of inhibitors of stress granule formation for targeting the regulation of immune responses

Also Published As

Publication number Publication date
PH12019502363B1 (en) 2023-11-15
IL288822A (en) 2022-02-01
PT4039675T (pt) 2024-09-16
US20210114985A1 (en) 2021-04-22
AU2018255191A1 (en) 2019-11-07
IL288822B2 (en) 2023-06-01
SMT202400357T1 (it) 2024-11-15
EP3612519A1 (en) 2020-02-26
MY199442A (en) 2023-10-28
JP7331212B2 (ja) 2023-08-22
SA519410320B1 (ar) 2022-05-08
RU2019136694A (ru) 2021-05-18
LT3612519T (lt) 2022-03-25
SMT202200100T1 (it) 2022-03-21
KR20190140966A (ko) 2019-12-20
ES2988739T3 (es) 2024-11-21
HRP20241188T1 (hr) 2024-12-06
IL270005B (en) 2022-01-01
CN110831927A (zh) 2020-02-21
RS65914B1 (sr) 2024-10-31
PT3612519T (pt) 2022-02-22
CO2019012767A2 (es) 2020-04-01
CY1125150T1 (el) 2023-06-09
EP3612519B1 (en) 2021-12-01
US20230373922A1 (en) 2023-11-23
NZ758291A (en) 2025-11-28
LT4039675T (lt) 2024-10-10
CN117510405A (zh) 2024-02-06
HRP20220263T1 (hr) 2022-04-29
AU2018255191B2 (en) 2022-04-21
SI4039675T1 (sl) 2024-10-30
CA3060564A1 (en) 2018-10-25
AU2022206702A1 (en) 2022-08-11
PH12019502363A1 (en) 2020-12-07
MX2019012428A (es) 2022-01-28
ZA201906811B (en) 2021-01-27
AU2022206702B2 (en) 2024-04-11
ES2906847T3 (es) 2022-04-20
KR20230129627A (ko) 2023-09-08
HUE057745T2 (hu) 2022-06-28
MX389724B (es) 2025-03-20
RU2019136694A3 (da) 2021-05-19
EP4039675A1 (en) 2022-08-10
KR102575246B1 (ko) 2023-09-06
EP4039675B1 (en) 2024-06-12
BR112019021867A2 (pt) 2020-05-26
JP7110232B2 (ja) 2022-08-01
US11655214B2 (en) 2023-05-23
JP2022141835A (ja) 2022-09-29
SI3612519T1 (sl) 2022-04-29
SG11201909680UA (en) 2019-11-28
PL4039675T3 (pl) 2025-01-07
JP2021517555A (ja) 2021-07-26
PL3612519T3 (pl) 2022-05-02
CN110831927B (zh) 2023-07-14
WO2018194885A1 (en) 2018-10-25
MX2022001310A (es) 2022-03-02
HUE068023T2 (hu) 2024-12-28
DK4039675T3 (da) 2024-09-02
CR20190519A (es) 2020-03-06
RS62933B1 (sr) 2022-03-31
FI4039675T3 (fi) 2024-09-10

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