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CL2019001537A1 - New T-cell receptors and immune therapy that uses them. - Google Patents

New T-cell receptors and immune therapy that uses them.

Info

Publication number
CL2019001537A1
CL2019001537A1 CL2019001537A CL2019001537A CL2019001537A1 CL 2019001537 A1 CL2019001537 A1 CL 2019001537A1 CL 2019001537 A CL2019001537 A CL 2019001537A CL 2019001537 A CL2019001537 A CL 2019001537A CL 2019001537 A1 CL2019001537 A1 CL 2019001537A1
Authority
CL
Chile
Prior art keywords
constructions
taa
cell receptors
antigen recognition
recognition
Prior art date
Application number
CL2019001537A
Other languages
Spanish (es)
Inventor
Claudia Wagner
Dominik Maurer
Leonie Alten
Sebastian Bunk
Original Assignee
Immatics Biotechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102016123859.7A external-priority patent/DE102016123859B3/en
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of CL2019001537A1 publication Critical patent/CL2019001537A1/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCIÓN SE RELACIONA CON CONSTRUCCIONES DE RECONOCIMIENTO DE ANTÍGENO CONTRA UN ANTÍGENO ASOCIADO A TUMOR (TAA) DERIVADO DE LA PROTEÍNA BLANCO 2 SIMILAR AL FACTOR 4 ASOCIADO CON DDB1 Y CUL4 (DCAF4L2). LA INVENCIÓN EN PARTICULAR PROVEE NUEVAS MOLÉCULAS BASADAS EN RECEPTORES DE CÉLULAS T (TCR) QUE SON SELECTIVAS Y ESPECIFICAS POR EL TAA DE LA INVENCIÓN. LOS TCR DE LA INVENCIÓN, Y LOS FRAGMENTOS DE UNIÓN A TAA DERIVADOS DE LOS MISMOS, SON ÚTILES PARA EL DIAGNÓSTICO, TRATAMIENTO Y PREVENCIÓN DE ENFERMEDADES CANCEROSAS QUE EXPRESAN TAA. ADEMÁS SE PROVEEN ÁCIDOS NUCLEICOS QUE CODIFICAN PARA LAS CONSTRUCCIONES DE RECONOCIMIENTO DE ANTÍGENO DE LA INVENCIÓN, VECTORES QUE COMPRENDEN ESTOS ÁCIDOS NUCLEICOS, CÉLULAS RECOMBINANTES QUE EXPRESAN LAS CONSTRUCCIONES DE RECONOCIMIENTO DE ANTÍGENO Y COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN LOS COMPUESTOS DE LA INVENCIÓN.THE PRESENT INVENTION IS RELATED TO ANTIGEN RECOGNITION CONSTRUCTIONS AGAINST A TUMOR-ASSOCIATED ANTIGEN (TAA) DERIVED FROM WHITE PROTEIN 2 SIMILAR TO FACTOR 4 ASSOCIATED WITH DDB1 AND CUL4 (DCAF4L2). THE INVENTION IN PARTICULAR PROVIDES NEW MOLECULES BASED ON T-CELL RECEPTORS (TCR) THAT ARE SELECTIVE AND SPECIFIC BY THE TAA OF THE INVENTION. THE TCRs OF THE INVENTION, AND THE TAA BINDING FRAGMENTS DERIVED THEREOF, ARE USEFUL FOR THE DIAGNOSIS, TREATMENT AND PREVENTION OF CANCER DISEASES THAT EXPRESS TAA. IN ADDITION, NUCLEIC ACIDS ARE PROVIDED THAT CODE FOR THE ANTIGEN RECOGNITION CONSTRUCTIONS OF THE INVENTION, VECTORS THAT INCLUDE THESE NUCLEIC ACIDS, RECOMBINANT CELLS THAT EXPRESS THE CONSTRUCTIONS OF CONSTRUCTION OF THE RECOGNITION OF ANTIGEN RECOGNITION AND COMPOSITION CONSTRUCTIONS.

CL2019001537A 2016-12-08 2019-06-05 New T-cell receptors and immune therapy that uses them. CL2019001537A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662431580P 2016-12-08 2016-12-08
DE102016123859.7A DE102016123859B3 (en) 2016-12-08 2016-12-08 New T cell receptors and their use in immunotherapy

Publications (1)

Publication Number Publication Date
CL2019001537A1 true CL2019001537A1 (en) 2019-10-11

Family

ID=67874111

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019001537A CL2019001537A1 (en) 2016-12-08 2019-06-05 New T-cell receptors and immune therapy that uses them.

Country Status (6)

Country Link
CL (1) CL2019001537A1 (en)
CO (1) CO2019006926A2 (en)
IL (1) IL267131A (en)
MY (1) MY196025A (en)
NZ (1) NZ754366A (en)
PH (1) PH12019501263A1 (en)

Also Published As

Publication number Publication date
CO2019006926A2 (en) 2019-09-18
MY196025A (en) 2023-03-07
IL267131A (en) 2019-08-29
NZ754366A (en) 2022-02-25
PH12019501263A1 (en) 2020-01-20

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