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CL2018000533A1 - Compuestos antibacterianos 1,2–dihidro–3h–pirrolo[1,2–c]imidazol–3–ona sustituidos - Google Patents

Compuestos antibacterianos 1,2–dihidro–3h–pirrolo[1,2–c]imidazol–3–ona sustituidos

Info

Publication number
CL2018000533A1
CL2018000533A1 CL2018000533A CL2018000533A CL2018000533A1 CL 2018000533 A1 CL2018000533 A1 CL 2018000533A1 CL 2018000533 A CL2018000533 A CL 2018000533A CL 2018000533 A CL2018000533 A CL 2018000533A CL 2018000533 A1 CL2018000533 A1 CL 2018000533A1
Authority
CL
Chile
Prior art keywords
pyrrolo
dihydro
imidazole
substituted
antibacterial compounds
Prior art date
Application number
CL2018000533A
Other languages
English (en)
Inventor
Philippe Panchaud
Jean-Philippe Surivet
Anne-Catherine Blumstein
Gaelle Mathieu
Loic Jacob
Florence Masse
Azely Mirre
Christine Schmitt
Jean-Luc Specklin
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of CL2018000533A1 publication Critical patent/CL2018000533A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

<p>La invención se refiere a compuestos antibacterianos de fórmula I I donde M es uno de los grupos MA, MB y MC que se representa debajo MA MB MC donde R1, MA, MB y MC son tal como se definió en la memoria descriptiva; y a sus sales.</p>
CL2018000533A 2015-09-03 2018-02-28 Compuestos antibacterianos 1,2–dihidro–3h–pirrolo[1,2–c]imidazol–3–ona sustituidos CL2018000533A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP2015070144 2015-09-03

Publications (1)

Publication Number Publication Date
CL2018000533A1 true CL2018000533A1 (es) 2018-06-29

Family

ID=56852279

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2018000533A CL2018000533A1 (es) 2015-09-03 2018-02-28 Compuestos antibacterianos 1,2–dihidro–3h–pirrolo[1,2–c]imidazol–3–ona sustituidos

Country Status (17)

Country Link
US (1) US10314823B2 (es)
EP (1) EP3344630B1 (es)
JP (1) JP2018526391A (es)
KR (1) KR20180049017A (es)
CN (1) CN108137596A (es)
AR (1) AR105889A1 (es)
AU (1) AU2016313794B2 (es)
BR (1) BR112018004343A2 (es)
CA (1) CA2994996A1 (es)
CL (1) CL2018000533A1 (es)
EA (1) EA201890626A1 (es)
HK (1) HK1256614A1 (es)
IL (1) IL257757A (es)
MX (1) MX2018002644A (es)
PH (1) PH12018500323A1 (es)
TW (1) TW201714885A (es)
WO (1) WO2017037221A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR099612A1 (es) 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
AR105646A1 (es) 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
TW201840569A (zh) * 2017-03-01 2018-11-16 瑞士商愛杜西亞製藥有限公司 (2r)-n-羥基-4-(6-((1-(2-羥基乙基)氮雜環丁烷-3-基)丁-1,3-二炔-1-基)-3-氧基-1h-吡咯并[1,2-c]咪唑-2(3h)-基)-2-甲基-2-(甲磺醯基)丁醯胺之結晶形式
WO2018224455A1 (en) 2017-06-07 2018-12-13 Basf Se Substituted cyclopropyl derivatives
WO2019038362A1 (en) 2017-08-24 2019-02-28 Idorsia Pharmaceuticals Ltd ANTIBACTERIAL PYRROLOIMIDAZOLONES
WO2019086452A1 (en) 2017-10-31 2019-05-09 Idorsia Pharmaceuticals Ltd Antibacterial heteroaromatic compounds
WO2019121143A1 (en) 2017-12-20 2019-06-27 Basf Se Substituted cyclopropyl derivatives
JP7156199B2 (ja) * 2018-08-09 2022-10-19 信越化学工業株式会社 レジスト材料及びパターン形成方法
KR20220034739A (ko) 2019-05-31 2022-03-18 이케나 온콜로지, 인코포레이티드 Tead 억제제 및 이의 용도
KR20220030222A (ko) 2019-05-31 2022-03-10 이케나 온콜로지, 인코포레이티드 Tead 억제제 및 이의 용도
CA3157279A1 (en) * 2019-11-21 2021-05-27 Paul Richard Sebahar Trpv4 receptor ligands

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2478374C (en) 2002-03-13 2009-01-06 Eli M. Wallace N3 alkylated benzimidazole derivatives as mek inhibitors
UA80500C2 (en) 2003-10-17 2007-09-25 Basf Ag Fungicidal mixture and agent for controlling rice pathogens, containing triazolopyrimidine derivative and metalaxyl-m, method for controlling rice pathogens and sowing material
DE102008044132A1 (de) 2008-11-27 2010-06-02 BSH Bosch und Siemens Hausgeräte GmbH Kältegerät mit zweiseitig anschlagbarer Tür
CA2774250C (en) 2009-10-13 2013-12-17 Pfizer Inc. C-linked hydroxamic acid derivatives useful as antibacterial agents
PL2512474T3 (pl) 2009-12-16 2015-03-31 Pfizer N-przyłączone pochodne kwasu hydroksamowego użyteczne jako środki przeciwbakteryjne
JP2014501274A (ja) 2011-01-03 2014-01-20 ハンミ ファーム． シーオー．， エルティーディー． Ｇタンパク質共役受容体調節のための新規な二環式化合物
AP3336A (en) 2011-03-07 2015-07-31 Pfizer Fluoro-pyridinone derivatives useful as antibacterial agents
SG193458A1 (en) 2011-04-08 2013-10-30 Pfizer Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents
CN103717582B (zh) 2011-04-08 2015-09-30 辉瑞大药厂 用作抗菌剂的异*唑衍生物
WO2013170165A1 (en) 2012-05-10 2013-11-14 Achaogen, Inc. Antibacterial agents
CA2891569A1 (en) 2012-11-16 2014-05-22 Bristol-Myers Squibb Company Pyrrolidine gpr40 modulators
WO2014165075A1 (en) 2013-03-12 2014-10-09 Achaogen, Inc. Antibacterial agents
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
WO2015066413A1 (en) 2013-11-01 2015-05-07 Novartis Ag Oxazolidinone hydroxamic acid compounds for the treatment of bacterial infections
TR201807881T4 (tr) 2013-12-19 2018-06-21 Idorsia Pharmaceuticals Ltd Antibakteriyel 1h-ındazol ve 1h-ındol türevleri.
AR099612A1 (es) * 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
JP2017515906A (ja) 2014-05-16 2017-06-15 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 抗菌性キナゾロン−４（３ｈ）−オン誘導体
KR20170086079A (ko) 2014-11-19 2017-07-25 액테리온 파마슈티칼 리미티드 항균성 벤조티아졸 유도체
AR105646A1 (es) * 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
US20190031676A1 (en) 2015-08-28 2019-01-31 Idorsia Pharmaceuticals Ltd Antibacterial annulated pyrrolidin-2-one derivatives
AR105848A1 (es) 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
RU2018124788A (ru) 2015-12-08 2020-01-15 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Замещенные бензазиноны в качестве антибактериальных соединений
AR108488A1 (es) 2016-05-17 2018-08-22 Idorsia Pharmaceuticals Ltd Derivados 6-(buta-1,3-diin-1-il)benzo[d]tiazol

Also Published As

Publication number Publication date
US10314823B2 (en) 2019-06-11
CA2994996A1 (en) 2017-03-09
WO2017037221A1 (en) 2017-03-09
MX2018002644A (es) 2018-06-20
TW201714885A (zh) 2017-05-01
PH12018500323A1 (en) 2018-08-13
BR112018004343A2 (pt) 2018-09-25
KR20180049017A (ko) 2018-05-10
IL257757A (en) 2018-04-30
AU2016313794B2 (en) 2020-06-04
EP3344630B1 (en) 2020-12-09
AU2016313794A1 (en) 2018-04-19
US20180250273A1 (en) 2018-09-06
EA201890626A1 (ru) 2018-09-28
EP3344630A1 (en) 2018-07-11
CN108137596A (zh) 2018-06-08
JP2018526391A (ja) 2018-09-13
AR105889A1 (es) 2017-11-22
HK1256614A1 (zh) 2019-09-27

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