AR108488A1 - Derivados 6-(buta-1,3-diin-1-il)benzo[d]tiazol - Google Patents
Derivados 6-(buta-1,3-diin-1-il)benzo[d]tiazolInfo
- Publication number
- AR108488A1 AR108488A1 ARP170101299A ARP170101299A AR108488A1 AR 108488 A1 AR108488 A1 AR 108488A1 AR P170101299 A ARP170101299 A AR P170101299A AR P170101299 A ARP170101299 A AR P170101299A AR 108488 A1 AR108488 A1 AR 108488A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydroxyalkyl
- haloalkyl
- phosphonooxy
- hydroxy
- Prior art date
Links
- -1 (4-hydroxypiperidin-1-yl) carbonyloxymethyl Chemical group 0.000 abstract 20
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 15
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 12
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 abstract 8
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000006299 oxetan-3-yl group Chemical group [H]C1([H])OC([H])([H])C1([H])* 0.000 abstract 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 229910018828 PO3H2 Inorganic materials 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 101150080168 XA21 gene Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Reivindicación 1: Un compuesto de fórmula (1), donde M es el grupo (4-hidroxipiperidin-1-il)carboniloximetilo, (3-hidroxiazetidin-1-il)carboniloximetilo o 1-(metilamino)ciclopropilo, o M representa uno de los grupos MA, MB, MC, MD, ME y MF que se representa en el grupo de fórmulas (2), donde XA¹ representa metil-d, metil-d2, alquilo C₁₋₄, w-haloalquilo C₂₋₃, w-hidroxialquilo C₂₋₄, 2,3-dihidroxiprop-1-ilo, 3-hidroxi-2-(hidroximetil)prop-1-ilo, oxetan-3-ilo, (oxetan-3-il)metilo, tietan-3-ilo, 1,1-dioxidotietan-3-ilo, cicloalquilo C₃₋₆, 3-hidroxiciclobut-1-ilo, 3-(w-hidroxialquil C₁₋₃)ciclobut-1-ilo, tetrahidropiran-4-ilo, cicloalquil C₃₋₆alquilo C₁₋₃ o w-fosfonooxi-alquilo C₂₋₄; XA²¹ y XA²² cada uno independientemente representa H, alquilo C₁₋₄, haloalquil C₁₋₃ o hidroxialquilo C₁₋₃; XA³ representa H, alquilo C₁₋₃ o halógeno; XB¹ representa alquilo C₁₋₄, w-hidroxialquilo C₂₋₃, cicloalquilo C₃₋₆, oxetan-3-ilo o tetrahidropiran-4-ilo; XB²¹ y XB²² cada uno independientemente representa H, alquilo C₁₋₄, haloalquilo C₁₋₃ o hidroxialquilo C₁₋₃; XB³¹ y XB³² cada uno independientemente representa H, halógeno, hidroxi, alquilo C₁₋₄, haloalquilo C₁₋₃ o hidroxialquilo C₁₋₃; XB⁴ representa H, halógeno, hidroxi o alquilo C₁₋₃; XC¹ representa H, alquilo C₁₋₄, cicloalquilo C₃₋₆, w-hidroxialquilo C₂₋₃, oxetan-3-ilo o tetrahidropiran-4-ilo; XC² representa H, alquilo C₁₋₄, haloalquilo C₁₋₃ o hidroxialquilo C₁₋₃; XC³ representa H, halógeno (especialmente flúor), hidroxi, alquilo C₁₋₄, haloalquilo C₁₋₃ o hidroxialquilo C₁₋₃; XC⁴ representa H, alquilo C₁₋₃, halógeno o hidroxi; XD¹ representa H, alquilo C₁₋₄, w-haloalquilo C₂₋₃ o w-hidroxialquilo C₂₋₄; XD² y XD³ cada uno independientemente representa H, alquilo C₁₋₄, haloalquilo C₁₋₃ o hidroxialquilo C₁₋₃; XE¹ representa H, alquilo C₁₋₄, haloalquilo C₁₋₃, 1,2-dihidroxietilo o hidroxialquilo C₁₋₃; XF¹ representa H, alquilo C₁₋₄, haloalquilo C₁₋₃, 1,2-dihidroxietilo o hidroxialquilo C₁₋₃; y uno de V o W representa -O-, -CH(OH)- o -CH₂-, y el otro representa -CH₂-; R¹ representa H, PO₃H₂, SO₃H, fosfonooximetilo o el grupo L que se representa en la fórmula (3), donde R² representa alquilamino C₁₋₄alquilo C₁₋₄, [dialquilamino C₁₋₄]alquilo C₁₋₄, fosfonooxi-alquilo C₁₋₄, fosfonooximetoxi, 2-(fosfonooxi-alquil C₁₋₄)-fenilo, (2-(fosfonooxi)-fenil)-alquil C₁₋₄ (especialmente 2-(2-(fosfonooxi)-fenil)-etil) o [2-(fosfonooxi-alquil C₁₋₄)-fenil]-alquilo C₁₋₄; o una sal del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2016061039 | 2016-05-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR108488A1 true AR108488A1 (es) | 2018-08-22 |
Family
ID=58772866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170101299A AR108488A1 (es) | 2016-05-17 | 2017-05-16 | Derivados 6-(buta-1,3-diin-1-il)benzo[d]tiazol |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20190315731A1 (es) |
| EP (1) | EP3458453A1 (es) |
| JP (1) | JP2019516723A (es) |
| KR (1) | KR20190009324A (es) |
| CN (1) | CN109153673A (es) |
| AR (1) | AR108488A1 (es) |
| AU (1) | AU2017267194A1 (es) |
| BR (1) | BR112018073580A2 (es) |
| CA (1) | CA3024756A1 (es) |
| EA (1) | EA201892585A1 (es) |
| MA (1) | MA45024A (es) |
| MX (1) | MX2018014170A (es) |
| TW (1) | TW201741308A (es) |
| WO (1) | WO2017198647A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR105646A1 (es) | 2015-08-11 | 2017-10-25 | Actelion Pharmaceuticals Ltd | Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida |
| AR105889A1 (es) | 2015-09-03 | 2017-11-22 | Actelion Pharmaceuticals Ltd | Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5671545B2 (ja) * | 2009-10-13 | 2015-02-18 | ファイザー・インク | 抗菌薬として有用なｃ結合ヒドロキサム酸誘導体 |
| CA2782453C (en) * | 2009-12-16 | 2015-11-24 | Matthew Frank Brown | N-linked hydroxamic acid derivatives useful as antibacterial agents |
| KR20130140164A (ko) * | 2011-04-08 | 2013-12-23 | 화이자 인코포레이티드 | 항박테리아제로서 유용한 이미다졸, 피라졸 및 트라이아졸 유도체 |
| AR097617A1 (es) * | 2013-09-13 | 2016-04-06 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos del 2h-indazol |
| MA39189A1 (fr) * | 2013-12-19 | 2017-06-30 | Actelion Pharmaceuticals Ltd | Dérivés de 1h-indazole et de 1h-indole antibactériens |
| TW201625569A (zh) * | 2014-11-19 | 2016-07-16 | 艾克泰聯製藥有限公司 | 抗菌性苯并噻唑衍生物 |
-
2017
- 2017-05-16 AU AU2017267194A patent/AU2017267194A1/en not_active Abandoned
- 2017-05-16 JP JP2018560624A patent/JP2019516723A/ja active Pending
- 2017-05-16 US US16/303,019 patent/US20190315731A1/en not_active Abandoned
- 2017-05-16 EP EP17725917.3A patent/EP3458453A1/en not_active Withdrawn
- 2017-05-16 KR KR1020187036143A patent/KR20190009324A/ko not_active Withdrawn
- 2017-05-16 EA EA201892585A patent/EA201892585A1/ru unknown
- 2017-05-16 MA MA045024A patent/MA45024A/fr unknown
- 2017-05-16 CN CN201780029420.4A patent/CN109153673A/zh active Pending
- 2017-05-16 TW TW106116180A patent/TW201741308A/zh unknown
- 2017-05-16 AR ARP170101299A patent/AR108488A1/es unknown
- 2017-05-16 MX MX2018014170A patent/MX2018014170A/es unknown
- 2017-05-16 BR BR112018073580-9A patent/BR112018073580A2/pt not_active Application Discontinuation
- 2017-05-16 CA CA3024756A patent/CA3024756A1/en not_active Abandoned
- 2017-05-16 WO PCT/EP2017/061689 patent/WO2017198647A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019516723A (ja) | 2019-06-20 |
| KR20190009324A (ko) | 2019-01-28 |
| BR112018073580A2 (pt) | 2019-03-19 |
| CN109153673A (zh) | 2019-01-04 |
| EP3458453A1 (en) | 2019-03-27 |
| EA201892585A1 (ru) | 2019-05-31 |
| MA45024A (fr) | 2019-03-27 |
| WO2017198647A1 (en) | 2017-11-23 |
| CA3024756A1 (en) | 2017-11-23 |
| TW201741308A (zh) | 2017-12-01 |
| AU2017267194A1 (en) | 2019-01-17 |
| US20190315731A1 (en) | 2019-10-17 |
| MX2018014170A (es) | 2019-03-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |