CL2017000839A1 - Espiroindolinas para el tratamiento y profilaxis de infección por virus respiratorio sincitial (rsv) - Google Patents
Espiroindolinas para el tratamiento y profilaxis de infección por virus respiratorio sincitial (rsv)Info
- Publication number
- CL2017000839A1 CL2017000839A1 CL2017000839A CL2017000839A CL2017000839A1 CL 2017000839 A1 CL2017000839 A1 CL 2017000839A1 CL 2017000839 A CL2017000839 A CL 2017000839A CL 2017000839 A CL2017000839 A CL 2017000839A CL 2017000839 A1 CL2017000839 A1 CL 2017000839A1
- Authority
- CL
- Chile
- Prior art keywords
- rsv
- spiroindolins
- prophylaxis
- treatment
- alkenyl
- Prior art date
Links
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 title abstract 2
- 238000011321 prophylaxis Methods 0.000 title 1
- 208000030925 respiratory syncytial virus infectious disease Diseases 0.000 title 1
- 238000011282 treatment Methods 0.000 title 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
<p>Fórmula de Benzimidazoles (I):</p> <p>* incluir figura de estructura pagina 274,escrito 13-04-2017</p> <p>Fórmula (I):Donde: - uno de X e Y es un átomo de N o un átomo de C sustituido, y el otro es CH; - L es un enlace sencillo, alquileno C2-3, alquenileno C2-3 o alquinileno C2-3; - R 1 es alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo de 3 a 10 miembros, heterocíclico de 5 a 10 miembros o heteroarilo de 5 a 12 miembros, cada uno de los cuales está no sustituido o sustituido; - Z es halo, haloalquilo C1-6, nitro, -CN, -N(R2 )2, -OR2 , -SR2 , -S(=O)R2 o -S(=O)2R 2 - cada R2 es independientemente hidrógeno, alquilo C1-6, alquenilo C2-6, alquinilo C2- 6, en el que dichos grupos alquilo, alquenilo y alquinilo están no sustituido o sustituidos; y - m es 0 o 1; Y la sal farmacéuticamente aceptable de los mismos son inhibidores de RSV y por tanto pueden usarse para tratar o prevenir una infección por RSV.</p>
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1417707.5A GB201417707D0 (en) | 2014-10-07 | 2014-10-07 | Pharmaceutical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2017000839A1 true CL2017000839A1 (es) | 2017-10-13 |
Family
ID=51946966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017000839A CL2017000839A1 (es) | 2014-10-07 | 2017-04-06 | Espiroindolinas para el tratamiento y profilaxis de infección por virus respiratorio sincitial (rsv) |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US10106539B2 (es) |
| EP (1) | EP3204375B1 (es) |
| JP (1) | JP6695334B2 (es) |
| KR (2) | KR20230116097A (es) |
| CN (1) | CN107108557B (es) |
| AR (1) | AR102181A1 (es) |
| AU (1) | AU2015329778B2 (es) |
| BR (1) | BR112017007311B1 (es) |
| CA (1) | CA2963740C (es) |
| CL (1) | CL2017000839A1 (es) |
| CO (1) | CO2017004603A2 (es) |
| CY (1) | CY1121564T1 (es) |
| DK (1) | DK3204375T3 (es) |
| ES (1) | ES2718976T3 (es) |
| GB (1) | GB201417707D0 (es) |
| HR (1) | HRP20190808T1 (es) |
| HU (1) | HUE043553T2 (es) |
| LT (1) | LT3204375T (es) |
| MX (1) | MX373233B (es) |
| NZ (1) | NZ731323A (es) |
| PE (1) | PE20170949A1 (es) |
| PL (1) | PL3204375T3 (es) |
| PT (1) | PT3204375T (es) |
| RS (1) | RS58706B1 (es) |
| RU (1) | RU2734248C2 (es) |
| SG (1) | SG11201702766YA (es) |
| SI (1) | SI3204375T1 (es) |
| SM (1) | SMT201900249T1 (es) |
| TR (1) | TR201903362T4 (es) |
| TW (1) | TWI718107B (es) |
| WO (1) | WO2016055780A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6548751B2 (ja) * | 2015-06-08 | 2019-07-24 | シャンドン ダンホン ファーマスーティカル カンパニー リミテッドＳｈａｎｄｏｎｇ Ｄａｎｈｏｎｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． | イミダゾール誘導体及びその中間体の製造及び結晶型 |
| SI3494110T1 (sl) * | 2016-08-04 | 2021-12-31 | ReViral Limited | Derivati pirimidina in njihova uporaba v zdravljenju ali preprečevanju okužbe z respiratornim sincicijskim virusom |
| GB201711704D0 (en) * | 2017-07-20 | 2017-09-06 | Reviral Ltd | Pharmaceutical compounds |
| GB201721812D0 (en) | 2017-12-22 | 2018-02-07 | Reviral Ltd | Pharmaceutical compounds |
| CN116077494A (zh) * | 2023-01-11 | 2023-05-09 | 黑龙江中医药大学 | 一种治疗呼吸道合胞病毒的药物组合物及其制备方法 |
| WO2024174953A1 (zh) * | 2023-02-21 | 2024-08-29 | 苏州隆博泰药业有限公司 | 苯并咪唑类衍生物及其医药用途 |
| WO2024252355A1 (en) | 2023-06-08 | 2024-12-12 | Pfizer Inc. | Pediatric dosing regimens comprising a fusion inhibitor for the treatment of rsv |
| WO2025120500A1 (en) | 2023-12-06 | 2025-06-12 | Pfizer Inc. | Benzodiazepine compounds as n-protein inhibitors |
| WO2025153942A1 (en) | 2024-01-16 | 2025-07-24 | Pfizer Inc. | Benzodiazepine pyrazolo carboxamides as n-protein inhibitors |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57102863A (en) * | 1980-12-16 | 1982-06-26 | Takeda Chem Ind Ltd | Spiroindolinone and its preparation |
| PL194216B1 (pl) * | 1998-01-23 | 2007-05-31 | Sankyo Co | Pochodne spiropiperydyny, lekarstwo oraz środek zapobiegawczy lub terapeutyczny zawierające jako składnik czynny te pochodne i zastosowanie pochodnych spiropiperydyny |
| AU779516B2 (en) * | 1999-06-28 | 2005-01-27 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
| US6774134B2 (en) | 2000-12-20 | 2004-08-10 | Bristol-Myers Squibb Company | Heterocyclic substituted 2-methyl-benzimidazole antiviral agents |
| US6919331B2 (en) | 2001-12-10 | 2005-07-19 | Bristol-Myers Squibb Company | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents |
| US7205328B2 (en) * | 2002-10-21 | 2007-04-17 | Irm Llc | Oxindoles with anti-HIV activity |
| JO2355B1 (en) | 2003-04-15 | 2006-12-12 | ميرك شارب اند دوم كوربوريشن | Hereditary calcitonin polypeptide receptor antagonists |
| US7390798B2 (en) | 2004-09-13 | 2008-06-24 | Merck & Co., Inc. | Carboxamide spirolactam CGRP receptor antagonists |
| CA2583536A1 (en) | 2004-10-13 | 2006-04-27 | Merck & Co., Inc. | Cgrp receptor antagonists |
| WO2010103306A1 (en) | 2009-03-10 | 2010-09-16 | Astrazeneca Uk Limited | Benzimidazole derivatives and their use as antivaral agents |
| GB201119538D0 (en) * | 2011-11-10 | 2011-12-21 | Viral Ltd | Pharmaceutical compounds |
| US9617289B2 (en) | 2012-10-16 | 2017-04-11 | Janssen Sciences Ireland Uc | RSV antiviral compounds |
| KR20160007629A (ko) * | 2013-05-14 | 2016-01-20 | 에프. 호프만-라 로슈 아게 | 호흡기 세포융합 바이러스 감염의 치료 및 예방을 위한 아자-옥소-인돌 |
| MX2015015691A (es) * | 2013-05-14 | 2016-03-04 | Hoffmann La Roche | Aza-oxo-indoles novedosos para el tratamiento y profilaxis de la infeccion del virus sincital respiratorio. |
| CN105392787B (zh) * | 2013-05-14 | 2017-11-24 | 豪夫迈·罗氏有限公司 | 用于治疗和预防呼吸道合胞病毒感染的氮杂‑氧代‑吲哚 |
| KR20160030271A (ko) * | 2013-08-12 | 2016-03-16 | 에프. 호프만-라 로슈 아게 | 호흡기 세포융합 바이러스 감염의 치료 및 예방을 위한 아자-옥소-인돌 |
| CN105408330A (zh) * | 2013-08-12 | 2016-03-16 | 豪夫迈·罗氏有限公司 | 新的用于治疗和预防呼吸道合胞病毒感染的氮杂-氧代-吲哚 |
| JP6211195B2 (ja) * | 2013-08-12 | 2017-10-11 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 呼吸器合胞体ウイルス感染症の処置および予防のための新規アザ−オキソ−インドール |
| KR20160030569A (ko) * | 2013-08-15 | 2016-03-18 | 에프. 호프만-라 로슈 아게 | 호흡기 세포융합 바이러스 감염의 치료 및 예방을 위한 신규한 아자-옥소-인돌 |
| HK1222855A1 (zh) * | 2013-08-15 | 2017-07-14 | F. Hoffmann-La Roche Ag | 新的用於治疗和预防呼吸道合胞病毒感染的氮杂-氧代-吲哚 |
| CN105431419A (zh) * | 2013-08-15 | 2016-03-23 | 豪夫迈·罗氏有限公司 | 新的用于治疗和预防呼吸道合胞病毒感染的氮杂-氧代-吲哚 |
-
2014
- 2014-10-07 GB GBGB1417707.5A patent/GB201417707D0/en not_active Ceased
-
2015
- 2015-10-06 DK DK15782033.3T patent/DK3204375T3/en active
- 2015-10-06 HU HUE15782033A patent/HUE043553T2/hu unknown
- 2015-10-06 US US15/517,290 patent/US10106539B2/en active Active
- 2015-10-06 SM SM20190249T patent/SMT201900249T1/it unknown
- 2015-10-06 CN CN201580066385.4A patent/CN107108557B/zh active Active
- 2015-10-06 CA CA2963740A patent/CA2963740C/en active Active
- 2015-10-06 PE PE2017000576A patent/PE20170949A1/es unknown
- 2015-10-06 ES ES15782033T patent/ES2718976T3/es active Active
- 2015-10-06 WO PCT/GB2015/052920 patent/WO2016055780A1/en not_active Ceased
- 2015-10-06 EP EP15782033.3A patent/EP3204375B1/en active Active
- 2015-10-06 AU AU2015329778A patent/AU2015329778B2/en active Active
- 2015-10-06 SG SG11201702766YA patent/SG11201702766YA/en unknown
- 2015-10-06 HR HRP20190808TT patent/HRP20190808T1/hr unknown
- 2015-10-06 SI SI201530634T patent/SI3204375T1/sl unknown
- 2015-10-06 NZ NZ731323A patent/NZ731323A/en unknown
- 2015-10-06 TR TR2019/03362T patent/TR201903362T4/tr unknown
- 2015-10-06 AR ARP150103215A patent/AR102181A1/es not_active Application Discontinuation
- 2015-10-06 MX MX2017004425A patent/MX373233B/es active IP Right Grant
- 2015-10-06 RS RS20190515A patent/RS58706B1/sr unknown
- 2015-10-06 KR KR1020237025697A patent/KR20230116097A/ko active Pending
- 2015-10-06 BR BR112017007311-0A patent/BR112017007311B1/pt active IP Right Grant
- 2015-10-06 LT LTEP15782033.3T patent/LT3204375T/lt unknown
- 2015-10-06 JP JP2017519320A patent/JP6695334B2/ja active Active
- 2015-10-06 RU RU2017113026A patent/RU2734248C2/ru active
- 2015-10-06 KR KR1020177012311A patent/KR102561796B1/ko active Active
- 2015-10-06 PL PL15782033T patent/PL3204375T3/pl unknown
- 2015-10-06 PT PT15782033T patent/PT3204375T/pt unknown
- 2015-10-07 TW TW104133092A patent/TWI718107B/zh active
-
2017
- 2017-04-06 CL CL2017000839A patent/CL2017000839A1/es unknown
- 2017-05-05 CO CONC2017/0004603A patent/CO2017004603A2/es unknown
-
2019
- 2019-04-11 CY CY20191100403T patent/CY1121564T1/el unknown
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