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CL2017000080A1 - Métodos para tratar el cáncer con inhibidores de tigit y agentes contra el cáncer - Google Patents

Métodos para tratar el cáncer con inhibidores de tigit y agentes contra el cáncer

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Publication number
CL2017000080A1
CL2017000080A1 CL2017000080A CL2017000080A CL2017000080A1 CL 2017000080 A1 CL2017000080 A1 CL 2017000080A1 CL 2017000080 A CL2017000080 A CL 2017000080A CL 2017000080 A CL2017000080 A CL 2017000080A CL 2017000080 A1 CL2017000080 A1 CL 2017000080A1
Authority
CL
Chile
Prior art keywords
methods
anticancer agents
treat cancer
tigit
tigit inhibitors
Prior art date
Application number
CL2017000080A
Other languages
English (en)
Inventor
Jane L Grogan
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55079055&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2017000080(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CL2017000080A1 publication Critical patent/CL2017000080A1/es

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Abstract

<p>LA PRESENTE DIVULGACIÓN PROVEE MÉTODOS QUE COMPRENDEN LA ADMINISTRACIÓN AL INDIVIDUO DE UNA CANTIDAD EFICAZ DE UN AGENTE QUE REDUCE O INHIBE LA ACTIVIDAD Y/O LA EXPRESIÓN DE TIGIT Y UN AGENTE CONTRA EL CÁNCER Y/O UNA TERAPIA CONTRA EL CÁNCER. TAMBIÉR SE PROVEEN KITS QUE COMPRENDEN UN AGENTE CONTRA EL CÁNCER, UN AGENTE QUE REDUCE O INHIBE LA ACTIVIDAD Y/O LA EXPRESIÓN DE TIGIT, O AMBAS, ASÍ COMO INSTRUCCIONES PARA SU USO.</p>
CL2017000080A 2014-07-16 2017-01-12 Métodos para tratar el cáncer con inhibidores de tigit y agentes contra el cáncer CL2017000080A1 (es)

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US201462025394P 2014-07-16 2014-07-16

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CL2017000080A1 true CL2017000080A1 (es) 2017-06-23

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CL2017000080A CL2017000080A1 (es) 2014-07-16 2017-01-12 Métodos para tratar el cáncer con inhibidores de tigit y agentes contra el cáncer

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11390678B2 (en) 2008-04-09 2022-07-19 Genentech, Inc. Compositions and methods for the treatment of immune related diseases

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2357505T3 (es) 2002-09-11 2011-04-27 Genentech, Inc. Composición y procedimientos novedosos para el tratamiento de enfermedades inmunorelacionadas.
HRP20190044T1 (hr) 2011-09-23 2019-02-22 Oncomed Pharmaceuticals, Inc. Agensi koji vežu vegf/dll4 i njihove uporabe
DK3021869T3 (da) 2013-07-16 2020-09-21 Hoffmann La Roche Fremgangsmåder til behandling af cancer ved anvendelse af PD-1-aksebindende antagonister og TIGIT-hæmmere
KR102050082B1 (ko) 2014-08-19 2019-11-29 머크 샤프 앤드 돔 코포레이션 항-tigit 항체
SG10202006538TA (en) 2014-12-23 2020-08-28 Bristol Myers Squibb Co Antibodies to tigit
CA2976926A1 (en) 2015-02-19 2016-08-25 Compugen Ltd. Anti-pvrig antibodies and methods of use
EP3283508B1 (en) 2015-04-17 2021-03-17 Alpine Immune Sciences, Inc. Immunomodulatory proteins with tunable affinities
TWI715587B (zh) 2015-05-28 2021-01-11 美商安可美德藥物股份有限公司 Tigit結合劑和彼之用途
US11371066B2 (en) 2015-07-13 2022-06-28 Modular Genetics, Inc. Generation of acyl alcohols
US10766957B2 (en) 2015-08-14 2020-09-08 Merck Sharp & Dohme Corp Anti-TIGIT antibodies
WO2017053705A1 (en) 2015-09-23 2017-03-30 Oncomed Pharmaceuticals, Inc. Methods and compositions for treatment of cancer
EP3353210B8 (en) 2015-09-25 2024-12-18 F. Hoffmann-La Roche AG Anti-tigit antibodies and methods of use
IL261188B (en) 2016-03-04 2022-08-01 Jn Biosciences Llc An anti-tigit antibody that binds to the tigit polypeptide on one or more amino acid residues
EP3443000B1 (en) 2016-04-15 2025-11-12 Alpine Immune Sciences, Inc. Cd80 variant immunomodulatory proteins and uses thereof
US11834490B2 (en) 2016-07-28 2023-12-05 Alpine Immune Sciences, Inc. CD112 variant immunomodulatory proteins and uses thereof
US11471488B2 (en) 2016-07-28 2022-10-18 Alpine Immune Sciences, Inc. CD155 variant immunomodulatory proteins and uses thereof
US11230596B2 (en) * 2016-11-30 2022-01-25 Mereo Biopharma 5, Inc. Methods for treatment of cancer comprising TIGIT-binding agents
US10759855B2 (en) 2016-12-02 2020-09-01 Rigel Pharmaceuticals, Inc. Antigen binding molecules to TIGIT
JP7249287B2 (ja) * 2017-03-31 2023-03-30 ザ・ボード・オブ・トラスティーズ・オブ・ザ・リーランド・スタンフォード・ジュニア・ユニバーシティ T細胞受容体シグナル伝達を阻害または調節することによって、t細胞枯渇を処置する方法
TW202402800A (zh) 2017-05-01 2024-01-16 美商艾吉納斯公司 抗tigit抗體類和使用彼等之方法
CN110799213A (zh) 2017-06-01 2020-02-14 康姆普根有限公司 三联组合抗体疗法
WO2018229163A1 (en) 2017-06-14 2018-12-20 King's College London Methods of activating v delta 2 negative gamma delta t cells
IL272227B2 (en) 2017-07-27 2025-09-01 iTeos Belgium SA Anti-tigit antibodies
KR102813968B1 (ko) 2017-10-10 2025-05-29 알파인 이뮨 사이언시즈, 인코포레이티드 Ctla-4 변이체 면역조절 단백질 및 이의 용도
TWI877769B (zh) 2017-12-30 2025-03-21 英屬開曼群島商百濟神州有限公司 抗tigit抗體及其作為治療和診斷的用途
EP3735417A1 (en) 2018-01-03 2020-11-11 Alpine Immune Sciences, Inc. Multi-domain immunomodulatory proteins and methods of use thereof
CN111601826B (zh) * 2018-01-15 2023-12-15 南京传奇生物科技有限公司 针对tigit的抗体及其变体
EP3568415B1 (en) 2018-02-06 2025-01-22 I-Mab Biopharma (Hangzhou) Co., Ltd. Antibodies to t cell immunoreceptor with ig and itim domains (tigit) and uses thereof
US20190247560A1 (en) 2018-02-13 2019-08-15 Gambro Lundia Ab Extracorporeal devices and methods of treating complement factor related diseases
AU2019233581B2 (en) 2018-03-13 2025-08-28 Cancer Research Technology Limited Anti-CD25 for tumour specific cell depletion
US20210024873A1 (en) 2018-03-27 2021-01-28 Bristol-Myers Squibb Company Real-time monitoring of protein concentration using ultraviolet signal
AU2019256539A1 (en) 2018-04-18 2020-11-26 Xencor, Inc. PD-1 targeted heterodimeric fusion proteins containing IL-15/IL-15Ra Fc-fusion proteins and PD-1 antigen binding domains and uses thereof
CA3097625A1 (en) 2018-04-18 2019-10-24 Xencor, Inc. Il-15/il-15ra heterodimeric fc fusion proteins and uses thereof
EP3823673A4 (en) 2018-07-20 2022-05-11 Surface Oncology, Inc. Anti-cd112r compositions and methods
AU2019324170A1 (en) 2018-08-23 2021-02-18 Seagen, Inc. Anti-TIGIT antibodies
SG11202103192RA (en) 2018-10-03 2021-04-29 Xencor Inc Il-12 heterodimeric fc-fusion proteins
CR20210239A (es) 2018-10-12 2021-12-15 Xencor Inc Proteínas de fusión de il-15/il-15ralfa-fc dirigidas a pd-1 y usos de las mismas en terapias combinadas
US11618776B2 (en) 2018-12-20 2023-04-04 Xencor, Inc. Targeted heterodimeric Fc fusion proteins containing IL-15/IL-15RA and NKG2D antigen binding domains
US20220135619A1 (en) 2019-02-24 2022-05-05 Bristol-Myers Squibb Company Methods of isolating a protein
WO2020176748A1 (en) * 2019-02-27 2020-09-03 Genentech, Inc. Dosing for treatment with anti-tigit and anti-cd20 or anti-cd38 antibodies
SG11202110261QA (en) * 2019-03-21 2021-10-28 Gamida Cell Ltd Expanded nk cell fractions for transplantation in combination therapy
KR20220012292A (ko) 2019-05-23 2022-02-03 브리스톨-마이어스 스큅 컴퍼니 세포 배양 배지를 모니터링하는 방법
TWI760751B (zh) 2019-05-29 2022-04-11 美商美國禮來大藥廠 Tigit及pd-1/tigit-結合分子
CN112300279A (zh) * 2019-07-26 2021-02-02 上海复宏汉霖生物技术股份有限公司 针对抗cd73抗体和变体的方法和组合物
CA3157024A1 (en) 2019-10-03 2021-04-08 Xencor, Inc. Targeted il-12 heterodimeric fc-fusion proteins
TW202128757A (zh) 2019-10-11 2021-08-01 美商建南德克公司 具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白
EP4054722A1 (en) 2019-11-05 2022-09-14 Merck Patent GmbH Anti-tigit antibodies and uses thereof
US20230057899A1 (en) 2019-12-05 2023-02-23 Compugen Ltd. Anti-pvrig and anti-tigit antibodies for enhanced nk-cell based tumor killing
CN112409450B (zh) * 2020-03-29 2023-01-24 郑州大学 TIGIT-IgV的亲和剂及其应用
CN114507284B (zh) * 2020-05-09 2023-05-26 华博生物医药技术(上海)有限公司 抗tigit的抗体、其制备方法和应用
CR20220611A (es) 2020-06-02 2023-06-07 Arcus Biosciences Inc Anticuerpos anti-tigit
US20210395366A1 (en) 2020-06-18 2021-12-23 Genentech, Inc. Treatment with anti-tigit antibodies and pd-1 axis binding antagonists
TW202216778A (zh) 2020-07-15 2022-05-01 美商安進公司 Tigit及cd112r阻斷
CN116406369A (zh) 2020-10-05 2023-07-07 百时美施贵宝公司 用于浓缩蛋白质的方法
WO2022111612A1 (zh) * 2020-11-26 2022-06-02 信达生物制药(苏州)有限公司 包含抗tigit/pd-1双特异性抗体的制剂及其制备方法和用途
AR125753A1 (es) 2021-05-04 2023-08-09 Agenus Inc Anticuerpos anti-tigit, anticuerpos anti-cd96 y métodos de uso de estos
JP2024527049A (ja) 2021-07-28 2024-07-19 ジェネンテック, インコーポレイテッド がんを治療するための方法及び組成物
TW202321308A (zh) 2021-09-30 2023-06-01 美商建南德克公司 使用抗tigit抗體、抗cd38抗體及pd—1軸結合拮抗劑治療血液癌症的方法
CN114149489B (zh) * 2021-11-18 2023-12-15 厦门大学 一种靶向tigit的放射性标记化合物及其制备方法和应用
WO2023173011A1 (en) 2022-03-09 2023-09-14 Bristol-Myers Squibb Company Transient expression of therapeutic proteins
CN119031933B (zh) * 2022-04-12 2025-08-26 正大天晴(广州)医药有限公司 蛋白酶体抑制剂与抗pd-1抗体的药物组合
JP2025523387A (ja) 2022-06-07 2025-07-23 ジェネンテック, インコーポレイテッド 抗pd-l1アンタゴニストおよび抗tigitアンタゴニスト抗体を含む、肺がん治療の有効性を判定するための方法
WO2024163477A1 (en) 2023-01-31 2024-08-08 University Of Rochester Immune checkpoint blockade therapy for treating staphylococcus aureus infections
CN120826478A (zh) 2023-03-06 2025-10-21 基因泰克公司 用于非小细胞肺癌的预后和治疗方法
WO2025174933A1 (en) 2024-02-14 2025-08-21 Genentech, Inc. Methods for treatment of pancreatic cancer with anti-pd-l1 ab, anti-tigit ab, gemcitabine and nab-placlitaxel

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0811857A2 (pt) * 2007-05-14 2014-10-21 Biogen Idec Inc Regiões fc (scfc) de cadeia simples, polipeptídeos de aglutinação que as compreendem e métodos relacionados.
MX2010011088A (es) * 2008-04-09 2010-11-05 Genentech Inc Composiciones y metodos novedosos para el tratamiento de las enfermedades relacionadas con la inmunidad.
DK2925350T3 (da) * 2012-12-03 2019-05-13 Bristol Myers Squibb Co Øgning af virksomheden mod cancer af immunomodulatoriske fc- fusionsproteiner
US9327014B2 (en) * 2012-12-04 2016-05-03 Oncomed Pharmaceuticals, Inc. Immunotherapy with binding agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11390678B2 (en) 2008-04-09 2022-07-19 Genentech, Inc. Compositions and methods for the treatment of immune related diseases

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